Tag: 200-300

Abi Fayssal, Sandra et al. published their research in Advanced Synthesis & Catalysis in 2022 | CAS: 474709-71-2

Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 474709-71-2

Synthesis, Catalytic Activity and Comparative Leaching Studies of Calix[8]arene-Supported Pd-NHC Complexes for Suzuki-Miyaura Cross-Couplings was written by Abi Fayssal, Sandra;Naret, Timothee;Buendia, Julien;Labattut, Axel;Huc, Vincent;Martini, Cyril;Schulz, Emmanuelle. And the article was included in Advanced Synthesis & Catalysis in 2022.Application of 474709-71-2 This article mentions the following:

A rapid and scalable synthesis of supported NHC-Pd(II)-pyridine complexes on a benzyloxycalix[8]arene macrocycle is reported. Their subsequent use in Suzuki-Miyaura benchmark reactions led to the optimization of the nature of the ligands around the metal center, delivering two very active precatalysts. They both promote the cross-coupling of challenging API precursors at low catalytic loadings, when used as insoluble species in EtOH as a green reaction solvent. Moreover, their activity has been shown to be comparable or even superior to that of more conventional homogeneous catalysts. Of main importance, a simple filtration of the insoluble supported catalysts after reaction afforded the lowest Pd contamination values in the target products, in some cases directly approaching the levels authorized by the industrial regulations. Offering furthermore the possibility of easy palladium recovery in the current context of its overconsumption, we are convinced that these calixarene-supported NHC-PEPPSI Pd complexes are valuable tools for the fine chem. industry, to prepare metal-free functionalized biaryl compounds in high yields, ranging from 76 to 94%. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2Application of 474709-71-2).

Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 474709-71-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vega, A. et al. published their research in Anales de Quimica (1968-1979) in 1977 | CAS: 6515-58-8

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C8H7BrO2

Synthesis, resolution, and characterization of the E and Z oximes of m-benzoylphenylacetic acid was written by Vega, A.;Prieto, J.;Moragues, J.. And the article was included in Anales de Quimica (1968-1979) in 1977.Synthetic Route of C8H7BrO2 This article mentions the following:

Oximation of m-PhCOC6H4CH2CO2H with H2NOH.HCl in pyridine and recrystallization from absolute EtOH gave (E)- and (Z)-m-PhC(:NOH)C6H4CH2CO2H. Beckmann rearrangement of the resp. oximes gave m-PhNHCOC6H4CH2CO2H and m-PhCONHC6N4CH2CO2H, which were also prepared from m-MeC6H4CO2H or m-O2NC6H4CO2H. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Synthetic Route of C8H7BrO2).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Former, Carsten et al. published their research in Journal fuer Praktische Chemie/Chemiker-Zeitung in 1998 | CAS: 6515-58-8

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 3-(Bromomethyl)benzoic acid

From donor- and acceptor-substituted meta- and para-xylenes to para-quinodimethanes and poly(meta-phenylenevinylene)s was written by Former, Carsten;Klaerner, Gerrit;Wagner, Manfred;Muellen, Klaus. And the article was included in Journal fuer Praktische Chemie/Chemiker-Zeitung in 1998.Name: 3-(Bromomethyl)benzoic acid This article mentions the following:

1,2-, 1,3- And 1,4-xylenes with donor and acceptor substituents at the α- and α’ positions, lead to a remarkable variety of intermediates and reaction products after deprotonation of the benzylic proton. Thus, the reaction of [4-NCCH2C6H4CH(SMe)NR2]+BF4– (R = Me, Et) with NaH affords the corresponding 1,4-quinodimethanes (I). Polymeric [:C(NBu2)C6H4-3-C(CN):]n is obtained when starting from [3-NCCH2C6H4CH(SMe)NBu2]+BF4–. A successive approach towards 1,3-phenylenevinylenes of definite length starting from 3-NCCH2C6H4CH(S)NMe2. Moreover, the stability and reactivity of I are compared with those of the corresponding 1,2-quinodimethane. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Name: 3-(Bromomethyl)benzoic acid).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 3-(Bromomethyl)benzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Diemer, Vincent et al. published their research in European Journal of Organic Chemistry in 2011 | CAS: 858843-50-2

3,4-Dibromo-2-methylaniline (cas: 858843-50-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Formula: C7H7Br2N

Efficient and Complementary Methods Offering Access to Synthetically Valuable 1,2-Dibromobenzenes was written by Diemer, Vincent;Leroux, Frederic R.;Colobert, Francoise. And the article was included in European Journal of Organic Chemistry in 2011.Formula: C7H7Br2N The following contents are mentioned in the article:

1,2-Dibromobenzenes are highly valuable precursors for various organic transformations, in particular, reactions based on the intermediate formation of benzynes. This report describes short sequences for the synthesis of various derivatives based on regioselective bromination, ortho-metalation, and halogen/metal permutations. 1,2-Dibromo-3-iodobenzene, 1,2-dibromo-4-iodobenzene, and 2,3-dibromo-1,4-diiodobenzene act as intermediates in these syntheses. This study involved multiple reactions and reactants, such as 3,4-Dibromo-2-methylaniline (cas: 858843-50-2Formula: C7H7Br2N).

3,4-Dibromo-2-methylaniline (cas: 858843-50-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Formula: C7H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Porcheddu, Andrea et al. published their research in Organic & Biomolecular Chemistry in 2011 | CAS: 422560-40-5

2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 422560-40-5

A fast and efficient one-pot microwave assisted synthesis of variously di-substituted 1,2,4-oxadiazoles was written by Porcheddu, Andrea;Cadoni, Roberta;De Luca, Lidia. And the article was included in Organic & Biomolecular Chemistry in 2011.Product Details of 422560-40-5 The following contents are mentioned in the article:

A one-pot two-step microwave assisted synthesis of variously disubstituted 1,2,4-oxadiazoles from carboxylic acids and amidoximes is reported. This methodol. is characterized by short reaction times, is versatile, robust and high-yielding and allows for the preparation of heterocycles with a stereocenter with 100% enantiomeric purity. This study involved multiple reactions and reactants, such as 2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5Product Details of 422560-40-5).

2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 422560-40-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Williams, John D. et al. published their research in Bioorganic & Medicinal Chemistry in 2014 | CAS: 1261675-06-2

3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Synthetic Route of C10H11BrO3

Small molecule inhibitors of anthrax lethal factor toxin was written by Williams, John D.;Khan, Atiyya R.;Cardinale, Steven C.;Butler, Michelle M.;Bowlin, Terry L.;Peet, Norton P.. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Synthetic Route of C10H11BrO3 The following contents are mentioned in the article:

This manuscript describes the preparation of new small mol. inhibitors of Bacillus anthracis lethal factor. The authors’ starting point was the sym., bis-quinolinyl compound (I) (NSC 12155). Optimization of one half of this mol. led to new LF inhibitors that were desymmetrized to afford more drug-like compounds This study involved multiple reactions and reactants, such as 3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2Synthetic Route of C10H11BrO3).

3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Synthetic Route of C10H11BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, He et al. published their research in Journal of the American Chemical Society in 2020 | CAS: 154650-22-3

2-Bromo-6-fluoro-3-methoxybenzaldehyde (cas: 154650-22-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Related Products of 154650-22-3

Enantioselective Cross-Coupling for Axially Chiral Tetra-ortho-Substituted Biaryls and Asymmetric Synthesis of Gossypol was written by Yang, He;Sun, Jiawei;Gu, Wei;Tang, Wenjun. And the article was included in Journal of the American Chemical Society in 2020.Related Products of 154650-22-3 The following contents are mentioned in the article:

A powerful Suzuki-Miyaura coupling enabled by a P-chiral monophosphorus ligand BaryPhos, providing a broad range of synthetically challenging chiral tetra-ortho-substituted biaryls in excellent enantioselectivities and yields was described. In addition to the enhanced reactivity for sterically hindered cross-coupling, the rational design of BaryPhos also enabled a new catalysis mode of asym. cross-coupling involving noncovalent interactions between the ligand and two coupling partners, to effect efficient stereoinduction. This protocol was robust and practical, allowing for a concise enantioselective synthesis of therapeutically valuable male contraceptive and antitumor agent gossypol. This study involved multiple reactions and reactants, such as 2-Bromo-6-fluoro-3-methoxybenzaldehyde (cas: 154650-22-3Related Products of 154650-22-3).

2-Bromo-6-fluoro-3-methoxybenzaldehyde (cas: 154650-22-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Related Products of 154650-22-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Moloney, Gerard P. et al. published their research in European Journal of Medicinal Chemistry in 2008 | CAS: 422560-40-5

2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 422560-40-5

Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB1 receptor was written by Moloney, Gerard P.;Angus, James A.;Robertson, Alan D.;Stoermer, Martin J.;Robinson, Michael;Wright, Christine E.;McRae, Ken;Christopoulos, Arthur. And the article was included in European Journal of Medicinal Chemistry in 2008.Application of 422560-40-5 The following contents are mentioned in the article:

An exploratory chem. effort has been undertaken to develop a novel series of compounds as selective CB1 agonists. It is hoped that compounds of this type will have clin. utility in pain control, and cerebral ischemia following stroke or traumatic head injury. Medicinal chem. studies directed towards the investigation of a series of 1-substituted-indole-3-oxadiazoles, e.g., I, as potential CB1 agonists have been disclosed. This study involved multiple reactions and reactants, such as 2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5Application of 422560-40-5).

2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 422560-40-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vu, Chi B. et al. published their research in Journal of Medicinal Chemistry in 1999 | CAS: 422560-40-5

2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application In Synthesis of 2-(4-Bromophenyl)-N-hydroxyacetimidamide

Discovery of Potent and Selective SH2 Inhibitors of the Tyrosine Kinase ZAP-70 was written by Vu, Chi B.;Corpuz, Evelyn G.;Merry, Taylor J.;Pradeepan, Selvaluxmi G.;Bartlett, Catherine;Bohacek, Regine S.;Botfield, Martyn C.;Eyermann, Charles J.;Lynch, Berkley A.;MacNeil, Ian A.;Ram, Mary K.;Van Schravendijk, Marie Rose;Violette, Shelia;Sawyer, Tomi K.. And the article was included in Journal of Medicinal Chemistry in 1999.Application In Synthesis of 2-(4-Bromophenyl)-N-hydroxyacetimidamide The following contents are mentioned in the article:

A series of 1,2,4-oxadiazole analogs has been shown to be potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70, a potential therapeutic target for immune suppression. These compounds typically are 200-400-fold more potent than the native, monophosphorylated tetrapeptide sequences. When compared with the high-affinity ζ-1-ITAM peptide (Ac-NQL-pYNELNLGRREE-pYDVLD-NH2, wherein pY refers to phosphotyrosine) some of the best 1,2,4-oxadiazole analogs are approx. 1 order of magnitude less active. This series of compounds displays an unprecedented level of selectivity over the closely related tyrosine kinase Syk, as well as other SH2-containing proteins such as Src and Grb2. Gel shift studies using a protein construct consisting only of C-terminal ZAP-70 SH2 demonstrate that these compounds can effectively engage this particular SH2 domain. This study involved multiple reactions and reactants, such as 2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5Application In Synthesis of 2-(4-Bromophenyl)-N-hydroxyacetimidamide).

2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application In Synthesis of 2-(4-Bromophenyl)-N-hydroxyacetimidamide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, He et al. published their research in Nature Communications in 2022 | CAS: 154650-22-3

2-Bromo-6-fluoro-3-methoxybenzaldehyde (cas: 154650-22-3) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application of 154650-22-3

Enantioselective construction of ortho-sulfur- or nitrogen-substituted axially chiral biaryls and asymmetric synthesis of isoplagiochin D was written by Yang, He;Tang, Wenjun. And the article was included in Nature Communications in 2022.Application of 154650-22-3 The following contents are mentioned in the article:

Taking advantage of the BaryPhos-facilitated asym. Suzuki-Miyaura cross-coupling, a general, efficient and enantioselective construction of the ortho sulfur- or nitrogen-substituted axially chiral biaryls was established. The protocol showed excellent compatibility to various functional groups and structural features, delivering chiral biaryl structures with ortho-sulfonyl groups or with ortho-nitro groups at a broad range of mol. diversity and complexity. The immobilization of BaryPhos on polyethylene glycol (PEG) support has enabled homogeneous enantioselective cross-coupling in aqueous media and the palladium catalyst recycling for multiple times. The method has enabled a concise 10-step asym. synthesis of isoplagiochin D as well as the construction of chiroptical mols. with circularly polarized luminescence (CPL) properties. This study involved multiple reactions and reactants, such as 2-Bromo-6-fluoro-3-methoxybenzaldehyde (cas: 154650-22-3Application of 154650-22-3).

2-Bromo-6-fluoro-3-methoxybenzaldehyde (cas: 154650-22-3) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application of 154650-22-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary