Tag: 100-200

In 2019,Monatshefte fuer Chemie included an article by Anschuber, Martin; Pollice, Robert; Schnuerch, Michael. Electric Literature of C6H11BrO2. The article was titled 《Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides》. The information in the text is summarized as follows:

The development and substrate scope evaluation of a direct alkylation protocol of the C(sp3)-H bond of benzylic amines using alkyl bromides was reported. This pyridine-directed method was initiated by elimination of the alkyl bromide to a terminal olefin, which was then the true alkylating agent. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromobutyrate(cas: 2969-81-5Electric Literature of C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Electric Literature of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Journal of Medicinal Chemistry included an article by Hao, Meixi; Hou, Siyuan; Xue, Lingjing; Yuan, Haoliang; Zhu, Lulu; Wang, Cong; Wang, Bin; Tang, Chunming; Zhang, Can. Computed Properties of C4H7BrO2. The article was titled 《Further Developments of the Phenyl-Pyrrolyl Pentane Series of Nonsteroidal Vitamin D Receptor Modulators as Anticancer Agents》. The information in the text is summarized as follows:

The vitamin D3 receptor (VDR), which belongs to the nuclear-receptor superfamily, is a potential mol. target for anticancer-drug discovery. In this study, a series of nonsteroidal vitamin D mimics with phenyl-pyrrolyl pentane skeletons with therapeutic potentials in cancer treatment were synthesized. Among them, 11b (N-(3-(diethylamino)propyl)-1-ethyl-5-(3-(4-((3-ethyl-3-hydroxypentyl)oxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxamide) and 11g (1-ethyl-5-{1-ethyl-1-[4-(3-ethyl-3-hydroxypentyloxy)-3-methylphenyl]propyl}-1H-pyrrole-2-carboxylic acid (3-morpholin-4-yl-propyl)amide) were identified as the most effective agents in reducing the viability of four cancer-cell lines, particularly those of breast-cancer cells, with IC50 values in the submicromolar-concentration range. In addition, 11b and 11g possessed VDR-binding affinities and displayed significant partial VDR-agonistic activities determined by dual-luciferase-reporter assays and human-leukemia-cell-line (HL-60)-differentiation assays. Furthermore, 11b and 11g inhibited tumor growth in an orthotopic breast-tumor model via inhibition of cell proliferation and induction of cell apoptosis. More importantly, 11b and 11g exhibited favorable pharmacokinetic behavior in vivo and did not increase serum calcium levels or cause any other apparent side effects. In summary, 11b and 11g act as novel VDR modulators and may be promising candidates for cancer chemotherapy. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Computed Properties of C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhu, Hong; Liu, Zhichao; Xu, Chenbo; Chen, Caiqi; Wen, Jinxuan; Yang, Keqin; Chen, Suqin; Pan, Yuexiao published an article in Journal of Alloys and Compounds. The title of the article was 《Large red shift from blue to green in the photoluminescence of pure CsPbBr3 nanoplatelets triggered by the cooperative effect of ligands combination》.Recommanded Product: 4-Bromobutanoic acid The author mentioned the following in the article:

A viable design strategy toward cubic CsPbBr3 (CPB) nanoplatelet (NPs) with blue emission at 450-467 nm and a large red shift to the green region at 500-512 nm occurs was developed through a cooperative effect of the ligands 4-bromobutyric acid (BBA) and oleylamine (OLA). The influence of the mol. ratio of BBA/OLA, reaction time and temperature on the transformation from blue to green was studied systematically. The red shift in the PL of CPB NPs is ascribed to the growth of the crystals with decreased quantum confinement. The luminescence quantum yields (PLQYs) of the blue and green luminescence of the obtained CPB NPs reach 94.4 and 84.4%, resp. This proposed strategy not only exptl. fabricates size-adjustable CPB NPs but also helps to reveal in depth the mechanisms of the large variation of quantum confinement in pure cubic CPB NPs. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Jiao, Nianming; Yuan, Yanyan; Yao, Yuan; Liu, Long; Zhang, Yanqiang published an article in Fuel Processing Technology. The title of the article was 《Strained carbocycle based hypergolic ionic fuels with the improved energy capacity》.Product Details of 7051-34-5 The author mentioned the following in the article:

Different from the previous nitrogenous groups, we present a new strategy of improving the ionic liquids (ILs) energy capacity by introducing the strained carbocycles. The ILs with three- and/or four-member carbocycles were prepared, and their physicochem. properties as rocket fuels were studied. The ignition tests show that all of these ILs have the expected hypergolic reactivity with the oxidizer (white fuming HNO3). In virtue of the strained cyclopropane and cyclobutane substituents, the resulting hypergolic ILs possess better energy properties (heats of formation 0.784-1.968 kJ g-1; specific impulses 313.0-315.7 s) and densities (1.03-1.15 g cm-3) than the corresponding ILs with n-alkyl substituents. This strategy of introducing strained ring groups into hypergolic ILs gives a new approach to improve energy properties of hypergolic ILs. The experimental part of the paper was very detailed, including the reaction process of (Bromomethyl)cyclopropane(cas: 7051-34-5Product Details of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Product Details of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Jie; Xu, Xinxin; Wu, Aihong; Song, Shanshan; Xu, Liguang; Xu, Chuanlai; Kuang, Hua; Liu, Liqiang published an article in LWT–Food Science and Technology. The title of the article was 《Immunochromatographic assay for the rapid and sensitive detection of etoxazole in orange and grape samples》.Name: Ethyl 4-bromobutyrate The author mentioned the following in the article:

Etoxazole, a novel organofluorine pesticide, has been widely used against various mites in fruits and vegetables. In this study, we designed an etoxazole-hapten and produced a highly sensitive monoclonal antibody (mAb) against etoxazole with a half-maximal inhibitory concentration of 4.04 ng/mL. Based on the mAb, we developed an immunochromatog. assay (ICA) for the detection of etoxazole in orange and grape samples. In the qual. detection, the visible limit of detection (vLOD) and cut-off value were 10 and 100 ng/g (fresh weight), resp. In the quant. detection, the LOD value was 2.03 ng/g (fresh weight) in orange and 2.52 ng/g (fresh weight) in grape samples. The recovery rates ranged from 94.7 ± 4.0% to 103.3 ± 3.8%, with CVs of 3.7-4.2% and 96.4 ± 3.4% to 106.1 ± 5.5%, with CVs of 3.5-5.2% for etoxazole in grape and orange samples, resp. The ICA results were similar to those of LC-MS/MS. Therefore, our developed ICA is a rapid, sensitive, and simple tool for screening etoxazole residues in fruits and vegetables. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Name: Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Thiocyanation and 2-Amino-1,3-thiazole Formation in Water Using Recoverable and Reusable Glycosylated Resorcin[4]arene Cavitands》 was published in Journal of Organic Chemistry in 2020. These research results belong to Husain, Ali A.; Bisht, Kirpal S.. Safety of Ethyl 3-bromopropanoate The article mentions the following:

A family of three spatially directional resorcin[4]arene cavitand glycoconjugates (RCGs) have been applied as efficient recoverable and reusable inverse phase transfer catalysts for eco- and environmentally friendly thiocyanation and 2-amino-1,3-thiazole formation reactions in water. The results show that RCGs (1 mol %) were capable of hosting and catalyzing various water-insoluble bromo/thiocyanato substrates in water without the use of any co-organic solvents. The recoverability and reusability of RCG catalytic systems, i.e., RCG1 and RCG3, were also examined upon a simple extraction of the desired products using DCM or Et acetate, followed by subjecting the recovered aqueous solution containing the RCG catalysts to the next reaction cycles. The experimental process involved the reaction of Ethyl 3-bromopropanoate(cas: 539-74-2Safety of Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Safety of Ethyl 3-bromopropanoate Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis and characterization of analogues of glycine-betaine ionic liquids and their use in the formation of aqueous biphasic systems》 were Pereira, Matheus M.; Pedro, Sonia N.; Gomes, Joana; Sintra, Tania E.; Ventura, Sonia P. M.; Coutinho, Joao A. P.; Freire, Mara G.; Mohamadou, Aminou. And the article was published in Fluid Phase Equilibria in 2019. Product Details of 2969-81-5 The author mentioned the following in the article:

A series of novel analogs of glycine-betaine ionic liquids (AGB-ILs), viz. 1-(4-ethoxy-4-oxobutyl)-1-methylpyrrolidin-1-ium, N,N,N-tri(n-butyl)(4-ethoxy-4-oxobutyl)-1-phosphonium and N,N,N-trialkyl(4-ethoxy-4-oxobutyl)-1-aminium cations with Et, Pr and Bu alkyl chains, combined with the bromide anion, have been synthesized and characterized. Their synthesis and characterization by spectroscopic methods and elemental anal. is here reported. These ILs were further characterized in what concerns their thermal properties and ecotoxicity against Allvibrio fischeri, and compared with the com. tetra(n-butyl)ammonium and tetra(n-butyl)phosphonium bromide. The novel AGB-ILs described in this work have low m.ps., below 100°C, display high degradation temperatures (180-310°C), and low toxicity as shown by being harmless or practically harmless towards the marine bacteria Allvibrio fischeri. Finally, the ability of the synthesized AGB-ILs to form aqueous biphasic systems with potassium citrate/citric acid (at pH 7) was evaluated, and the resp. ternary phase diagrams were determined It is shown that the increase of the cation alkyl chain length facilitates the creation of ABS, and that phosphonium-based ILs present a slightly better separation performance in presence of aqueous solutions of the citrate-based salt. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Product Details of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Product Details of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synergistic cooperation of bi-active hydrogen atoms in protic carboxyl imidazolium ionic liquids to push cycloaddition of CO2 under benign conditions》 were Wang, Tengfei; Zhu, Xinrui; Mao, Lemin; Liu, Yi; Ren, Tiegang; Wang, Li; Zhang, Jinglai. And the article was published in Journal of Molecular Liquids in 2019. Formula: C6H11BrO2 The author mentioned the following in the article:

Nine protic carboxyl imidazolium ionic liquids were synthesized. Then, they were employed to catalyze the chem. fixation of carbon dioxide (CO2) and propylene oxide leading to propylene carbonate in the absence of co-catalyst and organic solvent. HCPImBr presents the best catalytic activity with the product yield of 92% under reaction temperature 120°C, CO2 initial pressure 1.5 MPa, catalyst amount 0.5 mol%, and reaction time 2.0 h. Even if the reaction temperature and CO2 initial pressure are decreased to 80°C and 1.0 MPa, resp., the 85% of product yield would be kept with the 1.0% catalyst dosage along with 12.0 h. With the exception of the most optimal reaction conditions, generality, and recyclability of HCPImBr are also investigated. More importantly, the reaction mechanism is investigated by the d. functional theory, which is the first time to report the mechanism for protic carboxyl imidazolium ionic liquids The catalytic activity of ionic liquids would be further improved with the reasonable combination of cation and anion. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5Formula: C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Formula: C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Advanced Synthesis & Catalysis included an article by Zhang, Heng; Yu, Yinghua; Huang, Shenlin; Huang, Xueliang. Synthetic Route of C7H5BrO. The article was titled 《Palladium-Catalyzed Cascade Reaction of o-Bromobenzaldehydes with N-Sulfonylhydrazones: An Efficient Approach to the Naphthalene Skeleton》. The information in the text is summarized as follows:

A new strategy for the construction of the naphthalene backbone was described. The reaction essentially started from two simple aldehydes. The key step was enabled by a palladium-carbene migratory insertion. After that, a sequence of reversible allylic alkylation and intramol. condensation took place to give the substituted naphthalene derivatives Addnl. manipulations on the sulfonyl group in the product via palladium-catalyzed Kumada coupling were also investigated.o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Organic Chemistry included an article by Shin, Jung-Ah; Kim, Jiheon; Lee, Hongsoo; Ha, Sura; Lee, Hee-Yoon. Computed Properties of C4H7BrO2. The article was titled 《Cu(OTf)2-Promoted 1,4-Addition of Alkyl Bromides to Dehydroalanine》. The information in the text is summarized as follows:

Zn/Cu(OTf)2 mediated addition of alkyl bromides to dehydroalanine (Dha) derivatives including dipeptides and tripeptides in high yields under aqueous medium was developed. This protocol allows selective and biocompatible access to various amino acid units from Dha derivatives In the experiment, the researchers used many compounds, for example, Methyl 3-bromopropanoate(cas: 3395-91-3Computed Properties of C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary