Tag: 200-300

New method of synthesis of polyene ketones with conjugated double bonds was written by Samokhvalov, G. I.;Miropol’skaya, M. A.;Preobrazhenskii, N. A.. And the article was included in Doklady Akademii Nauk SSSR in 1956.Recommanded Product: 827-24-7 This article mentions the following:

Alcs. of propargyl type react with diketene yielding esters of acetoacetic acid, whose Raman spectrum shows a triple bond line (2112 cm.^-1) indicating no reaction at the terminal link. Heating to 160-70鎺?eliminates CO₂ and yields unsaturated ketones. Condensation of 6-methyl-2-heptenone with C₂H₂ in Na-liquid NH₃ gave 74% 3,7-dimethyloct-6-en-1-yn-3-ol, b₆ 83-4鎺?n_D²⁰ 1.4622, d₂₀ 0.8861. This with diketene in the presence of a little Na gave 72% Me₂C:CHCH₂CH₂CMe(C椤氬挵H)O₂CCH₂Ac, b_0.2 93-4鎺? n_D²⁰ 1.4665, d₂₀ 0.9879. This heated in N stream to 160-70鎺?3 hrs. gave 61% pseudoionone, b_0.1 90-2鎺? absolute maximum 290 m娓? 2,4-dinitrophenylhydrazone, m. 134-6鎺? Fractionation of the latter gave mainly the geometric isomer, m. 147.5-48鎺? and only traces of isomer, m. 119鎺? The isomer found in major amounts corresponds to the structure of geranial form of citral. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Recommanded Product: 827-24-7).

2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 827-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Combination of Methods for in Vitro Study of Antioxidant Properties of Chemical Compounds was written by Menshchikova, E. B.;Zenkov, N. K.;Kandalintseva, N. V.;Prosenko, A. E.. And the article was included in Bulletin of Experimental Biology and Medicine in 2008.HPLC of Formula: 57293-19-3 This article mentions the following:

We proposed a combination of methods to study antioxidant properties of compounds, including evaluation of the capacity of the test preparations to inhibit peroxidation of unsaturated lipids (in model systems with oxidation of Et oleate; aqueous emulsion medium) and low-d. lipoproteins (in the presence of transition metal ions), generation of superoxide anion radical (system of lucigenin, xanthine oxidase, and xanthine) and NO璺?ONOO- (system of SIN-1 and lucigenin), and induction of respiratory burst in blood granulocytes (luminol-induced and lucigenin-induced reaction after zymosan stimulation). In vitro study showed that the antioxidant properties of synthetic watersol. phenols depend strongly on masking of the phenol OH group and nature of the ionogenic fragment in the p-Pr substituent. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide was written by Kankanala, Jayakanth;Ribeiro, Carlos J. A.;Kiselev, Evgeny;Ravji, Azhar;Williams, Jessica;Xie, Jiashu;Aihara, Hideki;Pommier, Yves;Wang, Zhengqiang. And the article was included in Journal of Medicinal Chemistry in 2019.COA of Formula: C8H7BrO2 This article mentions the following:

Topoisomerase II (TOP2) poisons as anticancer drugs work by trapping TOP2 cleavage complexes (TOP2cc) to generate DNA damage. Repair of such damage by tyrosyl DNA phosphodiesterase 2 (TDP2) could render cancer cells resistant to TOP2 poisons. Inhibiting TDP2, thus, represents an attractive mechanism-based chemosensitization approach. Currently known TDP2 inhibitors lack cellular potency and/or permeability. We report herein two novel subtypes of the deazaflavin TDP2 inhibitor core. By introducing an addnl. Ph ring to the N-10 Ph ring (subtype 11) or to the N-3 site of the deazaflavin scaffold (subtype 12), we have generated novel analogs with considerably improved biochem. potency and/or permeability. Importantly, many analogs of both subtypes, particularly compounds 11a, 11e, 12a, 12b, and 12h, exhibited much stronger cancer cell sensitizing effect than the best previous analog 4a toward the treatment with etoposide, suggesting that these analogs could serve as effective cellular probes. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8COA of Formula: C8H7BrO2).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.COA of Formula: C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pyridylbenzimidazole-Based Gold(III) Complexes: Lysozyme Metalation, DNA Binding Studies, and Biological Activity was written by Mansour, Ahmed M.;Shehab, Ola R.. And the article was included in European Journal of Inorganic Chemistry in 2019.Related Products of 954-81-4 This article mentions the following:

The lysozyme binding affinity of new Au(III) complexes, bearing pyridylbenzimidazole ligands, was studied by ESI-MS and UV/visible. Metalation of lysozyme happened mainly by {Au}ⁿ⁺, {AuCl}^0/n+ and {AuCl₂}^n+/-. The appendage sulfonate group of pyridylbenzimidazole ligand system played a role in determining the products of interaction of HEWL with Au(III) complexes. The hydrophilic sulfonate group inhibited the ligand cleavage via the participation in several coulombic and H-bond interactions giving several AuLⁿ⁺ containing adduct peaks (L = 1-[(pyridin-2-yl) benzimidazole]-propyl-sulfonic acid). The stability of the complexes in presence of ascorbic acid was examined by UV/visible and ¹³C NMR. To recognize if His15 side-chain is the metalation site of HEWL, the interactions between the complexes and imidazole, as a simple model of histidine, were studied by ¹H and ¹³C NMR. The DNA binding studies of the complexes are reported. For this class of Au(III) complexes, it is preferred to decorate the pyridylbenzimidazole system with Et group rather than sulfonate and phthalimido group to have a complex with interesting antifungal activity against Candida albicans and Cryptococcus neoformans var. grubii. Au(III) complex, having sulfonate group, is noncytotoxic to non-malignant cells (human embryonic kidney cells (HEK293)), shows negligible Hb release and is safe to the normal cells if applicable. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Related Products of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase was written by Genin, Michael J.;Gonzalez Valcarcel, Isabel C.;Holloway, William G.;Lamar, Jason;Mosior, Marian;Hawkins, Eric;Estridge, Thomas;Weidner, Jeffrey;Seng, Thomas;Yurek, David;Adams, Lisa A.;Weller, Jennifer;Reynolds, Vincent L.;Brozinick, Joseph T.. And the article was included in Journal of Medicinal Chemistry in 2016.COA of Formula: C6H5BrN2O2 This article mentions the following:

To develop novel treatments for type 2 diabetes and dyslipidemia, we pursued inhibitors of serine palmitoyl transferase (SPT). To this end compounds (I) and (II) were developed as potent SPT inhibitors in vitro. I and II reduce plasma ceramides in rodents, have a slight trend toward enhanced insulin sensitization in DIO mice, and reduce triglycerides and raise HDL in cholesterol/cholic acid fed rats. Unfortunately these mols. cause a gastric enteropathy after chronic dosing in rats. In the experiment, the researchers used many compounds, for example, 6-Amino-5-bromonicotinic acid (cas: 180340-69-6COA of Formula: C6H5BrN2O2).

6-Amino-5-bromonicotinic acid (cas: 180340-69-6) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.COA of Formula: C6H5BrN2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Robust and Broadly Applicable Cobalt-Catalyzed Cross-Coupling of Functionalized Bench-Stable Organozinc Pivalates with Unsaturated Halides was written by Hammann, Jeffrey M.;Lutter, Ferdinand H.;Haas, Diana;Knochel, Paul. And the article was included in Angewandte Chemie, International Edition in 2017.HPLC of Formula: 474709-71-2 This article mentions the following:

We report a robust and broadly applicable CoCl₂-catalyzed cross-coupling between functionalized aryl and heteroaryl zinc pivalates and various electron-poor aryl and heteroaryl halides (X=Cl, Br, I). Couplings with (E)- or (Z)-bromo- or iodo-alkenes proceed with retention of configuration. Also, alkynyl bromides react with arylzinc pivalates providing arylated alkynes. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2HPLC of Formula: 474709-71-2).

Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 474709-71-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The addition of halogen derivatives to allylbenzenes in the presence of peroxides; preparation of 锠?bromopropylbenzenes was written by Quelet, Raymond;Durand-Dran, Raymonde;Pineau, Robert. And the article was included in Compt. rend. in 1957.Electric Literature of C10H13BrO This article mentions the following:

Despite the presence of a normally unreactive double bond, RC₆H₄CH₂CH:CH₂ (I) were converted to RC₆H₄CH₂CH₂Br (II) by treatment with HBr under the conditions of the Kharasch reaction (cf. C.A. 41, 4769h). Although no details are given, CCl₄ and CHBr₃ also added to I in the presence of Ac₂O to give satisfactory yields of the polyhalogenated butylbenzenes. I (in C₆H₆ solution only if the II crystallized) were treated gradually with 4-8% Bz₂O₂ in C₆H₆ or Ac₂O in Et₂O and saturated with dry HBr gas at 0-10鎺?in a long cylindrical tube. The saturated mixture was freed of excess HBr at room temperature with a stream of air, washed, neutralized, treated with Na₂S₂O₄ solution, and distilled in vacuo. The II were identified by conversion to RC₆H₄CH₂CH₂CH₂CO₂H (III) by formation of their Grignard compounds in Et₂O or tetrahydrofuran or in some cases via the nitriles. The following II were prepared (R, b.p./mm., % yield, and m.p. of III given): H, 113-15鎺?16, 80, 50鎺? o-Me, 75-6鎺?0.35, 66, 59-60鎺? m-Me, 85-6鎺?1.1, 80, 37.5鎺? p-Me, 75-8鎺?0.7, 70, 58鎺? p-MeO, 85鎺?0.8, 70, 58鎺? 3,4-di-MeO (IV), 108-10鎺?0.01, 55, -. III were formed in good yields except from IV where demethylation took place in the Grignard preparation In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Electric Literature of C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Electric Literature of C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nanostructures from Self-Assembling Triazine Tertiary Amine N-Oxide Amphiphiles was written by Beecham, Matthew P.;Clarkson, Guy J.;Hall, Gareth;Marsh, Andrew. And the article was included in ChemPhysChem in 2013.Reference of 954-81-4 This article mentions the following:

A set of amphiphilic tertiary amine N-oxides has been prepared and their self-assembly was observed in aqueous solution by tensiometry, dynamic, and static light scattering. X-ray crystallog. anal. of parent amines and sulfoxide congeners indicated the formation of hydrogen-bonded dimers as the primary assembly unit for formation of vesicles in preference to the compact micelles typical of lauryl dimethylamine N-oxide (LDAO). 6-Benzyloxy-N,N’-bis(5-diethylaminopentylamine oxide)[1,3,5]triazine-2,4-diamine formed a 1 娓璵 vesicle observed to entrap fluorescein. The [1,3,5]triazine core thus allowed for the variation of the new self-assembled structures from nano- to micrometer length scales. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Reference of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Silicon-Carbon Bond Formation via Nickel-Catalyzed Cross-Coupling of Silicon Nucleophiles with Unactivated Secondary and Tertiary Alkyl Electrophiles was written by Chu, Crystal K.;Liang, Yufan;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2016.Reference of 57293-19-3 This article mentions the following:

A wide array of cross-coupling methods for the formation of C-C bonds from unactivated alkyl electrophiles were described in recent years. In contrast, progress in the development of methods for the construction of C-heteroatom bonds has lagged; for example, there were no reports of metal-catalyzed cross-couplings of unactivated secondary or tertiary alkyl halides with Si nucleophiles to form C-Si bonds. The authors address this challenge, establishing that a simple, com. available Ni catalyst (NiBr₂璺痙iglyme) can achieve couplings of alkyl bromides with nucleophilic Si reagents under unusually mild conditions (e.g., -20鎺?; especially noteworthy is the authors’ ability to employ unactivated tertiary alkyl halides as electrophilic coupling partners, which is still relatively uncommon in the field of cross-coupling chem. Stereochem., relative reactivity, and radical-trap studies are consistent with a homolytic pathway for C-X bond cleavage. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Reference of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media was written by Cohen, Daniel T.;Buchwald, Stephen L.. And the article was included in Organic Letters in 2015.Product Details of 1196-90-3 This article mentions the following:

A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)aryl halides and triflates at 2-5 mol % catalyst loadings with temperatures ranging from rt to 40 鎺矯. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3Product Details of 1196-90-3).

Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 1196-90-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary