Tag: 100-200

HPLC of Formula: 401-55-8On November 28, 2020 ,《Recyclable Ruthenium Catalyst for Distal meta-C-H Activation》 appeared in Chemistry – A European Journal. The author of the article were Choi, Isaac; Mueller, Valentin; Wang, Yanhui; Xue, Kai; Kuniyil, Rositha; Andreas, Loren B.; Karius, Volker; Alauzun, Johan G.; Ackermann, Lutz. The article conveys some information:

The unprecedented hybrid-ruthenium catalysis for distal meta-C-H activation was disclosed. The hybrid-ruthenium catalyst was recyclable, as was proven by various heterogeneity tests, and fully characterized with various microscopic and spectroscopic techniques, highlighting the phys. and chem. stability. Thereby, the hybrid-ruthenium catalysis proved broadly applicable for meta-C-H alkylations of among others purine-based nucleosides and natural product conjugates. Addnl., its versatility was further reflected by meta-C-H activations through visible-light irradiation, as well as para-selective C-H activations.Ethylbromofluoroacetate(cas: 401-55-8HPLC of Formula: 401-55-8) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.HPLC of Formula: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Vinyl Azides as Radical Acceptors in the Vitamin B12-Catalyzed Synthesis of Unsymmetrical Ketones》 was written by Dworakowski, Krzysztof R.; Pisarek, Sabina; Hassan, Sidra; Gryko, Dorota. Recommanded Product: 2969-81-5This research focused onunsym ketone preparation; vinyl azide alkyl bromide Vitamin B12 catalyst light irradiation. The article conveys some information:

Vitamin B12 catalyzed the reaction of vinyl azides with electrophiles under light irradiation to afforded unsym. carbonyl compounds R1C(O)CH2R2 [R1 = Ph, 4-t-BuC6H4, 4-ClC6H4, etc.; R2 = (CH2)3CN, (CH2)3Ph, (CH2)3C(O)OEt, etc.] in decent yields. Mechanistic studies revealed that alkyl radicals were key intermediates in this transformation. In the experimental materials used by the author, we found Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Li, Renwu; Yan, Lingling; Sun, Xun; Zheng, Weiping. Electric Literature of C4H7BrO2 The article mentions the following:

Past few years have seen an active pursuit of the inhibitors for the deacylation catalyzed by the seven human sirtuins (i.e. SIRT1-7) as valuable chem. biol./pharmacol. probes of this enzymic deacylation and lead compounds for developing novel therapeutics for human diseases. In the current study, we prepared eight monocyclic and one bicyclic analogs of a linear pentapeptide-based potent (sub-μM IC50’s) pan-SIRT1/2/3 inhibitor Zheng laboratory discovered recently that harbors the catalytic mechanism-based SIRT1/2/3 inhibitory warhead Nε-thioacetyl-lysine at its central position. We found that the bicyclic analog exhibited largely comparable SIRT1/2/3 inhibitory potencies to those of the parent linear pentapeptide, however, the former is proteolytically much more stable than the latter. Moreover, the bicyclic analog displayed very weak inhibition against SIRT5/6/7, was cell permeable, and exhibited an anti-proliferative effect on the human SK-MEL-2 melanoma cells. This bicyclic analog could be a lead for the future development of more potent and still selective pan-SIRT1/2/3 inhibitors whose use in studies on human sirtuin biol., pharmacol., and medicinal chem. could complement with the use of the potent inhibitors selective for a single human sirtuin. In the experimental materials used by the author, we found 4-Bromobutanoic acid(cas: 2623-87-2Electric Literature of C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Electric Literature of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Asymmetric α-alkylation of cyclic β-keto esters and β-keto amides by phase-transfer catalysis》 were Wang, Yakun; Li, Yueyun; Lian, Mingming; Zhang, Jixia; Liu, Zhaomin; Tang, Xiaofei; Yin, Hang; Meng, Qingwei. And the article was published in Organic & Biomolecular Chemistry in 2019. COA of Formula: C4H7BrO2 The author mentioned the following in the article:

Without employing any transition metal, a highly enantioselective α-alkylation of cyclic β-keto esters and β-keto amides has been realized by phase-transfer catalysis. This improved procedure is applicable to different kinds of bromides with cinchona derivatives and gives the corresponding products e.g., I and e.g., II, in excellent enantiopurities (up to 98% ee) and good yields (up to 98%). Moreover, the reaction was scalable and the phase-transfer catalyst was recyclable. This provided an alternative and competitive method to the asym. α-alkylation of β-dicarbonyl compounds The experimental process involved the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3COA of Formula: C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine》 was written by Keglevich, Andras; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba; Keglevich, Peter; Hazai, Laszlo. COA of Formula: C4H7BrO2This research focused onvindoline preparation antitumor activity. The article conveys some information:

An important approach to the development of new antitumor agents is the synthesis of conjugates containing two or more structural units. Taking this into consideration, vindoline derivatives I (n = 1, 3, 4) were coupled with triphenylphosphine, to afford the expected phosphonium salts II. The new hybrid entities were characterized by NMR spectroscopy, and their anticancer activity was also evaluated. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobutanoic acid(cas: 2623-87-2COA of Formula: C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives》 was written by Bugera, Maksym; Trofymchuk, Serhii; Tarasenko, Karen; Zaporozhets, Olga; Pustovit, Yurii; Mykhailiuk, Pavel K.. Application of 2623-87-2This research focused ontrifluoromethyl substituted derivative preparation; aliphatic carboxylic acid deoxofluorination sulfur tetrafluoride water additive. The article conveys some information:

A practical method for the synthesis of functionalized aliphatic trifluoromethyl-substituted derivatives from aliphatic acids was developed. The transformation proceeds with sulfur tetrafluoride in the presence of water as a key additive. Compared to previous methods, the reaction gives products with full retention of stereo- and absolute configuration of chiral centers. After reading the article, we found that the author used 4-Bromobutanoic acid(cas: 2623-87-2Application of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of Ethyl 4-bromobutyrateIn 2019 ,《Tetraphenylporphyrin-based dual-functional medical agent for magnetic resonance and fluorescence imaging》 was published in Applied Organometallic Chemistry. The article was written by Jin, Manyu; Zhang, Yanqun; Gao, Ge; Xi, Qiaoyue; Tong, Jie; Zhao, Yongxia; Wu, Cunqi; Zhou, Hua; Yang, Qiuxia; Yang, Wei; Xu, Jingwei. The article contains the following contents:

A bimodal magnetic resonance imaging contrast agent, TPP-M-Gd, was developed by modifying tetraphenylporphyrin (TPP) with a small dendritic mol. as a ligand (M) to chelate gadolinium (Gd) ions. The ligand featured four carboxylate groups, which contributed to good water solubility and a strong combination with metal ions. The longitudinal relaxivity (R1) of the resulting agent is 12.45 mM-1s-1, which is much higher than that of DTPA-Gd (4.49 mM-1s-1). The magnetic resonance imaging experiments showed that the newly synthesized contrast agent could enhance T1-weighted magnetic resonance imaging quality both in vitro and in vivo. In addition, TPP-M-Gd exhibited good fluorescent property as shown in cell imaging experiments The cytotoxicity of TPP-M-Gd was even better than that of clin. approved DTPA-Gd, which makes it a promising dual-functional medical imaging agent to provide more detailed information about biol. and disease-related events. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Safety of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Shenghao; Luo, Chun; Zhao, Lei; Zhao, Junsong; Zhang, Lanlan; Zhu, Bolin; Wang, Chao published their research in Cell Reports Physical Science in 2021. The article was titled 《Regioselective nickel-catalyzed dicarbofunctionalization of unactivated alkenes enabled by picolinamide auxiliary》.Safety of (Bromomethyl)cyclopropane The article contains the following contents:

A removable bidentate picolinamide-assisted regioselective dicarbofunctionalization of homoallylic amines I [R = 1-(prop-2-en-1-yl)cyclohexyl, 3-methylbut-3-en-1-yl, 1-phenylbut-3-en-1-yl, etc.] with organohalides R1X (R1 = 4-methoxyphenyl, pyridin-4-yl, Bu, etc.; X = I, Br) and arylboronic acids ArB(OH)2 (Ar = Ph, 2H-1,3-benzodioxol-5-yl, 1H-indol-3-yl, etc.) was developed. The catalytic system, using cost-effective and air-stable Ni(II) precatalyst, which could be activated by arylboronic acids, provides access to the regioselective diarylation and arylalkylation of inactivated alkenes. This reaction is compatible with α- or α-substituted terminal alkenes and internal alkenes and exhibits excellent functional group and heterocycle tolerance. Preliminary mechanistic studies suggest that the reaction proceeds via a NiI/NiIII catalytic cycle rather than a Ni0/NiII cycle. Notably, the general and practical protocol developed here represents, the first example of Ni-catalyzed 3-component 2,1-diarylation and arylalkylation of alkenes with arylboronic acids and organohalides. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Safety of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Safety of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Stepwise dual targeting and dual responsive polymer micelles for mitochondrion therapy》 was published in Journal of Controlled Release in 2020. These research results belong to Zhang, Xiaobin; Wang, Yi; Wei, Guoqing; Zhao, Jingya; Yang, Guang; Zhou, Shaobing. Product Details of 2623-87-2 The article mentions the following:

Methods to selectively destroy mitochondria of tumor cells and induce cell apoptosis with nanomedicine constitute challenges in cancer therapy. In the present study, we develop cell membrane/mitochondria dual targeting and pH/redox dual responsive nanoparticles for mitochondrion therapy. The nanoparticles are fabricated by the self-assembly of triphenylphosphonium (TPP) grafted poly(ethylene glycol)(PEG)-poly(d,L-lactide)(PLA) copolymers (TPP-PEG-ss-PLA) using disulfide bonds as the intermediate linkers. To shield the surface pos. charge of the nanoparticles from TPP composition, chondroitin sulfate (CS) is employed to coat the nanoparticles, and this prolongs blood circulation while endowing an active targeting ability to the cell membrane. In acidic lyso-somes/endosomes, the neg. charged CS layer falls away to expose the TPP component. Subsequently, in the cyto-plasm, the nanoparticles can anchor to the mitochondrial outer membrane by TPP-mediated targeting, thereby inducing a decrease in the membrane potential and opening of the permeability transition pore. Thus, the overproduction of ROS in the mitochondria promotes cell apoptosis. The released DOX directly diffuse into the mitochondria, thereby resulting in mito-chondrial DNA damage. Therefore, the nanoparticles exhibit significant potential in terms of a new avenue for mitochondrion therapy in cancer treatment. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Product Details of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Product Details of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Stereochemistry-Controlled Supramolecular Architectures of New Tetrahydroxy-Functionalized Amphiphilic Carbocyanine Dyes》 was published in Chemistry – A European Journal in 2020. These research results belong to Schade, Boris; Singh, Abhishek Kumar; Wycisk, Virginia; Cuellar-Camacho, Jose Luis; von Berlepsch, Hans; Haag, Rainer; Boettcher, Christoph. Computed Properties of C6H11BrO2 The article mentions the following:

The syntheses of novel amphiphilic 5,5′,6,6′-tetrachlorobenzimidacarbocyanine (TBC) dye derivatives with aminopropanediol head groups, which only differ in stereochem. (chiral enantiomers, meso form and conformer), are reported. For the achiral meso form, a new synthetic route towards asym. cyanine dyes was established. All compounds form J aggregates in water, the optical properties of which were characterized by means of spectroscopic methods. The supramol. structure of the aggregates is investigated by means of cryo-transmission electron microscopy, cryo-electron tomog. and AFM, revealing extended sheet-like aggregates for chiral enantiomers and nanotubes for the mesomer, resp., whereas the conformer forms predominately needle-like crystals. The experiments demonstrate that the aggregation behavior of compounds can be controlled solely by head group stereochem., which in the case of enantiomers enables the formation of extended hydrogen-bond chains by the hydroxyl functionalities. In case of the achiral meso form, however, such chains turned out to be sterically excluded. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Computed Properties of C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Computed Properties of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary