Tag: 100-200

Electric Literature of C7H5BrOIn 2019 ,《Co3O4/NiO@GQD@SO3H nanocomposite as a superior catalyst for the synthesis of chromene-pyrimidines》 was published in RSC Advances. The article was written by Safaei-Ghomi, Javad; Omidshafiei, Zahra. The article contains the following contents:

A three-component reaction involving substituted benzaldehydes, 6-amino-1,3-dimethyluracil and 4-hydroxycoumarin was achieved in the presence of the Co3O4/NiO@GQD@SO3H nanocomposite as a highly effective heterogeneous catalyst to produce chromene-pyrimidines. The catalyst was characterized via FT-IR, SEM, XRD, EDS, TGA, BET and VSM. This new catalyst was demonstrated to be highly effective in the preparation of chromene-pyrimidines. Atom economy, low catalyst loading, reusable catalyst, applicability to a wide range of substrates and high product yields are some of the important features of this protocol. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Electric Literature of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Electric Literature of C7H5BrOIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Konishi, Hideyuki; Fujita, Ririka; Yamaguchi, Miyuki; Manabe, Kei published an article in Organic Letters. The title of the article was 《Synthesis of Symmetrical Sulfides Enabled by a Sulfur Dioxide Surrogate Acting as a Divalent Sulfur Source》.Electric Literature of C9H11Br The author mentioned the following in the article:

A safe and practical methodol. for synthesizing sym. sulfides using iodoarenes and potassium metabisulfite (K2S2O5) was presented. While K2S2O5 was known as a convenient sulfur dioxide surrogate, here it acted as a divalent sulfur source, pioneering its potential utility. The reaction exhibited wide substrate generality in which even highly bulky substrates can be applied to afford sterically congested sulfides. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Electric Literature of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Electric Literature of C9H11Br The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Sisi; Shi, Weijia; Zou, Gang published an article in 2021. The article was titled 《Mechanical metal activation for Ni-catalyzed, Mn-mediated cross-electrophile coupling between aryl and alkyl bromides》, and you may find the article in New Journal of Chemistry.SDS of cas: 2969-81-5 The information in the text is summarized as follows:

Liquid-assisted grinding was successfully applied to eliminate the requirements of chem. activators and anhydrous solvents in nickel-catalyzed, manganese-mediated cross-electrophile coupling between aryl and alkyl bromides. In addition to the traditional reaction parameters, mech. ones, e.g. the rotational speed of mill, the filling degree of jar and ball size, was found to affect the catalytic efficiency remarkably, implying the involvement of the regeneration of nickel(0) species in the rate-determining steps. A combined evaluation of the reaction and mech. parameters led to an optimal condition under which a variety of n-alky aromatics with various functional groups was readily obtained in good yields with a 1 mol% catalyst loading. The practical application of liquid-assisted grinding-enabled aryl/alkyl cross-electrophile coupling was demonstrated in the gram-scale synthesis of 6-methoxytetralone. The experimental process involved the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5SDS of cas: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.SDS of cas: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Easy access to medium-sized lactones through metal carbene migratory insertion enabled 1,4-palladium shift》 was written by Yu, Yinghua; Chakraborty, Pushkin; Song, Jinshuai; Zhu, Lei; Li, Chunsen; Huang, Xueliang. Synthetic Route of C7H5BrO And the article was included in Nature Communications in 2020. The article conveys some information:

Herein, a valuable strategy for medium-sized lactones e.g., dibenzo[b,e]oxepin-6(11H)-one synthesis by accomplishing site-selective C-H bond functionalization via a palladium carbene migratory insertion enabled 1,4-palladium shift was described. The overall process achieves the formal dimerization of two readily available benzaldehyde derivatives RCHO (R = 6-bromo-1,3-dihydro-2-benzofuran-5-yl, 1-bromonaphthalen-2-yl, 2-iodophenyl, etc.), providing value-added products medium-sized lactones. The method is amenable to late-stage modification of approved drugs and other complex mols. Mechanistic studies including deuterium-labeling experiments and DFT calculation shed light on the reaction pathways. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Hapten Synthesis and the Development of an Ultrasensitive Indirect Competitive ELISA for the Determination of Diethylstilbestrol in Food Samples》 was written by Yang, Xingdong; Wang, Yinbiao; Song, Chunmei; Hu, Xiaofei; Wang, Fangyu; Zeng, Xianyin. Recommanded Product: 2969-81-5 And the article was included in Scientific Reports in 2020. The article conveys some information:

An ultrasensitive indirect competitive ELISA (ic ELISA) using monoclonal antibodies (mAbs) was developed for the specific detection of diethylstilbestrol (DES) residues. To establish an ELISA based on mAbs, hapten diethylstilbestrol mono-carboxypropyl-ether (DES-MCPE) was chem. synthesized and then conjugated to bovine serum albumin (BSA) for immunization in mice. This ic ELISA was further optimized for DES determination The sensitivity of the ic ELISA was found to be 0.49μg/kg and the limit of detection was 0.075μg/kg. DES residues in salmon meat and pork were tested with the recovery range from 74.0 to 85.2% and the coefficient of variation (CV) was less than 10%. Parallel anal. of DES samples from salmon meat showed comparable results from the ic ELISA with high-performance liquid chromatog. The ic ELISA provides a useful screening method for the quant. detection of DES residues in animal-derived food. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Formal Bromine Atom Transfer Radical Addition of Nonactivated Bromoalkanes Using Photoredox Gold Catalysis》 was published in Organic Letters in 2020. These research results belong to Zidan, Montserrat; McCallum, Terry; Swann, Rowan; Barriault, Louis. SDS of cas: 7051-34-5 The article mentions the following:

Organic transformations mediated by photoredox catalysis have been at the forefront of reaction discovery. Recently, it has been demonstrated that binuclear Au(I) bisphosphine complexes, such as [Au2(μ-dppm)2]X2, are capable of mediating electron transfer to nonactivated bromoalkanes for the generation of a variety of alkyl radicals. The transfer reactions of bromine, derived from nonactivated bromoalkanes, are largely unknown. Therefore, we propose that unique metal-based mechanistic pathways are at play, as this binuclear gold catalyst has been known to produce Au(III) Lewis acid intermediates. The scope and proposed mechanistic overview for the formal bromine atom transfer reaction of nonactivated bromoalkanes mediated by photoredox Au(I) catalysis is presented. The methodol. presented afforded good yields and a broad scope which include examples using bromoalkanes and iodoarenes. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5SDS of cas: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.SDS of cas: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Paradiso, Veronica; Bertolasi, Valerio; Costabile, Chiara; Caruso, Tonino; Dabrowski, Michal; Grela, Karol; Grisi, Fabia published 《Expanding the Family of Hoveyda-Grubbs Catalysts Containing Unsymmetrical NHC Ligands》.Organometallics published the findings.Electric Literature of C9H11Br The information in the text is summarized as follows:

Hoveyda-Grubbs 2nd-generation catalysts containing N-alkyl/N’-aryl N-heterocyclic carbene (NHC) ligands were synthesized and studied in representative olefin metathesis reactions. Steric perturbations of unsym. NHCs were achieved through modulation of the hindrance of alkyl (neopentyl, neophyl, cyclohexyl) and aryl (2-isopropylphenyl, mesityl) substituents at the N atoms in combination with different backbone configurations (syn and anti). The NHC substitution patterns strongly influence the stability and reactivity of the corresponding complexes. In general, complexes bearing an anti NHC backbone are more stable and more active than their corresponding syn isomers. In both the series, the presence of bulky, highly branched N-alkyl groups tends to give reduced catalytic differences between syn and anti isomers, whereas the nature of the N’-aryl substituent (2-isopropylphenyl or mesityl) gives rise to different activity and/or selectivity. Of note, an N’-mesityl catalyst with anti backbone is highly competent in the ethenolysis of Et oleate, achieving up to 90% selectivity for the formation of terminal olefins. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Electric Literature of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Electric Literature of C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis of 18F-difluoromethylarenes using arylboronic acids, ethyl bromofluoroacetate and [18F]fluoride》 were Sap, Jeroen B. I.; Wilson, Thomas C.; Kee, Choon Wee; Straathof, Natan J. W.; am Ende, Christopher W.; Mukherjee, Paramita; Zhang, Lei; Genicot, Christophe; Gouverneur, Veronique. And the article was published in Chemical Science in 2019. Application of 401-55-8 The author mentioned the following in the article:

Herein, the radiosynthesis of 18F-difluoromethylarenes RCHF18F (R = 4-C2H5, 4-OC6H5, 3,5-CH3, etc.) via the assembly of three components, a boron reagent, Et bromofluoroacetate, and cyclotron-produced non-carrier added [18F]fluoride was reported. The two key steps are a copper-catalyzed cross-coupling reaction, and a Mn-mediated 18F-fluorodecarboxylation. In the experiment, the researchers used many compounds, for example, Ethylbromofluoroacetate(cas: 401-55-8Application of 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application of 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cheng, Xinyi; Liu, Xingchen; Wang, Shengchun; Hu, Ying; Hu, Binjing; Lei, Aiwen; Li, Jie published their research in Nature Communications on December 31 ,2021. The article was titled 《Organozinc pivalates for cobalt-catalyzed difluoroalkylarylation of alkenes》.Application In Synthesis of Ethylbromofluoroacetate The article contains the following contents:

A cobalt-catalyzed regioselective difluoroalkylarylation of both activated and unactivated alkenes with solid arylzinc pivalates and difluoroalkyl bromides through a cascade Csp3-Csp3/Csp3-Csp2 bond formation under mild reaction conditions. Indeed, a wide range of functional groups on difluoroalkyl bromides, olefins, 1,3-dienes as well as (hetero)arylzinc pivalates are well tolerated by the cobalt-catalyst, thus furnished three-component coupling products in good yields and with high regio- and diastereoselectivity. Kinetic experiments compared arylzinc pivalates and conventional arylzinc halides highlighted the unique reactivity of these organozinc pivalates. Mechanistic studies strongly supported that the reaction involved direct halogen atom abstraction via single electron transfer to difluoroalkyl bromides from the in-situ formed cobalt(I) species, thus realized a Co(I)/Co(II)/Co(III) catalytic cycle. In the experiment, the researchers used Ethylbromofluoroacetate(cas: 401-55-8Application In Synthesis of Ethylbromofluoroacetate)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application In Synthesis of Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Baudet, Karine; Kale, Vishal; Mirzakhani, Mohsen; Babel, Lucille; Naseri, Soroush; Besnard, Celine; Nozary, Homayoun; Piguet, Claude published an article on January 6 ,2020. The article was titled 《Neutral Heteroleptic Lanthanide Complexes for Unravelling Host-Guest Assemblies in Organic Solvents: The Law of Mass Action Revisited》, and you may find the article in Inorganic Chemistry.Related Products of 583-69-7 The information in the text is summarized as follows:

The binding of lanthanide containers [Ln(β-diketonate)3dig] [dig = 1-methoxy-2-(2-methoxyethoxy)ethane] to aromatic tridentate N-donor ligands (L) in dichloromethane produces neutral nine-coordinate heteroleptic [LLn(β-diketonate)3] complexes, the equilibrium reaction quotients of which vary with the total concentrations of the reacting partners. This problematic drift prevents the determination of both reliable thermodn. stability constants and intrinsic host-guest affinities. The classical solution theory assigns this behavior to changes in the activity coefficients of the various partners in nonideal solutions, and a phenomenol. approach attempts to quant. attribute this effect to some partition of the solvent mols. between bulk-innocent and contact-noninnocent contributors to the chem. potential. This assumption eventually predicts an empirical linear dependence of the equilibrium reaction quotient on the concentration of the formed [LLn(β-diketonate)3] complexes, a trend exptl. supported in this contribution for various ligands L differing in lipophilicity and nuclearity and for lanthanide containers grafted with diverse β-diketonate coligands. Even if the origin of the latter linear dependence is still the subject of debate, this work demonstrates that this approach can be exploited by experimentalists for extracting reliable thermodn. constants suitable for analyzing and comparing host-guest affinities in organic solvents. In the experiment, the researchers used many compounds, for example, 2-Bromobenzene-1,4-diol(cas: 583-69-7Related Products of 583-69-7)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Related Products of 583-69-7 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary