Tag: 100-200

《Electrochemical Oxidation Enables Regioselective and Scalable α-C(sp3)-H Acyloxylation of Sulfides》 was written by Wang, Huamin; He, Meng; Li, Yongli; Zhang, Heng; Yang, Dali; Nagasaka, Masanari; Lv, Zongchao; Guan, Zhipeng; Cao, Yangmin; Gong, Fengping; Zhou, Zhilin; Zhu, Jingyun; Samanta, Supravat; Chowdhury, Abhishek Dutta; Lei, Aiwen. HPLC of Formula: 2623-87-2 And the article was included in Journal of the American Chemical Society in 2021. The article conveys some information:

A highly selective, environmentally friendly, and scalable electrochem. protocol for the construction of α-acyloxy sulfides e.g., (p-tolylthio)methyl acetate, through the synergistic effect of self-assembly-induced C(sp3)-H/O-H cross-coupling, is reported. It features exceptionally broad substrate scope, high regioselectivity, gram-scale synthesis, construction of complex mols. e.g., I, and applicability to a variety of nucleophiles such as acetic acid, cyclohexanecarboxylic acid, benzoic acid, benzotriazole, etc. Moreover, the soft X-ray absorption technique and a series of control experiments have been utilized to demonstrate the pivotal role of the self-assembly of the substrates, which indeed is responsible for the excellent compatibility and precise control of high regioselectivity in electrochem. protocol. The experimental process involved the reaction of 4-Bromobutanoic acid(cas: 2623-87-2HPLC of Formula: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).HPLC of Formula: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Nanoaggregate Probe for Breast Cancer Metastasis through Multispectral Optoacoustic Tomography and Aggregation-Induced NIR-I/II Fluorescence Imaging》 was written by Ouyang, Juan; Sun, Lihe; Zeng, Zhuo; Zeng, Cheng; Zeng, Fang; Wu, Shuizhu. Safety of o-Bromobenzaldehyde And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

An activatable nanoprobe (I) for imaging breast cancer metastases through near IR-I (NIR-I)/NIR-II fluorescence imaging and multispectral optoacoustic tomog. (MSOT) imaging was designed. With a dihydroxanthene moiety serving as the electron donor, quinolinium as the electron acceptor and nitrobenzyloxydiphenylamino as the recognition element, the probe can specifically respond to nitroreductase and transform into an activated D-π-A structure with a NIR emission band extending beyond 900 nm. The activated nanoprobe exhibits NIR emission enhanced by aggregation-induced emission (AIE) and produces strong optoacoustic signal. The nanoprobe was used to detect and image metastases from the orthotopic breast tumors to lymph nodes and then to lung in two breast cancer mouse models. Moreover, the nanoprobe can monitor the treatment efficacy during chemotherapeutic course through fluorescence and MSOT imaging. In the part of experimental materials, we found many familiar compounds, such as o-Bromobenzaldehyde(cas: 6630-33-7Safety of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Safety of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Green and efficient synthesis of fluorescent bis(pyrazolyl)methanes in choline chloride/urea deep eutectic solvent》 was written by Zonouz, Adeleh Moshtaghi; Beiranvand, Masoumeh; Mohammad-Rezaei, Rahim; Naderi, Soheila. Related Products of 6630-33-7 And the article was included in Letters in Organic Chemistry in 2020. The article conveys some information:

A series of pyrazole-based heteroaromatic compoundsI [R=H, 2-Me, 3-Me, 2-MeO, etc.] were synthesized by the reaction of 3-methyl-5-pyrazolone and aromatic aldehydes in Choline chloride/urea DES as a green solvent. This simple and green procedure has advantages such as easy operation, short reaction times, efficient yields, low cost and min. use of hazardous solvents and catalysts. The structure of compounds was determined by IR, 1H and 13C NMR spectra, and the crystal structure of compoundI [R=H] was confirmed using X-ray crystallog. anal. The optical properties of Pyrazole derivatives compoundsI [R=H, 2-Me, 3-Me, 2-MeO, etc.] was also studied with UV/vis and fluorescence spectroscopy. All of these pyrazole-containing heteroaromatic compounds displayed maximum emission peak from 340 to 360 nm. After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7Related Products of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Related Products of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents》 was written by Huo, Jun-Feng; Hu, Tian-Xing; Dong, Ya-Long; Zhao, Jin-Zhu; Liu, Xiao-Jie; Li, Lei-Lei; Zhang, Xue-Yan; Li, Yun-Fan; Liu, Hong-Min; Ke, Yu; Wang, Cong. SDS of cas: 2623-87-2 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

As our research focuses on anticancer drugs, a series of novel derivatives of flexicaulin A (I), an ent-kaurene diterpene, condensed with an aromatic ring were synthesized, and their antiproliferative activities against four human cancer cell lines (TE-1, EC109, MCF-7, and MGC-803) were evaluated. The activities of most of the new compounds were better than those of I. Compound II exhibited the best activity with an IC50 value reaching 0.13μM against oesophageal cancer cells (EC109 cells). The IC50 values for II in normal cells (GES-1 cells and HUVECs) were 0.52μM and 0.49μM, resp. Subsequent mechanistic investigations found that compound II can inhibit the proliferation of cancer cells and cell cloning. In addition, II could reduce the mitochondrial membrane potential, increase the apoptosis rate, and increase the ROS level in EC109 cells. Moreover, II can upregulate the expression of ROS/JNK pathway-related proteins (p-ASK1, p-MKK4, p-JNK, and p-Cjun (ser63)) and pro-apoptotic proteins (Bax, Bad, and Bim). In vivo experiments showed that II can inhibit tumor growth in nude mice. The mechanism involves an increase in protein expression in the ROS pathway, leading to changes in apoptosis-related proteins. In addition, compound II shows low toxicity. These results indicate that compound II holds promising potential as an antiproliferative agent. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobutanoic acid(cas: 2623-87-2SDS of cas: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).SDS of cas: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Toward the Synthesis of a Highly Strained Hydrocarbon Belt》 was published in Journal of the American Chemical Society in 2020. These research results belong to Shi, Tan-Hao; Guo, Qing-Hui; Tong, Shuo; Wang, Mei-Xiang. Recommanded Product: 1-Bromo-2-isopropylbenzene The article mentions the following:

In this communication a general approach to hydrocarbon belts and their derivatives was reported. Closing up all four fjords of resorcin[4]arene derivatives through multiple intramol. Friedel-Crafts alkylation reactions in an operationally simple one-pot reaction manner enabled efficient construction of octohydrobelt[8]arenes. Synthesis of belt[8]arene from DDQ-oxidized aromatization of octohydrobelt[8]arene under different conditions resulted in aromatization and simultaneous [4 + 2] cycloaddition reactions with DDQ or TCNE to produce selectively tetrahydrobelt[8]arene-DDQ2, tetrahydrobelt[8]arene-TCNE2, and belt[8]arene-DDQ4 adducts. Formation of belt[8]arene, a fully conjugated hydrocarbon belt, was observed from retro-Diels-Alder reaction of a belt[8]arene-DDQ4 adduct with laser irradiation under MALDI conditions. The new and practical synthetic method established would open an avenue to create belt-shaped mols. from easily available starting materials.1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 1-Bromo-2-isopropylbenzene) was used in this study.

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Recommanded Product: 1-Bromo-2-isopropylbenzene Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《SO4-2/SnO2-catalyzed cyclocondensation for the synthesis of fully functionalized pyridines》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Koduri, Ramesh Goud; Pagadala, Ramakanth; Boodida, Sathyanarayana; Varala, Ravi. SDS of cas: 6630-33-7 The article mentions the following:

An efficient and promising synthetic approach to assemble skeletons of multifunctionalized pyridine derivatives I [R = H, 4-Br, 2-Cl, 2-OMe, etc.; R1 = R2 = Me; R1R2 = -(CH2)5-] in presence of recyclable heterogeneous sulfated tin oxide (STO) catalyst has been evolved. The STO catalyst was used as a promoter for the cyclocondensation process in ethanol at 70°C. Overall performance of this catalyst was attributed to the cooperative contribution of its Lewis and Bronsted-Lowry acidic sites. Nanosized STO catalyst was synthesized by using sol-gel process and characterized by Fourier transform IR (FTIR) spectroscopy, X-ray diffraction (XRD), 1H-NMR, and SEM (SEM). This catalyst tolerates most of the substrates, and the protocol shows precious capabilities consisting of high yields, operational simplicity, less reaction time, and eco-friendly conditions. The newly synthesized heterogeneous catalyst was easily separated and reused. All the reactions are carried out for subsequent cycles without significant loss of catalytic activity and with good proficiency. In addition to this study using o-Bromobenzaldehyde, there are many other studies that have used o-Bromobenzaldehyde(cas: 6630-33-7SDS of cas: 6630-33-7) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.SDS of cas: 6630-33-7It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Ni-Catalyzed Reductive Liebeskind-Srogl Alkylation of Heterocycles》 were Ma, Yuanhong; Cammarata, Jose; Cornella, Josep. And the article was published in Journal of the American Chemical Society in 2019. Recommanded Product: 7051-34-5 The author mentioned the following in the article:

Herein we present a Ni-catalyzed alkylation of C-SMe with alkyl bromides for the decoration of heterocyclic frameworks I (R = H, 6-CN, 5-CF3, 2-thienyl, etc.; R1 = cyclohexyl, cyclobutyl, 4-pyranyl, etc.). The protocol, reminiscent to the Liebeskind-Srogl coupling, makes use of simple C(sp2)-SMe to be engaged in a reductive coupling. The reaction is suitable for a preponderance of highly valuable heterocyclic motifs. In addition to cyclic bromides, noncyclic alkyl bromides are well accommodated with exquisite levels of retention over isomerization. The protocol is scalable and permits orthogonal couplings in the presence of other functionalization handles. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis of binuclear isoquinoline- and pyridine-fused benzimidazole-4,7-diones by magnetic MOF-199-catalyzed C-C coupling/cyclization followed by oxidation》 were Diep, Thi Duyen; Dao, Pham Duy Quang; Cho, Chan Sik. And the article was published in European Journal of Organic Chemistry in 2019. HPLC of Formula: 6630-33-7 The author mentioned the following in the article:

Binuclear isoquinoline- and pyridine-fused benzimidazoles such as I [R = Ph, 4-FC6H4, 2-furyl, etc.; R1 = H, 3-Me, 2-F, 2-MeO] were prepared from 2-(2-bromoaryl)-4,7-dimethoxy-1H-benzo[d]imidazoles and (Z)-2-(2-bromovinyl)-4,7-dimethoxy-1H-benzo[d]imidazoles with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of recyclable Fe3O4@SiO2@MOF-199 along with a base. Treatment of such binuclear N-fused hybrid scaffolds with ceric ammonium nitrate in acetonitrile/H2O or HBr/FeCl3 in H2O afforded binuclear isoquinoline- and pyridine-fused benzimidazole-4,7-diones II [R2 = Me, 2-MeC6H4, 4-MeOC6H4, etc.; R3 = H, 3-Me, 2-F, 2-MeO] in good to high yields. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7HPLC of Formula: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.HPLC of Formula: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Iwami, Hikaru; Okamura, Masaya; Kondo, Mio; Masaoka, Shigeyuki published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Electrochemical Polymerization Provides a Function-Integrated System for Water Oxidation》.Electric Literature of C5H9BrO2 The article contains the following contents:

Water oxidation is a key reaction in natural and artificial photosynthesis. In nature, the reaction is efficiently catalyzed by a metal-complex-based catalyst surrounded by hole-transporting amino acid residues. However, in artificial systems, there is no example of a water oxidation system that has a catalytic center surrounded by hole transporters. Herein, we present a facile strategy to integrate catalytic centers and hole transporters in one system. Electrochem. polymerization of a metal-complex-based precursor afforded a polymer-based material (Poly-1). Poly-1 exhibited excellent hole-transporting ability and catalyzed water oxidation with high performance. It was also revealed that the catalytic activity was almost completely suppressed in the absence of the hole-transporting moieties. The present study provides a novel strategy for constructing efficient mol.-based systems for water oxidation In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-bromopropanoate(cas: 539-74-2Electric Literature of C5H9BrO2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Electric Literature of C5H9BrO2 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Singh, Abhishek Kumar; Schade, Boris; Wycisk, Virginia; Boettcher, Christoph; Haag, Rainer; von Berlepsch, Hans published their research in Journal of Physical Chemistry B in 2021. The article was titled 《Aggregation of Amphiphilic Carbocyanines: Fluorination Favors Cylindrical Micelles over Bilayered Tubes》.Safety of Ethyl 4-bromobutyrate The article contains the following contents:

The synthesis of a new amphiphilic 5,5,6,6-tetrachlorobenzimidacarbocyanine dye derivative with -(CH2)2-(CF2)5-CF3 chains attached to the nitrogen atoms in the 1,1-position, CF8O3, is reported. Depending on the dye concentration and the addition of MeOH, CF8O3 forms J- and H-aggregates in aqueous solutions The aggregation behavior was investigated using steady-state absorption, linear dichroism, and fluorescence spectroscopy, as well as by cryogenic transmission electron microscopy (cryo-TEM). The J-band of the MeOH-free solution is monomer-like, rather broad, and less red-shifted with respect to the monomer absorption, indicating weak excitonic coupling and disorder effects. Cryo-TEM reveals a diversity of supramol. structures, wherein linear and branched cylindrical micelles dominate. It is concluded that the high stiffness of fluoroalkyl chains does not allow the chains to splay and completely fill up the hydrophobic gap between opposing chromophores. This destabilizes the bilayers and favors the micellar structure motifs instead. The aggregates appearing at 30% MeOH show a split absorption spectrum consisting of a broad blue-shifted H-band and an accompanying sharp red-shifted J-band with perpendicular polarizations. These HJ-type aggregates are also composed of micellar fibers, but these bundle into rope-like strands. For 10% MeOH, a narrow bilayered tube is the dominating morphol. The observed MeOH dependence of aggregation reveals a clear cosolvent effect. The results came from multiple reactions, including the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5Safety of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Safety of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary