Tag: 1500-1600

Dendritic Cell Lectin-Targeting Sentinel-like Unimolecular Glycoconjugates To Release an Anti-HIV Drug was written by Zhang, Qiang;Su, Lu;Collins, Jennifer;Chen, Guosong;Wallis, Russell;Mitchell, Daniel A.;Haddleton, David M.;Becer, C. Remzi. And the article was included in Journal of the American Chemical Society in 2014.Recommanded Product: 53784-83-1 This article mentions the following:

A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and copper-mediated living radical polymerization These glycoconjugates showed high affinity binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations The star block glycopolymers showed high loading capacity of hydrophobic anticancer and anti-HIV drugs, indicating promising applications in HIV-therapeutic and smart drug delivery. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Recommanded Product: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Probing Secondary Carbohydrate-Protein Interactions with Highly Dense Cyclodextrin-Centered Heteroglycoclusters: The Heterocluster Effect was written by Gomez-Garcia, Marta;Benito, Juan M.;Rodriguez-Lucena, David;Yu, Jian-Xin;Chmurski, Kazimierz;Mellet, Carmen Ortiz;Gallego, Ricardo Gutierrez;Maestre, Alfredo;Defaye, Jacques;Fernandez, Jose M. Garcia. And the article was included in Journal of the American Chemical Society in 2005.Category: bromides-buliding-blocks This article mentions the following:

Comparison of the lectin-binding properties for highly dense β-cyclodextrin-centered homo- and heteroglycoclusters with defined architecture provides evidence for the existence of strong synergic effects (heterocluster effect) on carbohydrate-protein recognition events. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Category: bromides-buliding-blocks).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Mono-facially Functionalized Cyclodextrins Bearing Amino Pendent Groups was written by Vizitiu, Dragos;Walkinshaw, Caroline S.;Thatcher, Gregory R. J.. And the article was included in Journal of Organic Chemistry in 1997.HPLC of Formula: 53784-83-1 This article mentions the following:

Derivatives of the cyclodextrins, αCD, βCD, and γCD, in which all primary hydroxyls are substituted by amine pendent groups, may be synthesized efficiently from the per-6-bromo-6-deoxy-CD derivatives by direct reaction with amines. These cyclodextrin derivatives, which bear six, seven, or eight amine pendent groups, represent interesting biomimetic receptors and catalysts. A synthetic route to a CD per-substituted with primary amine functionalities at the primary face, per-6-(aminomethyl)-6-deoxy-CD, yields an alternative reagent to the simple per-6-amino-6-deoxy-CD, which is more suitable for further synthetic transformations. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1HPLC of Formula: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.HPLC of Formula: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pattern-based recognition of heparin contaminants by an array of self-assembling fluorescent receptors was written by Jagt, Richard B. C.;Gomez-Biagi, Rodolfo F.;Nitz, Mark. And the article was included in Angewandte Chemie, International Edition in 2009.Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

Tracking down potential killers: Strong host-guest interactions enable the facile combination of polycationic cyclodextrin binding motifs (blue) with fluorescent reporters (orange) tethered to a hydrophobic guest mol. (dark green). An array of supramol. fluorescent receptors prepared by this modular approach was used for the pattern-based recognition of neg. charged contaminants in the anticoagulant drug heparin. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Inclusion function of heptakis[6-(alkylthio)-6-deoxy-2-O-sulfo]-β-cyclodextrins, cylindrical surfactants derived from β-cyclodextrin. A study by fluorescent probes was written by Takahashi, Hisao;Irinatsu, Yuichi;Tsujimoto, Munekazu;Kozuka, Seizi;Tagaki, Waichiro. And the article was included in Nippon Kagaku Kaishi in 1987.SDS of cas: 53784-83-1 This article mentions the following:

Title compounds were synthesized by selective modification of β-cyclodextrin (β-CD), as a novel class of anionic cylindrical surfactants. Their inclusion functions were studied in water by using fluorescent probes as the guests. Their binding ability for the neutral probe 1-phenylnaphthalene was more than 10-fold stronger than that of β-CD; it was independent of mol. aggregation of the surfactant monomer. Inclusion occurs at the inside of a hydrophobic cavity undergoing the strong influence of the electrostatic effect of anionic sulfate groups and the effect of the chain length of the alkylthio groups. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1SDS of cas: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.SDS of cas: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A versatile δ-aminolevulinic acid (ALA)-cyclodextrin bimodal conjugate-prodrug for PDT applications with the help of intracellular chemistry was written by Aggelidou, Chrysie;Theodossiou, Theodossis A.;Goncalves, Antonio Ricardo;Lampropoulou, Mariza;Yannakopoulou, Konstantina. And the article was included in Beilstein Journal of Organic Chemistry in 2014.Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

Grafting of δ-aminolevulinic acid (1) moieties on the narrow periphery of a β-cyclodextrin (β-CD) derivative through hydrolysable bonds was implemented, in order to generate a water-soluble, mol./drug carrier with the capacity to undergo intracellular transformation into protoporphyrin IX (PpIX), an endogenous powerful photosensitizer for photodynamic therapy (PDT). The water-soluble derivative 2 was prepared by esterifying δ-azidolevulinic acid with heptakis(6-hydroxyethylamino-6-deoxy)-β-cyclodextrin, with an average degree of substitution, DS = 3. Delivery of water-soluble, colorless 2 to cells resulted in intense red fluorescence registered by confocal microscopy, evidently due to the engagement of the intracellular machinery towards formation of PpIX. Conjugate 2 was further complexed with a fluorescein-labeled model guest mol. which was successfully transported into the cells, thereby demonstrating the bimodal action of the derivative The present work shows the versatility of CDs in smart applications and constitutes advancement to our previously shown PpIX-β-CD conjugation both in terms of water solubility and lack of aggregation. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The synthesis and complexation properties of multidentate per-[6-deoxy-6-thio-(4-pyridyl)]-cyclodextrins was written by Chmurski, Kazimierz;Jurczak, Janusz;Coleman, Anthony W.. And the article was included in Journal of Coordination Chemistry in 1999.Recommanded Product: 53784-83-1 This article mentions the following:

The synthesis of chem. modified multidentate cyclodextrins capable of carrying pyridyl ligands is reported. Per-(6-bromo-6-deoxy)-α-, -β-, and -γ-cyclodextrins were treated with an excess of 4-mercaptopyridine affording per-[6-deoxy-thio-6-(4-pyridyl)]-α-, -β-, and -γ-cyclodextrin derivatives in very high yields (90-95% for isolated products). The solubilities of such systems in non-aqueous solvents were efficiently increased by acetylation of the secondary hydroxyl groups. The complexation properties of the derivatives with regard to copper(II) were investigated by solvent extraction, ESR and spectroscopic titration experiments In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Recommanded Product: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The first chiral HPLC separation of dicarba-nido-undecarborate anions and their chromatographic behavior was written by Horacek, Ondrej;Papajova-Janetkova, Monika;Gruner, Bohumir;Lochman, Lukas;Sterbova-Kovarikova, Petra;Vespalec, Radim;Kucera, Radim. And the article was included in Talanta in 2021.Recommanded Product: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

Boron cluster compounds are extensively studied due to their possible use in medicinal chem., mainly in the boron neutron capture anticancer therapy and as new innovative pharmacophores. Concerning this research, the chiral separations of exceptionally stable anionic 7,8-dicarba-nido-undecaborate(1-) and metal bis(dicarbollide)(1-) derivatives with asym. substitutions remain the unsolved challenge of the chiral chromatog. nowadays. Although the successful enantioseparation of some anionic 7,8-dicarba-nido-undecaborate(1-) ion derivatives were achieved in CZE with native β-cyclodextrins, it has not been observed with HPLC, yet. This study aimed to systematically investigate the enantioseparation of selected compounds in HPLC using native β-cyclodextrin and brominated β-cyclodextrin. The findings revealed pos. charged strong adsorption sites on a stationary phase, identified as the cationic metal impurities in the silica-gel backbone. All the anionic species under the study were at least partially enantiosepd. when a chelating agent blocked these cationic sites. Consequently, the first-ever HPLC enantioseparations of the 7,8-dicarba-nido-undecaborates(1-) were achieved. The brominated β-cyclodextrin seemed to be a better chiral selector for separation of these species, whereas the native β-cyclodextrin separated the anionic cobalt bisdicarbollide(1-). The results of this study bring new information concerning the chiral separation of anionic boron clusters and might be used in the chiral method development process on other chiral selectors. Furthermore, the possibility of chiral separation of these species could influence the ongoing research areas of anionic boron clusters. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Recommanded Product: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of symmetrical cyclodextrin derivatives bearing multiple charges was written by Guillo, Frederique;Hamelin, Bertrand;Jullien, Ludovic;Canceill, Josette;Lehn, Jean-Marie;De Robertis, Laurence;Driguez, Hugues. And the article was included in Bulletin de la Societe Chimique de France in 1995.Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

Several water-soluble sym. cyclodextrin derivatives bearing pos. charged or neg. charged groups were synthesized to examine the possibility of obtaining stable electrostatically linked hetero-dimers in water. The pos. charged species were obtained from per-amino functionalization of the 6-glucose positions, whereas the neg. units were obtained through introduction of thioglycolate or glycolate groups at the 6- or 3-glucose positions. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

β-Cyclodextrin-Derived Monolithic, Hierarchically Porous Polyimides Designed for Versatile Molecular Separation Applications was written by Leonhardt, Eric E.;Meador, Mary Ann B.;Wooley, Karen L.. And the article was included in Chemistry of Materials in 2018.Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

This work details the development of a chem. resistant, porous polyimide derived from β-cyclodextrin, pairing the interesting and unique sorption properties of cyclodextrins with the chem. robustness of polyimides to create versatile monolithic, porous frameworks. Cyclodextrin-based materials have achieved great notoriety, recently, for their utility in separation processes, such as in the near-instant removal of organic contaminants from wastewater streams and in the capture of odorous compounds from air, due to the unique ability of the cyclodextrins to reversibly bind guest mols. in their cyclic cavities. Inclusion of cyclodextrins as active host systems within a porous framework is crucial for their accessibility to enhance their performance in separation applications, relative to nonporous materials. However, the current generation of porous materials typically require long reaction times and yield insoluble powders that severely limit their use. The technol. presented herein offers a novel, scalable solution to the preparation of porous cyclodextrin-derived materials, and further increases their utility by enabling diverse applications through mold and film casting. Here, the authors demonstrate their rapid synthesis and processing, their inherent hierarchical porosity, their extraordinary chem. stability, and their efficacy as regenerable sorbents with powerful potential for a wide range of separation applications. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary