Tag: 200-300

Indole-Derived Arynes and Their Diels-Alder Reactivity with Furans was written by Buszek, Keith R.;Luo, Diheng;Kondrashov, Mikhail;Brown, Neil;VanderVelde, David. And the article was included in Organic Letters in 2007.Reference of 615-55-4 This article mentions the following:

Arynes derived from any position of the ubiquitous indole nucleus are unknown. We have now provided the first evidence for the formation and trapping of the 4,5-, 5,6-, and 6,7-indolynes. A series of o-dihalo indoles (Cl, Br, F) were synthesized and reacted under metal-halogen exchange conditions to give Diels-Alder cycloadducts in high yield with furan. The use of an excess of tert-butyllithium resulted in the rearrangement of the initially formed cycloadduct; however, employing only a slight excess of n-butyllithium cleanly gave cycloadducts with furan. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Reference of 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of new pyrrole-pyridine-based ligands using an in situ Suzuki coupling method was written by Boettger, Matthias;Wiegmann, Bjoern;Schaumburg, Steffen;Jones, Peter G.;Kowalsky, Wolfgang;Johannes, Hans-Hermann. And the article was included in Beilstein Journal of Organic Chemistry in 2012.Related Products of 22426-14-8 This article mentions the following:

The compounds 6-(pyrrol-2-yl)-2,2′-bipyridine, 2-(pyrrol-2-yl)-1,10-phenanthroline and 2-(2-(N-methylbenz[d,e]imidazole))-6-(pyrrol-2-yl)pyridine were synthesized by using an in situ generated boronic acid for the Suzuki coupling. Crystals of the products could be grown and exhibited interesting structures by X-ray anal., one of them showing a chain-like network with the adjacent mols. linked to each other via intermol. N-H···N hydrogen bonds. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Related Products of 22426-14-8).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Related Products of 22426-14-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bimetal Cooperatively Catalyzed Arylalkynylation of Alkynylsilanes was written by Chen, Xing;Li, Mengke;Liu, Zhipeng;Yang, Can;Xie, Haisheng;Hu, Xinwei;Su, Shi-Jian;Jiang, Huanfeng;Zeng, Wei. And the article was included in Organic Letters in 2021.Recommanded Product: 61150-57-0 This article mentions the following:

An unprecedented Pd/Rh cooperatively catalyzed arylalkynation of alkynylsilanes I (X = CH₂, CH₂CH₂, CHMeCH₂; R = Me, Ph; R¹ = n-pentyl, Ph, 4-MeOC₆H₄, etc.; R² = H, 4-Cl, 4-Me, 5-F) with propargylic alcs. R³CCCMe₂OH (R³ = Ph, 4-FC₆H₄, 1-naphthyl, 2-thienyl, 3-pyridinyl, etc.) has been developed to prepare alkynylidene-containing benzosilacycles II. These silaarenes II possess a particular aggregation-induced emission behavior. Mechanistic investigations demonstrated that the relay trimetallic transmetalation plays a pivotal role in governing this transformation. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Recommanded Product: 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

An Iodine-Catalyzed Hofmann-Loeffler Reaction was written by Martinez, Claudio;Muniz, Kilian. And the article was included in Angewandte Chemie, International Edition in 2015.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

Iodine reagents have been identified as economically and ecol. benign alternatives to transition metals, although their application as mol. catalysts in challenging C-H oxidation reactions has remained elusive. An attractive iodine oxidation catalysis is now shown to promote the convenient conversion of carbon-hydrogen bonds into carbon-nitrogen bonds with unprecedented complete selectivity. The reaction proceeds by two interlocked catalytic cycles comprising a radical chain reaction, which is initiated by visible light as energy source. This unorthodox synthetic strategy for the direct oxidative amination of alkyl groups has no biosynthetic precedence and provides an efficient and straightforward access to a general class of saturated nitrogenated heterocycles, i.e. I. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Photochemistry of N-(selenoalkyl)-phthalimides. Formation of N, Se-heterocyclic systems was written by Oksdath-Mansilla, Gabriela;Heredia, Adrian A.;Arguello, Juan E.;Penenory, Alicia B.. And the article was included in Photochemical & Photobiological Sciences in 2015.Computed Properties of C13H14BrNO2 This article mentions the following:

A variety of N-(selenomethyl)alkyl-phthalimides (alkyl = -(CH₂)_n, n = 2-5) and N-(selenobenzyl)propyl phthalimide were synthesized and their photochem. was studied at λ = 300 nm. Steady-state photolysis and laser time-resolved spectroscopy studies confirmed that these reactions proceeded by direct or acetone-sensitized excitation followed by intramol. electron transfer (ET) between Se atom and the phthalimide moiety. Two main pathways are possible after ET, proton transfer to the ketyl radical anion from the CH₃Se^+. or the -CH₂Se^+.– moieties, yielding the corresponding biradicals. Collapse of these biradicals yields cyclization products with the resp. endo or exo selenium-containing heterocycles. Competition between both proton transfer processes depends on the chain length of the alkyl spacer between the phthalimide and Se groups as well as the size of the cycle being formed. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Computed Properties of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Computed Properties of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sources of carbon dioxide formed during coal pyrolysis was written by Chatterjee, Kuntal;Bal, Balkrishna;Stock, Leon M.;Zabransky, Robert F.. And the article was included in Energy & Fuels in 1989.SDS of cas: 57293-19-3 This article mentions the following:

The CO₂ yield in coal pyrolysis is not uniquely dependent on the concentration of carboxyl groups in the coal. Other O-containing functional groups or coal mineral matter contribute to CO₂ formation. These conclusions are drawn from the results from pyrolysis of Wyodak and Illinois Number 6 coals that were modified by removal of carboxylic acids or by the incorporation of aliphatic or aromatic esters or aromatic methoxy groups. The coals were selectively O-alkylated. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3SDS of cas: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.SDS of cas: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Generation of Iminyl Copper Species from α-Azido Carbonyl Compounds and Their Catalytic C-C Bond Cleavage under an Oxygen Atmosphere was written by Chiba, Shunsuke;Zhang, Line;Ang, Gim Yean;Hui, Benjamin Wei-Qiang. And the article was included in Organic Letters in 2010.Formula: C10H11BrO2 This article mentions the following:

A copper-catalyzed reaction of α-azidocarbonyl compounds under an oxygen atm. is reported where nitriles are formed via C-C bond cleavage of a transient iminyl copper intermediate. The transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from α-azidocarbonyl compounds and their C-C bond cleavage, where mol. oxygen (1 atm) is a prerequisite to achieve the catalytic process and one of the oxygen atoms of O₂ was found to be incorporated into the β-carbon fragment as a carboxylic acid. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Formula: C10H11BrO2).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Formula: C10H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HDAC4 Inhibitors with Cyclic Linker and Non-hydroxamate Zinc Binding Group: Design, Synthesis, HDAC Screening and in vitro Cytotoxicity evaluation. was written by Tilekar, Kalpana;Hess, Jessica D.;Upadhyay, Neha;Schweipert, Markus;Flath, Felix;Gutierrez, Denisse A.;Loiodice, Fulvio;Lavecchia, Antonio;Meyer-Almes, Franz-Josef;Aguilera, Renato J.;Ramaa, C. S.. And the article was included in ChemistrySelect in 2021.Application of 615-55-4 This article mentions the following:

Recent evidences highlight the usefulness of small mol. (Histone deacetylase 4) HDAC4 inhibitors in the several preclin. paradigms. Major toxicity and mutagenicity issues associated with hydroxamate HDAC inhibitors, stimulated us to develop potent non-hydroxamate inhibitors. In the present work a novel series of thiazolidinedione (TZD) derivatives with pyridine as cyclic linker and TZD ring as zinc binding group was designed and screened in a panel of isoenzymes of HDACs, wherein the most potent compounds exhibiting HDAC4 IC₅₀-values<5 μM were 5 v, 5 w, 5 y and 5 z (IC₅₀=4.2±1 μM, 0.75±0.03 μM, 4.9±0.5 and 2.3±0.5 μM, resp.). The docking studies displayed the unique binding mode of this series of compound at active site of HDAC4, wherein TZD ring was indicated as zinc binding group. Further, 5 w and 5 y were found as the most potent antiproliferative agent in lymphoblastic leukemia (CCRF-CEM) and breast cancer MDA-MB-231 cells. Compound 5 y was found to induce the apoptosis and DNA fragmentation of CEM cells. The western blotting anal. of 5 y also showed the presence of cleaved caspases supporting their apoptotic nature. Further, Class IIa (HDAC4) selectivity of 5 y was also supported by western blotting observations, wherein 5 y caused the accumulation of acetylated H3 but not of acetylated Tubulin. Thus, our findings endorse the further investigation of this series of compounds for their potential as targeted cancer therapeutic agents. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Application of 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Application of 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Understanding Molecular Factors That Determine Performance in the Rare Earth (TriNOx) Separations System was written by Cole, Bren E.;Cheisson, Thibault;Nelson, Joshua J. M.;Higgins, Robert F.;Gau, Michael R.;Carroll, Patrick J.;Schelter, Eric J.. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.Application of 85118-24-7 This article mentions the following:

Rare earth metal complexes of the proligand: H₃TriNOx ([(2-tBuNOH)C₆H₃CH₂]₃N), have been shown to afford separations of simple mixtures of rare earth metal salts. In particular, separations systems were developed for applications to technol. relevant mixtures, e.g. Nd/Dy, and Eu/Y, for targeted, rare earths recycling chem. More recently, an electron-donating derivative of the proligand H₃TriNOxR (([(2-tBuNOH)C₆H₃RCH₂]₃N); R = 5-OMe) influenced the electronic and phys. properties to effect improved separations To further probe substituent effects, in the current work, derivatives with electron-donating and -withdrawing groups along the aryl-backbone were synthesized (R = 4-tBu, 5-Ph, 4-CF₃). The new proligands were coordinated to rare earths (RE) through protonolysis reactions and the resulting complexes (RE = Nd, Dy) were characterized. Dimerization equilibrium constants and molar solubility were determined where applicable. Overall, the studies indicated that increased electron-donation of the aryl-substituents resulted in an increased driving force for the dimerization of the Nd complexes. This dimerization equilibrium and resultant solubility differences were used to sep. mixtures of neodymium/dysprosium, as well as mixtures of europium/yttrium. These findings demonstrate the tunability of the TriNOx^3- framework to achieve tailored RE separations In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Application of 85118-24-7).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application of 85118-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A simple and efficient in situ generated ruthenium catalyst for chemoselective transfer hydrogenation of nitroarenes: kinetic and mechanistic studies and comparison with iridium systems was written by Paul, Bhaskar;Chakrabarti, Kaushik;Shee, Sujan;Maji, Milan;Mishra, Anju;Kundu, Sabuj. And the article was included in RSC Advances in 2016.Safety of 2-Bromo-1,10-phenanthroline This article mentions the following:

The catalytic activities of a series of in-situ generated homogeneous ruthenium systems based on com. available [RuCl₂(p-cymene)]₂ and various ligands in transfer hydrogenation of nitroarenes to anilines were investigated. Combination of [RuCl₂(p-cymene)]₂ and tridentate phenanthroline based ligand 2-(6-methoxypyridin-2-yl)-1,10-phenanthroline (phenpy-OMe) exhibited the highest catalytic activity for this reaction using 2-propanol as hydrogen source. This protocol provided a facile route to access aromatic amines under mild conditions in excellent yields. Notably, this system chemoselectively reduced the nitro groups over an array of other reactive functionalities such as ketone, alkene, amide, nitrile, and aryl halide. Operational simplicity, high yields, mild reaction conditions and short reaction times make this an attractive methodol. for accessing various functionalized anilines. A series of controlled experiments and careful mechanistic investigation with the possible intermediates suggested that transformation of nitrobenzene to aniline with ruthenium and iridium system proceeded via direct route and condensation route resp. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Safety of 2-Bromo-1,10-phenanthroline).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Safety of 2-Bromo-1,10-phenanthroline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary