Tag: 100-200

In 2019,ChemPhysChem included an article by Urner, Leonhard H.; Schade, Boris; Schulze, Maiko; Folmert, Kristin; Haag, Rainer; Pagel, Kevin. Electric Literature of C4H7BrO2. The article was titled 《Switchable Solubility of Azobenzene-Based Bolaamphiphiles》. The information in the text is summarized as follows:

The ability to design amphiphiles with predictable solubility properties is of everlasting interest in supramol. chem. Relevant structural parameters include the hydrophobic-hydrophilic balance and structural flexibility. In this work, we investigate the water solubility of azobenzene-based triglycerol bolaamphiphiles (TGBAs). In particular, we analyzed the structural effects of backbone hydrophobicity, flexibility, and cis/trans isomerization on the water solubility of a subset of five TGBAs. This leads to the first example of a non-ionic bolaamphiphile whose water solubility can be changed by irradiation with light. The underlying kinetics were monitored using liquid chromatog. and a closer anal. of the underlying aggregation processes provides a mechanistic understanding of the light-driven dissolution process. We anticipate that the results obtained will help to engineer bolaamphiphiles with predictable solution properties in the future. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Electric Literature of C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Electric Literature of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Yamada, Takeshi; Miki, Shouta; Ul’Husna, Anisa; Michikawa, Akiko; Nakatani, Kazuhiko published 《Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with Alkanethiol and Binding Properties of G-G Mismatch DNA》.Organic Letters published the findings.Product Details of 3395-91-3 The information in the text is summarized as follows:

Bis(naphthyridinecarbamates) of (mercaptoalkyl)dipropanolamines were prepared as thiol-containing DNA-binding compounds selective for G-G mismatches; in the presence of the G-G mismatch, the compounds undergo dimerization to form DNA complexes of the corresponding disulfides. The disulfide dimers of the naphthyridinecarbamates of (mercaptoalkyl)dipropanolamines produced 1:1 complexes with the dsDNA 5′-TCAACGGTTGA-3′:3′-AGTTGGCAACT-5′ with improved thermal stability and with higher pos. cooperativities than the corresponding thiols. The dimerization of bis(naphthyridinecarbamate) of a (mercaptoalkyl)dipropanolamine was selectively accelerated in the presence of CGG repeat DNA but not on CAG repeat DNA. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Product Details of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Product Details of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Serkov, I. V.; Proshin, A. N.; Ustinov, A. K.; Bachurin, S. O. published 《Nitroxyethylamides of carbazolecarboxylic acids》.Doklady Chemistry published the findings.Quality Control of Methyl 3-bromopropanoate The information in the text is summarized as follows:

A method of synthesis of carbazole-derived hybrid compounds containing nitroxy group as an NO-producing fragment was developed, the compounds were of interest as a base for designing potential remedies for the treatment of neurodegenerative diseases. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Quality Control of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Quality Control of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Exploring the Antiparasitic Activity of Tris-1,3,4-Thiadiazoles against Toxoplasma gondii-Infected Mice》 was written by Almutairi, Tahani M.; Rezki, Nadjet; Aouad, Mohamed Reda; Hagar, Mohamed; Bakr, Basant A.; Hamed, Moaaz T.; Hassen, Maha Khairy; Elwakil, Bassma H.; Moneer, Esraa Abdelhamid. Safety of Ethyl 4-bromobutyrateThis research focused onToxoplasma antiparasitic thiadiazoles antiinflammatory cytokines liver spleen brain; Toxoplasma gondii; antiparasite; docking studies; immunological studies; in vivo study; tris-1,3,4-thiadiazoles. The article conveys some information:

Nitrogen-containing atoms in their core structures have been exclusive building blocks in drug discovery and development. One of the most significant and well-known heterocycles is the 1,3,4-thidiazole nucleus, which is found in a wide range of natural products and therapeutic agents. In the present work, certain tris-1,3,4-thiadiazole derivatives (6, 7) were synthesized through a multi-step synthesis approach. All synthesized compounds were characterized using different spectroscopic tools. Previously, thiadiazole compounds as anti-Toxoplasma gondii agents have been conducted and reported in vitro. However, this is the first study to test the anti-Toxoplasma gondii activity of manufactured mol. hybrids thiadiazole in an infected mouse model with the acute RH strain of T. gondii. All the observed results demonstrated compound (7)′s powerful activity, with a considerable reduction in the parasite count reaching 82.6% in brain tissues, followed by liver and spleen tissues (65.35 and 64.81%, resp.). Inflammatory and anti-inflammatory cytokines assessments proved that Compound 7 possesses potent antiparasitic effect. Furthermore, docking tests against TgCDPK1 and ROP18 kinase (two major enzymes involved in parasite invasion and egression) demonstrated compound 7′s higher potency compared to compound 6 and megazol. According to the mentioned results, tris-1,3,4-thiadiazole derivatives under test can be employed as potent antiparasitic agents against the acute RH strain of T. gondii. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5Safety of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《B(C6F5)3-Catalyzed Hydrosilylation of Vinylcyclopropanes》 was written by Long, Peng-Wei; He, Tao; Oestreich, Martin. Recommanded Product: 1-Bromo-2-isopropylbenzeneThis research focused onvinylcyclopropane hydrosilane Lewis acid hydrosilylation catalyst; alkylsilane preparation. The article conveys some information:

A hydrosilylation of vinylcyclopropanes (VCPs) catalyzed by the strong boron Lewis acid B(C6F5)3 is reported. For the majority of VCPs, little or no ring opening of the cyclopropyl unit is observed Conversely, for VCPs with bulky R groups, such as ortho-substituted aryl rings or branched alkyl residues, ring opening is the exclusive reaction pathway. This finding is explained by the thwarted hydride delivery to a sterically shielded, β-silicon-stabilized cyclopropylcarbinyl cation intermediate. In addition to this study using 1-Bromo-2-isopropylbenzene, there are many other studies that have used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 1-Bromo-2-isopropylbenzene) was used in this study.

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Recommanded Product: 1-Bromo-2-isopropylbenzene The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C4H7BrIn 2022 ,《Rapid access to t-butylalkylated olefins enabled by Ni-catalyzed intermolecular regio- and trans-selective cross-electrophile t-butylalkylation of alkynes》 was published in Chemical Science. The article was written by Zhan, Yi-Zhou; Meng, Huan; Shu, Wei. The article contains the following contents:

Herein, we report the first Ni-catalyzed regio- and trans-selective cross-dialkylation of alkynes with two distinct alkyl bromides to afford olefins with two aliphatic substituents. The reductive conditions circumvent the use of organometallic reagents, enabling the cross-dialkylation process to occur at room temperature from two different alkyl bromides. This operationally simple protocol provides a straightforward and practical access to a wide range of stereodefined dialkylated olefins with broad functional group tolerance from easily available starting materials. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Synthetic Route of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Synthetic Route of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Catalyst-free ambient temperature synthesis of isoquinoline-fused benzimidazoles from 2-alkynylbenzaldehydes via alkyne hydroamination》 were Mishra, Manisha; Twardy, Dylan; Ellstrom, Clifford; Wheeler, Kraig A.; Dembinski, Roman; Torok, Bela. And the article was published in Green Chemistry in 2019. Electric Literature of C7H5BrO The author mentioned the following in the article:

An efficient environmentally benign route for the synthesis of benzimidazo[2,1-a]isoquinoline has been developed by reacting 2-ethynylbenzaldehyde and related substituted alkynylbenzaldehydes with variously substituted ortho-phenylenediamines and aliphatic amines in ethanol. This method provides a convenient, room temperature, atom-economical, and catalyst-free access to diversely substituted isoquinoline fused benzimidazoles. Regioselectivity of the reaction, as referred to o-phenylenediamines, was confirmed by X-ray crystallog. The reaction was found to occur in three major steps (imine formations, cyclization, and aromatization) and a mechanism has been proposed. In addition to this study using o-Bromobenzaldehyde, there are many other studies that have used o-Bromobenzaldehyde(cas: 6630-33-7Electric Literature of C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Electric Literature of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Visible-light-mediated Minisci C-H alkylation of heteroarenes with unactivated alkyl halides using O2 as an oxidant》 were Dong, Jianyang; Lyu, Xueli; Wang, Zhen; Wang, Xiaochen; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin. And the article was published in Chemical Science in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:

A protocol for direct visible-light-mediated Minisci C-H alkylation of heteroarenes, e.g., lepidine with unactivated alkyl halides RX (R = Pr, benzyl, 2-phenoxyethyl, adamantan-1-yl, etc.; X = Br, I) using mol. oxygen as an oxidant at room temp was reported. This mild protocol is compatible with a wide array of sensitive functional groups and has a broad substrate scope. Notably, functionalization of heterocyclic compounds e.g., I with unactivated alkyl halides proceeds smoothly under the standard conditions. The robustness of this protocol is further demonstrated by the late-stage functionalization of complex nitrogen-containing natural products and drugs e.g., II. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Category: bromides-buliding-blocks)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Organic Letters included an article by Tian, Ming-Qing; Wang, Cong; Hu, Xu-Hong; Loh, Teck-Peng. Synthetic Route of C4H7Br. The article was titled 《Divergent C-H Oxidative Radical Functionalization of Olefins to Install Tertiary Alkyl Motifs Enabled by Copper Catalysis》. The information in the text is summarized as follows:

An efficient tertiary alkylation reaction of olefins with 1,3-dicarbonyl compounds was developed by virtue of copper catalyst without the use of expensive ligands or additives. In contrast to alkyl Heck-type reaction, alkyl halide is not required. Notably, by varying the nitrogen and air atm., the reaction selectively produces alkylation and alkylation-oxygenation products, resp. Initial investigations revealed that an α-carbonyl alkyl radical species might be involved in the process. In addition to this study using (Bromomethyl)cyclopropane, there are many other studies that have used (Bromomethyl)cyclopropane(cas: 7051-34-5Synthetic Route of C4H7Br) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Synthetic Route of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Jiaguo; Xiao, Dian; Xie, Fei; Li, Wei; Zhao, Lei; Sun, Wei; Yang, Xiaohong; Zhou, Xinbo published an article in 2021. The article was titled 《Novel antibody-drug conjugate with UV-controlled cleavage mechanism for cytotoxin release》, and you may find the article in Bioorganic Chemistry.Application of 2969-81-5 The information in the text is summarized as follows:

Antibody-drug conjugates (ADCs) are being developed worldwide with the potential to revolutionize current cancer treatment strategies. However, off-target toxicity caused by the instability of linkers remains one of the main issues to be resolved. Developing a novel photocontrol-ADC with good stability and photocontrolled release seemed to be an attractive and practical solution In this study, we designed, for the first time, a novel UV light-controlled ADC by carefully integrating the UV-cleavable o-nitro-benzyl structure into the linker. Our preliminary work indicated that the ADC exhibited good stability and photocontrollability while maintaining a targeting effect similar to that of the naked antibody. Upon irradiation with UV light, the ADC rapidly released free cytotoxins and exerted significant cytotoxicity toward drug-resistant tumor cells. Compared to those of the unirradiated cells, the EC50 values of ADCs increased by up to 50-fold. Furthermore, our research confirmed that the degradation products of unirradiated ADC, Cys-1a, were relatively less toxic, thus potentially reducing the off-target toxicity caused by nonspecific uptake of ADCs. The novel design strategy of UV light-controlled ADCs may provide new perspectives for future research on ADCs and promote the development of photocontrol systems. The experimental part of the paper was very detailed, including the reaction process of Ethyl 4-bromobutyrate(cas: 2969-81-5Application of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Application of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary