Tag: 100-200

Zhang, Linfeng; Zheng, Jing; Zou, Wenya; Shu, Yongqi; Yang, Weiran published an article in 2021. The article was titled 《Microwave-Assisted Nickel-Catalyzed Rapid Reductive Coupling of Ethyl 3-iodopropionate to Adipic Acid》, and you may find the article in Catalysis Letters.Application of 539-74-2 The information in the text is summarized as follows:

3-Iodopropionic acid (3-IPA) can be efficiently synthesized from the glycerol derivative glyceric acid (GA), which is a potential biomaterial-based platform mol. In this report, Et 3-iodopropionate was rapidly dimerized to di-Et adipate in a microwave reactor using NiCl2.6H2O as a catalyst, co-catalyzed by Mn and the 1, 10-Phenanthroline monohydrate ligand. Under the optimum reaction conditions, di-Et adipate can be obtained with 84% yield at 90°C in just 5 min. Di-Et adipate was hydrolyzed to obtain the adipic acid (AA) in 89% yield with an acid catalyst. AA is an important chem. and a monomer for producing a wide range of high-performance polymeric substances. This rapid coupling method is also applicable to other alkyl halides. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-bromopropanoate(cas: 539-74-2Application of 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 539-74-2 Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Kai; Deng, Zi-Hao; Xie, Si-Jun; Zhai, Dan-Dan; Fang, Hua-Yi; Shi, Zhang-Jie published their research in Nature Communications in 2021. The article was titled 《Synthesis of arylamines and N-heterocycles by direct catalytic nitrogenation using N2》.HPLC of Formula: 7073-94-1 The article contains the following contents:

Herein, an example of direct catalytic nitrogenation was reported to afford valuable diarylamines, triarylamines, and N-heterocycles from easily available organohalides using dinitrogen (N2) as the nitrogen source in a one-pot/two-step protocol. In this protocol, lithium nitride, generated in situ with the use of lithium as a reductant, was confirmed as a key intermediate. Structurally diversified polyanilines were also generated in one pot, showing great potential for materials chem. This chem. provided an alternative pathway for catalytic nitrogenation to synthesize highly valuable N-containing chems. from dinitrogen. With this method, 15N atoms were easily incorporated into organic mols. In the experimental materials used by the author, we found 1-Bromo-2-isopropylbenzene(cas: 7073-94-1HPLC of Formula: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. HPLC of Formula: 7073-94-1 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Masked phenolic-selenium conjugates: potent and selective antiproliferative agents overcoming P-gp resistance》 was written by Begines, Paloma; Sevilla-Horrillo, Lucia; Puerta, Adrian; Puckett, Rebecca; Bayort, Samuel; Lagunes, Irene; Maya, Ines; Padron, Jose M.; Lopez, Oscar; Fernandez-Bolanos, Jose G.. Reference of 4-Bromobutanoic acid And the article was included in Pharmaceuticals in 2020. The article conveys some information:

Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number of cytotoxic agents developed so far, good therapeutic approaches are not always reached. In recent years, multitarget drugs are gaining great attention against multifactorial diseases in contraposition to polypharmacy. Herein we have accomplished the conjugation of phenolic derivatives with an ample number of organochalcogen motifs with the aim of developing novel antiproliferative agents. Their antioxidant, and antiproliferative properties (against six tumor and one non-tumor cell lines) were analyzed. Moreover, in order to predict P-gp-mediated chemoresistance, the P-glycoprotein assay was also conducted in order to determine whether compounds prepared herein could behave as substrates of that glycoprotein. Selenium derivatives were found to be significantly stronger antiproliferative agents than their sulfur isosters. Moreover, the length and the nature of the tether, together with the nature of the organoselenium scaffold were also found to be crucial features in the observed bioactivities. The lead compound, bearing a methylenedioxyphenyl moiety, and a diselenide functionality, showed a good activity (GI50 = 0.88-2.0μM) and selectivity towards tumor cell lines (selectivity index: 14-32); moreover, compounds considered herein were not substrates for the P-gp efflux pump, thus avoiding the development of chemoresistance coming from such mechanism, commonly found for widely-used chemotherapeutic agents. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Ferrocene functionalized upconversion nanoparticle nanosystem with efficient near-infrared-light-promoted fenton-like reaction for tumor growth suppression》 was written by Zhou, Jimin; Zhu, Xiangfeng; Cheng, Qianya; Wang, Yuxuan; Wang, Ruiqi; Cheng, Xingwen; Xu, Jiajia; Liu, Kuntang; Li, Lin; Li, Xueming; He, Mingfang; Wang, Jian; Xu, Heng; Jing, Su; Huang, Ling. Synthetic Route of C4H7BrO2 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

By taking advantage of the efficient Forster resonance energy transfer (FRET) between near-IR (NIR)-responsive lanthanide-doped upconversion nanoparticles (UCNPs) and Fenton reagent ferrocenyl compounds (Fc), a series of Fc-UCNPs was designed by functionalizing NaYF4:Yb,Tm nanoparticles with Fc1-Fc5via surface-coordination chem. Fc-UCNP-Lipo nanosystems were then constructed by encapsulating Fc-UCNP inside liposomes for efficient delivery. Fc-UCNP can effectively release ·OH via a NIR-promoted Fenton-like reaction. In vitro and in vivo studies of Fc1-UCNP-Lipo confirmed the preferential accumulation in a tumor site followed by an enhanced uptake of cancer cells. After cellular internalization, the released Fc1-UCNP can effectively promote ·OH generation for tumor growth suppression. Such a Fc1-UCNP-Lipo nanosystem exhibits advantages such as easy fabrication, low drug dosage, and no ferrous ion release. By integrating the advantages of NIR-responsive lanthanide-doped UCNPs, a ferrocenyl compound Fc that catalyzes intracellular H2O2 for ·OH generation in tumor sites, as well as good delivery capability of liposomes, Fc-UCNP-Lipo nanosystem was constructed to realize significant tumor growth suppression via a NIR-promoted Fenton-like reaction. A good overlap of absorption spectra of Fc and emission spectra of UCNP is essential for efficient FRET. This nanosystem exhibits merits of low dosage and sustained and on-demand cancer therapy. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobutanoic acid(cas: 2623-87-2Synthetic Route of C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Synthetic Route of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A Click-Chemistry-Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry》 was published in ChemBioChem in 2020. These research results belong to Stadlmeier, Michael; Runtsch, Leander Simon; Streshnev, Filipp; Wuehr, Martin; Carell, Thomas. Safety of Methyl 3-bromopropanoate The article mentions the following:

Mass spectrometry is the method of choice for the characterization of proteomes. Most proteins operate in protein complexes, in which their close association modulates their function. However, with standard MS anal., information on protein-protein interactions is lost and no structural information is retained. To gain structural and interactome data, new crosslinking reagents are needed that freeze inter- and intramol. interactions. Herein, the development of a new reagent, which has several features that enable highly sensitive crosslinking MS, is reported. The reagent enables enrichment of crosslinked peptides from the majority of background peptides to facilitate efficient detection of low-abundant crosslinked peptides. Due to the special cleavable properties, the reagent can be used for MS2 and potentially for MS3 experiments Thus, the new crosslinking reagent, in combination with high-end MS, should enable sensitive anal. of interactomes, which will help researchers to obtain important insights into cellular states in health and diseases. In addition to this study using Methyl 3-bromopropanoate, there are many other studies that have used Methyl 3-bromopropanoate(cas: 3395-91-3Safety of Methyl 3-bromopropanoate) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Safety of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 7073-94-1In 2018 ,《Silylation of Aryl Halides with Monoorganosilanes Activated by Lithium Alkoxide》 was published in Organic Letters. The article was written by Yoshida, Takumi; Ilies, Laurean; Nakamura, Eiichi. The article contains the following contents:

Li alkoxide activates a monoorganosilane to generate a transient LiH/alkoxysilane complex, which quickly reacts with aryl and alkenyl halides at 25° to deliver a diorganosilane product. Exptl. and theor. studies suggest that the reaction includes nucleophilic attack of LiH on the halogen atom of the organic halide to generate a transient organolithium/alkoxysilane intermediate, which undergoes quick C-Si bond formation within the complex. In the experimental materials used by the author, we found 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Product Details of 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Feng, Rui; Wang, Mian; Qian, Jingqi; He, Qingqing; Zhang, Man; Zhang, Jiaqi; Zhao, Hongwei; Wang, Baomin published an article in Microchemical Journal. The title of the article was 《Monoclonal antibody-based enzyme-linked immunosorbent assay and lateral flow immunoassay for the rapid screening of paraquat in adulterated herbicides》.Formula: C6H11BrO2 The author mentioned the following in the article:

The use of the herbicide paraquat has been banned in many countries due to its high toxicity. However, there is an issue that illegal addition of paraquat in herbicide products. Therefore, a rapid, sensitive, and portable method will be useful to detect paraquat in adulterated herbicides for regulation purpose. In the present study, an indirect competition ELISA (icELISA) was developed with a new paraquat-specific monoclonal antibody (mAb) for paraquat detection. The icELISA results showed a 50% inhibitory concentration (IC50) of 7.63 ng/mL with a working range (IC20-IC80) of 1.68-33.1 ng/mL. In addition, a lateral flow immunoassay (LFIA) with a cut-off value of 20.0 ng/mL was also developed. The LFIA showed no detection of the herbicides diquat, glyphosate and glufosinate up to 50μg/mL. Nine herbicide samples were collected across Hainan province, China and analyzed by the LFIA dipsticks. One out of the nine samples was tested pos., which was confirmed with icELISA and HPLC. The accuracy of the LFIA was further verified through onsite tests in different places in China. Forty-seven com. herbicide products were tested via the LFIA dipsticks, of which 9 samples were pos. and confirmed with HPLC anal. The paraquat LFIA exhibited the most promising potential as the point of care (POC) device for the rapid screening of paraquat in adulterated herbicide products. The experimental part of the paper was very detailed, including the reaction process of Ethyl 4-bromobutyrate(cas: 2969-81-5Formula: C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Formula: C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Jian-Xin; Shu, Wei published an article in Organic Letters. The title of the article was 《Ni-Catalyzed Reductive 1,2-Cross-Dialkylation of Unactivated Alkenes with Two Alkyl Bromides》.Category: bromides-buliding-blocks The author mentioned the following in the article:

Herein, a Ni-catalyzed reductive 1,2-dialkylation of unactivated aliphatic alkenes had been developed using two different alkyl bromides to gave (cyanoethyl)-alkyl-aryl-propanamides R1CH2CHR2CH2C(O)NHAr [R1 = cyanomethyl, H2CCO2Et, (2-oxotetrahydrofuran-3-yl); R2 = Et, n-Pr, 3-phenylpropyl, etc.; Ar = Ph, 4-MeC6H4, 3-MeOC6H4, etc.]. The reaction proceeded smoothly under mild conditions to install two Csp3-Csp3 bonds onto directed aliphatic alkenes, demonstrating excellent chemo- and regioselectivity with good functional group tolerance. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Category: bromides-buliding-blocks)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kvasovs, Nikita; Gevorgyan, Vladimir published an article in 2022. The article was titled 《Accessing Illusive E Isomers of α-Ester Hydrazones via Visible-Light-Induced Pd-Catalyzed Heck-Type Alkylation》, and you may find the article in Organic Letters.Category: bromides-buliding-blocks The information in the text is summarized as follows:

A visible-light-induced Pd-catalyzed stereoselective synthesis of alkylated ester hydrazones has been developed. This method operates via generation of a nucleophilic carbon-centered radical from alkyl bromide, iodide, or redox-active ester, followed by its addition to hydrazones, and a subsequent desaturation by palladium. The majority of products have E configuration, which are inaccessible by conventional condensation methods. In addition, a sequential C,N-alkylation protocol has been developed: a reaction between 1,3-dihalides and glyoxylate-derived hydrazone, delivering tetrahydropyridazines, e.g., I. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Category: bromides-buliding-blocks)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Decorated Peptide Nanofibers with Cu Nanoparticles: An Efficient Catalyst for the Multicomponent Synthesis of Chromeno[2,3-d]pyrimidin-8-amines, Quinazolines and 2H-Indazoles》 were Taherinia, Zahra; Ghorbani-Choghamarani, Arash; Hajjami, Maryam. And the article was published in ChemistrySelect in 2019. Safety of o-Bromobenzaldehyde The author mentioned the following in the article:

An efficient, simple and green protocol was developed for the synthesis of 7,10-diaryl-7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-amines I (R1 = Ph, 2-ClC6H4, 4-HOC6H4, etc.), 2-R2-substituted indazoles (R2 = Ph, 4-MeC6H4, 2,4-Cl2C6H3, etc.) and 2-R3-substituted quinazolines (R3 = Ph, 4-MeOC6H4) in the presence of peptide nanofibers decorated with Cu nanoparticles. Peptide nanofiber was synthesized by self-assembly technique. The effect of succinic anhydride was evaluated in two conditions: (i) without adding succinic anhydride at pH 4, (ii) by adding succinic anhydride at pH 5. Synthesized peptide nanofiber was characterized by 1H, 13C, DEPT NMR spectroscopies (Distortionless enhancement by polarization transfer), CHNSO, SEM, fluorescence spectroscopy, UV/Vis, FTIR and transmission electron microscopy (TEM). The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Safety of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Safety of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary