Tag: 100-200

Quality Control of Ethyl 4-bromobutyrateIn 2019 ,《Regioselective Alkylative Cross-Coupling of Remote Unactivated C(sp3)-H Bonds》 appeared in Journal of the American Chemical Society. The author of the article were Thullen, Scott M.; Treacy, Sean M.; Rovis, Tomislav. The article conveys some information:

The functionalization of unactivated C(sp3)-H bonds poses a significant challenge due to their ubiquity and relative similarity in most organic frameworks. Herein, we describe the use of a combined photoredox and nickel catalytic system for the regioselective C(sp3)-C(sp3) coupling of unactivated C(sp3)-H bonds and alkyl bromides. Positional selectivity is dictated by a 1,5-hydrogen atom transfer (HAT) reaction by a pendent amide. Interception of this radical by a Ni catalyst allows distal alkylation to occur in good yield and excellent selectivity. In the experimental materials used by the author, we found Ethyl 4-bromobutyrate(cas: 2969-81-5Quality Control of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4-Bromobutanoic acidIn 2021 ,《Remote C-H Pyridylation of Hydroxamates through Direct Photoexcitation of O-Aryl Oxime Pyridinium Intermediates》 appeared in Angewandte Chemie, International Edition. The author of the article were Kweon, Byeongseok; Kim, Changha; Kim, Seonyul; Hong, Sungwoo. The article conveys some information:

An efficient strategy for the remote C-H pyridylation of hydroxamates with excellent ortho-selectivity by designing a new class of photon-absorbing O-aryl oxime pyridinium salts generated in-situ from the corresponding pyridines and hydroxamates. When irradiated by visible light, the photoexcitation of oxime pyridinium intermediates generated iminyl radicals via the photolytic N-O bond cleavage, which does not require an external photocatalyst. The efficiency of light absorption and N-O bond cleavage of the oxime pyridinium salts was modulated through the electronic effect of substitution on the O-aryl ring. The resultant iminyl radicals enabled the installation of pyridyl rings at the γ-CN position, which yields synthetically valuable C2-substituted pyridyl derivatives This novel synthetic approach provided significant advantages in terms of both efficiency and simplicity and exhibits broad functional group tolerance in complex settings under mild and metal-free conditions. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: (Bromomethyl)cyclopropaneIn 2019 ,《Carbonylative C-C Bond Activation of Electron-Poor Cyclopropanes: Rhodium-Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides》 was published in Angewandte Chemie, International Edition. The article was written by Dalling, Andrew G.; Yamauchi, Takayuki; McCreanor, Niall G.; Cox, Lydia; Bower, John F.. The article contains the following contents:

Rh-catalyzed carbonylative C-C bond activation of cyclopropylamides generates configurationally stable rhodacyclopentanones that engage tethered alkenes in (3+1+2) cycloadditions These studies provide the first examples of multicomponent cycloadditions that proceed through C-C bond activation of “”simple”” electron poor cyclopropanes. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Name: (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Name: (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bao, Xin; Wang, Chunhong; Zhang, Zhenyu; Cao, Qinghua; Liu, Fei; Chen, Jing; Zhang, Chuanzhi; Na, Haining; Zhu, Jin published their research in Carbohydrate Polymer Technologies and Applications in 2021. The article was titled 《Wet spinning to prepare filaments from three cellulose carbonated derivatives: Synthesis, characterization and filament properties》.SDS of cas: 7051-34-5 The article contains the following contents:

In this article, three kinds of cellulose carbonated derivatives are synthesized by modifying cellulose with alkyl halides (namely bromopropane, benzyl bromide and bromomethyl cyclopropane) in DBU/DMSO/CO2 system. The wet spinnability and filament properties of the obtained cellulose carbonated derivatives are investigated. Through rheol. anal., the solutions of various cellulose carbonated derivative in Newtonian fluid state can show good wet spinnability. Filaments with smooth surface and uniform morphol. can be obtained from the solution with viscosity over 0.07Pa•s. The cellulose carbonated derivatives in the filament show similar in tight orderly rows. Among them, the cellulose Pr carbonated derivative filament exhibits the highest mech. properties and heat resistance. By using of DBU/DMSO/CO2 system, the wet spinning and key control condition of cellulose carbonated derivatives are combined to achieve for the formation of filament with uniform morphol. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5SDS of cas: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.SDS of cas: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors》 was written by Pilkington, Lisa I.; Sparrow, Kevin; Rees, Shaun W. P.; Paulin, Emily K.; van Rensburg, Michelle; Xu, Chris Sun; Langley, Ries J.; Leung, Ivanhoe K. H.; Reynisson, Johannes; Leung, Euphemia; Barker, David. Recommanded Product: o-Bromobenzaldehyde And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

Phospholipases are enzymes that are involved in the hydrolysis of acyl and phosphate esters of phospholipids, generating secondary messengers that have implications in various cellular processes including proliferation, differentiation and motility. As such inhibitors of phospholipases have been widely studied for their use as anti-cancer therapeutics. Phosphatidylcholine-specific phospholipase C (PC-PLC) is implicated in the progression of a number of cancer cell lines including aggressing triple-neg. breast cancers. Most current studies on PC-PLC have utilized D609 as the standard inhibitor however it is known to have multiple failings, including poor stability in aqueous media. 2-Morpholinobenzoic acids were recently identified using vHTS as a potential class of lead compounds, with improvements over D609. In this work 129 analogs in this class were prepared and their PC-PLC inhibitory activity was assessed. It was found that the majority of these novel compounds had improved activity when compared to D609 with the most potent inhibitors completely inhibiting enzyme activity. It was determined that the best compound/s contained a morpholino and 2-substituted N-benzyl moieties with these findings explained using mol. modeling. The compounds reported here will allow for improved study of PC-PLC activity. After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7Recommanded Product: o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Recommanded Product: o-BromobenzaldehydeSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Multikilogram Synthesis of a Potent Dual Bcl-2/Bcl-xL Antagonist. 2. Manufacture of the 1,3-Diamine Moiety and Improvement of the Final Coupling Reaction》 was published in Organic Process Research & Development in 2020. These research results belong to Hardouin, Christophe; Baillard, Sandrine; Bariere, Francois; Craquelin, Anthony; Grandjean, Mathieu; Janvier, Solenn; Le Roux, Stephane; Penloup, Christine; Russo, Olivier. Computed Properties of C4H7BrO2 The article mentions the following:

This paper describes the synthesis of kilogram quantities of the sulfonamide moiety I involved in a coupling reaction with acid moiety II to provide batches of drug candidate III for preclin. studies and first-in-human clin. trials. A first approach relying on a chiral separation furnished the desired enantiomer of 1,3-diamine IV, precursor of sulfonamide I. An enantiomeric synthesis of IV using the Ellman’s chiral auxiliary coupled with an aza-Reformatsky reaction to control the stereochem. is also discussed. Coupling conditions of the final step involving EDCI to provide III under a cGMP process are detailed. An alternative approach using N-(1-methanesulfonyl)benzotriazole is also presented. In the experimental materials used by the author, we found 4-Bromobutanoic acid(cas: 2623-87-2Computed Properties of C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Jankowska, Agnieszka; Satala, Grzegorz; Kolaczkowski, Marcin; Bucki, Adam; Gluch-Lutwin, Monika; Swierczek, Artur; Pociecha, Krzysztof; Partyka, Anna; Jastrzebska-Wiesek, Magdalena; Lubelska, Annamaria; Latacz, Gniewomir; Gawalska, Alicja; Bojarski, Andrzej J.; Wyska, Elzbieta; Chlon-Rzepa, Grazyna. HPLC of Formula: 2969-81-5 The article mentions the following:

A library of novel anilide and benzylamide derivatives of ω-(4-(2-methoxyphenyl)piperazin-1-yl)alkanoic acids as combined 5-HT1A/5-HT7 receptor ligands and phosphodiesterase PDE4B/PDE7A inhibitors was designed using a structure-based drug design approach. The in vitro studies of 33 newly synthesized compounds (7-39) allowed us to identify 22 as the most promising multifunctional 5-HT1A/5-HT7 receptor antagonist (5-HT1AKi = 8 nM, Kb = 0.04 nM; 5-HT7Ki = 451 nM, Kb = 460 nM) with PDE4B/PDE7A inhibitory activity (PDE4B IC50 = 80.4μM; PDE7A IC50 = 151.3μM). Compound 22 exerted a very good ability to passively penetrate through biol. membranes and a high metabolic stability in vitro. Moreover, the pharmacol. evaluation of 22 showed its procognitive and antidepressant properties in rat behavioral tests. Compound 22 at a dose of 3 mg/kg (i.p.) significantly reversed MK-801-induced episodic memory deficits in the novel object recognition test, while at a dose of 10 mg/kg (i.p.) reduced the immobility time of animals (by about 34%) in the forced swimming test. The antidepressant-like effect produced by compound 22 was stronger than that of escitalopram used as a reference drug. This study opens a new perspective in the search for efficacious drugs for the treatment of cognitive and depressive disorders. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5HPLC of Formula: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.HPLC of Formula: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Yang, Le; Zheng, Jing; Zou, Zhen; Cai, Haiyan; Qi, Peng; Qing, Zhihe; Yan, Qi; Qiu, Liping; Tan, Weihong; Yang, Ronghua. Product Details of 2969-81-5 The article mentions the following:

As the most abundant protein in blood, human serum albumin (HSA) is usually regarded as an interferent in clin. mol. diagnosis. Herein, the authors report that HSA is an endogenous signal amplifier for the detection of the prostate-specific antigen (PSA) in human plasma. This is the first study to use intrinsic biol. components as the signal amplifier in blood tests. The experimental process involved the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5Product Details of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Product Details of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis of novel 2-(piperazin-1-yl-alkyl)-1H-benzimidazole derivatives and assessment of their interactions with the D2 dopamine receptor》 were Penjisevic, Jelena Z.; Andric, Deana B.; Sukalovic, Vladimir B.; Roglic, Goran M.; Soskic, Vukic; Kostic-Rajacic, Sladana. And the article was published in Journal of the Serbian Chemical Society in 2019. Formula: C5H9BrO2 The author mentioned the following in the article:

A total of 14 novel arylpiperazines were synthesized, and pharmacol. evaluated by measuring their affinities towards the D2 dopamine receptor (DRD2) in a [3H]spiperone competition assay. All the herein described compounds consist of a benzimidazole moiety connected to N-(2-methoxyphenyl)piperazine via linkers of various lengths. Mol. docking anal. and mol. dynamics simulations were performed on the DRD2-arylpiperazine complexes with the objective of exploring the receptor-ligand interactions and properties of the receptor binding site. The recently published crystal structure of DRD2 was used throughout this study. The major finding is that high affinity arylpiperazines must interact with both the orthosteric binding site and the extended binding pocket of DRD2 and therefore should contain a linker of 5 or 6 methylene groups long. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-bromopropanoate(cas: 539-74-2Formula: C5H9BrO2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Formula: C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Hydrazone linkage based Schiff base: synthesis, characterization and their biological applications》 were Pradhan, Alka Prof.; Koshal, Anil Kumar; Khichi, Dharmendra Singh. And the article was published in World Journal of Pharmaceutical Research in 2019. Product Details of 6630-33-7 The author mentioned the following in the article:

Synthesis of hydrazone linkage based Schiff base derivatives I [X = H, OH, Cl, Br; Y = H, 4-NO2, 4-NH2] via condensation of 2-[1-(4-aminophenyl)ethylidene]-hydrazine-1-carbothioamide intermediate II with benzaldehydes was described. Thiosemicarbazide intermediate II was obtained from reaction of 1-(4-aminophenyl)ethan-1-one and thiosemicarbazide. All synthesized compounds were screened for their antibacterial and antifungal activity by using agar well diffusion method. The results revealed that the compound I [X = H, OH, Y = H, 4-NH2] showed excellent activity against E. coli and moderate show against P. aerugenosaand and S.aureus. compound I [X = OH, Cl, Br; Y = H] were showed excellent against S.aureus. All compounds showed moderate anti-fungal activity against A. flavus and A. fumigates and show excellent against Candida albicans. In the experiment, the researchers used o-Bromobenzaldehyde(cas: 6630-33-7Product Details of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Product Details of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary