Tag: 200-300

Fabrication and performance of all-solid-state dye-sensitized solar cells using synthetic carboxylated and pyridylated chlorophyll derivatives was written by Cui, Yuxiao;Zhao, Wenjie;Ogasawara, Shin;Wang, Xiao-Feng;Tamiaki, Hitoshi. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2018.Electric Literature of C8H7BrO2 This article mentions the following:

All-solid-state dye-sensitized solar cells (DSSCs) based on a mesoporous TiO₂ electrode were fabricated using synthetic chlorophyll derivatives as a photosensitizer and 2,2閳?7,7閳?tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9閳?spirobifluorene as a hole-transport material. Me pyropheophorbides-a possessing a carboxy group in the C3-substituent as the anchoring moiety to the TiO₂ surface were effective DSSCs. Direct conjugation of the COOH group with the terminus of the C3-vinyl group gave the highest solar energy-to-electricity conversion efficiency (鐣? of 2.25%. Insertion of a 1,3-phenylene group in the connection partially suppressed the efficiency by 25% (鐣?= 1.68%), whereas insertion of an isomeric 1,4-phenylene moiety decreased to one third (0.75%). A pyridyl group was not useful as the sensitizer anchor due to its low binding affinity to the TiO₂ electrode. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Electric Literature of C8H7BrO2).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Domino Direct Arylation and Cross-Aldol for Rapid Construction of Extended Polycyclic 锜?Scaffolds was written by Nitti, Andrea;Bianchi, Gabriele;Po, Riccardo;Swager, Timothy M.;Pasini, Dario. And the article was included in Journal of the American Chemical Society in 2017.Synthetic Route of C10H11BrO2 This article mentions the following:

Five-membered aromatic heterocycles are a ubiquitous skeleton of 锜?conjugated organic compounds, and their incorporation requires synthetic protocols that are not easily industrially sustainable or scalable. Improved methodologies for their insertion into 锜?scaffolds are therefore necessary. We report an efficient and scalable protocol involving a one-pot cross-Aldol direct arylation reaction protocol for the rapid construction of thiophene- and furan-based 锜?extended organic materials. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Synthetic Route of C10H11BrO2).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C10H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 浼?Aryl Esters and Nitriles: Deaminative Coupling of 浼?Amino-Esters and 浼?Aminoacetonitriles with Arylboronic Acids was written by Wu, Guojiao;Deng, Yifan;Wu, Chaoqiang;Zhang, Yan;Wang, Jianbo. And the article was included in Angewandte Chemie, International Edition in 2014.Related Products of 2178-24-7 This article mentions the following:

Transition-metal-free synthesis of 浼?aryl esters and nitriles using arylboronic acids with 浼?amino esters and 浼?(amino)acetonitrile derivatives, resp., as starting materials has been developed. The reaction represents a rare case of converting C(sp³)-N bonds (carbon-nitrogen bonds) into C(sp³)-C(sp²) bonds (carbon-carbon bonds). The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. The synthesis of the target compounds was achieved using glycine ester hydrochloride, leucine ester hydrochloride, aspartate ester hydrochloride, alanine ester hydrochloride as starting materials in a reaction with (aryl)boronic acids. The title compounds thus formed included benzeneacetic acid esters, 1-naphthaleneacetic acid ester, benzenepropanoic acid esters, 浼?phenyl-1H-indole-3-propanoic acid ester, benzenebutanoic acid ester and similar substances. A reaction of (aryl)boronic acids with 浼?(amino)acetonitrile gave 浼?(alkyl)benzeneacetonitrile derivatives Nitriles included 浼?(hexyl)benzeneacetonitrile, 浼?phenyl-3-thiophenepropanenitrile and similar compounds In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Related Products of 2178-24-7).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 2178-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Remarkably High Reactivity of Pd(OAc)₂/Pyridine Catalysts: Nondirected C-H Oxygenation of Arenes was written by Emmert, Marion H.;Cook, Amanda K.;Xie, Yushu J.;Sanford, Melanie S.. And the article was included in Angewandte Chemie, International Edition in 2011.Name: 3-Bromophenyl acetate This article mentions the following:

The rational optimization and general applicability of the catalytic system Pd(OAc)₂/pyridine is described (see scheme). The catalyst shows excellent reactivity in the C-H oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of one equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)₂ alone. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Name: 3-Bromophenyl acetate).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Name: 3-Bromophenyl acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and characterization of new tetra-substituted porphyrins with exo-donor carboxylic groups as building blocks for supramolecular architectures: Catalytic and structural studies of their metalated derivatives was written by Carlucci, Lucia;Ciani, Gianfranco;Maggini, Simona;Proserpio, Davide M.;Ragaini, Fabio;Gallo, Emma;Ranocchiari, Marco;Caselli, Alessandro. And the article was included in Journal of Porphyrins and Phthalocyanines in 2010.Reference of 100189-84-2 This article mentions the following:

The authors report herein the synthesis of the porphyrins 5,10,15,20-tetrakis(4-carboxybiphenyl)-porphyrin (H₂TCBP) and 5,10,15,20-tetrakis(4-carboxy-2,6-dimethylbiphenyl)porphyrin (H₂TCDMBP) bearing di-Ph units on meso-positions, and of their cobalt and silver derivatives The silver complexes of H₂TCDMBP and of H₂TCPP (H₂TCPP = 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin) were studied by x-ray crystallog. and their supramol. organization elucidated. Co(TCBP) was reacted with copper formate, yielding a polymeric compound that showed a catalytic activity in the benzylic amination of hydrocarbons using arylazide as aminating agent. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2Reference of 100189-84-2).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 100189-84-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological evaluation of novel sulfone derivatives containing 1,3,4-oxadiazole moiety was written by Su, Shihu;Zhou, Xia;Zhou, Yan;Liao, Guoping;Shi, Li;Yang, Xia;Zhang, Xian;Jin, Linhong. And the article was included in World Journal of Organic Chemistry in 2014.HPLC of Formula: 179232-29-2 This article mentions the following:

Series of novel sulfone derivatives containing 1,3,4-oxadiazole moiety I [R¹ = 4-F-2-Me, 2,5-Cl₂, 2-Br-4-F, etc.; R² = Me, Et, CH(CH₃)₂, n-propyl] and II [R² = Me, Et, CH₂Ph] were synthesized. All the target compounds were characterized by ¹H and ¹³C NMR, IR spectroscopy and elemental anal. Their antifungal activities were tested in vitro with six important phytopathogenic fungi, namely, Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica, Phytophthora infestans, Paralepetopsis sasakii and Sclerotinia sclerotiorum using the mycelium growth inhibition method. Their antibacterial activities were tested in vitro with two important phytopathogenic bacteria, namely, Xanthomonas oryzae and Ralstonia solanacearum from tobacco bacterial by the turbid meter test. Compounds I [R¹ = 2-Cl-4-F, 4-CF₃; R² = Me] and II [R² = Me, Et] exhibited the most potent inhibition against R. solanacearum and X. oryzae with 50% inhibition concentration (EC₅₀) from 1.97 to 7.75 娓璯/mL and 0.45 to 0.52 娓璯/mL, resp. Their antifungal tests indicated that among target compounds exhibited good antifungal activities against six kinds of fungi, especially against S. sclerotiorum with EC₅₀ from 3.71 to 17.44 娓璯/mL. In vivo antibacterial activities tests demonstrated that the controlling effect of compound II [R² = Me] (81.9%) against rice bacterial leaf blight were better than that of bismerthiazol (50.8%) and thiodiazole-copper (44.7%). The results also demonstrated that compounds I [R¹ = 2-Cl-4-F; R² = Me] and II [R² = Me, Et] had a better antifungal and antibacterial activity, with good characteristics of broad spectrum. The structure-activity relationships were also discussed. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2HPLC of Formula: 179232-29-2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 179232-29-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Photochromic dihetarylethenes. 12. Synthesis of 5-alkyl-2-(1,3,4-oxadiazol-2-yl)thiophenes and their photochromic derivatives was written by Krayushkin, M. M.;Stoyanovich, F. M.;Zolotarskaya, O. Yu.;Chernoburova, E. I.;Makhova, N. N.;Yarovenko, V. N.;Zavarzin, I. V.;Martynkin, A. Yu.;Uzhinov, B. M.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2002.Application In Synthesis of 4-Bromo-5-methylthiophene-2-carboxylic acid This article mentions the following:

Photochromic 5-alkyl-2-(1,3,4-oxadiazol-2-yl)thiophenes I (R¹ = Me, R² = Ph, 4-MeOC₆H₄; R¹ = n-hexyl, R² = 6-methoxy-2-benzothiazolyl) and II were synthesized, and their photochromic and fluorescent properties were studied. In the experiment, the researchers used many compounds, for example, 4-Bromo-5-methylthiophene-2-carboxylic acid (cas: 29421-99-6Application In Synthesis of 4-Bromo-5-methylthiophene-2-carboxylic acid).

4-Bromo-5-methylthiophene-2-carboxylic acid (cas: 29421-99-6) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application In Synthesis of 4-Bromo-5-methylthiophene-2-carboxylic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Improved Flavodoxin Inhibitors with Potential Therapeutic Effects against Helicobacter pylori Infection was written by Galano, Juan J.;Alias, Miriam;Perez, Reyes;Velazquez-Campoy, Adrian;Hoffman, Paul S.;Sancho, Javier. And the article was included in Journal of Medicinal Chemistry in 2013.Application of 14425-64-0 This article mentions the following:

A variety of electron-deficient chromenes and styrenes and nitrobenzooxadiazolyl thioethers and other compounds were tested (and in some cases prepared) as selective inhibitors of flavodoxin in Helicobacter pylori for potential use in the treatment of gastric ulcer and prevention of stomach cancer with fewer side effects and reduced susceptibilities to drug resistance; their inhibition of flavodoxin and of Helicobacter pylori and their cytotoxicities were determined For example, (E)-ArCH:CHNO₂ (Ar = 2-F-5-F₃CC₆H₃, 4-Cl-2,6-F₂C₆H₂) inhibited H. pylori with IC₅₀ values of 0.53 娓璏 and therapeutic indexes of 38 and 15, resp. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds was written by Pallesen, Jakob S.;Narayanan, Dilip;Tran, Kim T.;Solbak, Sara M. Oe.;Marseglia, Giuseppe;Soerensen, Louis M. E.;Hoej, Lars J.;Munafo, Federico;Carmona, Rosa M. C.;Garcia, Anthony D.;Desu, Haritha L.;Brambilla, Roberta;Johansen, Tommy N.;Popowicz, Grzegorz M.;Sattler, Michael;Gajhede, Michael;Bach, Anders. And the article was included in Journal of Medicinal Chemistry in 2021.Category: bromides-buliding-blocks This article mentions the following:

Targeting the protein-protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six classes of known small-mol. Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in a fragment-based deconstruction reconstruction (FBDR) study and tested in four orthogonal assays. This gave 17 fragment hits of which six were shown by X-ray crystallog. to bind in the Keap1 Kelch binding pocket. Two hits were merged into pyrazole I with a 220-380-fold stronger affinity (K_i = 16娓璏) relative to the parent fragments. Systematic optimization resulted in several novel analogs with K_i values of 0.04-0.5娓璏, binding modes determined by X-ray crystallog., and enhanced microsomal stability. This demonstrates how FBDR can be used to find new fragment hits, elucidate important ligand-protein interactions, and identify new potent inhibitors of the Keap1-Nrf2 PPI. In the experiment, the researchers used many compounds, for example, 3-Bromo-5-chlorophenylamine (cas: 96558-78-0Category: bromides-buliding-blocks).

3-Bromo-5-chlorophenylamine (cas: 96558-78-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular Acetyl Transfer to Olefins by Catalytic C-C Bond Activation of Unstrained Ketones was written by Rong, Zi-Qiang;Lim, Hee Nam;Dong, Guangbin. And the article was included in Angewandte Chemie, International Edition in 2018.SDS of cas: 85118-24-7 This article mentions the following:

A rhodium-catalyzed intramol. acetyl-group transfer was achieved through a “cut and sew” process. The challenge arises from the existence of different competitive pathways. Preliminary success was achieved with unstrained enones that contain a biaryl linker. The use of an electron-rich N-heterocyclic carbene (NHC) ligand is effective to inhibit undesired 灏?hydrogen elimination. Various 9,10-dihydrophenanthrene derivatives can be prepared with excellent functional-group compatibility. The ¹³C-labeling study suggests that the reaction begins with cleavage of the unstrained C-C bond, followed by migratory insertion and reductive elimination. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7SDS of cas: 85118-24-7).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. SDS of cas: 85118-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary