Tag: 100-200

《Synthesis, labeling and biological evolution of new thiopyrano[2,3-b]pyridine derivatives as potential anticancer agents》 was written by Sofan, Mamdouh Abdel-Monem; Hamama, Wafaa Salama; El-Hawary, Ibrahim Ibrahim; Ibrahim, Ismail Taha; Zoorob, Hanafi Hassan. Product Details of 539-74-2This research focused onthiopyranopyridine preparation anticancer. The article conveys some information:

The new thiopyrano[2,3-b]pyridines could be synthesized from the nicotinonitrile derivative The cytotoxicity activity of the selected compounds I, II and III was tested against MCF-7 and HCT-116 cell lines. The compound I (TP5) exhibited significant inhibitory activity and displayed the most potent activity, more than II and III. The compound I with potent inhibitory activity in tumor growth inhibition would be a potential anticancer agent. In the light of this result, the labeled 125I-compound I (125I-TP5) was prepared and its cytotoxicity against ascites tumor in mice has been evaluated. The results show that compound I (TP5) may be potentially used as a radiopharmaceutical for tumor diagnosis when labeled with 125I. In addition to this study using Ethyl 3-bromopropanoate, there are many other studies that have used Ethyl 3-bromopropanoate(cas: 539-74-2Product Details of 539-74-2) was used in this study.

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Product Details of 539-74-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: (Bromomethyl)cyclopropaneIn 2019 ,《Introducing broadened antibacterial activity to rhodanine derivatives targeting enoyl-acyl carrier protein reductase》 appeared in Chemical & Pharmaceutical Bulletin. The author of the article were Sun, Zhi-Gang; Xu, Yun-Jie; Xu, Jian-Fei; Liu, Qi-Xing; Yang, Yu-Shun; Zhu, Hai-Liang. The article conveys some information:

Broadened antibacterial activity was introduced to rhodanine derivatives targeting Mycobacterial tuberculosis enoyl-acyl carrier protein reductase (Mtb InhA) by recruiting feature of xacins to bring DNA Gyrase B inhibitory capability. This is significant for preventing further bacterial injections in the tuberculosis treatment. The most potent compound Cy14 suggested comparable bioactivity (IC50 = 3.18 microM for Mtb InhA; IC50 = 10 nM for DNA Gyrase B) with pos. controls. Structure-activity relationship discussion and mol. docking model revealed the significance of rhodanine moiety and derived methoxyl on meta-position, pointing out orientations for future modification. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 2969-81-5In 2020 ,《In situ NMR metrology reveals reaction mechanisms in redox flow batteries》 appeared in Nature (London, United Kingdom). The author of the article were Zhao, Evan Wenbo; Liu, Tao; Jonsson, Erlendur; Lee, Jeongjae; Temprano, Israel; Jethwa, Rajesh B.; Wang, Anqi; Smith, Holly; Carretero-Gonzalez, Javier; Song, Qilei; Grey, Clare P.. The article conveys some information:

Large-scale energy storage is becoming increasingly critical to balancing renewable energy production and consumption. Organic redox flow batteries, made from inexpensive and sustainable redox-active materials, are promising storage technologies that are cheaper and less environmentally hazardous than vanadium-based batteries, but they have shorter lifetimes and lower energy d. Thus, fundamental insight at the mol. level is required to improve performance. Here we report two in situ NMR methods of studying redox flow batteries, which are applied to two redox-active electrolytes: 2,6-dihydroxyanthraquinone (DHAQ) and 4,4′-((9,10-anthraquinone-2,6-diyl)dioxy) dibutyrate (DBEAQ). In the first method, we monitor the changes in the 1H NMR shift of the liquid electrolyte as it flows out of the electrochem. cell. In the second method, we observe the changes that occur simultaneously in the pos. and neg. electrodes in the full electrochem. cell. Using the bulk magnetization changes (observed via the 1H NMR shift of the water resonance) and the line broadening of the 1H shifts of the quinone resonances as a function of the state of charge, we measure the potential differences of the two single-electron couples, identify and quantify the rate of electron transfer between the reduced and oxidized species, and determine the extent of electron delocalization of the unpaired spins over the radical anions. These NMR techniques enable electrolyte decomposition and battery self-discharge to be explored in real time, and show that DHAQ is decomposed electrochem. via a reaction that can be minimized by limiting the voltage used on charging. We foresee applications of these NMR methods in understanding a wide range of redox processes in flow and other electrochem. systems. The results came from multiple reactions, including the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5Product Details of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Rong; Wang, Wan-Li; Yang, Ying-Yue; Hu, Xia-Tong; Wang, Qi-Wei; Zuo, Wei-Qiong; Xu, Ying; Feng, Qiang; Wang, Ning-Yu published an article in 2022. The article was titled 《Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor》, and you may find the article in European Journal of Medicinal Chemistry.Electric Literature of C4H7BrO2 The information in the text is summarized as follows:

BRD4-targeted proteolysis targeting chimera (PROTAC) have exhibited promising in vitro and in vivo anticancer activity in a number of cancer models. However, the clin. development of current reported BRD4-PROTACs have stagnated, largely due to the safety risks caused by their poor degradation selectivity. In this study, we designed and synthesized a series of PROTACs based on our recently reported dual BET/PLK1 inhibitor WNY0824, which led to the discovery of an isoform-selective and potent BRD4-PROTAC 12a (WWL0245). WWL0245 exhibited excellent selective cytotoxicity in the BETi sensitive cancer cell lines, including AR-pos. prostate cancer cell lines. It could also efficiently induce ubiquitin-proteasomal degradation of BRD4 in AR-pos. prostate cancer cell lines, with sub-nanomolar half-maximal degrading concentration (DC50) and maximum degradation (Dmax) > 99%. Moreover, WWL0245 induced cell cycle arrest at the G0/G1 phase and apoptosis in AR-pos. prostate cancer by downregulation of the protein levels of AR, PSA and c-Myc as well as transcriptionally suppressed AR-regulated genes. WWL0245 was thus expected to be developed as a promising drug candidate for AR-pos. prostate cancer and a valuable tool compound to study the biol. function of BRD4. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Electric Literature of C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Electric Literature of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Highly frustrated liquid crystal phases in optically active dimers: synthesis and rich phase transitional behavior》 were Nayak, Rashmi Ashwathama; Bhat, Sachin A.; Shanker, G.; Rao, D. S. Shankar; Yelamaggad, C. V.. And the article was published in New Journal of Chemistry in 2019. Product Details of 2623-87-2 The author mentioned the following in the article:

Herein the authors report on the synthesis and characterization of four new series of optically active, nonsym. dimers in which cholesterol is covalently linked to a Schiff base core through an ω-oxyalkanoyl spacer. While the Schiff base core is substituted with n-butyloxy, n-hexyloxy, n-octyloxy, n-decyloxy and n-dodecyloxy tails, three even-parity spacers, namely, 4-oxybutanoyl, 6-oxyhexanoyl, 8-oxyoctanoyl, and an odd-parity spacer, namely, 5-oxypentanoyl, were used to join the two cores. The length and parity of the spacer and the length of the terminal tail play a vital role in deciding the phase sequences of the dimers. In general, the dimers possessing an even-parity spacer display enantiotropic LC phases such as chiral nematic (N*), twist grain boundary (TGB), smectic A (SmA), chiral smectic C (SmC*) and twist grain boundary phase with SmC* slabs (TGBC*). Some of these dimers display TGBC* over a wide temperature range. The dimers with an odd-parity (5-oxypentanoyl) spacer display, unlike their even-membered counterparts, blue phases (BPIII/II/I); besides, they stabilize N* and/or unknown smectic (SmX) phases. The CD measurements were carried out as a function of temperature on the planar texture formed by three even-membered dimers and an odd-membered dimer. The occurrence of a strong neg. CD band in the N* phase of the even-membered dimers suggests a left-handed screw sense of the macroscopic helical structure, and the scenario is opposite in the case of an odd-membered dimer. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Product Details of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Product Details of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A water soluble light activated hydrogen sulfide donor induced by an excited state meta effect》 were Bera, Manoranjan; Maji, Somnath; Paul, Amrita; Ray, Souvik; Maiti, Tapas Kumar; Singh, N. D. Pradeep. And the article was published in Organic & Biomolecular Chemistry in 2019. COA of Formula: C4H7BrO2 The author mentioned the following in the article:

We have utilized an m-amino benzyl based photoremovable protecting group (PRPG) to develop a new water soluble H2S donor. It efficiently releases H2S on demand in a spatio-temporally controlled fashion by an excited state “”meta effect”” with good chem. and photochem. quantum yield in an aqueous environment. The efficient photorelease of H2S under physiol. conditions was also demonstrated by in vitro studies.4-Bromobutanoic acid(cas: 2623-87-2COA of Formula: C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Ruthenium-Catalyzed Alternating Ring-Opening Metathesis Copolymerization of Norborn-2-ene with Cyclic Olefins》 were Paradiso, Veronica; Grisi, Fabia. And the article was published in Advanced Synthesis & Catalysis in 2019. Safety of 1-Bromo-2-isopropylbenzene The author mentioned the following in the article:

A Grubbs-type olefin metathesis catalyst bearing a backbone-substituted unsym. N-heterocyclic carbene (NHC) ligand has been prepared from readily available reagents using a four-step synthetic protocol. This catalyst was found able to promote the alternating ring-opening metathesis copolymerization of norborn-2-ene (NBE) with cis-cyclooctene (COE) or cyclopentene (CPE) with a high degree of chemoselectivity (98% and 95% of alternating diads, resp.) at low comonomers ratios. The results came from multiple reactions, including the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Safety of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Safety of 1-Bromo-2-isopropylbenzene The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,European Journal of Medicinal Chemistry included an article by Li, Zheng; Liu, Chunxia; Yang, Jianyong; Zhou, Jiaqi; Ye, Zhiwen; Feng, Dazhi; Yue, Na; Tong, Jiayi; Huang, Wenlong; Qian, Hai. Reference of 1-Bromo-2-isopropylbenzene. The article was titled 《Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold》. The information in the text is summarized as follows:

Based on an old phenoxyacetic acid scaffold, CPU014 (compound 14) has been identified as a superior agonist by comprehensive exploration of structure-activity relationship. In vitro toxicity study suggested that CPU014 has lower risk of hepatotoxicity than TAK-875. During acute toxicity study (5-500 mg/kg), a favorable therapeutic window of CPU014 was observed by evaluation of plasma profiles and liver slices. Moreover, CPU014 promotes insulin secretion in a glucose-dependent manner, while no GLP-1 secretion has been enhanced. Other than good pharmacokinetic properties, CPU014 significantly improved glucose tolerance both in normal and diabetic models without the risk of hypoglycemia. These subversive findings provided a safer candidate CPU014, which is currently in preclin. study to assess its potential for the treatment of diabetes. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Reference of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Reference of 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Angewandte Chemie, International Edition included an article by Yi, Hong; Mao, Wenbin; Oestreich, Martin. Recommanded Product: 2969-81-5. The article was titled 《Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling》. The information in the text is summarized as follows:

An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes. In the experimental materials used by the author, we found Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of the American Chemical Society included an article by Li, Yang; Liang, Yujie; Dong, Junchao; Deng, Yi; Zhao, Chunyang; Su, Zhongmin; Guan, Wei; Bi, Xihe; Liu, Qun; Fu, Junkai. Application of 7051-34-5. The article was titled 《Directed Copper-Catalyzed Intermolecular Aminative Difunctionalization of Unactivated Alkenes》. The information in the text is summarized as follows:

A diverse collection of copper-catalyzed intermol. aminative difunctionalizations of unactivated alkenes with N-halodialkylamines as the terminal dialkylamino source is reported. A bidentate auxiliary tethered on the alkene substrates is crucial, which can promote the migratory insertion of nonactivated alkenes into the aminyl radical-metal complex and stabilize the resultant high-valent copper intermediate to allow for further transformations. By employing this strategy, the intermol. aminohalogenation reactions and a three-component aminoazidation reaction of unactivated alkenes with dialkylamino source were successively achieved in a remarkable regio- and stereoselective manner. These reactions were performed under neutral conditions and maintained excellent functional group tolerance toward a wide range of N-halodialkylamines and unactivated alkenes. Further mechanistic studies and DFT calculations supported a concerted migratory insertion of the C-C double bond into the aminyl radical-metal complex to form a Cu(III) intermediate. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary