Tag: 200-300

Lu, Xu; Kawazu, Ryohei; Song, Jizhou; Yoshigoe, Yusuke; Torigoe, Takeru; Kuninobu, Yoichiro published their research in Organic Letters in 2021. The article was titled 《Regioselective C-H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins》.Related Products of 626-40-4 The article contains the following contents:

A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. 1H NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity. After reading the article, we found that the author used 3,5-Dibromoaniline(cas: 626-40-4Related Products of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Related Products of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Wholly Visible-Light-Responsive Host-Guest Supramolecular Gels Based on Methoxy Azobenzene and β-Cyclodextrin Dimers》 was written by Yan, Hongchao; Qiu, Yuan; Wang, Jing; Jiang, Qian; Wang, Hong; Liao, Yonggui; Xie, Xiaolin. Formula: C6H12Br2 And the article was included in Langmuir in 2020. The article conveys some information:

Much attention has been paid to construct photoresponsive host-guest supramol. gels; however, red-shifting the responsive wavelength remains a formidable challenge. Here, a wholly visible-light-responsive supramol. gel was fabricated through the host-guest interaction between a β-cyclodextrin (β-CD) dimer and a tetra-ortho-methoxy-substituted azobenzene (mAzo) dimer (binary gelator) in DMSO/H2O (V/V = 8/2). The min. gelation concentration of the low-mol.-weight binary gelator was 6 wt % measured via the tube inversion method. The substituted methoxy groups shifted the responsive wavelengths of trans-mAzo and cis-mAzo to the green and blue light regions, resp. The host-guest interaction between mAzo and β-CD as the driving force for gelation was confirmed using the 1H-NMR and 2D 1H NOESY spectra. The supramol. gel showed good self-supporting ability with a storage modulus higher than 104 Pa. The release of Rhodamine B loaded in the gel as a model drug could be controlled by green light irradiation We envisioned the potential applications of the wholly visible-light-responsive supramol. compounds ranging from biomedical materials to smart materials. In the experimental materials used by the author, we found 1,6-Dibromohexane(cas: 629-03-8Formula: C6H12Br2)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.Formula: C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Stanazolol derived ELISA as a sensitive forensic tool for the detection of multiple 17α-methylated anabolics》 was written by Huml, Lukas; Havlova, Dominika; Longin, Ondrej; Stankova, Eliska; Holubova, Barbora; Kuchar, Martin; Prokudina, Elena; Rottnerova, Zdenka; Zimmermann, Tomas; Drasar, Pavel; Lapcik, Oldrich; Jurasek, Michal. Formula: C7H13BrO2 And the article was included in Steroids in 2020. The article conveys some information:

Two valuable forensic tools based on enzyme-linked immunoassays (ELISAs) for the anal. of 17α-methylated steroids were developed using haptens of stanazolol and its conjugates with biotin. Haptens containing terminal carboxylic group were conjugated to bovine serum albumin (BSA), rabbit serum albumin (RSA) or ovalbumin (OVA). Eight batches of antisera (RAbs) obtained by immunization of rabbits were tested in an indirect competitive ELISA system using immobilization of RSA conjugate (RSA/hapten) and competitor immobilization of the biotinylated conjugate (AB-ELISA) to avidin (avidin/hapten). The best results were achieved with the RAb 212 antibodies in RSA/ST-3 and avidin/ST-10 assembled variants. For the RSA/ST-3 system, an IC50 of 0.3 ng/mL and a detection limit of 0.02 ng/mL were measured. In case of avidin/ST-10 variant, IC50 was of 3.9 ng/mL and a detection limit of 0.57 ng/mL were obtained. The effect of solvent was tested as well as the stability of coated microtiter plates over four-month period. The cross-reactivity of the developed assays with other anabolic steroids was tested and high sensitivity towards 17α-methylated steroids was observed RSA/ST-3 assay showed significant cross-reactivity with 17α-methyltestosterone (81.2%), oxymetholone (30.4%), methandienone (10.0%) and Me dihydrotestosterone (7.7%). Similarly, in the avidin/ST-10 assay, 17α-methyltestosterone (34.5%), mestanolone (32.1%), oxymetholone (22.7%), methandienone (14.2%), 9-dehydromethyltestosterone (12.5%) and oxandrolone (1.2%) exhibited high cross-reactivity. The functionality of the developed systems was verified by the successful identification of a series of 17α-methylated anabolic steroids in a set of real samples including pharmaceutical preparations seized by the Police of the Czech Republic on the black market. In the experimental materials used by the author, we found Ethyl 5-bromovalerate(cas: 14660-52-7Formula: C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Formula: C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Direct C-H Arylation of Aldehydes by Merging Photocatalyzed Hydrogen Atom Transfer with Palladium Catalysis》 was published in ACS Catalysis in 2020. These research results belong to Wang, Lu; Wang, Ting; Cheng, Gui-Juan; Li, Xiaobao; Wei, Jun-Jie; Guo, Bin; Zheng, Caijuan; Chen, Guangying; Ran, Chongzhao; Zheng, Chao. Application of 402-43-7 The article mentions the following:

Herein, we report that merging palladium catalysis with hydrogen atom transfer (HAT) photocatalysis enabled direct arylations and alkenylations of aldehyde C-H bonds, facilitating visible light-catalyzed construction of a variety of ketones. Tetrabutylammonium decatungstate and anthraquinone were found to act as synergistic HAT photocatalysts. D. functional theory calculations suggested a Pd0-PdII-PdIII-PdI-Pd0 pathway and revealed that regeneration of the Pd0 catalyst and the photocatalyst occurs simultaneously in the presence of KHCO3. This regeneration features a low energy barrier, promoting efficient coupling of the palladium catalytic cycle with the photocatalytic cycle. The work reported herein suggests great promise for further applications of HAT photocatalysis in palladium-catalyzed cross-coupling and C-H functionalization reactions to be successful. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Application of 402-43-7)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Application of 402-43-7 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Pd(CH3CN)2Cl2/pipecolinic acid as a highly efficient catalytic system for Suzuki-Miyaura cross-coupling reaction of bromoaryl carboxylic acids in water》 were Li, Xiaogang; Zhang, Wenbin; Fu, Leiqing; Guo, Mengping. And the article was published in Catalysts in 2019. Application of 586-76-5 The author mentioned the following in the article:

In this study, a convenient and highly efficient catalytic system for the Suzuki-Miyaura coupling reaction was investigated under mild conditions. A combination of Pd(CH3CN)2Cl2 and pipecolinic acid showed excellent catalytic performance and afforded high turnover numbers; turnover numbers were up to 4.9 × 105 for the coupling reaction of 4-bromobenzoic acid and tetraphenylboron sodium. The catalytic system was also effective for the indexes of 4-bromobenzoic acid, and high turnover numbers were obtained. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Visible Light-Mediated Direct C-H Aroylation and Alkylation of Heteroarenes》 were Chang, Rui; Fang, Jie; Chen, Jian-Qiang; Liu, Dan; Xu, Guo-Qiang; Xu, Peng-Fei. And the article was published in ACS Omega in 2019. SDS of cas: 14660-52-7 The author mentioned the following in the article:

Herein, we describe the photocatalytic generation of nucleophilic aroyl radicals from simple aroyl chlorides as a universal and efficient cross-coupling strategy for the direct aroylation of heteroarenes. Furthermore, visible light-mediated direct alkylation of heteroarenes has also been achieved using unactivated bromoalkanes as radical precursors. These two strategies feature high functional group tolerance, exclusive regioselectivity for reaction at the more electrophilic position of heteroarenes, easily accessible substrates, and mild reaction conditions. Moreover, mechanism studies of two reactions are carried out to support our hypotheses. After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7SDS of cas: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.SDS of cas: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 1,4-Bis(bromomethyl)benzeneIn 2020 ,《Synthesis and properties of a stimulus-responsive block polymer》 was published in RSC Advances. The article was written by Wang, B.; Liu, F. Q.. The article contains the following contents:

In this study, the synthesis of small mols. and use of an improved “”one-pot”” method to synthesize the reversible addition-fragmentation chain transfer polymerization (RAFT) reagents have been reported. By comparing with the RAFT reagents synthesized by the traditional “”step-by-step”” method, it was observed that the reagents synthesized by the two methods had the same structure, however, the improved “”one-pot”” preparation method results in a significantly higher yield. Subsequently, two different macromol. CTA segments (PVP-CTA-PVP and PDMAEMA-CTA-PDMAEMA) were prepared by RAFT polymerization, followed by the synthesis of the block polymer PDMAEMA-b-PVP-CTA-PVP-b-PDMAEMA. Through FITR, NMR, GPC and DLS anal. of the block polymer, it was observed that the isotacticity gradually became dominant as the d.p. increased. Further, using NMR spectroscopy to study the effect of pH on the block polymer, the ionization degree of the synthesized polymer in the tumor tissue environment was observed to range between 86.32% to 99.50%, which proved that the synthesized polymers exhibit significant prospects in the medical application. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Safety of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of 1,4-Bis(bromomethyl)benzene Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 3141-27-3In 2021 ,《Electrochromic properties of pyrene conductive polymers modified by chemical polymerization》 appeared in RSC Advances. The author of the article were Li, Rui; Xu, Haoran; Zhang, Yuhang; Chang, Lijing; Ma, Yang; Hou, Yanjun; Miao, Shoulei; Wang, Cheng. The article conveys some information:

Pyrene is composed of four benzene rings and has a unique planar melting ring structure. Pyrene is the smallest condensed polycyclic aromatic hydrocarbon, and its unique structural properties have been extensively studied. Pyrene has excellent properties such as thermal stability, high fluorescence quantum efficiency and high carrier mobility. This paper mainly used thiophene, EDOT and triphenylamine groups to enhance the pyrene based π-conjugated system and control the mol. accumulation of organic semiconductors, and improve their charge transport performances. Five kinds of polymer were synthesized and correspondingly characterized. The five kinds of pyrene conductive polymer had outstanding properties in terms of solubility, fluorescence intensity and thermal stability, good film-forming properties, stable electrochromic properties and high coloring efficiency. The coloration efficiency (CE) of PPYTP was as high as 277 cm2 C-1, and the switching response time was short. The coloring time of PPYEDOT was 1.3 s and the bleaching time was 3.2 s. The lower impedance will also provide the possibility of such polymers being incorporated into electrochromic devices in the future. In short, the synthesized new pyrene conductive polymers will have wide application prospects in the field of electrochromic materials. After reading the article, we found that the author used 2,5-Dibromothiophene(cas: 3141-27-3SDS of cas: 3141-27-3)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .SDS of cas: 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Zheqi; Wu, Dong; Ding, Chao; Yin, Guoyin published their research in CCS Chemistry in 2021. The article was titled 《Modular synthesis of diarylalkanes by nickel-catalyzed 1,1-diarylation of unactivated terminal alkenes》.Product Details of 402-43-7 The article contains the following contents:

A nickel-catalyzed 1,1-diarylation of electronically unbiased alkenes was developed, providing straightforward access to diarylalkanes from readily available materials. Importantly, both the efficiency and the regioselectivity of this transformation were ensured by reaction conditions, rather than the coordinating group of substrates. It was also demonstrated that under balloon pressure, ethylene and propylene was also be utilized as substrates. Preliminary mechanistic experiments suggested that this transformation involves a Ni(0)/Ni(II) catalytic cycle rather than a Ni(I)/Ni(III) cycle. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Product Details of 402-43-7)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Product Details of 402-43-7 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Facile synthesis of NH-free 5-(hetero)aryl-pyrrole-2-carboxylates by catalytic C-H borylation and Suzuki coupling》 was written by Kanwal, Saba; Noor-ul-Ann; Fatima, Saman; Emwas, Abdul-Hamid; Alazmi, Meshari; Gao, Xin; Ibrar, Maha; Saleem, Rahman Shah Zaib; Chotana, Ghayoor Abbas. Quality Control of 1-Bromo-3,4,5-trimethoxybenzene And the article was included in Molecules in 2020. The article conveys some information:

A convenient two-step preparation of NH-free 5-aryl-pyrrole-2-carboxylates is described. The synthetic route consists of catalytic borylation of com. available pyrrole-2-carboxylate ester followed by Suzuki coupling without going through pyrrole N-H protection and deprotection steps. The resulting 5-aryl substituted pyrrole-2-carboxylates were synthesized in good to excellent yields. This synthetic route can tolerate a variety of functional groups including those with acidic protons on the aryl bromide coupling partner. This methodol. is also applicable for cross-coupling with heteroaryl bromides to yield pyrrole-thiophene, pyrrole-pyridine, and 2,3′-bi-pyrrole based bi-heteroaryls. In the experiment, the researchers used many compounds, for example, 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Quality Control of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Quality Control of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary