Tag: 100-200

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Liu, Lin; Lei, Lin-Sheng; Zhan, Zong-Song; Liu, Si-Zhan; Wang, Yu-Xiao; Tu, Yong-Qiang; Zhang, Fu-Min; Zhang, Xiao-Ming; Ma, Ai-Jun; Wang, Shao-Hua. Category: bromides-buliding-blocks. The article was titled 《A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] skeleton》. The information in the text is summarized as follows:

A facile and efficient method to form a chiral multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] structural unit was developed via a one-pot [3+2] cycloaddition/semipinacol rearrangement cascade. A catalysis system of Cu(II)/BOX was used to efficiently construct a key stereogenic center via a cyclization between substituted benzoquinones and allylic alcs. afforded the desired products in good yields and with excellent enantioselectivities and diastereoselectivities (21 examples; up to 67% yields; up to 92% ee and up to >20 : 1 dr). This method provided an alternative strategy for the synthesis of the corresponding bioactive mols. containing spiro[benzofurancyclopentane] skeleton units. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Category: bromides-buliding-blocks)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Guo, Lei; Xu, Chen; Wu, Ding-Chuan; Hu, Guang-Qi; Zhang, Hong-Hai; Hong, Kunlun; Chen, Su; Liu, Xiang. Recommanded Product: (Bromomethyl)cyclopropane. The article was titled 《Cascade alkylation and deuteration with aryl iodides via Pd/norbornene catalysis: an efficient method for the synthesis of congested deuterium-labeled arenes》. The information in the text is summarized as follows:

An efficient approach for the synthesis of congested deuterium-labeled arenes, e.g., I via cascade alkylation and deuteration with aryl iodides was disclosed. The adoption of sodium formate-d as a deuterium source was the key for achieving high deuterium incorporation >98%. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 583-69-7On May 31, 2019, Li, Yang-Yang; Liu, Hong; Xu, Ying; Zhou, Ning-Yi published an article in International Biodeterioration & Biodegradation. The article was 《A two-component monooxygenase initiates a novel 2-bromo-4-nitrophenol catabolic pathway in newly isolated Cupriavidus sp. strain NyZ375》. The article mentions the following:

As a vital byproduct of chem. intermediates for pesticides and cytotoxin inhibitors, 2-bromo-4-nitrophenol (2B4NP) is toxic to aquatic life. However, bacterial cultures mineralizing 2B4NP have not been reported. In this study, Cupriavidus sp. strain NyZ375 was isolated from aromatics-polluted soil and identified by 16S rRNA gene sequencing. Via an oxidative pathway, it grows on 120μM 2B4NP as the only carbon source, releasing approx. equivalent amount of nitrite. Three genes (bnpABC) in a 4.8-kb DNA fragment from a draft genome was found to be responsible for the initial reactions in 2B4NP degradation BnpAB are the monooxygenase and flavin reductase components, resp., catalyzing the monooxygenation of 2B4NP to bromohydroquinone (BHQ, 63%) and 1,2,4-benzenetriol (BT, 37%) with concomitant nitrite release, in the presence of NADH and FAD. BnpC is a hydroxyquinol 1,2-dioxygenase catalyzing the ring-cleavage oxidation of BT to maleylacetate. The byproduct BHQ was not further degraded by strain NyZ375 but was not toxic to its growth at a concentration of 100μM. It can be tentatively concluded that BnpAB is evolutionary close to the 2,4,6-trichlorophenol monooxygenase TcpAX from Cupriavidus necator JMP134. The 2B4NP catabolism by this new isolate illustrates a pathway distinct from those of all identified 2-chloro-4-nitrophenol utilizers. In addition to this study using 2-Bromobenzene-1,4-diol, there are many other studies that have used 2-Bromobenzene-1,4-diol(cas: 583-69-7Product Details of 583-69-7) was used in this study.

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Product Details of 583-69-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of remote fluoroalkylated alkenes by a palladium-catalyzed relay Heck-type reaction》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Li, Lixin; Zhao, Zhengguang; Xu, Jing; Luo, Haotian; Li, Yong; Ma, Xiantao; Tang, Lin; Ren, Bo; Cao, Xinhua; Ma, Yan-Na. HPLC of Formula: 401-55-8 The article mentions the following:

Palladium-catalyzed relay Heck-type reaction of fluoroalkyl bromide and terminal alkenes was reported. The reaction involved fluoroalkylation of alkenes and migration of double bonds via a 1,5-hydrogen atom transfer strategy. Through this method, a series of remote fluoroalkylated alkenes was obtained under mild conditions.Ethylbromofluoroacetate(cas: 401-55-8HPLC of Formula: 401-55-8) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.HPLC of Formula: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Dual character of peroxymonosulfate oxidation process to treat salty wastewater containing 2,4,6-tribromophenol》 was written by Fang, Changling; Lou, Xiaoyi; Tang, Yunyu; Tian, Liangliang; Cai, Youqiong; Xiao, Dongxue; Guo, Yaoguang; Liu, Jianshe. Name: 2-Bromobenzene-1,4-diol And the article was included in Journal of Environmental Chemical Engineering on August 31 ,2020. The article conveys some information:

Nowadays, increasing attention has been paid on the peroxymonosulfate (PMS) in situ oxidation for environmental decontamination. Chloride ion (Cl-) could directly react with PMS to produce some reactive halogen agents via non-radical pathways. In present study, the degradation kinetics of 2,4,6-tribromophenol (TBP) and the total organic carbon (TOC) removal by adding PMS in salty wastewater were inspected. TBP could effectively degraded by PMS in salty wastewater over the pH range of 3.0-7.0, and the degradation ratio increased with the pH of reaction solution Pos. effects of Cl- concentration (1-100 mM) on TBP degradation kinetics were also examined Moreover, the oxidation products and their evolution with reaction time were conducted in order to further evaluate the environmental benefits with co-existence of PMS and Cl-. Instead of complete mineralization, TBP was mainly transformed to new halogenated products which also have long half-lives. The chlorination of TBP is the dominant pathway in the presence of Cl-, since the main oxidant (HOCl) played an important role. The formation of undesirable halogenated products provides that adding PMS into salty wastewater might not be an unexpected proposal for TBP depletion involving of the attendance of chloride. The experimental process involved the reaction of 2-Bromobenzene-1,4-diol(cas: 583-69-7Name: 2-Bromobenzene-1,4-diol)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Name: 2-Bromobenzene-1,4-diol The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of Methyl 3-bromopropanoateIn 2018 ,《A Sulfoxide-Based Isobaric Labeling Reagent for Accurate Quantitative Mass Spectrometry》 was published in Angewandte Chemie, International Edition. The article was written by Stadlmeier, Michael; Bogena, Jana; Wallner, Miriam; Wuehr, Martin; Carell, Thomas. The article contains the following contents:

Modern proteomics requires reagents for exact quantification of peptides in complex mixtures Peptide labeling is most typically achieved with isobaric tags that consist of a balancer and a reporter part that sep. in the gas phase. An ingenious distribution of stable isotopes provides multiple reagents with identical mol. weight but a different mass of the reporter groups, allowing relative quantification of multiple samples in one measurement. Here the authors report a new isobaric labeling reagent, where the balancer and the reporter are linked by a sulfoxide group, which, based on the sulfoxide pyrolysis, leads to easy and asym. cleavage at low fragmentation energy. The fragmentation of the new design is significantly improved, yielding more intense complementary ion signals, allowing complementary ion cluster anal. as well. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Quality Control of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 2969-81-5In 2022 ,《Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids》 appeared in Beilstein Journal of Organic Chemistry. The author of the article were Jakubkiene, Virginija; Valiulis, Gabrielius Ernis; Schweipert, Markus; Zubriene, Asta; Matulis, Daumantas; Meyer-Almes, Franz-Josef; Tumkevicius, Sigitas. The article conveys some information:

Here, the synthesis of new compounds in which a hydroxamic acid residue was attached to differently substituted pyrimidine rings via a methylene group bridge of varying length as potential HDAC inhibitors was described. The target compounds were obtained by alkylation of 2-(alkylthio)pyrimidin-4(3H)-ones with Et 2-bromoethanoate, Et 4-bromobutanoate, or Me 6-bromohexanoate followed by aminolysis of the obtained esters with hydroxylamine. Oxidation of the 2-methylthio group to the methylsulfonyl group and following treatment with amines resulted in the formation of the corresponding 2-amino-substituted derivatives, the ester group of which reacted with hydroxylamine to give the corresponding hydroxamic acids. The synthesized hydroxamic acids were tested as inhibitors of the HDAC4 and HDAC8 isoforms. Among the synthesized pyrimidine-based hydroxamic acids -hydroxy-6-[6-methyl-2-(methylthio)-5-propylpyrimidin-4-yloxy]hexanamide was found to be the most potent inhibitor of both the HDAC4 and HDAC8 isoforms, with an IC50 of 16.6μM and 1.2μM, resp. The results came from multiple reactions, including the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Patel, Kaushalendra; Lanke, Veeranjaneyulu; Marek, Ilan published an article in Journal of the American Chemical Society. The title of the article was 《Stereospecific Construction of Quaternary Carbon Stereocenters from Quaternary Carbon Stereocenters》.Application of 7051-34-5 The author mentioned the following in the article:

Organoaluminum species promote a smooth nucleophilic substitution at quaternary C stereocenter of stereodefined polysubstituted cyclopropyl Me phosphate with a complete inversion of configuration, even when more reactive functional groups are present. The regio- and diastereoselectivity of the substitution is attributed to the existence of a bicyclobutonium intermediate. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Han, C. Q.; Xia, Y. Y.; Sun, Q.; Zou, Q. G. published their research in Organic Preparations and Procedures International in 2021. The article was titled 《Improved Synthesis of Bepotastine Besilate》.Computed Properties of C6H11BrO2 The article contains the following contents:

Authors have described here improvements in the preparation of bepotastine besilate. The improvements may be suitable for industrial application. The optimized conditions have the advantages of simple operation, minimizing impurities and high yield. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Computed Properties of C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Computed Properties of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Rodrigalvarez, Jesus; Reeve, Luke A.; Miro, Javier; Gaunt, Matthew J. published an article in Journal of the American Chemical Society. The title of the article was 《Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Cyclopropanes and Cyclobutanes Guided by Tertiary Alkylamines》.Formula: C4H7Br The author mentioned the following in the article:

Here, a palladium-catalyzed enantioselective C(sp3)-H arylation of aminomethyl-cyclopropanes I [R = H, Me, (CH2)2OMe, 4-ClC6H44; R1 = NMe2, NEt2, N-piperidinyl, etc.; Ar = Ph, 2-naphthyl, 6-Cl-3-pyridinyl, etc.; n = 1] and -cyclobutanes I [n = 2] with aryl boronic acids was reported. A range of native tertiary alkylamine groups were able to direct C-H cleavage and forge carbon-aryl bonds on the strained cycloalkanes framework as single diastereomers and with excellent enantiomeric ratios. Central to the success of this strategy was the use of a simple N-acetyl amino acid ligand, which not only controls the enantioselectivity but also promotes γ-C-H activation of over other pathways. Computational anal. of the cyclopalladation step provided an understanding of how enantioselective C-H cleavage occurred and revealed distinct transition structures to our previous work on enantioselective desymmetrization of N-iso-Bu tertiary alkylamines. This straightforward and operationally simple method simplified the construction of functionalized aminomethyl-strained cycloalkanes, which was believed will find widespread use in academic and industrial settings relating to the synthesis of biol. active small mols.(Bromomethyl)cyclopropane(cas: 7051-34-5Formula: C4H7Br) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary