Tag: 100-200

Recommanded Product: 4-Bromobutanoic acidIn 2019 ,《Synthesis of solandelactone F, constanolactone A and an advanced intermediate towards solandelactone E from a common synthetic intermediate》 was published in Organic & Biomolecular Chemistry. The article was written by Yalla, Raju; Raghavan, Sadagopan. The article contains the following contents:

The stereoselective synthesis of solandelactone F, constanolactone A and an advanced intermediate towards solandelactone E, from a common synthetic intermediate, is disclosed. The propargylic sulfide stereo-center is created stereoselectively via carbon-carbon bond formation in the reaction of α-chloro sulfides with alkynyl zinc reagents via 1,2-asym. induction by a β-siloxy group. The characteristic 1,4-diol motif of the natural products is introduced by a [2,3] sigmatropic rearrangement of an allylic sulfoxide or by the Mislow-Evans-Braverman rearrangement of a propargylic sulfoxide followed by stereoselective reduction of the ensuing α,β-unsaturated ketone. Unlike earlier reports, the C11/C9 carbinol center is created with excellent stereocontrol and derivatives of natural products differing at C14/C12 can be readily obtained. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jia, Xuhong; Huang, Rui; Yang, Xiaoguang; Tao, Wan; Zhu, Xinhua published an article in 2021. The article was titled 《Synthesis and Characterization of a Novel Class of Zwitterionic Fluorocarbon Surfactants Based on Perfluorobutyl》, and you may find the article in Tenside, Surfactants, Detergents.Formula: C4H7BrO2 The information in the text is summarized as follows:

Perfluorooctane sulfonate (PFOS) and its derivatives had been banned due to their potential environmental hazards, although they possessed excellent surface activity. An effective method to solve this problem was to shorten the fluorocarbon chain of these surfactants from C8H17 to C4F9. As previous studies had shown, zwitterionic surfactants possess higher surface activity but have lower toxicity compared to other types of surfactants. In view of this, a class of novel zwitterionic fluorocarbon surfactants (n-CFNA-Br) with perfluorobutyl moiety was synthesized in this work. Their structures were characterized by FTIR, 1H NMR, 13C NMR, 19F NMR and MS. The results showed that all synthesized n-CFNA-Br had almost the same min. surface tension, but their critical micelle concentration (CMC) decreased with increasing length of hydrophobic carbon chain. In pure water, the surface tension at the CMC (γCMC) of the four n-CFNA-Br were about 20 mN/m, and the CMC values were 7.73 mmol/L for 1-CFNA-Br, 4.70 mmol/L for 2-CFNA-Br, 4.13 mmol/L for 3-CFNA-Br, and 3.36 mmol/L for 4-CFNA-Br, indicating high efficiency and effectiveness. In 0.1 mol/L NaCl, the CMC values reduced to less than half of the CMC values measured in the pure aqueous surfactant solution, while the surface tensions γCMC remained almost unchanged, indicating good salinity tolerance of the synthesized surfactants. The acidic surfactant solutions exhibited similar CMC values to the saline solutions, but the surface tension γCMC increased slightly to 25 mN/m. However, further investigation showed that the n-CFNA-Br surfactants exhibited poor surface activity in alk. solution (0.1 mol/L NaOH). In the pH range of 6.6 to 10.4, white precipitates appeared in the surfactant solutions after some time, indicating that the n-CFNA-Br are not suitable for use in alk. systems with pH greater than 6.6. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Formula: C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists》 were Festa, Carmen; Finamore, Claudia; Marchiano, Silvia; Di Leva, Francesco Saverio; Carino, Adriana; Monti, Maria Chiara; del Gaudio, Federica; Ceccacci, Sara; Limongelli, Vittorio; Zampella, Angela; Fiorucci, Stefano; De Marino, Simona. And the article was published in ACS Medicinal Chemistry Letters in 2019. Related Products of 3395-91-3 The author mentioned the following in the article:

Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR antagonists featured by a 3,5-disubstituted oxadiazole core. In total, 35 new derivatives were designed and synthesized, and notably, compounds I and II, containing a piperidine ring, displayed the best antagonistic activity against FXR with promising cellular potency (IC50 = 0.58 ± 0.27 and 0.127 ± 0.02 μM, resp.). The excellent pharmacokinetic properties make compound I the most promising lead identified in this study. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Related Products of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Related Products of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Microwave assisted synthesis and antibacterial activities of some N-Benzylideneaniline halogen derivatives》 were Celik, Hulya. And the article was published in Fresenius Environmental Bulletin in 2019. SDS of cas: 6630-33-7 The author mentioned the following in the article:

In this study a series of Schiff base N-benzylideneaniline halogen derivatives were synthesized by microwave-irradiation method the 4-fluoroaniline was condensed with various aromatic aldehydes to give Schiff base. The present work involved condensation of various benzaldehyde with aromatic amine in under microwave irradiation The microwave irradiation method offered advantages such as reduction of reaction time, increase in conversion, reduced wastes and good quality. The chem. structure of the compound was characterized using Mass Spectrometry, 1H-NMR and 13C-NMR techniques. The prepared compounds were tested for their in-vitro antibacterial activity. The agar well diffusion assay method was used for the assessment of in vitro antibacterial activity compounds against Escherichia coli (ATCC 10536), Pseudomonas aeruginosa (ATCC 15442), Staphylococcus aureus (ATCC 6538) and Bacillus subtilis (ATCC 6633). In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7SDS of cas: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.SDS of cas: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Yoon, Dong-Oh; Zhao, Xiaodi; Son, Dohyun; Han, Jung Tae; Yun, Jaesook; Shin, Dongyun; Park, Hyun-Ju published 《SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists》.ACS Medicinal Chemistry Letters published the findings.Name: 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

G-protein coupled receptor 40 (GPR40) has been considered to be an attractive drug target for the treatment of type 2 diabetes because of its role in free fatty acids-mediated enhancement of glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. A series of indole-5-propanoic acid compounds were synthesized, and their GPR40 agonistic activities were evaluated by nuclear factor of activated T-cells reporter assay and GSIS assay in the MIN-6 insulinoma cells. Three compounds, 8h (3-(2-(2-chlorophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 58.6 nM), 8i (3-(2-(3-chlorophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 37.8 nM), and 8o (3-(2-(2-bromophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 9.4 nM), were identified as potent GPR40 agonists with good GSIS effects. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Name: 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 1-Bromo-2-isopropylbenzene Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Walker, Ann L.; Ancellin, Nicolas; Beaufils, Benjamin; Bergeal, Marylise; Binnie, Margaret; Clapham, David; Haslam, Carl P.; Holmes, Duncan S.; Hutchinson, Jonathan P.; Liddle, John; McBride, Andrew; Mirguet, Olivier; Mowat, Christopher G.; Rowland, Paul; Tiberghien, Nathalie; Trottet, Lionel; Uings, Iain; Webster, Scott P.; Zheng, Xiaozhong; Mole, Damian J. published 《Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis》.Journal of Medicinal Chemistry published the findings.Application of 3395-91-3 The information in the text is summarized as follows:

Recently, we reported a novel role for KMO in the pathogenesis of acute pancreatitis (AP). A number of inhibitors of kynurenine 3-monooxygenase (KMO) have previously been described as potential treatments for neurodegenerative conditions and particularly for Huntington’s disease. However the inhibitors reported to date have insufficient aqueous solubility relative to their cellular potency to be compatible with the i.v. (i.v.) dosing route required in AP. We have identified and optimized a novel series of high affinity KMO inhibitors with favorable physicochem. properties. The leading example is exquisitely selective, has low clearance in two species, prevents lung and kidney damage in a rat model of acute pancreatitis and is progressing into preclin. development. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Application of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Application of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis of difluoroalkylated 2-azaspiro[4.5]decane derivatives via copper-catalyzed difluoroalkylation/dearomatization of N-benzylacrylamides》 were Li, Chengwen; Zhao, Yilin; Zhou, Jiaxin; Wang, Xue; Hou, Jingli; Song, Yuguang; Liu, Wenjuan; Han, Guifang. And the article was published in Organic & Biomolecular Chemistry in 2020. Formula: C4H6BrFO2 The author mentioned the following in the article:

An efficient method for the synthesis of difluoroalkylated 2-azaspiro[4.5]decanes I [R1 = H, 7-OMe, 7-F, etc.; R2 = iPr, tBu, adamantan-1-yl; R3 = H, Me; R4 = EtO2C, Et2NCO, 1-pyrrolidinylcarbonyl, 1-piperidinylcarbonyl, 2,3-dihydro-1-indolylcarbonyl] via copper-catalyzed difluoroalkylation of N-benzylacrylamides with halo- fluoroacetate/difluoroacetate was established. The reaction experienced a tandem radical addition and dearomatizing cyclization process. In addition, the resultant products could be smoothly converted into a difluoroalkylated quinolinone and saturated spirocyclohexanone scaffold. The experimental part of the paper was very detailed, including the reaction process of Ethylbromofluoroacetate(cas: 401-55-8Formula: C4H6BrFO2)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Formula: C4H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Photoredox-catalyzed redox-neutral difluoroalkylation to construct perfluoroketones with difluoroenoxysilanes》 were Zou, Jian-Yu; Wang, Yu-Zhao; Sun, Wen-Hui; Lin, Wu-Jie; Liu, Xue-Yuan. And the article was published in Organic & Biomolecular Chemistry in 2021. Product Details of 401-55-8 The author mentioned the following in the article:

A mild and facile approach to construct various perfluoroketones via photo-catalyzed difluoroalkylation of difluoroenoxysilanes is developed. The reaction includes a strategy of combination of two fluorine-containing functional groups, which confers the reaction with characteristics like high efficiency, mild conditions, and broad scope. A variety of fluoroalkyl halides including perfluoroalkyl iodides, bromo difluoro esters and amides can be employed as radical precursors. Control experiments indicate that a single-electron transfer pathway may be involved in the reaction. In the experiment, the researchers used many compounds, for example, Ethylbromofluoroacetate(cas: 401-55-8Product Details of 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Product Details of 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of EthylbromofluoroacetateOn May 28, 2020, Wang, Pingyuan; Luchowska-Stanska, Urszula; van Basten, Boy; Chen, Haiying; Liu, Zhiqing; Wiejak, Jolanta; Whelan, Padraic; Morgan, David; Lochhead, Emma; Barker, Graeme; Rehmann, Holger; Yarwood, Stephen J.; Zhou, Jia published an article in Journal of Medicinal Chemistry. The article was 《Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators》. The article mentions the following:

EPAC plays a central role in various biol. functions, and activation of the EPAC1 protein has shown potential benefits for the treatment of various human diseases. Herein, the synthesis and biochem. evaluation of a series of non-cyclic nucleotide EPAC1 activators is reported. Several potent EPAC1 binders were identified, e.g., I, which promote EPAC1 GEF activity in vitro. These agonists can also activate EPAC1 protein in cells, where they exhibit excellent selectivity towards EPAC over PKA and GPCRs. Moreover, four compounds exhibited improved selectivity towards activation of EPAC1 over EPAC2 in cells. Of these, I was found to robustly inhibit IL-6-activated STAT3 and subsequent induction of the pro-inflammatory VCAM1 cell adhesion protein. These novel EPAC1 activators may therefore act as useful pharmacol. tools for elucidation of EPAC function as well as promising drug leads for the treatment of relevant human diseases. After reading the article, we found that the author used Ethylbromofluoroacetate(cas: 401-55-8Reference of Ethylbromofluoroacetate)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Reference of Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Peng, Xiaopeng; Chen, Jingxuan; Li, Ling; Sun, Zhiqiang; Liu, Jin; Ren, Yichang; Huang, Junli; Chen, Jianjun published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents》.Recommanded Product: Methyl 3-bromopropanoate The article contains the following contents:

Novel dual HDAC3/tubulin inhibitors were designed and efficiently synthesized by combining the pharmacophores of SMART (tubulin inhibitor) and MS-275 (HDAC inhibitor), among which compound 15c was found to be the most potent and balanced HDAC3/tubulin dual inhibitor with high HDAC3 activity (IC50 = 30 nM) and selectivity (SI > 1000) as well as excellent antiproliferative potency against various cancer cell lines, including an HDAC-resistant gastric cancer cell line (YCC3/7) with IC50 values in the range of 30-144 nM. Compound 15c inhibited B16-F10 cancer cell migration and colony formation. In addition, 15c demonstrated significant in vivo antitumor efficacy in a B16-F10 melanoma tumor model with a better TGI (70.00%, 10 mg/kg) than that of the combination of MS-275 and SMART. Finally, 15c presented a safe cardiotoxicity profile and did not cause nephro-/hepatotoxicity. Collectively, this work shows that compound 15c represents a novel tubulin/HDAC3 dual-targeting agent deserving further investigation as a potential anticancer agent. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Recommanded Product: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary