Tag: 100-200

Zhang, Pengbo; Li, Wenwu; Qu, Weilong; Shu, Zhigang; Tao, Yingjun; Lin, Jinming; Gao, Xia published their research in Organic Letters on December 3 ,2021. The article was titled 《Copper and Photocatalytic Radical Relay Enabling Fluoroalkylphosphorothiolation of Alkenes: Modular Synthesis of Fluorine-Containing S-Alkyl Phosphorothioates and Phosphorodithioates》.Application In Synthesis of Ethylbromofluoroacetate The article contains the following contents:

A photoredox and copper-catalyzed fluoroalkylphosphorothiolation of activated and unactivated alkenes via a radical relay mechanism is reported. By employing fluoroalkyl halides as radical precursors and P(O)SH or P(S)SH compounds as coupling partners, a wide range of β-monofluoroalkyl-, -difluoroalkyl-, -trifluoromethyl-, or -perfluoroalkyl-substituted S-alkyl phosphorothioates and phosphorodithioates can be easily constructed under mild conditions with good functional group tolerance. Furthermore, this modular reaction system can be successfully applied to late-stage functionalization of bioactive mols. In the experimental materials used by the author, we found Ethylbromofluoroacetate(cas: 401-55-8Application In Synthesis of Ethylbromofluoroacetate)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application In Synthesis of Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Huihui; Kou, Luyao; Chen, Dong; Ji, Meishan; Bao, Xiaoguang; Wu, Xinxin; Zhu, Chen published their research in Organic Letters on August 7 ,2020. The article was titled 《Radical-Mediated Distal Ipso-Migration of O/S-Containing Heteroaryls and DFT Studies for Migratory Aptitude》.COA of Formula: C4H6BrFO2 The article contains the following contents:

Herein we describe an efficient distal ipso-migration of O- and S-containing heteroaryls and the radical heteroarylation of unactivated alkenes. The migration is triggered by various fluoroalkyl radicals, leading to valuable multifunctionalized ketones. The comparisons of migratory aptitude for O-/S-containing heteroaryls are comprehensively investigated. The origin of the chemoselective migration could be partially attributed to the discrepancy in the energy level of the LUMO of each heteroaryl group. The results came from multiple reactions, including the reaction of Ethylbromofluoroacetate(cas: 401-55-8COA of Formula: C4H6BrFO2)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.COA of Formula: C4H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Luan, Yu-Yong; Gou, Xue-Ya; Shi, Wei-Yu; Liu, Hong-Chao; Chen, Xi; Liang, Yong-Min published an article on February 11 ,2022. The article was titled 《Three-Component Ruthenium-Catalyzed meta-C-H Alkylation of Phenol Derivatives》, and you may find the article in Organic Letters.SDS of cas: 401-55-8 The information in the text is summarized as follows:

Herein, synthesis of phenyl-(pyrimidinyloxyphenyl)butanoates I [R1 = H, Me, Cl, etc.; R2 = H, Me, F, etc; R3 = Me, F; R4 = Ph, 4-FC6H4, 4-BrC6H4, etc.; R2 = R3 = Me, F; R5 = OEt, piperidin-1-yl, N(n-Bu)2] via three-component ruthenium catalyzed C-H alkylation of phenoxypyrimidines and vinylbenzene and ethyl-bromo-difluoroacetates/alkyl bromides was reported. This strategy exhibited good substrates suitability and functional group tolerance with various phenol derivatives, which provided a synthetic potential drug approach. Mechanistic studies showed that a radical process might be involved in this process. In addition, the meta alkylated phenol was obtained by further removal of the directing group. The experimental process involved the reaction of Ethylbromofluoroacetate(cas: 401-55-8SDS of cas: 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.SDS of cas: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of EthylbromofluoroacetateOn May 1, 2020 ,《Photocatalytic Remote Oxyfluoroalkylation of Heteroalkynes: Regio-, Stereo-, and Site-Selective Access to Complex Fluoroalkylated (Z)-Alkenes》 appeared in Organic Letters. The author of the article were Shang, Tianbo; Zhang, Junhua; Zhang, Yan; Zhang, Fang; Li, Xin-Sheng; Zhu, Gangguo. The article conveys some information:

A visible-light-induced remote oxyfluoroalkylation, including ketofluoroalkylation and hydroxytrifluoromethylation, of heteroalkynes is developed with DMSO (DMSO) and H2O as the oxygen source, resp. It provides a facile access to complex fluoroalkylated (Z)-alkenes in satisfactory yields with excellent regio-, stereo-, and site-selectivity. The reaction involves an uncommon vinyl radical-induced intermol. C(sp3)-H functionalization, thus offering a good platform for the development of remote difunctionalization of alkynes. The results came from multiple reactions, including the reaction of Ethylbromofluoroacetate(cas: 401-55-8Safety of Ethylbromofluoroacetate)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Safety of Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 1-Bromo-2-isopropylbenzeneIn 2016 ,《Enantiopure C1-symmetric N-heterocyclic carbene ligands from desymmetrized meso-1,2-diphenylethylenediamine: application in ruthenium-catalyzed olefin metathesis》 was published in Catalysts. The article was written by Paradiso, Veronica; Menta, Sergio; Pierini, Marco; Della Sala, Giorgio; Ciogli, Alessia; Grisi, Fabia. The article contains the following contents:

In order to design improved chiral ruthenium catalysts for asym. olefin metathesis, enantiomeric catalysts incorporating C1-sym. N-Heterocyclic carbenes (NHC) ligands with syn-related substituents on the backbone were synthesized starting from meso-1,2-diphenylethylenediamine. The absolute configuration of the enantiomers of the desymmetrized meso diamine was assigned by optical rotation anal. and in silico calculations, and was found to be maintained in their resp. ruthenium catalysts by comparison of the relative electronic CD (ECD) spectra. The catalytic behavior of the enantiomeric ruthenium complexes was investigated in model asym. metathesis transformations and compared to that of analogus complexes bearing C1-sym. NHC ligands with an anti backbone. Modest enantioselectivities were registered and different catalyst properties depending on the nature of stereochem. relationship of substituents on the backbone were observed After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. Recommanded Product: 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 3395-91-3In 2020 ,《Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation》 was published in Bioorganic Chemistry. The article was written by Xu, Ana; He, Feng; Zhang, Xiangna; Li, Xiaoyang; Ran, Yingying; Wei, Chao; James Chou, C.; Zhang, Rui; Wu, Jingde. The article contains the following contents:

In order to develop multitarget-directed ligands as potential treatments for Alzheimer’s disease, twenty-eight new tacrine-hydroxamate derivatives were designed, synthesized, and biol. evaluated. As expected, most of the compounds exhibited inhibitory activities against cholinesterases (ChEs) and histone deacetylase (HDACs). Among the tested compounds, I showed not only potent and selective inhibition on AChE at sub-nanomolar potency (AChEIC50 = 0.12 nM, BChEIC50 = 361.52 nM) but also potent inhibition on HDAC (IC50 = 0.23 nM). Moreover, I exhibited inhibitory activity on Aβ1-42 self-aggregation as well as disaggregation activity on pre-formed Aβ fibrils. Furthermore, I exhibited antioxidant activity and metal chelating properties. Further mechanistic studies demonstrated that I is a pan-inhibitor of HDACs and a mixed-type inhibitor for AChE. It was shown that I is a BBB penetrant by online prediction. Taken together, the results indicate that I can serve as a lead compound to develop promising candidate analogs as AD therapeutics. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Application of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C4H7BrIn 2020 ,《General sulfone construction via sulfur dioxide surrogate control》 was published in Green Chemistry. The article was written by Chen, Shihao; Li, Yaping; Wang, Ming; Jiang, Xuefeng. The article contains the following contents:

A highly efficient one-step synthesis of alkyl-alkyl and aryl-alkyl sulfones with a facile combination of halides, sulfur dioxide surrogates and phosphate esters is described. When thiourea dioxide was employed as a reductive sulfur dioxide surrogate, alkyl-alkyl sulfones were obtained under transition metal free conditions. Aryl-alkyl sulfones were obtained with an extremely low catalytic loading (0.2 mol%) via altering the mask of sulfur dioxide surrogates to sodium dithionite. A phosphate ester was employed as a stable and readily available alkyl source. Notably, this protocol has been applied to the late-stage modification of natural products and bioactive mols. Thus, e.g., treatment of (2-bromoethyl)benzene with thiourea dioxide and P(:O)(OMe)3 in presence of Cs2CO3, KI and TBAI afforded [2-(methylsulfonyl)ethyl]benzene (71%). In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Synthetic Route of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Synthetic Route of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 4-Bromobutanoic acidIn 2019 ,《Commercial Polymer Microsphere Grafted TBD-Based Ionic Liquids as Efficient and Low-Cost Catalyst for the Cycloaddition of CO2 with Epoxides》 appeared in Catalysis Letters. The author of the article were Dai, Weili; Mao, Jie; Liu, Ying; Mao, Pei; Luo, Xubiao; Zou, Jianping. The article conveys some information:

Development of efficient, cheap and recyclable catalysts for the synthesis of cyclic carbonates from CO2 and epoxides is still a very attractive topic. Herein, the polymer grafted TBD-(1,5,7-triazabicyclo[4.4.0]dec-5-ene)-based ionic liquids (ILs) were fabricated from com. available polystyrene (PS) and ingredients of the ILs, and used as heterogeneous catalysts for the conversion of CO2 into cyclic carbonates in the absence of solvent and co-catalyst. To improve the catalytic performance, various substitutes (such as -COOH, -OH and -NH2) were functionalized on the TBD cation. Among the as-obtained catalysts, carboxyl-containing catalyst (PS-[CETBD]Br) showed superior activity than others, which may be attributed to the stronger polarization capability of -COOH on the C-O bond of epoxide through the formed hydrogen bonding. Addnl., the combined synergistic effect of the nucleophilic attack by the halide anions also account for the facile ring-opening of epoxide. It is noted that CO2 can be activated by the formation of carbamate between CO2 and alk. nitrogen of the TBD cations, thus facilitating the formation of cyclic carbonates. Moreover, the catalyst shows good chem. stability and catalytic reusability, which is very important for the practical conversion of CO2 in chem. industry. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Safety of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Safety of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Dependence of the Properties of 2D Nanocomposites Generated by Covalent Crosslinking of Nanosheets on the Interlayer Separation: A Combined Experimental and Theoretical Study》 were Singh, Reetendra; Gupta, Uttam; Kumar, V. Sampath; Ayyub, Mohd Monis; Waghmare, Umesh V.; Rao, C. N. R.. And the article was published in ChemPhysChem in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:

Covalently cross-linked heterostructures of 2D materials are a new class of materials which possess electrochem. and photochem. hydrogen evolution properties. It was of considerable interest to investigate the role of interlayer spacing in the nanocomposites involving MoS2 and graphene sheets and its control over electronic structures and catalytic properties. We have investigated this problem with emphasis on the hydrogen evolution properties of these structures by a combined exptl. and theor. study. We have linked MoS2 based nanocomposites with other 2D materials with varying interlayer spacing by changing the linker and studied their hydrogen evolution properties. The hydrogen evolution activity for these composites decreases with increasing linker length, which we can link to a decrease in magnitude of charge transfer across the layers with increasing interlayer spacing. Factors such as the nature of the sheets, interlayer distance as well as the nature of the linker provide pathways to tune the properties of covalently cross-linked 2D material rendering this new class of materials highly interesting. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Category: bromides-buliding-blocks)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《End-Chain Fluorescent Highly Branched Poly(L-lactide)s: Synthesis, Architecture-Dependence, and Fluorescent Visible Paclitaxel-Loaded Microspheres》 were Bian, Yufei; Leng, Xuefei; Wei, Zhiyong; Wang, Zefeng; Tu, Zhu; Wang, Yanshai; Li, Yang. And the article was published in Biomacromolecules in 2019. COA of Formula: C6H11BrO2 The author mentioned the following in the article:

A facile method in combination of “”grafting from”” and “”end-functionalization”” was developed for the synthesis of fluorescent highly branched poly(L-lactide)s (PLLA-COU) via ring opening polymerization (ROP) and esterification end-capping. These resulting PLLA-COU with four kinds of architectures, including linear, star, linear-comb, and star-comb structures, were subjected to characterization and application as fluorescent visible paclitaxel-loaded microspheres. The mutual effects of architecture and end-groups on thermal and fluorescence properties, enzymic degradation, and drug release behaviors were focused. Contrast to linear and star PLLA-COU, two comb-shaped analogs demonstrated higher fluorescence quantum yield, faster drug release, and lower enzymic degradation rate. All the fluorescent microspheres could maintain fluorescence traceability. The fluorescent PLLA-COU displayed negligible toxicity and good biocompatibility. This work highlights that the fluorescent highly branched poly(L-lactide)s are properties-tailored and used as fluorescent visible drug delivery systems (DDS) for potential theranostic applications. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5COA of Formula: C6H11BrO2) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.COA of Formula: C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary