Tag: 100-200

In 2019,Nanotechnology included an article by Wu, Hongshuai; You, Chaoqun; Jiao, Jia; Chen, Fanghui; Sun, Baiwang; Zhu, Xiaoli. SDS of cas: 2623-87-2. The article was titled 《A novel near-infrared triggered dual-targeted nanoplatform for mitochondrial combined photothermal-chemotherapy of cancer in vitro》. The information in the text is summarized as follows:

A combination of photothermal-chemotherapy has received widespread attention in drug delivery systems for cancer treatment. However, the combination therapy operated in subcellular organelles, such as mitochondria, has been rarely reported. Herein, we designed a novel near-IR (NIR) triggered dual-targeted nanoplatform (FA/TPP-DINPs) based on mitochondrial combined photothermal-chemotherapy by co-loading FDA-approved NIR dye indocyanine green (ICG) and anticancer drug doxorubicin (DOX). The resulting nanoparticles showed a monodispersed sphere and excellent colloidal stability. Specially, the simultaneous introduction of targeted ligands folic acid (FA) and triphenylphosphine (TPP) to nanoparticles significantly promoted the cellular internalization and mitochondrial co-localization of nanoparticles. Moreover, the encapsulated dye could convert NIR light into heat with high efficiency, which makes the FA/TPP-DINPs an effective platform for mitochondrial combination therapy with chemotherapy drug DOX. Meanwhile, the thermal expansion in response to the change of temperature after sustained 808 nm laser irradiation could cause the disintegration of nanoparticles, which triggered the rapid release of DOX from nanoparticles. As expected, the prepared FA/TPP-DINPs exhibited evidently enhanced cytotoxicity and preeminent combination therapy efficiency on MCF-7 cells. Thus, the NIR triggered dual-targeted nanoplatform provides a new drug delivery strategy for mitochondrial combined photothermal-chemotherapy of cancer. The experimental process involved the reaction of 4-Bromobutanoic acid(cas: 2623-87-2SDS of cas: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).SDS of cas: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yang, Peng-Fei; Zhu, Lei; Liang, Jian-Xing; Zhao, Han-Tong; Zhang, Jian-Xin; Zeng, Xian-Wang; Ouyang, Qin; Shu, Wei published an article in ACS Catalysis. The title of the article was 《Regio- and Enantioselective Hydroalkylations of Unactivated Olefins Enabled by Nickel Catalysis: Reaction Development and Mechanistic Insights》.Quality Control of (Bromomethyl)cyclopropane The author mentioned the following in the article:

Direct construction of fully alkyl-substituted tertiary chiral centers remote to activating groups is highly challenging and desirable. Herein, a Ni-catalyzed enantioselective hydroalkylation of unactivated alkenes with unactivated alkyl halides at room temperature is reported, providing a general and practical access to fully alkyl-substituted tertiary stereogenic carbon centers not adjacent to activating groups. This reaction undergoes regio- and stereoselective hydrometalation of unactivated alkenes with a nontrivial Markovnikov selectivity, followed by cross-coupling with unactivated alkyl electrophiles to access trialkyl tertiary saturated stereogenic centers not adjacent to activating groups. The mild and robust conditions enable the use of terminal and internal unactivated alkenes and unactivated primary and secondary alkyl, benzyl and propargyl halides to construct diverse trialkyl tertiary stereogenic carbon centers with broad functional group tolerance. Moreover, exptl. investigations support the reaction undergoing irreversible and stereoselective hydrometalation of alkenes. D. functional theory calculations provide further insights into the reaction mechanism, suggesting a stereoselective migration insertion of alkenes with Ni(II)-H species. Finally, the origin of the regio- and enantioselectivities was also investigated. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Quality Control of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Quality Control of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Gong; Zhao, Chao-Yang; Min, Xiang-Ting; Li, Ying; Zhang, Xiang-Xin; Liu, Heng; Ji, Ding-Wei; Hu, Yan-Cheng; Chen, Qing-An published an article in Nature Catalysis. The title of the article was 《Nickel-catalysed asymmetric heteroarylative cyclotelomerization of isoprene》.Recommanded Product: 7051-34-5 The author mentioned the following in the article:

Monoterpenoids are a class of isoprenoids produced from geranyl diphosphate by various monoterpene synthases. Nature has evolved over millions of years to produce various cyclic monoterpenoids. Herein, authors present a serendipitous creation of an unnatural monoterpene skeleton through heteroarylative telomerization of isoprene with heterocycles. Under nickel catalysis, a series of cyclic monoterpene derivatives bearing quaternary carbon stereocentre are constructed with up to 98% yield and 97% enantiomeric excess. Preliminary mechanistic studies suggest this atom-economic reaction proceeds through an enantioselective dimerization of isoprene and a sequential C-H alkylation of heterocycles pathway. This work not only contributes an efficient enantioselective transformation of bulk chem. isoprene, but also provides a guide to create an unnatural monoterpene framework that may exhibit different biol. activities. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Tan, Yu-Fang; Long, Chao-Jiu; Guan, Zhi; He, Yan-Hong published an article in Green Chemistry. The title of the article was 《Selective electrochemical oxidation of tetrahydroquinolines to 3,4-dihydroquinolones》.Related Products of 7051-34-5 The author mentioned the following in the article:

Authors report an environmentally friendly electrochem. oxidation of tetrahydroquinolines to 3,4-dihydroquinolones. The reaction uses electricity as a “”traceless”” oxidant, O2 as a “”green”” oxygen source, and 2,2,6,6-tetramethylpiperidinooxy (TEMPO) as a redox mediator. NaI not only acts as an electrolyte, but may also act as a redox mediator. The reaction shows high selectivity and good functional group tolerance. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Related Products of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Related Products of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Rui; Liu, Wentao; Wang, Qian; Lu, Yang published an article in Analytical Methods. The title of the article was 《A paper-analytical device for detecting bisphenol-A in foods》.Electric Literature of C6H11BrO2 The author mentioned the following in the article:

Bisphenol A (BPA) is a plastic monomer that can leach into food and cause adverse health effects with long-term exposure. In this study, we developed simple paper-anal. devices (PADs) for detecting BPA in food. The PADs were designed with hydrophilic and hydrophobic areas via wax printing. The hydrophilic areas were designed as a detection zone and modified with CM-cellulose (CMC) for the immobilization of BPA-bovine serum albumin (BSA). The monoclonal antibodies against BPA were generated and modified with quantum dots (QDs) to synthesize QD-antibody (QD-Ab) probes. Detection conditions of the assay were optimized, with results of 0.1 μg of BPA-BSA and 30-fold diluted QD-Ab probes. The detection limit was 0.098 μg L-1 using ImageJ anal. Samples of drinking water, green tea beverage and peanut cooking oil were selected to conduct the matrix effect study. The recovery rates of BPA in different samples ranged from 78.77% to 118.96%, proving that the PADs were a simple and sensitive detection method for easy, low-cost anal. of real food samples. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Electric Literature of C6H11BrO2) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Electric Literature of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Guang-Qi; Bai, Jing-Wen; Li, En-Ci; Liu, Kai-Hui; Sheng, Fei-Fei; Zhang, Hong-Hai published an article in 2021. The article was titled 《Synthesis of Multideuterated (Hetero)aryl Bromides by Ag(I)-Catalyzed H/D Exchange》, and you may find the article in Organic Letters.Reference of 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

Herein, a direct H/D exchange protocol was disclosed for deuteration of (hetero)aryl bromides using Ag2CO3 as catalyst and D2O as deuterium source. This protocol was highly efficient, simply manipulated and appliable for deuterium-labeling of over 55 (hetero)aryl bromides including bioactive druglike mols. and key intermediates of functional materials. In addition, this method showed distinguishing site-selectivity toward the existing transition-metal-catalyzed HIE process, leading to multideuterated (hetero)aryl bromides in one step. In the experiment, the researchers used many compounds, for example, 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Reference of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Reference of 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Jialong; Mason, Alexander H.; Motta, Alessandro; Cesar, Laryssa G.; Kratish, Yosi; Lohr, Tracy L.; Miller, Jeffrey T.; Gao, Yanshan; Marks, Tobin J. published an article in 2021. The article was titled 《Surface vs Homogeneous Organo-Hafnium Catalyst Ion-Pairing and Ligand Effects on Ethylene Homo- and Copolymerizations》, and you may find the article in ACS Catalysis.Formula: C9H11Br The information in the text is summarized as follows:

Heterogeneous catalysts have long dominated polyethylene and polypropylene production, but understanding their catalysis is challenged by uncertainties in active site structures and percentages. Surface-bound organometallic catalysts are an emerging strategy to combine successful homogeneous catalysts having well-understood structures, relatively high percentages of active sites, and exceptional control of selectivity, with the attractions of surface catalysts, to transition promising homogeneous systems to large-scale heterogeneous ones. Nevertheless, surface-bound olefin polymerization catalysts typically produce ultrahigh Mw’s but with low activity and comonomer selectivity. Here, the authors report the systematic synthesis and characterization of pyridylamido-Hf complexes and their corresponding surface catalysts chemisorbed on sulfated alumina (AlS) and zirconia (ZrS). Comparative ethylene homo- and 1-octene copolymerizations reveal similar activity and 1-octene selectivity trends in the homogeneous and heterogeneous systems. For the surface pyridylamido-Hf catalyst series, large variations in activity (up to 10x) and 1-octene incorporation (up to 28x) are achieved by ligand and support manipulation. While the homogeneous catalysts exhibit pos. comonomer effects in ethylene/1-octene copolymerization, the surface catalysts behave oppositely. Extended x-ray absorption fine structure (EXAFS) reveals significantly elongated Hf···O bond distances vs. typical Hf-O covalent bonds (2.06 vs. 1.97 Å). D. functional theory (DFT) anal. of the heterolytic ion pair separation enthalpies, olefin insertion energetics, and NBO/Bader charges also suggest electrostatic Hf cation-anionic support binding and catalytic patterns, which are modulated by the ion-pairing energetics and ligand architecture. The results came from multiple reactions, including the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Formula: C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Formula: C9H11Br Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Feng, Haowei; Zhao, Yukun; Liu, Pengkang; Hu, Lin published an article in 2021. The article was titled 《Sc(OTf)3-Catalyzed C-C Bond-Forming Reaction of Cyclic Peroxy Ketals for the Synthesis of Highly Functionalized 1,2-Dioxene Endoperoxides》, and you may find the article in Organic Letters.Recommanded Product: 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

Scandium triflate-catalyzed C-C bond-forming reaction of 3-(2-methoxyethoxy)-endoperoxy ketals with silyl ketene acetals, silyl enol ethers, allyltrimethylsilane, and trimethylsilyl cyanide was developed via the reactive peroxycarbenium ions. A wide range of complicated 3,3,6,6-tetrasubstituted 1,2-dioxenes bearing adjacent quaternary carbons and 3-acetyl/allyl/cyano functional groups in good yields at room temp were prepared Notably, the resultant 1,2-dioxenes were structurally stable, which was transformed into another important 1,2-dioxane endoperoxide under conventional hydrogenation conditions without deconstructing the weak O-O bond. In addition to this study using 1-Bromo-2-isopropylbenzene, there are many other studies that have used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 1-Bromo-2-isopropylbenzene) was used in this study.

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Recommanded Product: 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Zichen; Fang, Huaquan; Liu, Guixia; Huang, Zheng published their research in Organic Letters in 2021. The article was titled 《Ruthenium-Catalyzed Dual Dehydrogenative Silylation of C(sp3)-H Bonds: Access to Diverse Silicon-Centered Spirocycles》.Computed Properties of C9H11Br The article contains the following contents:

The authors report herein a pincer Ru-catalyzed dual intramol. dehydrogenative silylation of primary C(sp3)-H bonds. The reaction features high efficiency, scalability, and good functional group tolerance, allowing a facile and atom-economical access to structurally diverse Si-centered spirocycles, including unprecedented oxa-spirosilabiindanes and aza-spirosilabiindanes. In the experiment, the researchers used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Computed Properties of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Computed Properties of C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Saleh, Maysaa M.; Laughton, Charles A.; Bradshaw, Tracey D.; Moody, Christopher J. published 《Correction: Development of a series of bis-triazoles as G-quadruplex ligands [Erratum to document cited in CA170:314024]》.RSC Advances published the findings.Reference of Methyl 3-bromopropanoate The information in the text is summarized as follows:

The country of affiliation c was shown incorrectly in the original article; the correction is provided here. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3Reference of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Reference of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary