Tag: 100-200

Recommanded Product: 7073-94-1In 2018 ,《Au-Catalyzed Oxidative Arylation: Chelation-Induced Turnover of ortho-Substituted Arylsilanes》 was published in ACS Catalysis. The article was written by Robinson, Matthew P.; Lloyd-Jones, Guy C.. The article contains the following contents:

Ortho-Substituted aryl silanes have previously been found to undergo much slower Au-catalyzed intermol. arylation than their m,p-substituted isomers, with many examples failing to undergo turnover at all. A method to indirectly quantify the rates of C-Si auration of o-substituted aryl silanes, under conditions of turnover, has been developed. All examples are found to undergo very efficient C-Si auration, indicative that it is the subsequent C-H auration that is inhibited by the ortho substituent. A simple Ar-Au conformational model suggests that C-H auration can be accelerated by chelation. A series of ortho-functionalized aryl silanes are shown to undergo efficient arylation. In the experimental materials used by the author, we found 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Recommanded Product: 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2021 ,《Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer′s disease》 was published in Bioorganic Chemistry. The article was written by Zhang, Panpan; Wang, Ze; Mou, Chenye; Zou, Jiamei; Xie, Yanfei; Liu, Zhiwen; Benjamin Naman, C.; Mao, Yuechun; Wei, Jiaxin; Huang, Xinghan; Dong, Jiahui; Yang, Mengxiang; Wang, Ning; Jin, Haixiao; Liu, Fufeng; Lin, Dongdong; Liu, Hao; Zhou, Fei; He, Shan; Zhang, Bin; Cui, Wei. The article contains the following contents:

Alzheimer′s disease (AD) is a prevalent neurodegenerative disorder that has multiple causes. Therefore, multiple-target-directed ligands (MTDLs), which act on multiple targets, have been developed as a novel strategy for AD therapy. In this study, novel drug candidates were designed and synthesized by the covalent linkings of tacrine, a previously used anti-AD acetylcholinesterase (AChE) inhibitor, and dipicolylamine, an β-amyloid (Aβ) aggregation inhibitor. Most tacrine-dipicolylamine dimers potently inhibited AChE and Aβ1-42 aggregation in vitro, and 13a exhibited nanomolar level inhibition. Mol. docking anal. suggested that 13a could interact with the catalytic active sites and the peripheral anion site of AChE, and bind to Aβ1-42 pentamers. Moreover, 13a effectively attenuated Aβ1-42 oligomers-induced cognitive dysfunction in mice by activating the cAMP-response element binding protein/brain-derived neurotrophic factor signaling pathway, decreasing tau phosphorylation, preventing synaptic toxicity, and inhibiting neuroinflammation. The safety profile of 13a in mice was demonstrated by acute toxicity experiments All these results suggested that novel tacrine-dipicolylamine dimers, especially 13a, have multi-target neuroprotective and cognitive-enhancing potentials, and therefore might be developed as MTDLs to combat AD.Methyl 3-bromopropanoate(cas: 3395-91-3Category: bromides-buliding-blocks) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Haichao; Lau, Vincent Ho Man; Xu, Pan; Chan, Tsz Hin; Huang, Zhongxing published an article in Nature Communications. The title of the article was 《Diverse synthesis of α-tertiary amines and tertiary alcohols via desymmetric reduction of malonic esters》.Electric Literature of C9H11Br The author mentioned the following in the article:

While conventional methods towards these motifs often rely on enantioselective carbon-carbon or carbon-heteroatom bond formation reactions, a desym. method was developed here by selectively hydrosilylating one of the esters of easily accessible α-substituted α-amino- and -oxymalonic esters. The desymmetrization was enabled by a suite of dinuclear zinc catalysts with pipecolinol-derived tetradentate ligands and could accommodate a diverse panel of heteroatom substituents, including secondary amides, tertiary amines and ethers of different sizes. The polyfunctionalized reduction products, in return, had provided expeditious approaches to enantioenriched nitrogen- and oxygen-containing mols., including dipeptides, vitamin analogs, and natural metabolites. The experimental process involved the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Electric Literature of C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Electric Literature of C9H11Br The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhou, Xuechen; Zheng, Mengzhu; Zhao, Na; Hu, Yixin; Yang, Kaiyin; Huo, Junfeng; Liu, Guangyuan; Huang, Jiangeng; Chen, Lixia; Zhou, Yirong; Li, Hua published an article in Bioorganic Chemistry. The title of the article was 《Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction》.HPLC of Formula: 2623-87-2 The author mentioned the following in the article:

Isocitrate dehydrogenases 1 (IDH1) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutaric acid (α-KG). It is the most frequently mutated metabolic gene in human cancer and its mutations interfere with cell metabolism and epigenetic regulation, thus promoting tumorigenesis. In order to discover potent new mutant IDH1 inhibitors, based on the structure of marketed inhibitor AG-120 (Ivosidenib), we designed, synthesized and evaluated a series of linear unnatural peptide analogs via Ugi reaction, as potential mutant IDH1 inhibitors. All these compounds were evaluated for their inhibition on mutant IDH1 enzyme activity. The structure-activity relationship was discussed on the basis of exptl. data, with an attempt to pave the way for future studies. Among them, 43 exhibited potent and selective enzyme inhibitory activity, and showed strong binding affinity with mutant IDH1. It can decrease the cellular concentration of 2-HG, and suppress the proliferation of HT1080 and IDH1 mutant-U-87 cells by selectively inhibiting the activity of mutant IDH1. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2HPLC of Formula: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).HPLC of Formula: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Genyan; Zhou, Congwei; Zhang, Zhisong; Wang, Chenchen; Luo, Xiaogang; Ju, Xiulian; Zhao, Chunqing; Ozoe, Yoshihisa published an article in Pest Management Science. The title of the article was 《Novel insecticidal 1,6-dihydro-6-iminopyridazine derivatives as competitive antagonists of insect RDL GABA receptors》.SDS of cas: 539-74-2 The author mentioned the following in the article:

BACKGROUND : The ionotropic γ-aminobutyric acid (GABA) receptor (iGABAR) is an important target for insecticides and parasiticides. Our previous studies showed that competitive antagonists (CAs) of insect iGABARs have the potential to be used for developing novel insecticides and that the structural modification of gabazine (a representative CA of mammalian iGABARs) could lead to the identification of novel CAs of insect iGABARs. RESULTS : In the present study, a novel series of 1,3-di- and 1,3,5-trisubstituted 1,6-dihydro-6-iminopyridazines (DIPs) was designed using a versatile strategy and synthesized using facile methods. Electrophysiol. studies showed that several target DIPs (30μM) exhibited excellent antagonistic activities against common cutworm and housefly iGABARs consisting of RDL subunits. The IC50 values of 3-(4-methoxyphenyl), 3-(4-trifluoromethoxyphenyl), 3-(4-biphenylylphenyl), 3-(2-naphthyl), 3-(3,4-methylenedioxyphenyl), and 3,5-(4-methoxyphenyl) analogs ranged from 2.2 to 24.8μM. Addnl., several 1,3-disubstituted DIPs, especially 3-(4-trifluoromethoxyphenyl) and 3-(3,4-methylenedioxyphenyl) analogs, exhibited moderate insecticidal activity against common cutworm larvae, with >60% mortality at a concentration of 100 mg kg-1. Mol. docking studies showed that the oxygen atom on the three-substituted aromatic ring could form a hydrogen bond with Arg254, which may enhance the activity of these DIPs against housefly iGABARs. CONCLUSION : This systematic study indicated that the presence of a carboxyl side chain shorter by one methylene than that of gabazine at the 1-position of the pyridazine ring is effective for maintaining the stable binding of these DIPs in insect iGABARs. Our study provides important information for the design of novel insect iGABAR CAs. 2022 Society of Chem. Industry. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-bromopropanoate(cas: 539-74-2SDS of cas: 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.SDS of cas: 539-74-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Hartman, Tomas; Konecny, Jan; Mazanek, Vlastimil; Sturala, Jiri; Sofer, Zdenek published an article in Inorganic Chemistry. The title of the article was 《A Decade of Germananes: Four Approaches to Their Functionalization》.Name: Methyl 3-bromopropanoate The author mentioned the following in the article:

Since the 1st synthesis of germanane (GeH) reported in 2013, two-dimensional Ge-based materials were intensively studied. Over the past decade, several methodologies for the functionalization of germanane were introduced. The 1st approach used exfoliation of Zintl phase CaGe2 with alkyl halides. Liu’s solvothermal method was used for the synthesis of Me germanane. Another methodol. used Ge-H activation with Na naphthalenide and its subsequent alkylation. All of these methods provide functionalized germananes; thus, a comparison of these methods is needed. Such a comparison of current synthetic approaches towards alkyl germananes is reported, and addnl., a new method for Ge-H activation using a NaK equimolar alloy is presented as a 4th approach. For this purpose, eight alkyl reagents were chosen representing reactive benzyl bromides as well as linear esters and nitriles because they contain easily trackable functional groups. The materials were characterized using FTIR spectroscopy, Raman spectroscopy, XPS, and TGA, and the data were compared. The comparison of all methods revealed not only some drawbacks for each method but also their advantages. The method using Na naphthalenide provided the lowest degree of surface coverage, whereas the solvothermal method seemed to provide materials with the highest degree of functionalization; unfortunately, the functionalization was also accompanied by a high degree of surface oxidation, i.e., (Ge-OH/Ge = O) formation. The highest degree of surface coverage accompanied by the lowest degree of surface oxidation was achieved employing Goldberger’s phase transfer direct exfoliation of CaGe2 as well as Ge-H activation using the NaK alloy with subsequent alkylation. The results came from multiple reactions, including the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bhat, Sachin A.; Rao, D. S. Shankar; Prasad, S. Krishna; Yelamaggad, Channabasaveshwar V. published their research in Nanoscale Advances in 2021. The article was titled 《Chiral plasmonic liquid crystal gold nanoparticles: self-assembly into a circular dichroism responsive helical lamellar superstructure》.Application In Synthesis of 4-Bromobutanoic acid The article contains the following contents:

Owing to their proven and promising potential in various technol. endeavors ranging from catalysis and sensing to invisibility cloaks made from metamaterials, chiral plasmonic superstructures resulting from the directed self-assembly of optically active metal nanoparticles (MNPs) have been pursued intensively in recent years. Several strategic efforts have emerged especially to accomplish advanced nanomaterials assembling into liquid crystalline (LC) helical structures, where MNPs are regularly packed in fluid/frozen arrays/layers or wires (columns). While the helical fluid columnar arrays (mol. wires) showing CD (CD) have been realized, the discovery of fluid chiral lamellar ordering, where the dielec. and conducting regimes are arranged alternatively, has hitherto remained highly elusive. Herein we report the first examples of monodisperse LC-gold NPs (LC-GNPs) self-assembling into a fluid/frozen lamellar structure exhibiting CD activity. Notably, these new, exceptional LC-GNPs have been realized by simple, hassle-free protocols that involve the room temperature addition of LC dimer-like arylamines to Au(III), where the amines not only reduce Au(III) to Au(0) but also bind strongly to the central GNP scaffold. Their mol. structure, mesomorphism, and ability to interact with circularly polarized light have been evidenced unambiguously and could play an important role in realizing metamaterials in the visible region. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Application In Synthesis of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application In Synthesis of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium-catalyzed C(sp3)-P(III) bond formation reaction with acylphosphines as phosphorus source》 was written by Zhang, Mengyue; Ma, Zhichao; Du, Hongguang; Wang, Zhiqian. Computed Properties of C4H7Br And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

Pd-catalyzed C(sp3)-P(III) bond formation reaction for alkyl substituted phosphines preparation was developed. In this reaction, various alkyl bromides and limited alkyl chlorides reacted with acylphosphine under relative mild and easily accessible condition, and differential phosphines were afforded in good yields. This reaction made up the application of Pd catalysis in C(sp3)-P(III) bond formation, and indicated a practical application of acylphosphine as a phosphination reagent. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Computed Properties of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Computed Properties of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Nickel-catalyzed reductive coupling of homoenolates and their higher homologues with unactivated alkyl bromides》 was written by Lin, Tingzhi; Gu, Yuanyun; Qian, Pengcheng; Guan, Haixing; Walsh, Patrick J.; Mao, Jianyou. HPLC of Formula: 7051-34-5 And the article was included in Nature Communications in 2020. The article conveys some information:

A nickel-catalyzed generation of homoenolates, and their higher homologues, via decarbonylation of readily available cyclic anhydrides was developed. The utility of nickel-bound homoenolates and their higher homologues was demonstrated by cross-coupling with unactivated alkyl bromides, generated a diverse array of aliphatic acids. A broad range of functional groups was tolerated. Preliminary mechanistic studies demonstrated that the oxidative addition of anhydrides by the catalyst was faster than oxidative addition of alkyl bromides. The nickel bound metallocycles were involved in this transformation. The catalyst undergoes a single electron transfer (SET) process with the alkyl bromide. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5HPLC of Formula: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.HPLC of Formula: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《The development of unimolecular conjugated polymeric micelles for the highly selective detection and recovery of gold from electronic waste》 were Liu, Jilin; Yang, Ting; Hu, Zhiru; Feng, Guodong. And the article was published in New Journal of Chemistry in 2019. Recommanded Product: 2969-81-5 The author mentioned the following in the article:

Gold is a widely used precious metal. In this paper, a novel conjugated polymer is designed and synthesized that can be used to detect and sep. gold from electronic waste with satisfactory sensitivity and selectivity. Therefore, this strategy is of great significance for the recycling of gold resources. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary