Tag: 100-200

Reference of Ethyl 3-bromopropanoateIn 2022 ,《Photochemical aerobic oxidation of sulfides to sulfoxides: the crucial role of wavelength irradiation》 was published in Green Chemistry. The article was written by Skolia, Elpida; Gkizis, Petros L.; Nikitas, Nikolaos F.; Kokotos, Christoforos G.. The article contains the following contents:

Herein, a novel, sustainable, light-driven protocol was reported for photochem. aerobic oxidation of sulfides to sulfoxides RS(O)R1 [R = Ph, naphth-2-yl, n-Bu, etc.; R1 = Me, Et, n-Pr, etc.], where the impact of wavelength irradiation on sulfide aerobic photooxidation was examined In this work, two different low-catalyst loading (0.05-0.5 mol%) protocols, utilizing anthraquinone as the photocatalyst (under CFL lamps or 427 nm irradiation) were developed and a catalyst-free protocol (under 370 nm irradiation) was also assessed. In addition, a broad scope of substrates was tested and extensive mechanistic studies were performed, in order to distinguish the mechanistic pathways that were followed in the different cases of aryl or alkyl sulfide oxidation under different wavelength irradiation Also implemented this protocols toward the oxidation of several intermediates en route to Sulforaphane. After reading the article, we found that the author used Ethyl 3-bromopropanoate(cas: 539-74-2Reference of Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Reference of Ethyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cruz, Daniel A.; Sinka, Victoria; de Armas, Pedro; Steingruber, Hugo Sebastian; Fernandez, Israel; Martin, Victor S.; Miranda, Pedro O.; Padron, Juan I. published their research in Organic Letters in 2021. The article was titled 《Iron(II) and Copper(I) Control the Total Regioselectivity in the Hydrobromination of Alkenes》.Related Products of 539-74-2 The article contains the following contents:

A new method that allowed the complete control of the regioselectivity of the hydrobromination reaction of alkenes was described. Herein, a radical procedure with TMSBr and oxygen as common reagents, where the formation of the anti-Markovnikov product occurs in the presence of ppm amounts of the Cu(I) species and the formation of the Markovnikov product occurred in the presence of 30 mol % iron(II) bromide was reported. D. functional theory calculations combined with Fukui’s radical susceptibilities support the obtained results. In the experiment, the researchers used Ethyl 3-bromopropanoate(cas: 539-74-2Related Products of 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Related Products of 539-74-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Oxidative Addition of C-X Bonds and H-H Activation Using PNNP-Iron Complexes》 was published in ChemistrySelect in 2020. These research results belong to Gautam, Monika; Yatabe, Takafumi; Tanaka, Shinji; Satou, Naoto; Takeshita, Tomohiro; Yamaguchi, Kazuya; Nakajima, Yumiko. Safety of (Bromomethyl)cyclopropane The article mentions the following:

Iron(0) complex bearing a phenanthroline-based meridional PNNP ligand [{Fe(PNNP)}2(μ-N2)] (1) (PNNP = 2,9-bis((diphenylphosphino)methyl)-1,10-phenanthroline) smoothly reacted with CH3I at ambient temperature to cleave C-I bond, resulting in the formation of the corresponding oxidative addition product, [Fe(CH3)(I)(PNNP)] (2). Complex 2 was fully identified by NMR and its structure was determined by a single crystal x-ray diffraction study. Mechanistic study using cyclopropylmethyl bromide as a radical clock supported a radical pathway for the C-I bond cleavage of CH3I. Complex 2 underwent deprotonation on treatment with NaOtBu to form 4, which possessed a dearomatized phenanthroline backbone. Complex 4 further reacted with H2 to cleave H-H bond. The reaction was mediated by metal-ligand cooperation process that involves re-aromatization of the phenanthroline backbone of the PNNP ligand. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Safety of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Safety of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold》 were Li, Zheng; Ren, Qiang; Wang, Xuekun; Zhou, Zongtao; Hu, Lijun; Deng, Liming; Guan, Li; Qiu, Qianqian. And the article was published in Bioorganic Chemistry in 2019. Application of 7051-34-5 The author mentioned the following in the article:

Based on a previously reported phenoxyacetic acid scaffold, compound 7 (HWL-088) has been identified as a superior free fatty acid receptor 1 (FFA1) agonist by comprehensive structure-activity relationship study. Our results indicated that the introduction of ortho-fluoro greatly increased the activity of phenoxyacetic acid series, and the unique structure-activity relationship in biphenyl moiety is different from previously reported FFA1 agonists. Moreover, the modeling study was also performed to better understand the binding mode of present series. Compound 7 significantly improved glucose tolerance both in normal and diabetic models, and even exerted greater potential on glucose control than that of TAK-875. These findings provided a novel candidate HWL-088, which is currently in preclin. study to evaluate its potential for the treatment of diabetes. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Dong, Pei-Zhen; Qiu, Bin; An, Xiao-De; Xiao, Jian published an article in Green Chemistry. The title of the article was 《Cascade dearomative [4 + 2] cycloaddition of indoles with in situ generated ortho-quinone methides: practical access to divergent indoline-fused polycycles》.Computed Properties of C7H5BrO The author mentioned the following in the article:

A rationally designed cascade dearomative [4 + 2] cycloaddition of indoles with in-situ generated ortho-quinone methide (o-QM) provided a practical, atom and step economical access to diverse indoline-fused polycycles with high yields and excellent diastereoselectivity in one step. These polycyclic indolines featured divergent [6-6-5] and [6-5-5] tricyclic core skeletons bearing three contiguous stereogenic centers. Appealingly, most of the products precipitating in ethanol solution, the use of room temperature, easy handling, broad substrate scope and gram-scale synthesis made this transformation an environmentally benign, effective and attractive method for the synthesis of polycyclic indolines. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Computed Properties of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Computed Properties of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Inomata, Tomohiko; Matsunaga, Ayaka; Jin, Guangzhu; Kitagawa, Takuma; Muramatsu, Mizuho; Ozawa, Tomohiro; Masuda, Hideki published an article in RSC Advances. The title of the article was 《Improvements in photoelectric performance of dye-sensitised solar cells using ionic liquid-modified TiO2 electrodes》.Reference of 4-Bromobutanoic acid The author mentioned the following in the article:

One of the major problems in dye-sensitized solar cells (DSSCs) is the aggregation of dyes on TiO2 electrodes, which leads to undesirable electron transfer. Various anti-aggregation agents, such as deoxycholic acid, have been proposed and applied to prevent dye aggregation on the electrodes. In this study, we designed and synthesized a phosphonium-type ionic liquid that can be modified on the TiO2 electrode surface and used as a new anti-aggregation agent. Although the modification of the ionic liquid onto the electrode reduced the amount of dye adsorbed on the electrode, it showed a significant anti-aggregation effect, thereby improving the photovoltaic performance of DSSCs with N3 and J13 dyes. This finding suggests that ionic liquids are effective as anti-aggregation agents for DSSCs. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kachkovskyi, Georgii; Cieslak, Marcin; Graczyk, Piotr; Zawadzki, Przemyslaw; Kalinowska-Tluscik, Justyna; Werlos, Mateusz published an article in 2022. The article was titled 《Photocatalytic Approach to α,α-Difluoroalkyl Alcohols》, and you may find the article in Synthesis.Quality Control of 4-Bromobutanoic acid The information in the text is summarized as follows:

A convenient approach to previously poorly accessible α,α-difluoroalkyl alcs. R1R2OHCCF2R3 [R1 = Ph, 3-MeC6H4, 4-MeOC6H4, etc.; R2 = H, Me; R3 = i-Pr, t-Bu, cyclohexyl, etc.] by visible light-mediated photocatalysis was developed. Broad scope of the transformation together with exptl. simplicity and scalability using flow techniques opened good prospects for further studies of properties (including biol.) of these novel products. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Quality Control of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Quality Control of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Yu-Zhong; Li, Yang; Lv, Gui-Fen; He, De-Liang; Li, Jin-Heng published an article in 2022. The article was titled 《Nickel-Catalyzed C-S Reductive Cross-Coupling of Alkyl Halides with Arylthiosilanes toward Alkyl Aryl Thioethers》, and you may find the article in Organic Letters.Reference of (Bromomethyl)cyclopropane The information in the text is summarized as follows:

A nickel-catalyzed C-S reductive cross-coupling of alkyl halides with arylthiosilanes for producing alkyl aryl thioethers is developed. This reaction is initiated by umpolung transformations of arylthiosilanes followed by C-S reductive cross-coupling with alkyl halides to manage an electrophilic alkyl group onto the electrophilic sulfur atom and then construct a C(sp3)-S bond, and features exquisite chemoselectivity, excellent tolerance of diverse functional groups, and wide applications for late-stage modification of biol. relevant mols. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Reference of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Reference of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pantelic, Nebojsa D.; Bozic, Bojan; Zmejkovski, Bojana B.; Banjac, Nebojsa R.; Dojcinovic, Biljana; Wessjohann, Ludger A.; Kaluderovic, Goran N. published an article in 2021. The article was titled 《In vitro evaluation of antiproliferative properties of novel organotin(IV) carboxylate compounds with propanoic acid derivatives on a panel of human cancer cell lines》, and you may find the article in Molecules.Name: Methyl 3-bromopropanoate The information in the text is summarized as follows:

The synthesis of novel triphenyltin(IV) compounds, Ph3SnLn (n = 1-3), with oxaprozin (3-(4,5-diphenyloxazol-2-yl)propanoic acid), HL1, and the new propanoic acid derivatives 3-(4,5-bis(4-methoxylphenyl)oxazol-2-yl)propanoic acid, HL2, and 3-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)propanoic acid, HL3, has been performed. The ligands represent com. drugs or their derivatives and the tin complexes have been characterized by standard anal. methods. The in vitro antiproliferative activity of both ligands and organotin(IV) compounds has been evaluated on the following tumor cell lines: human prostate cancer (PC-3), human colorectal adenocarcinoma (HT-29), breast cancer (MCF-7), and hepatocellular cancer (HepG2), as well as on normal mouse embryonic fibroblast cells (NIH3T3) with the aid of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. Contrary to the inactive ligand precursors, all organotin(IV) carboxylates showed very good activity with IC50 values ranging from 0.100 to 0.758 μM. According to the CV assay (IC50 = 0.218 ± 0.025 μM), complex Ph3SnL1 demonstrated the highest cytotoxicity against the caspase 3 deficient MCF-7 cell line. Inductively coupled plasma mass spectrometry (ICP-MS) anal. indicated a two-fold lower concentration of tin in MCF-7 cells in comparison to platinum. To investigate the mechanism of action of the compound Ph3SnL1 on MCF-7 cells, morphol., autophagy and cell cycle anal., as well as the activation of caspase and ROS/RNS and NO production, has been performed. Results suggest that Ph3SnL1 induces caspase-independent apoptosis in MCF-7 cells.Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Qiu, Shaotong; Gao, Xiang; Zhu, Shifa published their research in Chemical Science in 2021. The article was titled 《Dirhodium(II)-catalysed cycloisomerization of azaenyne: rapid assembly of centrally and axially chiral isoindazole frameworks》.Computed Properties of C4H7Br The article contains the following contents:

A dirhodium(II)-catalyzed asym. cycloisomerization reaction of azaenynes through a cap-tether synergistic modulation strategy, which represents the first catalytic asym. cycloisomerization of azaenynes. This reaction is highly challenging because of its inherent strong background reaction leading to racemate formation and the high capability of coordination of the nitrogen atom resulting in catalyst deactivation. Varieties of centrally chiral isoindazole derivatives was prepared in up to 99 : 1 d.r., 99 : 1 er and 99% yield and diverse enantiomerically enriched atropisomers bearing two five-membered heteroaryls was accessed by using an oxidative central-to-axial chirality transfer strategy. The tethered nitrogen atom incorporated into the starting materials enabled easy late-modifications of the centrally and axially chiral products via C-H functionalizations, which further demonstrated the appealing synthetic utilities of this powerful asym. cyclization.(Bromomethyl)cyclopropane(cas: 7051-34-5Computed Properties of C4H7Br) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Computed Properties of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary