Tag: 1500-1600

Synthesis and photophysics of a water-soluble, naphthalene-containing β-cyclodextrin was written by Gravett, David M.;Guillet, James E.. And the article was included in Journal of the American Chemical Society in 1993.Name: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

A water-soluble, naphthalene-containing β-cyclodextrin I has been synthesized by reaction of 6-hydroxy-2-naphthalene sulfonic acid (disodium salt) with heptakis(6-bromo-6-deoxy)-β-cyclodextrin. Lifetime, fluoroescence polarization, and solvent studies show the presence of mainly monomer fluorescence emission with a small amount of excimer. Quenching studies show that singlet energy transfer from the naphthalene substituents to a suitably included acceptor mol. can occur. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Name: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Name: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rational design of cationic cyclooligosaccharides as efficient gene delivery systems was written by Diaz-Moscoso, Alejandro;Balbuena, Patricia;Gomez-Garcia, Marta;Ortiz Mellet, Carmen;Benito, Juan M.;Le Gourrierec, Loic;Di Giorgio, Christophe;Vierling, Pierre;Mazzaglia, Antonino;Micali, Norberto;Defaye, Jacques;Garcia Fernandez, Jose M.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2008.Formula: C42H63Br7O28 This article mentions the following:

Self-assembled cyclodextrin (CD)-DNA nanoparticles (CDplexes) exhibiting transfection efficiencies significantly higher than PEI-based polyplexes have been prepared from homogeneous seven-fold sym. polyaminothiourea amphiphiles constructed on a β-cyclodextrin scaffold. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Formula: C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Formula: C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thiolated amphiphilic β-cyclodextrin-decorated gold colloids: Synthesis, supramolecular nanoassemblies and controlled release of dopamine was written by Trapani, Mariachiara;Scala, Angela;Mineo, Placido G.;Pistone, Alessandro;Diaz-Moscoso, Alejandro;Fragoso, Alex;Monsu Scolaro, Luigi;Mazzaglia, Antonino. And the article was included in Journal of Molecular Liquids in 2021.Application In Synthesis of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

We report a hybrid nanoassembly based on gold colloids decorated with a new thiolated amphiphilic cyclodextrin complexing dopamine (AuNPs@SC16SH/DA). The novel amphiphilic β-cyclodextrin SC16SH, bearing on average one thiol group at the end of an oligoethylene glycol chain per CyD unit, was obtained in a multi-step synthesis and fully characterized by NMR spectroscopy and MALDI anal. The AuNPs@SC16SH hybrid assembly was prepared by mixing AuNPs and SC16SH in aqueous solution and investigated by UV/Vis and TEM measurements. The AuNPs@SC16SH/DA supramol. assembly, bearing both thiol-stabilized gold nanoparticles and the neurotransmitter dopamine, has been conceived as stimuli-responsive delivery system able to control the release of dopamine upon proper stimuli. Two redox functionalities (i.e. the Au-S bond and the redox behavior of dopamine) have been exploited to detach SC16SH/DA complex from the AuNPs@SC16SH/DA progenitor platform, using dithiothreitol (DTT), and to detect the complex by cyclic voltammetry (CV). Following, dopamine was finally released from the SC16SH/DA assembly upon treatment with Brij S20 and the free dopamine was monitored by CV. Overall, our hybrid nanoassemblies turned out to be able to release dopamine, upon combined action of redox and digestion agents in medium emulating biol. environment. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Application In Synthesis of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application In Synthesis of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Transport of Nucleoside Triphosphates into Cells by Artificial Molecular Transporters was written by Zawada, Zbigniew;Tatar, Ameneh;Mocilac, Pavle;Budesinsky, Milos;Kraus, Tomas. And the article was included in Angewandte Chemie, International Edition in 2018.Computed Properties of C42H63Br7O28 This article mentions the following:

Chem. modified nucleoside triphosphates (NTPs) are widely exploited as unnatural metabolites in chem. biol. and medicinal chem. Because anionic NTPs do not permeate cell membranes, their corresponding neutral precursors were employed in cell-based assays. These precursors become active metabolites after enzymic conversion, which often proceeds insufficiently. Metabolically-active NTPs can be directly transported into eukaryotic cells and bacteria by the action of designed synthetic nucleoside triphosphate transporters (SNTTs). The transporter is composed of a receptor, which forms a noncovalent complex with a triphosphate anion, and a cell-penetrating agent, which translocates the complex across the plasma membrane. NTP is then released from the complex in the intracellular milieu and accumulates in nuclei and nucleoli in high concentration The transport of NTPs proceeds rapidly (seconds to minutes) and selectively even in the presence of other organic anions. This operationally simple and efficient means of transport of fluorescently labeled NTPs into cells can be used for metabolic labeling of DNA in live cells. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Computed Properties of C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Computed Properties of C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and in vitro evaluation of cyclodextrin hyaluronic acid conjugates as a new candidate for intestinal drug carrier for steroid hormones was written by Hesler, Michelle;Schwarz, Dennis H.;Daehnhardt-Pfeiffer, Stephan;Wagner, Sylvia;von Briesen, Hagen;Wenz, Gerhard;Kohl, Yvonne. And the article was included in European Journal of Pharmaceutical Sciences in 2020.Category: bromides-buliding-blocks This article mentions the following:

Steroid hormones became increasingly interesting as active pharmaceutical ingredients for the treatment of endocrine disorders. However, medical applications of many steroidal drugs are inhibited by their very low aqueous solubilities giving rise to low bioavailabilities. Therefore, the prioritized oral administration of steroidal drugs remains problematic. Cyclodextrins are promising candidates for the development of drug delivery systems for oral route applications, since they solubilize hydrophobic steroids and increase their rate of transport in aqueous environments. In this study, the synthesis and characterization of polymeric β-cyclodextrin derivates is described, which result from the attachment of a hydrophilic β-CD-thioether to hyaluronic acid. Host-guest complexes of the synthesized β-cyclodextrin hyaluronic acid conjugates were formed with two poorly soluble model steroids (β-estradiol, dexamethasone) and compared to monomeric β-cyclodextrin derivates regarding solubilization and complexation efficiency. The β-cyclodextrin-drug (host-guest) complexes were evaluated in vitro for their suitability (cytotoxicity and transport rate) as intestinal drug carriers for steroid hormones. In case of β-estradiol, higher solubilities could be achieved by complexation with both synthesized β-cyclodextrin derivates, leading to significantly higher intestinal transport rates in vitro. However, this success could not be shown for dexamethasone, which namely solubilized better, but could not enhance the transport rate significantly. Thus, this study demonstrates the biocompatibility of the synthesized and characterized β-cyclodextrin derivates and shows their potential as new candidate for intestinal drug carrier for steroid hormones like β-estradiol. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Category: bromides-buliding-blocks).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 6-bromo-6-deoxy-β-cyclodextrin from its silyl and tosyl derivatives was written by Sipin, S. V.;Grachev, M. K.;Vasyanina, L. K.;Nifant’ev, E. E.. And the article was included in Russian Journal of General Chemistry in 2006.Recommanded Product: 53784-83-1 This article mentions the following:

Easily available per-6-O-(tert-butyl-dimethyl-silyl)-β-cyclodextrin and per-6-O-tosyl-β-cyclodextrin containing free secondary hydroxy groups, under the treatment with 10 mol equivalent of dibromotriphenylphosphorane readily undergo desilylation or detosylation with the formation of per-6-bromo-6-deoxy-p-cyclodextrin. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Recommanded Product: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mixed monolayers of amphiphilic cyclodextrins and phospholipids. I. Miscibility under dynamic conditions of compression was written by Kasselouri, Athena;Coleman, Anthony William;Baszkin, Adam. And the article was included in Journal of Colloid and Interface Science in 1996.Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

The miscibility of per-(6-amino-2,3-di-O-hexyl) β-CD hydrochloride salt (NH₃-β-CD-OC6) with 1,2-dipalmitoyl,3-sn-phosphatidyl choline (DPPC) and 1,2 dipalmitoyl,3-sn-phosphatidic acid (DPPA) and of per-(6-dodecanoylamino-6-deoxy) β-CD (C₁₁CONH-β-CD) with DPPC was assessed by surface pressure-area experiments under dynamic conditions. The determination of their mixing behavior was approached by thermodn. characterization derived from a comparison of the composition dependence of collapse pressure for various contents of 2 components in monolayers with that predicted from a model of ideal mixing. Component miscibility has addnl. been addressed by the use of the J. Smaby-H. Brockman (1992) state equation for liquid-expanded monolayers which characterizes interaction between monolayer components by using the H₂O activity coefficient While for both NH₃-β-CD-OC6-DPPC and NH₃-β-CD-OC6-DPPA systems, the average surface areas followed the additivity rule, for the latter system, surface pressures at collapse deviated significantly from ideality. The occurrence of an interaction at the level of oppositely charged polar groups of NH₃-β-CD-OC6 and DPPA was also demonstrated by the nonideal composition dependence of the H₂O activity coefficient (f₁) characterizing the interfacial H₂O. The mixing energies and interaction parameters at collapse pressures were calculated by using the P. Joos et al. (1969) approach. Pos. values of these factors indicate that NH₃-β-CD-OC6 and DPPA mixed films are less stable thermodynamically than are films in which ideal mixing of components occurs. The mixing of NH₃-β-CD-OC6 with DPPC appears to be almost ideal. In the case of the C₁₁CONH-β-CD-DPPC system, anal. according to both the Joos and F. Goodrich (1957) approaches shows the occurrence of an important interaction which results in neg. mixing energies characteristic of thermodynamically stable mixed films. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Effect of the net surface charge density of heptakis-6-bromo-6-deoxy-β-cyclodextrin bonded silica gels on the retention behaviors of neutral cresol isomers in HPLC was written by Nakagawa, Hiroyuki;Kitagawa, Shinya;Ohtani, Hajime. And the article was included in Analytical Sciences in 2006.Recommanded Product: 53784-83-1 This article mentions the following:

The effect of the surface charge d. of heptakis-6-bromo-6-deoxy-β-cyclodextrin (β-CD-BR) bonded silica gels, which was used as the stationary phase of a packed capillary column for HPLC, was studied concerning the retention behaviors of neutral cresol isomers. On the whole, the retention factors of the cresol isomers increased with an increase in the pH values of the mobile phase, although they were slightly smaller at pH 6.1 than at pH 4.7. A study on the retention variation using a van’t Hoff plot revealed that the increase in the retention factor (k) at a higher pH region could be mainly attributed to the increase in ΔS, while a partial decrease in k around pH 5-6 was caused by a decrease in the -ΔH/T value. However, a measurement of the electroosmotic flow velocity under various pH of the mobile phase solutions revealed that the retention variations of the neutral cresol isomers were strongly correlated with the surface charge on the packing materials. The pos. charge of secondary ammonium functional groups to bind β-CD-BR inhibit the insertion of the cresol isomers into the cavity of β-CD-BR while reducing the retention factor, whereas the neg. charge of silanol group enhanced it through a local change in the mobile phase composition In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Recommanded Product: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

An improved and alternative method for the preparation of per(6-bromo-6-deoxy)cyclodextrins was written by Xue, Weihua;Zhang, Lifen. And the article was included in Synthesis in 2011.Reference of 53784-83-1 This article mentions the following:

A practical and efficient approach to the regioselective synthesis of per(6-bromo-6-deoxy)cyclodextrins is described. The method utilizes the easily accessible (chloro(phenylthio)methylene)dimethylammonium chloride (CPMA), circumventing disadvantages of earlier protocols. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Reference of 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Derivatized cyclodextrins as peptidomimetics: influence on neurite growth was written by Borrajo, Alison M. P.;Gorin, Boris I.;Dostaler, Suzanne M.;Riopelle, Richard J.;Thatcher, Gregory R. J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1997.Formula: C42H63Br7O28 This article mentions the following:

Per-6-bromo-6-deoxy-cyclodextrins may be functionalized to yield amine-derivatized cyclodextrin mimics of glycosaminoglycan sulfate binding domains of peptides, which inhibit neurite growth in vitro. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Formula: C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Formula: C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary