Tag: 200-300

Electric Field-Assisted Alignment of Self-Assembled Fibers Composed of Hydrogen-Bonded Molecules Having Laterally Fluorinated Mesogens was written by Yoshio, Masafumi;Shoji, Yoshiko;Tochigi, Yusuke;Nishikawa, Yohei;Kato, Takashi. And the article was included in Journal of the American Chemical Society in 2009.Reference of 954-81-4 This article mentions the following:

Aligned fibrous aggregates of amide compounds having laterally fluorinated aromatic mesogens have been successfully obtained by the application of the a.c. elec. field (1.0 V/μm, 1 kHz) in dodecylbenzene. In contrast, randomly entangled fibers are formed in the solvent without elec. fields. For the analogous compounds without fluorine substituent, no aligned fibrous aggregates have been obtained under the elec. fields. The elec. field alignment of the fibers should be assisted by the fluorinated rod-shaped mesogens that exhibit neg. dielec. anisotropy. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Reference of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Reference of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structurally Informative Isotopic Shifts in Ion Mobility Spectra for Heavier Species was written by Pathak, Pratima;Baird, Matthew A.;Shvartsburg, Alexandre A.. And the article was included in Journal of the American Society for Mass Spectrometry in 2020.HPLC of Formula: 615-55-4 This article mentions the following:

The isotopic mol. envelopes due to stable isotopes for most elements were a staple of mass spectrometry since its origins, often leveraged to identify and quantify compounds However, all isomers share one MS envelope. As the mol. motion in media also depends on the isotopic composition, separations such as liquid chromatog. (LC) and ion mobility spectrometry (IMS) must also feature isotopic envelopes. These were largely not observed because of limited resolution, except for the (structurally uninformative) shifts in LC upon H/D exchange. We recently found the isotopic shifts in FAIMS for small haloanilines (∼130-170 Da) to hinge on the halogen position, opening a novel route to isomer characterization. Here, we extend the capability to heavier species: dibromoanilines (DBAs, ∼250 Da) and tribromoanilines (TBAs, ∼330 Da). The ¹³C shifts for DBAs and TBAs vary across isomers, some changing sign. While ⁸¹Br shifts are less specific, the 2-D ¹³C/⁸¹Br shifts unequivocally differentiate all isomers. The trends for DBAs track those for dichloroanilines, with the ¹³C shift order preserved for most isomers. The peak broadening due to merged isotopomers is also isomer-specific. The absolute shifts for TBAs are smaller than those for lighter haloanilines, but differentiate isomers as well because of compressed uncertainties. These results showcase the feasibility of broadly distinguishing isomers in the more topical ∼200-300 Da range using the isotopic shifts in IMS spectra. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4HPLC of Formula: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids was written by Jiao, Ke-Jin;Ma, Cong;Liu, Dong;Qiu, Hui;Cheng, Bin;Mei, Tian-Sheng. And the article was included in Organic Chemistry Frontiers in 2021.Related Products of 14425-64-0 This article mentions the following:

A highly regioselective Ni-catalyzed electrochem. (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides was developed. This strategy allowed the direct acylation of benzylic C(sp³)-H bonds in good yields from com. available alkyl carboxylic acids, thus provided an alternative strategy for the synthesis of dialkyl ketones. Various functional groups were tolerated under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Related Products of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological evaluation of new retinoid derivatives was written by Xu, Zhihan;Pan, Shen;Huang, Yan-gen. And the article was included in Youji Huaxue in 2014.Recommanded Product: 179232-29-2 This article mentions the following:

The key intermediate boronic acid 2 was synthesized via sequential reactions of Friedel-Crafts alkylation, bromination and nucleophilic reaction by using anisole as starting material. Hydroxyacetone was converted to bromide compound 3 by the Wittig reaction, bromination, Arbuzov reaction and Homer-Wadsworth-Emmons (HWE) reaction. Three novel retinoid derivatives 1a-1c can be obtained via the Suzuki coupling reaction of the boronic acid 2 with bromide compound 3, Me 4-bromo-2-fluorobenzoate (4) or Me 6-bromonicotinate (5) and followed by hydrolysis of the corresponding esters. In addition, trifluoromethyl substituted retinoid derivative 1d was synthesized via sequential reactions of Friedel-Crafts alkylation nitration, trifluoromethylation, reduction and nucleophilic reaction with bromobenzene as starting material. The structures of four new retinoid derivatives 1a-1d were confirmed by ¹H NMR, ¹³C NMR, IR and HRMS analyses. Furthermore, the inducing differentiation abilities of mols. 1a-1d for HL-60 cells were tested, and the results revealed that these four retinoid derivatives are biol. active. The IC₅₀ values of fluorinated derivatives 1b and 1d are lower than that of com. medicine all trans retinoid acid (ATRA). In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Recommanded Product: 179232-29-2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 179232-29-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Coupling N-H Deprotonation, C-H Activation, and Oxidation: Metal-Free C(sp³)-H Aminations with Unprotected Anilines was written by Evoniuk, Christopher J.;Gomes, Gabriel dos Passos;Hill, Sean P.;Fujita, Satoshi;Hanson, Kenneth;Alabugin, Igor V.. And the article was included in Journal of the American Chemical Society in 2017.Related Products of 14425-64-0 This article mentions the following:

An intramol. oxidative C(sp³)-H amination from unprotected anilines and C(sp³)-H bonds readily occurs under mild conditions using t-BuOK, mol. oxygen and N,N-dimethylformamide (DMF). Success of this process, which requires mildly acidic N-H bonds and an activated C(sp³)-H bond (BDE < 85 kcal/mol), stems from synergy between basic, radical, and oxidizing species working together to promote a coordinated sequence of deprotonation: H atom transfer and oxidation that forges a new C-N bond. This process is applicable for the synthesis of a wide variety of N-heterocycles, ranging from small mols. to extended aromatics without the need for transition metals or strong oxidants. Computational results reveal the mechanistic details and energy landscape for the sequence of individual steps that comprise this reaction cascade. The importance of base in this process stems from the much greater acidity of transition state and product for the 2c,3e C-N bond formation relative to the reactant. In this scenario, selective deprotonation provides the driving force for the process. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Related Products of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fluorescence sensing of a ribonucleoside 5′-triphosphate was written by Patterson, Steven;Smith, Bradley D.;Taylor, Richard E.. And the article was included in Tetrahedron Letters in 1997.Name: 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane This article mentions the following:

Conjugation of a fluorescent saccharide sensor to poly(allylamine) produces a sensing compound with selectivity for ribonucleoside 5′-triphosphate. An association constant (log K_a) of 5.6 was determined for UTP in pH 7.3 phosphate solution (15 mM, 298 K), whereas log K_a was less than 2 for uridine, UMP, and UDP. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1Name: 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carbonylative Suzuki-Miyaura couplings of sterically hindered aryl halides: synthesis of 2-aroylbenzoate derivatives was written by Ismael, Aya;Skrydstrup, Troels;Bayer, Annette. And the article was included in Organic & Biomolecular Chemistry in 2020.HPLC of Formula: 653-92-9 This article mentions the following:

A carbonylative approach to the synthesis of diversely substituted 2-aroylbenzoate esters ArC(O)R¹ (Ar = 2-methoxyphenyl, thiophen-2-yl, 2-naphthyl, etc.; R¹ = 2-methoxycarbonyl-6-methylphenyl, 2-methoxycarbonylphenyl, 2-methoxycarbonyl-4,5-dimethoxyphenyl, etc.) featuring a new protocol for the carbonylative coupling of aryl bromides R¹Br with boronic acids ArB(OH)₂ and a new strategy to favor carbonylative over non-carbonylative reactions were developed. Two different synthetic pathways – (i) the alkoxycarbonylation of 2-bromo benzophenones R²C₆H₄C(O)(2-BrC₆H₅) (R² = 2-F, 4-F, 3-OMe, 4-OMe) and (ii) the carbonylative Suzuki-Miyaura coupling of 2-bromobenzoate esters – were evaluated. The latter approach provided a broader substrate tolerance, and thus it was the preferred pathway. Here observed that 2-substituted aryl bromides were challenging substrates for carbonylative chem. favoring the non-carbonylative pathway. However, it is found that carbonylative Suzuki-Miyaura couplings can be improved by slow addition of the boronic acid, suppressing the unwanted direct Suzuki coupling and, thus increasing the yield of the carbonylative reaction. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9HPLC of Formula: 653-92-9).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.HPLC of Formula: 653-92-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies was written by Johnson, Steven M.;Connelly, Stephen;Wilson, Ian A.;Kelly, Jeffery W.. And the article was included in Journal of Medicinal Chemistry in 2008.Computed Properties of C8H6Br2O2 This article mentions the following:

To develop potent and highly selective transthyretin (TTR) amyloidogenesis inhibitors, it is useful to systematically optimize the three substructural elements that compose a typical TTR kinetic stabilizer: the two aryl rings and the linker joining them. Herein, the authors evaluated 40 bisaryl mols. based on 10 unique linker substructures to determine how these linkages influence inhibitor potency and selectivity. These linkers connect one unsubstituted aromatic ring to either a 3,5-X₂ or a 3,5-X₂-4-OH Ph substructure (X = Br or CH₃). Consideration of amyloid inhibition and ex vivo plasma TTR binding selectivity data reveal that direct connection of the two aryls or linkage through nonpolar E-olefin or -CH₂CH₂– substructures generates the most potent and selective TTR amyloidogenesis inhibitors exhibiting minimal undesirable binding to the thyroid hormone nuclear receptor or the COX-1 enzyme. Five high-resolution TTR·inhibitor crystal structures (1.4-1.8 Å) provide insight into why such linkers afford inhibitors with greater potency and selectivity. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Computed Properties of C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Computed Properties of C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of a series of brominated 1-phenyl-2-pyridylethenes as inhibitors of the protein-tyrosine kinase p56^lck was written by He, Hu-Ming;Geahlen, Robert L.;Cushman, Mark. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1994.Product Details of 108940-96-1 This article mentions the following:

A series of brominated 1-phenyl-2-pyridylethenes was prepared and tested for inhibition of p56^lck, a protein-tyrosine kinase of the src family which is overexpressed in several lymphomas. The most potent compound of the series proved to be 2-(3,5-dibromo-4-hydroxybenzylidene)-2-(2-pyridyl)acetonitrile. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Product Details of 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Product Details of 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Target-Selective Fluorescence Imaging and Photocytotoxicity against H₂O₂ High-Expressing Cancer Cells Using a Photoactivatable Theranostic Agent was written by Takagi, Ryoma;Takeda, Ayano;Takahashi, Daisuke;Toshima, Kazunobu. And the article was included in Chemistry – An Asian Journal in 2017.Synthetic Route of C7H7BrO2 This article mentions the following:

A purpose-designed and synthesized H₂O₂-reactive and photoactivatable theranostic agent I consisting of 1) an arylboronic acid moiety, 2) pro-fluorophore moiety, and 3) photoactivatable moiety (photosensitizer), selectively and effectively reacted with H₂O₂ while simultaneously releasing resorufin for fluorescence detection under neutral aqueous conditions. In addition, I was cell-permeable, and exhibited effective photocytotoxicity against fluorescently visualized cells only upon photoirradiation The results also showed that I produced a selective fluorescence response to H₂O₂, even in living cultured cells. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-(hydroxymethyl)phenol (cas: 170434-11-4Synthetic Route of C7H7BrO2).

5-Bromo-2-(hydroxymethyl)phenol (cas: 170434-11-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Synthetic Route of C7H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary