Tag: 100-200

《Copper-Catalyzed Construction of Trinuclear N-Fused Hybrid Scaffolds Using Cyclic Ureas as New Building Blocks》 was written by Dao, Pham Duy Quang; Cho, Chan Sik. Synthetic Route of C7H5BrOThis research focused ontrinuclear fused hetereocycle preparation cyclization benzimidazole cyclic urea. The article conveys some information:

2-(2-Bromoaryl)- and 2-(2-bromovinyl)-benzimidazoles are coupled and cyclized with cyclic ureas as new building blocks in DMF in the presence of a catalytic amount of a copper catalyst and a base to give the corresponding trinuclear N-fused hybrid scaffolds in good yields. Trinuclear N-fused hybrid scaffolds having methoxy group on benzimidazole moiety are readily oxidized to unprecedented benzimidazolequinone-fused hybrid scaffolds in high yields by treatment of ceric ammonium nitrate in acetonitrile/H2O.o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, Akash; Verma, Shruti; Pathak, Devendra Deo published an article in 2021. The article was titled 《Synthesis and characterization of a recyclable graphene oxide-surface- engineered copper(II) Schiff base complex: Catalytic application in synthesis of 1,2,3-triazoles and 2H-indazoles》, and you may find the article in Journal of Environmental Chemical Engineering.Related Products of 6630-33-7 The information in the text is summarized as follows:

A new graphene oxide (GO) supported Cu(II) Schiff base complex (GO-SB-Cu) was synthesized by utilizing Schiff base functionalized GO (GO-SB) and copper acetate in ethanol under reflux. The synthesized complex was characterized using several techniques such as fourier transform IR spectroscopy (FTIR), powd. X-ray diffraction (PXRD), fourier transform (FT-Raman), thermo gravimetric anal. (TGA), field emission SEM (FESEM), high resolution transition electron microscopy (HRTEM), elemental dispersive X-ray anal. (EDX), elemental mapping, X-ray photo electron spectroscopy (XPS) and at. absorption spectroscopy (AAS) anal. The complex was found to be highly efficient in the click reaction for synthesis of 1,4-disubstituted 1,2,3-triazoles at room temperature and an operationally simple and efficient one-pot synthesis of 2H-indazoles from com. accessible reactants at ambient temperature, without using any base, additive or co-catalyst. A variety of electron donating/withdrawing groups were employed to explore the scope of the reactions. Interestingly, aliphatic and heterocyclic amines were also tested and found active in the synthesis of 2H-indazoles. The results demonstrated that the reaction could be scaled up conveniently and the catalyst could be easily recycled up to successive four times without any noteworthy loss in the catalytic action. High yield of the products, easy workup, environmentally benign, high stability of the catalyst and mild reaction conditions are the key points of this catalyst. All the synthesized organic products were identified by 1H and 13C NMR spectroscopy. In addition to this study using o-Bromobenzaldehyde, there are many other studies that have used o-Bromobenzaldehyde(cas: 6630-33-7Related Products of 6630-33-7) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Related Products of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bhukya, Balakishan; Kaushal, Tanu; Kumar, Deepak; Singh, Diksha; Parveen, Shahnaz; Khan, Sana; Luqman, Suaib; Konwar, Rituraj; Chanda, Debabrata; Khan, Feroz; Kumar, Shailesh; Meena, Abha; Negi, Arvind S. published their research in Indian Journal of Heterocyclic Chemistry in 2021. The article was titled 《Antiproliferative activity of diarylnaphthofurans through microtubule destabilization》.Quality Control of Ethyl 3-bromopropanoate The article contains the following contents:

The present communication deals with pharmacophore designing based on ”Fragment-Based Drug Discovery” approach. Two series of compounds diaryl naphthofurans I (R = (3-nitrophenyl)carbonyl, 4-fluorophenyl, 5-formylfuran-2-yl, etc.) and II (R1 = H, 2-ethoxy-2-oxoethyl, 3-ethoxy-3-oxopropyl, 4-ethoxy-4-oxobut-2-en-1-yl, etc.) were synthesized and evaluated against human cancer cell lines by sulforhodamine assay, target studies through tubulin kinetics, in silico predictions of binding pocket, and drugability and safety studies by acute oral toxicity in mice model. Out of 24 varied analogs, seven compounds exhibited significant antiproliferative activity against both hormone-dependent and hormone-independent breast cancer cell lines. Among these, two of the most active representative compounds I (R = 3-carboxyphenyl) and II (R1 = H) showed potential antiproliferative activity against MDA-MB-231 with IC50 at 10.04μM and 10.70μM and significant anti-tubulin effect at their half IC50 and IC50. In mol. docking studies, both the compounds occupied colchicine binding pocket at β-tubulin with high binding energies of -8.3 Kcal/mol and -7.9 Kcal/mol, resp. Both the identified investigational leads were found to be safe and non-toxic in rodent model up to 1000 mg/kg oral dose. Optimization of these lead compounds may yield some better candidates in future. In the experimental materials used by the author, we found Ethyl 3-bromopropanoate(cas: 539-74-2Quality Control of Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Quality Control of Ethyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A dual light-driven palladium catalyst: Breaking the barriers in carbonylation reactions》 was written by Torres, Gerardo M.; Liu, Yi; Arndtsen, Bruce A.. Recommanded Product: Ethyl 4-bromobutyrate And the article was included in Science (Washington, DC, United States) in 2020. The article conveys some information:

Transition metal-catalyzed coupling reactions have become one of the most important tools in modern synthesis. However, an inherent limitation to these reactions is the need to balance operations, because the factors that favor bond cleavage via oxidative addition ultimately inhibit bond formation via reductive elimination. Here, we describe an alternative strategy that exploits simple visible-light excitation of palladium to drive both oxidative addition and reductive elimination with low barriers. Palladium-catalyzed carbonylations can thereby proceed under ambient conditions, with challenging aryl or alkyl halides and difficult nucleophiles, and generate valuable carbonyl derivatives such as acid chlorides, esters, amides, or ketones in a now-versatile fashion. Mechanistic studies suggest that concurrent excitation of palladium(0) and palladium(II) intermediates is responsible for this activity. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging》 was written by Morozumi, Akihiko; Kamiya, Mako; Uno, Shin-nosuke; Umezawa, Keitaro; Kojima, Ryosuke; Yoshihara, Toshitada; Tobita, Seiji; Urano, Yasuteru. Recommanded Product: 2623-87-2 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Single-mol. localization microscopy (SMLM) allows the reconstruction of super-resolution images but generally requires prior intense laser irradiation and in some cases additives to induce blinking of conventional fluorophores. The authors previously introduced a spontaneously blinking rhodamine fluorophore based on an intramol. spirocyclization reaction for live-cell SMLM under physiol. conditions. Here, the authors report a novel principle of spontaneous blinking in living cells, which utilizes reversible ground-state nucleophilic attack of intracellular glutathione (GSH) upon a xanthene fluorophore. Structural optimization afforded two pyronine fluorophores with different colors, both of which exhibit equilibrium (between the fluorescent dissociated form and the nonfluorescent GSH adduct form) and blinking kinetics that enable SMLM of microtubules or mitochondria in living cells. Furthermore, by using spontaneously blinking fluorophores working in the near-IR (NIR) and green ranges, the authors succeeded in dual-color live-cell SMLM without the need for optimization of the imaging medium. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,European Journal of Organic Chemistry included an article by Esteves, Henrique A.; Darbem, Mariana P.; Pimenta, Daniel C.; Stefani, Helio A.. Related Products of 3395-91-3. The article was titled 《Carbonylative Negishi-Type Coupling of 2-Iodoglycals with Alkyl and Aryl Halides》. The information in the text is summarized as follows:

C-Glycosides are valuable organic compounds in the field of medicinal chem. due to their ubiquity inside living systems and pronounced biol. activity. Herein, we describe an approach to alkyl-ketones bearing glycal units, e.g. I, via the Pd-catalyzed carbonylative coupling of 2-iodoglycals and alkyl and aryl halides. Examples bearing a variety of functional groups are presented as well as a mechanistic proposal for this transformation. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Related Products of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Related Products of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,European Journal of Pharmacology included an article by Wojcik-Pszczola, Katarzyna; Chlon-Rzepa, Grazyna; Jankowska, Agnieszka; Ellen, Eugenie; Swierczek, Artur; Pociecha, Krzysztof; Koczurkiewicz, Paulina; Piska, Kamil; Gawedzka, Anna; Wyska, Elzbieta; Knapik-Czajka, Malgorzata; Pekala, Elzbieta; Gosens, Reinoud. Safety of Ethyl 4-bromobutyrate. The article was titled 《Novel phosphodiesterases inhibitors from the group of purine-2,6-dione derivatives as potent modulators of airway smooth muscle cell remodelling》. The information in the text is summarized as follows:

Airway remodelling (AR) is an important pathol. feature of chronic asthma and chronic obstructive pulmonary disease. The etiol. of AR is complex and involves both lung structural and immune cells. One of the main contributors to airway remodelling is the airway smooth muscle (ASM), which is thickened by asthma, becomes more contractile and produces more extracellular matrix. As a second messenger, adenosine 3′,5′-cyclic monophosphate (cAMP) has been shown to contribute to ASM cell (ASMC) relaxation as well as to anti-remodelling effects in ASMC. Phosphodiesterase (PDE) inhibitors have drawn attention as an interesting new group of potential anti-inflammatory and anti-remodelling drugs. Recently, new hydrazide and amide purine-2,6-dione derivatives with anti-inflammatory properties have been synthesized by our team (compounds 1 and 2). The results show that both compounds have subtype specificity for several PDE isoforms (including inhibition of PDE1, PDE3, PDE4 and PDE7). Interestingly, such combined PDE subtype inhibition exerts improved anti-remodelling efficacies against several ASMC-induced responses such as proliferation, contractility, extracellular matrix (ECM) protein expression and migration when compared to other non-selective and selective PDE inhibitors. Our findings open novel perspectives in the search for new chem. entities with dual anti-inflammatory and anti-remodelling profiles in the group of purine-2,6-dione derivatives as broad-spectrum PDE inhibitors. The experimental part of the paper was very detailed, including the reaction process of Ethyl 4-bromobutyrate(cas: 2969-81-5Safety of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Safety of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Muramatsu, Tatsuya; Okado, Yuji; Traeger, Hanna; Schrettl, Stephen; Tamaoki, Nobuyuki; Weder, Christoph; Sagara, Yoshimitsu published an article in Journal of the American Chemical Society. The title of the article was 《Rotaxane-Based Dual Function Mechanophores Exhibiting Reversible and Irreversible Responses》.Application of 583-69-7 The author mentioned the following in the article:

Mechanochromic mechanophores permit the design of polymers that indicate mech. events through optical signals. Here we report rotaxane-based supramol. mechanophores that display both reversible and irreversible fluorescence changes. These responses are triggered by different forces and are achieved by exploiting the mol. shuttling function and force-induced dethreading of rotaxanes. The new rotaxane mechanophores are composed of a ring featuring a luminophore, which is threaded onto an axle with a matching quencher and two stoppers. In the stress-free state, the luminophore is preferentially located in the proximity of the quencher, and the emission is quenched. The luminophore slides away from the quencher when a force is applied and the fluorescence is switched on. This effect is reversible, unless the force is so high that the luminophore-carrying ring slips past the stopper and dethreading occurs. We show that the combination of judiciously selected ring and stopper moieties is crucial to attain interlocked structures that display such a dual response. PU elastomers that contain such doubly responsive rotaxanes exhibit reversible fluorescence changes over multiple loading-unloading cycles due to the shuttling function, whereas permanent changes are observed upon repeated deformations to high strains due to breakage of the mech. bond upon dethreading of the ring from the axle. This response allows one, at least conceptually, to monitor the actual deformation of polymer materials and examine mech. damage that was inflicted in the past on the basis of an optical signal. In the experiment, the researchers used 2-Bromobenzene-1,4-diol(cas: 583-69-7Application of 583-69-7)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 583-69-7 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C6H5BrO2On May 25, 2019, Sattar, Omar D. Abdul; Shneshil, Mustafa K.; Mohammed, Mustafa K.; Dheyab, Hiba B.; Alwan, Osama K.; Hussein, Suaad A.; Mahmood, Maha A. published an article in Journal of Physics: Conference Series. The article was 《Synthesis and anti-bacterial activity of some azo compounds》. The article mentions the following:

Some azo compounds were prepared as I (R = 4-hydroxyphenyl, 3-chloro-4-hydroxyphenyl, 4-hydroxy-2-nitrophenyl, etc.) by the reaction of 4-amino benzamide with benzoyl chloride forming N-benzoyl-4-amino benzamide, the later was diazotized to give N-benzoyl-4-((substituted phenyl)diazenyl)benzamide I. The azo derivatives I were tested for their antibacterial activity against (S. aureus, S. epidermidis, E. coli and P. aeruginosa) by using disk diffusion method. The min. inhibitory concentrations (MICs) of the compounds also calculated by agar streak dilution method. In the experiment, the researchers used many compounds, for example, 2-Bromobenzene-1,4-diol(cas: 583-69-7COA of Formula: C6H5BrO2)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.COA of Formula: C6H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 4-Bromobutanoic acidIn 2020 ,《Supramolecular Design of Unsymmetric Reverse Bolaamphiphiles for Cell-Sensitive Hydrogel Degradation and Drug Release》 was published in Angewandte Chemie, International Edition. The article was written by Chakroun, Rami W.; Sneider, Alexandra; Anderson, Caleb F.; Wang, Feihu; Wu, Pei-Hsun; Wirtz, Denis; Cui, Honggang. The article contains the following contents:

Self-assembly of peptide-based building units into supramol. nanostructures creates an important class of biomaterials with robust mech. properties and improved resistance to premature degradation Yet, upon aggregation, substrate-enzyme interactions are often compromised because of the limited access of macromol. proteins to the peptide substrate, leading to either a reduction or loss of responsiveness to biomol. cues. Reported here is the supramol. design of unsym. reverse bolaamphiphiles (RBA) capable of exposing a matrix metalloproteinase (MMP) substrate on the surface of their filamentous assemblies. Upon addition of MMP-2, these filaments rapidly break into fragments prior to reassembling into spherical micelles. Using 3D cell culture, it is shown that drug release is commensurate with cell d., revealing more effective cell killing when more cancer cells are present. This design platform could serve as a cell-responsive therapeutic depot for local chemotherapy. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Safety of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Safety of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary