Tag: 200-300

Design and synthesis of diheterocyclic compounds containing tetrazolinone and 1,2,4-triazole was written by Luo, Yan-Ping;Lin, Long;Yang, Guang-Fu. And the article was included in Journal of Heterocyclic Chemistry in 2007.Related Products of 61150-57-0 This article mentions the following:

A novel series of 1-(4-chlorophenyl)-4-{[5-(alkylthio)-4-phenyl-4H-1,2,4-triazol-3-yl] methyl}-1,4-dihydro-5H-tetrazol-5-ones I (R = Me, Et, H₂C:CHCH₂, PhCH₂, 2,6-F₂C₆H₃CH₂, etc.) was synthesized in good to excellent yields and the structures of the products were identified by ¹H NMR, ¹³C NMR, MS and elemental anal. The X-ray crystallog. of I (R = PhCH₂) indicated the presence of strong intermol. hydrogen bonds in the stacking interactions. The bioassay results showed that I (R = 3-MeC₆H₄CH₂) exhibited good insecticidal activities against T cinnabarinus at the dosage of 250 mg.L^-1. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stereoselective Synthesis of New Conformationally Restricted Analogues of a Potent CGRP Receptor Antagonist was written by Zuev, Dmitry;Michne, Jodi A.;Huang, Hong;Beno, Brett R.;Wu, Dedong;Gao, Qi;Torrente, John R.;Xu, Cen;Conway, Charles M.;Macor, John E.;Dubowchik, Gene M.. And the article was included in Organic Letters in 2005.COA of Formula: C8H6Br2O2 This article mentions the following:

A stereocontrolled racemic synthesis of conformationally restricted analogs of a potent CGRP receptor antagonist [i.e., N-[(1R)-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinecarboxamide] by novel functionalization of 2-substituted pyrido[1,2-a]pyrazin-6-ones is described. The new diastereoselective LDA-promoted α-nitration of intermediate lactams established the required trans-configuration in the desired products. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1COA of Formula: C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.COA of Formula: C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, synthesis, and biological evaluation of dibromotyrosine analogues inspired by marine natural products as inhibitors of human prostate cancer proliferation, invasion, and migration was written by Sallam, Asmaa A.;Ramasahayam, Sindhura;Meyer, Sharon A.;El Sayed, Khalid A.. And the article was included in Bioorganic & Medicinal Chemistry in 2010.Recommanded Product: 57293-19-3 This article mentions the following:

Bioactive secondary metabolites originating from dibromotyrosine are common in marine sponges, such as sponges of the Aplysina species. Verongiaquinol (1), 3,5-dibromo-1-hydroxy-4-oxocyclohexa-2,5-diene-1-acetamide, and aeroplysinin-1 are examples of such bioactive metabolites. Previous studies have shown the potent antimicrobial as well as cytotoxic properties of verongiaquinol and the anti-angiogenic activity of aeroplysinin-1. The work presented herein shows the design and synthesis of dibromotyrosine-inspired phenolic ester and ether analogs with anti-angiogenic, anti-proliferative and anti-migratory properties and negligible cytotoxicity. Several analogs were synthesized based on docking experiments in the ATP binding site of VEGFR2 and their anti-angiogenic potential and ability to inhibit angiogenesis and prostate cancer proliferation, migration and invasion were evaluated using the chick chorioallantoic membrane (CAM) assay, MTT, wound-healing, and Cultrex BME cell invasion assay models, resp. Analogs with high docking scores showed promising anti-angiogenic activity in the CAM assay. In general, ester analogs proved to be of higher anti-migratory activity whereas ether analogs showed better anti-proliferative activity. These results demonstrate the potential of dibromotyrosines as promising inhibitory scaffolds for the control of metastatic prostate cancer proliferation and migration. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Recommanded Product: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rhodium-Catalyzed Parallel Kinetic Resolution of Racemic Internal Allenes Towards Enantiopure Allylic 1,3-Diketones was written by Hilpert, Lukas J.;Breit, Bernhard. And the article was included in Angewandte Chemie, International Edition in 2019.HPLC of Formula: 14425-64-0 This article mentions the following:

A rare case of a parallel kinetic resolution of racemic 1,3-disubstituted allenes by means of a rhodium-catalyzed addition to 1,3-diketones furnishing enantiopure allylic 1,3-diketones is described. Mechanistic experiments demonstrate that the different allene enantiomers react in parallel to either the diastereomeric E- or Z-allylic 1,3-diketones with the same absolute configuration of the newly formed stereogenic center. A broad substrate scope demonstrates the synthetic utility of this new method. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0HPLC of Formula: 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Preparation and Properties of Phosphaethynes Bearing Bulky Aryl Groups with Electron-Donating Substituents at the Para Position was written by Toyota, Kozo;Kawasaki, Subaru;Yoshifuji, Masaaki. And the article was included in Journal of Organic Chemistry in 2004.Computed Properties of C8H8Br2 This article mentions the following:

Phosphaethynes bearing a 2,6-di-tert-butyl-4-(dimethylamino)phenyl, 2,6-di-tert-butyl-4-methoxyphenyl, or 2,6-di-tert-butylphenyl group were prepared A ³¹P NMR spectroscopic study of the chem. shifts indicated that electron-donating groups at the para position cause shifts to a higher field. Bathochromic shifts caused by the electron-donating groups were apparently observed in UV-visible spectra. The structure of 2-[2,6-di-tert-butyl-4-(dimethylamino)phenyl]-1-phosphaethyne was analyzed by x-ray crystallog. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2Computed Properties of C8H8Br2).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Computed Properties of C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and Antioxidative Activity of N,N-Dialkyl-ω-[4-hydroxy(methoxy)aryl]alkylamines and Their N-Oxides was written by Dyubchenko, O. I.;Nikulina, V. V.;Terakh, E. I.;Prosenko, A. E.;Grigor’ev, I. A.. And the article was included in Russian Journal of Applied Chemistry in 2005.Name: 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:

(Aminoalkyl)phenols of various structures were prepared by reactions of ω-[4-hydroxy(methoxy)aryl]haloalkanes with dialkylamines. The corresponding N-oxides were prepared by oxidation of (aminoalkyl)phenols with H₂O₂ and cumene hydroperoxide. The inhibiting activities of these compounds in a model reaction of thermal autoxidation of lard were compared. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Name: 1-(3-Bromopropyl)-4-methoxybenzene).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Name: 1-(3-Bromopropyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Palladium-catalyzed annulation reactions of methyl o-halobenzoates with azabicyclic alkenes: a general protocol for the construction of benzo[c]phenanthridine derivatives was written by Guo, Cui;Huang, Kanglun;Wang, Bo;Xie, Longguang;Xu, Xiaohua. And the article was included in RSC Advances in 2013.Recommanded Product: 653-92-9 This article mentions the following:

The annulation reaction of Me o-halobenzoates with azabicyclic alkenes proceeds efficiently to give the corresponding benzo[c]phenanthridine derivatives in good to excellent yields using a developed base-free methodol. based on our preliminary studies. Thirty-seven application examples validate the compatibility of the present strategy with different groups, particularly with the electron-deficient ones, that are difficult to access using other traditional methods. In addition, annulation reactions with non-sym. azabicyclic alkenes are achieved in high regioselectivity. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Recommanded Product: 653-92-9).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 653-92-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rigid Rod Conjugated Polymers for Nonlinear Optics. 3. Intramolecular H Bond Effects on Poly(phenyleneethynylene) Chains was written by Moroni, M.;Le Moigne, J.;Pham, T. A.;Bigot, J.-Y.. And the article was included in Macromolecules in 1997.Recommanded Product: 2-Amino-5-bromo-4-fluorobenzoic acid This article mentions the following:

The synthesis and the X-ray and optical characterization of conjugated soluble poly(phenyleneethynylene)s, in which the planarity of the backbone has been improved by intramol. H bonds, are described. The solubility of the polymers was enhanced by increasing the number of alkyl chains on the aryl group. The electron d. on the Ph ring was also modified by the amino and ester groups, introducing electron-donor or electron-acceptor groups, which also increase the polarizability. The polymers have been synthesized by polycondensation using a palladium-catalyzed coupling reaction, between a bromoaryl and an ethynylaryl unit, with HBr elimination. This method allows the insertion of a triple bond between two Ph groups. It was initially used to obtain oligomers or high mol. weight polymers, having important nonlinear susceptibilities. The new polymers have been characterized by UV-visible and Raman spectroscopies, as well as nonlinear optical measurements of the third-order susceptibilities (χ⁽³⁾). These measurements show the influence of the H bonds between the aryl groups on the absorption wavelength. In addition, the nonlinear optical measurements show that the χ⁽³⁾ value of the pPY (6.8 × 10^-10 esu) is close to the highest values obtained in acetylenic polymers such as polydiacetylenes. In the experiment, the researchers used many compounds, for example, 2-Amino-5-bromo-4-fluorobenzoic acid (cas: 143945-65-7Recommanded Product: 2-Amino-5-bromo-4-fluorobenzoic acid).

2-Amino-5-bromo-4-fluorobenzoic acid (cas: 143945-65-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 2-Amino-5-bromo-4-fluorobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation was written by Upadhyay, Neha;Tilekar, Kalpana;Jansch, Niklas;Schweipert, Markus;Hess, Jessica D.;Henze Macias, Luca;Mrowka, Piotr;Aguilera, Renato J.;Choe, Jun-yong;Meyer-Almes, Franz-Josef;Ramaa, C. S.. And the article was included in Bioorganic Chemistry in 2020.Name: 3,4-Dibromoaniline This article mentions the following:

Among Class I and II HDACs, HDAC8 is one of the essential epigenetic players in cancer progression. Therefore, authors designed, synthesized, and purified novel compounds containing N-substituted thiazolidinediones I (Ar = C₆H₅, 2-FC₆H₄, pyridin-2-yl, etc.). Cell viability assay of all compounds on leukemic cell lines showed the cytotoxic potential of I (Ar = 2,3-FC₆H₃, 2-Cl,5CF₃C₆H₃, 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl, 4-MeC₆H₄, benzo[d]thiazol-2-yl, 3,4-BrC₆H₃). In-vitro screening of different HDACs isoforms revealed that I (Ar = benzo[d]thiazol-2-yl) was the most potent and selective inhibitor for HDAC8 (IC₅₀ – 9.3μM). Thermal shift anal. confirmed the binding of I (Ar = benzo[d]thiazol-2-yl) to HDAC8. In-vitro screening of I on the transport activity of GLUT1, 4, and 5 indicated that I (Ar = benzo[d]thiazol-2-yl) inhibited GLUT1 (IC50 – 28.2μM). Thiazolidinedione I (Ar = 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) and I (Ar = benzo[d]thiazol-2-yl) induced apoptotic cell death in CEM cells (55.19% and 60.97% resp.) and I (Ar = benzo[d]thiazol-2-yl) was less cytotoxic on normal WBCs (CC₅₀ – 104.2μM) and human fibroblasts (HS27) (CC₅₀ – 105.0μM). Thus, among these, compound I (Ar = benzo[d]thiazol-2-yl) was most promising HDAC8 inhibitor and cytotoxic on leukemic cells. Thus, I (Ar = benzo[d]thiazol-2-yl) could serve as a lead for further development of optimized mols. with enhanced selectivity and potency. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Name: 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed N-Arylation of Diarylamines for Triarylamine Synthesis was written by Hu, Kunjun;Gao, Yunlong;Jin, Jian. And the article was included in Organometallics in 2022.Recommanded Product: 100189-84-2 This article mentions the following:

A practical Ni-catalyzed C-N cross-coupling reaction between diarylamines and aryl halides was developed using com. available NiCl₂(dppf) as the catalyst. This robust method can be efficiently applied to a variety of diarylamines which are privileged motifs in materials science, including phenoxazines, phenothiazines, carbazoles, diphenylamines, 9-10-dihydroacridines, 10,11-Dihydro-5H-dibenzo[b,f]azepines, 5H-dibenzo[b,f]azepines, and 9H-tribenzo[b,d,f]azepines. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2Recommanded Product: 100189-84-2).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 100189-84-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary