Tag: 200-300

Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu published their research in Chem in 2021. The article was titled 《Quantum dots enable direct alkylation and arylation of allylic C(sp3)-H bonds with hydrogen evolution by solar energy》.Name: Benzyl 2-bromoacetate The article contains the following contents:

A general and mild strategy using semiconductor quantum dots (QDs) as photocatalysts for coupling a broad range of available allylic C(sp3)-H bonds with α-amino C-H bonds or heteroarenes, resp., under sunlight irradiation (> 85 examples) was reported. The protocol bypasses stoichiometric oxidant or reductant and pre-functionalization of both the coupling partners and produces hydrogen (H2) as the byproduct. The outstanding efficiency and selectivity and step- and atom-economy represents the first direct alkylation and arylation of allylic C(sp3)-H bonds with hydrogen evolution powered by solar energy. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Name: Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Name: Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chem included an article by Deng, Ruixian; Xi, Junwei; Li, Qigang; Gu, Zhenhua. Application In Synthesis of 1-Bromo-4-(trifluoromethyl)benzene. The article was titled 《Enantioselective Carbon-Carbon Bond Cleavage for Biaryl Atropisomers Synthesis》. The information in the text is summarized as follows:

Development of new synthetic strategies for enantioselective carbon-carbon and carbon-heteroatom bond formation is one of the pillars of modern organic chem. Whereas significant advances have been achieved in center chirality construction, catalytically asym. construction of axial chirality is still under development. Moreover, axially chiral mols. constructed through carbon-carbon and carbon-heteroatom bond cleavage are extremely limited. Authors report an asym. synthesis of biaryl atropisomers I (R = OCF3, Ph, CO2tBu, etc.; R2 = Ph, 3-MeC6H4, 4-ClC6H4, etc.; Ar3 = Ph, p-Tol, 2-thienyl, etc.) via palladium-catalyzed chemoselective carbon-carbon cleavage of 9-aryl-9H-fluoren-9-ols. The reaction demonstrated broad substrate scope and produced the atropisomers in high yields and enantioselectivity. The ring-opening reactivity was considerably accelerated by the torsional strain created by the steric repulsion between two ortho-substituents of the biaryl skeleton in the substrates. The high enantiocontrol hinges on the evolvement of a new TADDOL-based phosphoramidite as ligand. These findings set up a new platform for the development of novel synthetic methods via asym. carbon-carbon cleavage. The experimental process involved the reaction of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Application In Synthesis of 1-Bromo-4-(trifluoromethyl)benzene)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Application In Synthesis of 1-Bromo-4-(trifluoromethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 2,5-DibromothiopheneIn 2021 ,《Upgrading of thiophenic compounds from fuels over a silver-modified MoO3 catalyst under ambient conditions》 was published in Fuel. The article was written by Miao, Guang; Chong, Peng; Yang, Cuiting; Liu, Zewei; Yu, Hao; Dong, Lei; Li, Guoqing; Xiao, Jing. The article contains the following contents:

The demand for heterocyclic sulfur compounds is increasingly in fine chem. industry, where the thiophenic sulfur impurities in fuels can be a potential recyclable feedstock. In this work, the catalytic upgrading of thiophenic sulfur compounds over a silver-modified MoO3 catalyst under ambient conditions was reported. Br2 and H2O2/HBr were used to convert thiophenic compounds in alkane and alc. solutions The conversion of various thiophenic compounds (thiophene, benzothiophene and dibenzothiophene) to the corresponding bromides reached up to 81.6 ∼ 99.8%. The bromination path undergoes electrophilic substitution mechanism, and the transformation of mono- to dibromides is identified as the rate-determining step. The introduction of MoAg2O4 phase on MoO3 is rationalized to boost the conversion of mono-bromothiophene, which results in the selectivity of 2,5-dibromothiophene increased from 10% to over 50%. The optimized silver loading was 10% due to its high thiophene conversion and selectivity of dibromides. Silver modification of MoO3 rods not only stabilized the textural property of catalysts but also improved its bromination activity compared to the bulk MoO3 indicated by SEM and FTIR characterization. D. functional theory (DFT) calculation suggested that the formation of 2-bromothiphene and 2,5-dibromothiophene were preferred on the MoO3(111) and MoAg2O4(111) sites, resp. The catalytic upgrading approach paves the way for the efficient utilization of thiophenic sulfur impurities in fuels to their value-added under mild conditions. In the experiment, the researchers used many compounds, for example, 2,5-Dibromothiophene(cas: 3141-27-3Safety of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Safety of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 3141-27-3In 2022 ,《An all-C-H-activation strategy to rapidly synthesize high-mobility well-balanced ambipolar semiconducting polymers》 was published in Matter. The article was written by Shen, Tao; Li, Wenhao; Zhao, Yan; Liu, Yunqi; Wang, Yang. The article contains the following contents:

Ambipolar semiconducting polymers are of significant fundamental and tech. interest. However, the tedious syntheses of using classic C(sp2)-C(sp2) coupling reactions make high-performance ambipolar polymers seriously absent. In order to address this dilemma, we report here an all-C-H-activation strategy to efficiently synthesize high-performance ambipolar polymers. Diketopyrrolopyrrole-dimer-type monomers and their acceptor-acceptor-type polymers are used as examples. Remarkably, two-step C-H activation reactions from monomer syntheses to polymerization can be accomplished within 2 h, affording a series of semiconducting polymers applied in flexible organic transistors with high and ideally balanced hole and electron mobilities up to 3.56 and 3.75 cm2 V-1 s-1, resp. Furthermore, controlled mol. weight can be realized by varying the polymerization time, which is very important for regulating the trade-off between high mobility and suitable solution processability. Overall, this work offers a general strategy for the rapid synthesis of semiconducting polymers, potentially leading to wide applications of organic electronics. In addition to this study using 2,5-Dibromothiophene, there are many other studies that have used 2,5-Dibromothiophene(cas: 3141-27-3Recommanded Product: 3141-27-3) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Recommanded Product: 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Rui; Dai, Pei; Zhang, Shu; Xu, Ri-Wei; Hong, Song; Lin, Wen-Feng; Wu, Yi-Xian published their research in Polymer in 2021. The article was titled 《In-situ synthesis of cross-linked imidazolium functionalized Poly(styrene-b-isobutylene-b-styrene) for anion exchange membranes》.Product Details of 629-03-8 The article contains the following contents:

The crosslinked imidazolium functionalized anion-exchange membranes is in-situ prepared via reaction of chloromethylated poly(styrene-b-isobutylene-b-styrene) with 1,1′-(1,6-hexanediyl)bisimidazole and N-methylimidazole. The composite membranes of cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) with a small amount of modified graphene oxide grafted with octadecyl and Pr Ph imidazolium could be further prepared These membranes exhibit significantly high chem. stability and ionic conductivity (σ), marked by low methanol permeability, together with improved dynamic mech. properties. The ionic conductivity of crosslinked imidazolium poly(styrene-b-isobutylene-b-styrene) reaches 2.09 x 10-2 S cm-1 at 80°C by introduction of 0.5 wt% loading of modified graphene oxide. This membrane also behaves an excellent chem. stability and σ can remain ca. 82% of the original value after immerged in strong alk. medium (2 M NaOH) at 60°C for 500 h, which is almost the same as that (ca. 82%) of com. Nafion 115 in acid medium (2 M H2SO4) at 60°C for 500 h. The cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) is characterized as a promising anion exchange membrane materials in fuel cell for its high ionic conductivity, chem. stability and low methanol permeability. In the experiment, the researchers used 1,6-Dibromohexane(cas: 629-03-8Product Details of 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Product Details of 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 623-24-5In 2022 ,《Tailored Polymeric Hole-Transporting Materials Inducing High-Quality Crystallization of Perovskite for Efficient Inverted Photovoltaic Devices》 appeared in Small. The author of the article were Xu, Wenxin; Zhao, Guiqiu; Li, Mubai; Pan, Yuyu; Ma, Hongzhuang; Sun, Riming; Wang, Jungan; Liu, You; Chen, Cheng; Huang, Wei; Wang, Fangfang; Qin, Tianshi. The article conveys some information:

For achieving high-performance p-i-n perovskite solar cells (PSCs), hole transporting materials (HTMs) are critical to device functionality and represent a major bottleneck to further enhancing device stability and efficiency in the inverted devices. Three dopant-free polymeric HTMs are developed based on different linkage sites of triphenylamine and phenylenevinylene repeating units in their main backbone structures. The backbone curvatures of the polymeric HTMs affect the morphol. and hole mobility of the polymers and further change the crystallinity of perovskite films. By using PTA-mPV with moderate mol. curvature, p-i-n PSCs with high efficiency of 19.5% and long-term stability can be achieved. The better performance is attributed to the more effective hole extraction ability, higher charge-carrier mobility, and lower interfacial charge recombination. Furthermore, these three polymeric HTMs are synthesized without any noble metal catalyst, and show great advantages in future application owing to the low-cost. In the experiment, the researchers used many compounds, for example, 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Recommanded Product: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Recommanded Product: 623-24-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Acylation of 25-hydroxyprotopanaxatriol with aromatic acids increases cytotoxicity》 were Lv, Liyan; Lu, Jincai; Zhang, Hongyu; Wang, Xude; Su, Guangyue; Piao, Huri; Zhao, Yuqing. And the article was published in Fitoterapia in 2019. Product Details of 586-76-5 The author mentioned the following in the article:

20(R)-25-hydroxyprotopanaxadiol (25-OH-PPD) is a natural compound showing a variety of anti-tumor effects. In an attempt to discover a new anti-cancer compound with higher antitumor activities, we designed and synthesized a series of 25-OH-PPD derivatives The cytotoxicity assay of these derivatives towards MCF-7, A549, U87, HO-8901, Hela cancer cell lines and normal IOSE144 cell lines were tested by MTT assay. Results showed that compared with compound 25-OH-PPD, acylated derivatives I [R = 4-ClC6H4, 2-FC6H4, 2,4-F2C6H3, 2-O2NC6H4, 3,5-(O2N)2C6H3] showed strong anticancer activity, and all compounds showed low toxicity or no toxicity for normal cells. In particular, compound I (R = 2,4-F2C6H3) (II) exhibited the best anti-tumor activity in all cancer cell lines (MCF-7, A549, U87, HO-8901, and Hela) with IC50 values of 5.04μM, 1.36μM, 3.24μM, 3.47μM, 4.57μM, resp. Among the five cell lines, all the compounds showed strong inhibition on A549 cells. Further studies showed that II significantly inhibited the proliferation of A549 cells by inducing apoptosis. Our results indicate that II is a potential anticancer inhibitor and provides a theor. basis for further research. In addition to this study using 4-Bromobenzoic acid, there are many other studies that have used 4-Bromobenzoic acid(cas: 586-76-5Product Details of 586-76-5) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Product Details of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Synthesis included an article by Singh, Mala; Singh, Anoop S.; Mishra, Nidhi; Agrahari, Anand K.; Tiwari, Vinod K.. Product Details of 586-76-5. The article was titled 《Trichloroisocyanuric Acid Mediated High-Yielding Synthesis of N-Acylbenzotriazoles under Mild Reaction Conditions》. The information in the text is summarized as follows:

N-Acylbenzotriazoles I (R = C6H5, (E)-CH3(CH2)7CH=CH(CH2)7, furan-2-yl, etc.) are achieved in good yields from the corresponding carboxylic acids RC(O)OH by using only 0.35 equiv of trichloroisocyanuric acid and 1.2 equiv of PPh3. The salient features of the developed reaction path include an economic, facile, base-free, and equally useful method in milligram to gram scale. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Product Details of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Product Details of 586-76-5 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Tang, Qi; Liu, Jing; Wang, Cheng-Bin; An, Lu; Zhang, Hai-Lin; Wang, Yi; Ren, Bing; Yang, Shi-Ping; Liu, Jin-Gang published an article in Nanoscale. The title of the article was 《A multifunctional nanoplatform delivering carbon monoxide and a cysteine protease inhibitor to mitochondria under NIR light shows enhanced synergistic anticancer efficacy》.Electric Literature of C5BrMnO5 The author mentioned the following in the article:

Photoactivated chemotherapy has attracted widespread attention due to its ability to circumvent the shortcomings of hypoxia in tumor tissues compared with traditional photodynamic therapy. In this work, novel multifunctional nanoplatform (1), Ru-inhibitor@TPPMnCO@N-GQDs, was designed and prepared, which was capable of mitochondria-targeted co-delivery of the cysteine protease inhibitor and carbon monoxide (CO) stimulated with an 808 nm near IR (NIR) laser. Nanoplatform (1) was prepared by covalent attachment of a mitochondria-targeted CO donor (TPPMnCO) and a Ru(II)-caged cysteine protease inhibitor (Ru-inhibitor) on the surface of fluorescent N-doped graphene quantum dots (N-GQDs). Nanoplatform (1) preferentially accumulated in the mitochondria of cancer cells and instantly delivered CO and the cysteine protease inhibitor upon 808 nm NIR light irradiation, thus damaging mitochondria and leading to significant in vitro and in vivo anticancer efficacy. In addition, nanoplatform (1) has good biocompatibility and did not exert any toxic side effects on mice during the period of treatment. The targeted subcellular mitochondrial co-delivery of CO and the cysteine protease inhibitor may provide new insights into CO and enzyme inhibitor combined therapies for cancer treatment. The experimental part of the paper was very detailed, including the reaction process of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Electric Literature of C5BrMnO5)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Electric Literature of C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 14516-54-2In 2020 ,《Manganese-Catalyzed Enantioselective Hydrogenation of Simple Ketones Using an Imidazole-Based Chiral PNN Tridentate Ligand》 was published in Synlett. The article was written by Ling, Fei; Chen, Jiachen; Nian, Sanfei; Hou, Huacui; Yi, Xiao; Wu, Feifei; Xu, Min; Zhong, Weihui. The article contains the following contents:

A series of Mn(I) catalysts containing imidazole-based chiral PNN tridentate ligands I (R = diphenylphosphanyl, bis(3,5-dimethylphenyl)phosphanyl, bis(propan-2-yl)phosphanyl; R1 = 1-benzyl-1H-imidazol-2-yl, 1-benzyl-1H-1,3-benzodiazol-2-yl, 1-(propan-2-yl)-1H-1,3-benzodiazol-2-yl, etc.) with controllable ‘side arm’ groups have been established, enabling the inexpensive base-promoted asym. hydrogenation of simple ketones R2C(O)R3 (R2 = naphthalen-2-yl, 9H-fluoren-1-yl, benzofuran-2-yl, etc.; R3 = Me, cyclohexyl, propan-2-yl, etc.) and 1,2,3,4-tetrahydronaphthalen-1-one with outstanding activities (up to 8200 TON) and good enantioselectivities (up to 88.5% ee). This protocol features wide substrate scope and functional group tolerance, thereby providing easy access to a key intermediate of crizotinib. The experimental part of the paper was very detailed, including the reaction process of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Related Products of 14516-54-2)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Related Products of 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary