Tag: 200-300

Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity was written by Betti, Marco;Catarzi, Daniela;Varano, Flavia;Falsini, Matteo;Varani, Katia;Vincenzi, Fabrizio;Pasquini, Silvia;di Cesare Mannelli, Lorenzo;Ghelardini, Carla;Lucarini, Elena;Dal Ben, Diego;Spinaci, Andrea;Bartolucci, Gianluca;Menicatti, Marta;Colotta, Vittoria. And the article was included in Journal of Medicinal Chemistry in 2019.Formula: C8H7BrO2 This article mentions the following:

A new series of amino-3,5-dicyanopyridines was synthesized and biol. evaluated in order to further investigate the potential of this scaffold to obtain adenosine receptor (AR) ligands. In general, the modifications performed have led to compounds having high to good human (h) A₁AR affinity and an inverse agonist profile. While most of the compounds are hA₁AR-selective, some derivatives behave as mixed hA₁AR inverse agonists/A_2A and A_2B AR antagonists. The latter compounds showed that they reduce oxaliplatin-induced neuropathic pain by a mechanism involving the alpha7 subtype of nAchRs, similar to the nonselective AR antagonist caffeine, taken as the reference compound Along with the pharmacol. evaluation, chem. stability of Me 3-(((6-amino-3,5-dicyano-4-(furan-2-yl)pyridin-2-yl)sulfanyl)methyl)benzoate I was assessed in plasma matrixes (rat and human), and mol. modeling studies were carried out to better rationalize the available structure-activity relationships. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Formula: C8H7BrO2).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Formula: C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain was written by Denny, R. Aldrin;Flick, Andrew C.;Coe, Jotham;Langille, Jonathan;Basak, Arindrajit;Liu, Shenping;Stock, Ingrid;Sahasrabudhe, Parag;Bonin, Paul;Hay, Duncan A.;Brennan, Paul E.;Pletcher, Mathew;Jones, Lyn H.;Chekler, Eugene L. Piatnitski. And the article was included in Journal of Medicinal Chemistry in 2017.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

Chem. probes are required for preclin. target validation to interrogate novel biol. targets and pathways. Selective inhibitors of the CREB binding protein (CREBBP)/EP300 bromodomains are required to facilitate the elucidation of biol. associated with these important epigenetic targets. Medicinal chem. optimization that paid particular attention to physiochem. properties delivered chem. probes with desirable potency, selectivity, and permeability attributes. An important feature of the optimization process was the successful application of rational structure-based drug design to address bromodomain selectivity issues (particularly against the structurally related BRD4 protein). In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Targeting Serotonin 2A and Adrenergic α₁ Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives was written by Furlotti, Guido;Alisi, Maria Alessandra;Cazzolla, Nicola;Ceccacci, Francesca;Garrone, Beatrice;Gasperi, Tecla;La Bella, Angela;Leonelli, Francesca;Loreto, Maria Antonietta;Magaro, Gabriele;Mangano, Giorgina;Bettolo, Rinaldo Marini;Masini, Emanuela;Miceli, Martina;Migneco, Luisa Maria;Vitiello, Marco. And the article was included in ChemMedChem in 2018.Computed Properties of C9H11BrO This article mentions the following:

Glaucoma affects millions of people worldwide and causes optic nerve damage and blindness. The elevation of the intraocular pressure (IOP) is the main risk factor associated with this pathol., and decreasing IOP is the key therapeutic target of current pharmacol. treatments. As potential ocular hypotensive agents, the authors studied compounds that act on two receptors (serotonin 2A and adrenergic α₁) linked to the regulation of aqueous humor dynamics. Herein, the design, synthesis, and pharmacol. profiling of a series of novel bicyclic and tricyclic N2-alkyl-indazole-amide derivatives is described. This study identified a 3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one derivative I with potent serotonin 2A receptor antagonism, >100-fold selectivity over other serotonin subtype receptors, and high affinity for the α₁ receptor. Moreover, upon local administration, this compound showed superior ocular hypotensive action in vivo relative to the clin. used reference compound timolol. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Computed Properties of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Computed Properties of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Selective debenzylation of benzyl esters by silica-supported sodium hydrogen sulphate was written by Hu, Yan Wei;Zuo, Li;Ye, De Yong;Duan, Wen Hu. And the article was included in Chinese Chemical Letters in 2009.Application In Synthesis of 3-(Bromomethyl)benzoic acid This article mentions the following:

A new debenzylation of benzyl esters by silica-supported sodium hydrogen sulfate was described. The debenzylation could be achieved selectively and efficiently in good to excellent yields without affecting sensitive functional groups such as nitro, unsaturated bonds, and Et ester. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Application In Synthesis of 3-(Bromomethyl)benzoic acid).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Application In Synthesis of 3-(Bromomethyl)benzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A convenient and regioselective oxidative bromination of electron-rich aromatic rings using potassium bromide and benzyltriphenylphosphonium peroxymonosulfate under nearly neutral reaction conditions was written by Adibi, Hadi;Hajipour, Abdol R.;Hashemi, Majid. And the article was included in Tetrahedron Letters in 2007.Safety of 4-Bromo-2-chloro-6-nitrophenol This article mentions the following:

Regioselective oxidative bromination of electron-rich aromatic rings was studied using potassium bromide as a bromine source in the presence of benzyltriphenylphosphonium peroxymonosulfate as oxidant under nearly neutral reaction conditions. In most cases we obtained monobrominated derivatives regioselectively and in good to high yields without the aid of strong acids. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-chloro-6-nitrophenol (cas: 58349-01-2Safety of 4-Bromo-2-chloro-6-nitrophenol).

4-Bromo-2-chloro-6-nitrophenol (cas: 58349-01-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Safety of 4-Bromo-2-chloro-6-nitrophenol

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hydantoin-Based Molecular Photoswitches was written by Martinez-Lopez, David;Yu, Meng-Long;Garcia-Iriepa, Cristina;Campos, Pedro J.;Frutos, Luis Manuel;Golen, James A.;Rasapalli, Sivappa;Sampedro, Diego. And the article was included in Journal of Organic Chemistry in 2015.Safety of 3,5-Dibromo-4-methoxybenzaldehyde This article mentions the following:

A new family of mol. photoswitches based on arylidenehydantoins is described together with their synthesis and photochem. and photophys. studies. A series of hydantoin derivatives have been prepared as single isomers using simple and versatile chem. in good yields. Our studies show that the photostationary states of these compounds can be easily controlled by means of external factors, such as the light source or filters. Moreover, the detailed investigations proved that these switches are efficient (i.e., they make efficient use of the light energy, are high fatigue resistant, and are very photostable). In some cases, the switches can be completely turned on/off, a desirable feature for specific applications. A series of theor. calculations have also been carried out to understand the photoisomerization mechanism at the mol. level. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Safety of 3,5-Dibromo-4-methoxybenzaldehyde).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of 3,5-Dibromo-4-methoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A saccharide ‘sponge’. Synthesis and properties of a dendritic boronic acid was written by James, Tony D.;Shinmori, Hideyuki;Takeuchi, Masayuki;Shinkai, Seiji. And the article was included in Chemical Communications (Cambridge) in 1996.Application of 166821-88-1 This article mentions the following:

Very low concentrations of D-galactose and D-fructose are bound to a dendrimer containing eight boronic acids and eight anthracene units; the binding events are sensitively monitored by changes in the fluorescence intensity. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1Application of 166821-88-1).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 166821-88-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor was written by Wheeler, Rob C.;Baxter, Emma;Campbell, Ian B.;MacDonald, Simon J. F.. And the article was included in Organic Process Research & Development in 2011.Formula: C8H6BrFO2 This article mentions the following:

Flow chem. is a rapidly emerging technol. within the pharmaceutical industry, both within medicinal and development chem. groups. The advantages of flow chem., increased safety, improved reproducibility, enhanced scalability, are readily apparent, and we aimed to exploit this technol. in order to provide small amounts of pharmaceutically interesting fragments via a safe and scalable route, which would enable the rapid synthesis of multigram quantities on demand. Here we report a general and versatile route which utilizes flow chem. to deliver a range of known and novel indazoles, including 3-amino and 3-hydroxy analogs. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Formula: C8H6BrFO2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and antibacterial activities of marine natural product ianthelliformisamines and subereamine synthetic analogues was written by Khadake, Shivaji Narayan;Karamathulla, Shaik;Jena, Tapan Kumar;Monisha, Mohan;Tuti, Nikhil Kumar;Khan, Faiz Ahmed;Anindya, Roy. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Safety of 3,5-Dibromo-4-methoxybenzaldehyde This article mentions the following:

Marine sponges of the genus Suberea produce a variety of brominated tyrosine alkaloids which display a diverse range of biol. activities including antiproliferative, antimicrobial and antimalarial activities. In continuation of our search for biol. active marine natural products as antibacterial compounds, we report here the synthesis and evaluation of the biol. activity of a panel of ianthelliformisamines and subereamine analogs using the literature-known acid-amine coupling reaction. Several derivatives of ianthelliformisamine were obtained by coupling Boc-protected polyamines with brominated aromatic acrylic acid derivatives followed by Boc-deprotection using TFA. The aromatic acrylic acid derivatives varied in bromine substitution and geometry of the double bond. Similarly, subereamine analogs were synthesized by employing the coupling reaction between various brominated phenylacrylic acids with com. available chiral amino ester derivatives followed by ester hydrolysis. These synthetic analogs were screened for antibacterial activity against both Gram-neg. (Escherichia coli) and Gram-pos. (Staphylococcus aureus) strains. Ianthelliformisamine derivative I showed bactericidal activity against Staphylococcus aureus with an IC₅₀ value of 3.8μM (MIC = 25μM). In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Safety of 3,5-Dibromo-4-methoxybenzaldehyde).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of 3,5-Dibromo-4-methoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes was written by Chen, Jingjing;Li, Yalei;Zhang, Jie;Zhang, Minmin;Wei, Aihuan;Liu, Hongchun;Xie, Zhicheng;Ren, Wenming;Duan, Wenwen;Zhang, Zhuo;Shen, Aijun;Hu, Youhong. And the article was included in European Journal of Medicinal Chemistry in 2021.Safety of Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

According to the binding mode of ABBV-744 with bromodomains and the cape space of HDAC, the novel selective HDAC/BRD4 dual inhibitors were designed and synthesized by the pharmacophore fusion strategy. Evaluating the biomol. activities through SARs exploration identified three kinds of selective dual inhibitors 41c (HDAC1/BRD4), 43a (pan-HDAC/BRD4) and 43d (HDAC6/BRD4(BD2)), whose target-related cellular activities in MV-4-11 cells were also confirmed. Significantly, the selective dual inhibitor 41c(I) (HDAC1/BRD4) exhibited synergistic effects against MV-4-11 cells, which strongly induced G0/G1 cell cycle arrest and apoptosis, and the first HDAC6/BRD4(BD2) dual inhibitor was found. This study provides support for selective HDAC/BRD4 dual inhibitors as epigenetic probes based on pyrrolopyridone core for the future biol. evaluation in different cancer cell lines. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Safety of Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Safety of Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary