Tag: 200-300

HPLC of Formula: 626-40-4In 2022 ,《Structural Development of Silicon-Containing Retinoids: Structure-Activity Relationship Study of the Hydrophobic Pharmacophore of Retinobenzoic Acids Using Silyl Functionalities》 was published in ChemMedChem. The article was written by Oikawa, Tsuyoshi; Fujii, Shinya; Mori, Shuichi; Masuno, Hiroyuki; Kawachi, Emiko; Kagechika, Hiroyuki. The article contains the following contents:

We designed and synthesized a series of retinobenzoic acids bearing various silyl functionalities in order to explore in detail the structure-activity relationship (SAR) at the hydrophobic moiety of retinoids. Among the synthesized compounds, 24 c bearing a t-butyldimethylsilyl (TBS) group at the hydrophobic site exhibited potent retinoid activity comparable to that of the lead compound Am555S (4). Compound 24 c exhibited transcription-promoting activity towards all three subtypes of retinoic acid receptor (RAR), but showed the highest activity towards RARγ, in contrast to the high RARα-selectivity of Am80 (3) and Am555S (4). The SARs presented here should be helpful in the development of subtype-selective retinoids, and in particular 24 c might be a promising lead compound for new RARγ ligands. In the experiment, the researchers used 3,5-Dibromoaniline(cas: 626-40-4HPLC of Formula: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.HPLC of Formula: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C9H11BrO3In 2021 ,《Synthesis and biological evaluation of 1-(diarylmethyl)-1H-1,2,4-triazoles and 1-(diarylmethyl)-1H-imidazoles as a novel class of anti-mitotic agent for activity in breast cancer》 appeared in Pharmaceuticals. The author of the article were Ana, Gloria; Kelly, Patrick M.; Malebari, Azizah M.; Noorani, Sara; Nathwani, Seema M.; Twamley, Brendan; Fayne, Darren; O’Boyle, Niamh M.; Zisterer, Daniela M.; Pimentel, Elisangela Flavia; Endringer, Denise Coutinho; Meegan, Mary J.. The article conveys some information:

Synthesis and biochem. evaluation of diaryl(heterocyclyl)methanes R1CH(X)R2 (I) [X = 1,2,4-triazol-1-yl, 1-imidazolyl, 1-pyrrolidinyl, 1-piperidinyl, N-R3-piperazin-1-yl, 1,2,3-triazol-2-yl; R1, R2 = Ph, 4-HOC6H4, 3-HO-4-MeOC6H3, 3,4,5-(MeO)3C6H2, etc.; R3 = H, Ph, PhCH2, etc.], that were designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole, are described. A preliminary screening in estrogen receptor (ER)-pos. MCF-7 breast cancer cells identified the compound I [X = 1,2,3-triazol-2-yl; R1 = 3,4,5-(MeO)3C6H2; R2 = 3-HO-4-MeOC6H3] as a potent antiproliferative compound with an IC50 value of 52 nM in MCF-7 breast cancer cells (ER+/PR+) and 74 nM in triple-neg. MDA-MB-231 breast cancer cells. The compounds I demonstrated significant G2/M phase cell cycle arrest and induction of apoptosis in the MCF-7 cell line, inhibited tubulin polymerization, and were selective for cancer cells when evaluated in non-tumorigenic MCF-10A breast cells. The immunofluorescence staining of MCF-7 cells confirmed that these compounds targeted tubulin and induced multinucleation, which was a recognized sign of mitotic catastrophe. Computational docking studies of compounds I [X = 1,2,4-triazol-1-yl, imidazol-1-yl, 1,2,3-triazol-2-yl; R1 = 3,4,5-(MeO)3C6H2; R2 = 3-OH-4-MeOC6H3] in the colchicine binding site of tubulin indicated potential binding conformations for the compounds The compounds I [X = 1,2,4-triazol-1-yl, imidazol-1-yl; R1 = 3,4,5-(MeO)3C6H2; R2 = 3-OH-4-MeOC6H3] were also shown to selectively inhibit aromatase. These compounds are promising candidates for development as antiproliferative, aromatase inhibitory, and microtubule-disrupting agents for breast cancer. The experimental process involved the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Electric Literature of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Electric Literature of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 3141-27-3In 2020 ,《High refractive index inverse vulcanized polymers for organic photonic crystals》 appeared in Crystals. The author of the article were Tavella, Christian; Lova, Paola; Marsotto, Martina; Luciano, Giorgio; Patrini, Maddalena; Stagnaro, Paola; Comoretto, Davide. The article conveys some information:

Photonic technologies are nowadays dominated by highly performing inorganic structures that are commonly fabricated via lithog. or epitaxial growth. Unfortunately, the fabrication of these systems is costly, time consuming, and does not allow for the growth of large photonic structures. All-polymer photonic crystals could overcome this limitation thanks to easy solubility and melt processing. On the other hand, macromols. often do not offer a dielec. constant large enough to approach the performances of their inorganic counterparts. In this work, the authors demonstrate a new approach to achieve high dielec. constant distributed Bragg reflectors with a photonic band gap that is tunable in a very broad spectral region. A highly transparent medium was developed through a blend of a com. polymer with a high refractive index inverse vulcanized polymer that is rich in sulfur, where the large polarizability of the S-S bond provides refractive index values that are unconceivable with common non-conjugated polymers. This approach paves the way to the recycling of sulfur byproducts for new high added-value nanostructures. In the experiment, the researchers used 2,5-Dibromothiophene(cas: 3141-27-3Product Details of 3141-27-3)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Product Details of 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Bui, Hue Thi Buu; Nguyen, Phuong Hong; Pham, Quan Minh; Tran, Hoa Phuong; Tran, De Quang; Jung, Hosun; Hong, Quang Vinh; Nguyen, Quoc Cuong; Nguyen, Quy Phu; Le, Hieu Trong; Yang, Su-Geun published an article in Molecules. The title of the article was 《Target Design of Novel Histone Deacetylase 6 Selective Inhibitors with 2-Mercaptoquinazolinone as the Cap Moiety》.Computed Properties of C7H13BrO2 The author mentioned the following in the article:

Epigenetic alterations found in all human cancers are promising targets for anticancer therapy. In this sense, histone deacetylase inhibitors (HDACIs) are interesting anticancer agents that play an important role in the epigenetic regulation of cancer cells. Here, we report 15 novel hydroxamic acid-based histone deacetylase inhibitors with quinazolinone core structures. Five compounds exhibited antiproliferative activity with IC50 values of 3.4-37.8μM. Compound 8 with a 2-mercaptoquinazolinone cap moiety displayed the highest antiproliferative efficacy against MCF-7 cells. For the HDAC6 target selectivity study, compound 8 displayed an IC50 value of 2.3μM, which is 29.3 times higher than those of HDAC3, HDAC4, HDAC8, and HDAC11. Western blot assay proved that compound 8 strongly inhibited tubulin acetylation, a substrate of HDAC6. Compound 8 also displayed stronger inhibition activity against HDAC11 than the control drug Belinostat. The inhibitory mechanism of action of compound 8 on HDAC enzymes was then explored using mol. docking study. The data revealed a high binding affinity (-7.92 kcal/mol) of compound 8 toward HDAC6. In addition, dock pose anal. also proved that compound 8 might serve as a potent inhibitor of HDAC11. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7Computed Properties of C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Computed Properties of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Effect of Aryl Ligand Identity on Catalytic Performance of Trineopentylphosphine Arylpalladium Complexes in N-Arylation Reactions》 was written by Hu, Huaiyuan; Burlas, Corrie E.; Curley, Sabrina J.; Gruchala, Tomasz; Qu, Fengrui; Shaughnessy, Kevin H.. Computed Properties of C7H5BrO2 And the article was included in Organometallics in 2020. The article conveys some information:

Air-stable [(Np3P)Pd(Ar)Br]2 (Np = neopentyl) and (Np3P)Pd(Ar)(amine)Br complexes (amine = morpholine and isobutylamine) were prepared and tested as precatalysts for the coupling of sterically demanding aryl bromides and aniline derivatives The complexes are more active than the catalyst generated in situ from Pd2(dba)3 and PNp3. Increasing steric demand of the aryl group on Pd correlates with increased catalyst activity. Reactions catalyzed by [(Np3P)Pd(2,6-Me2C6H3)Br]2 occur efficiently at lower temperatures and with similar or higher yields than those using Pd2(dba)3/PNp3. The amine adducts give lower reaction rates and conversion to product than the [(Np3P)Pd(Ar)Br]2 complexes. The lower activity of the amine adducts appears to result from slow base-promoted reductive elimination to generate the catalytically active LPd(0) species. The results came from multiple reactions, including the reaction of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Computed Properties of C7H5BrO2)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Computed Properties of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and evaluation of aromatic methoxime derivatives against five postharvest phytopathogenic fungi of fruits. Main structure-activity relationships》 was written by Cortes, Ivan; di Liberto, Melina G.; Kaufman, Teodoro S.; Derita, Marcos G.; Bracca, Andrea B. J.. Safety of 8-Bromooctanoic acid And the article was included in Food Chemistry in 2020. The article conveys some information:

The antifungal activity of a library of twenty-four aromatic methoximes was examined against five representative postharvest phytopathogenic fungi. The panel included Penicillium digitatum, Penicillium italicum, Rhizopus stolonifer, Botrytis cinerea and Monilinia fructicola, all of which cause relevant economic losses worldwide as a result of affecting harvested fruits. The min. inhibitory concentrations and min. fungicidal concentrations of each compound were defined and the main structure-activity relationships were determined Although other congeners were more potent, drug likeliness considerations pointed to the methoxime derived from 2,4-dihydroxypropiophenone as the compound with the most suitable profile. The morphol. of the colonies of the fungal strains treated with the methoxime was examined microscopically and the compound was also tested in freshly harvested peaches and oranges, exhibiting promising control profiles in both fruits, similar to those of the com. agents Imazalil and Carbendazim. The experimental part of the paper was very detailed, including the reaction process of 8-Bromooctanoic acid(cas: 17696-11-6Safety of 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Safety of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Structure-Function Studies on IMD-0354 Identifies Highly Active Colistin Adjuvants》 was written by Nemeth, Ansley M.; Basak, Akash K.; Weig, Alexander W.; Marrujo, Santiana A.; Barker, William T.; Jania, Leigh A.; Hendricks, Tyler A.; Sullivan, Ashley E.; O’Connor, Patrick M.; Melander, Roberta J.; Koller, Beverly H.; Melander, Christian. Quality Control of 3,5-Dibromoaniline And the article was included in ChemMedChem in 2020. The article conveys some information:

Infections caused by multidrug-resistant (MDR) bacteria, particularly Gram-neg. bacteria, are an escalating global health threat. Often clinicians are forced to administer the last-resort antibiotic colistin; however, colistin resistance is becoming increasingly prevalent, giving rise to the potential for a situation in which there are no treatment options for MDR Gram-neg. infections. The development of adjuvants that circumvent bacterial resistance mechanisms is a promising orthogonal approach to the development of new antibiotics. We recently disclosed that the known IKK-β inhibitor IMD-0354 potently suppresses colistin resistance in several Gram-neg. strains. In this study, we explore the structure-activity relationship (SAR) between the IMD-0354 scaffold and colistin resistance suppression, and identify several compounds with more potent activity than the parent against highly colistin-resistant strains of Acinetobacter baumannii and Klebsiella pneumoniae. In the experimental materials used by the author, we found 3,5-Dibromoaniline(cas: 626-40-4Quality Control of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Quality Control of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Directing-Group-Controlled Ring-Opening Addition and Hydroarylation of Oxa/azabenzonorbornadienes with Arenes via C-H Activation》 was published in Organic Letters in 2020. These research results belong to Zhang, Keyang; Khan, Ruhima; Chen, Jingchao; Zhang, Xuexin; Gao, Yang; Zhou, Yongyun; Li, Kangkui; Tian, Youxian; Fan, Baomin. Related Products of 586-76-5 The article mentions the following:

An efficient method for the directing group controlled rhodium-catalyzed addition reaction of oxa/azabicylic alkenes with aromatic ketones and benzoic acids has been developed. The ketones and benzoic acids afforded different addition products when reacted with oxa/azabicyclic alkenes. The reaction between ketones and azabenzonorbornadienes furnished the ring-opening addition products. The reaction between benzoic acids and aza/oxabicyclic alkenes proceeded in the absence of silver salt, giving the 1:2 hydroarylation products in yields up to 96%. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Related Products of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Related Products of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Rh-Catalyzed Annulation of Benzoic Acids, Formaldehyde, and Malonates via ortho-Hydroarylation to Indanones》 was published in Organic Letters in 2020. These research results belong to Yu, Shuling; Lv, Ningning; Hong, Chao; Liu, Zhanxiang; Zhang, Yuhong. Product Details of 76006-33-2 The article mentions the following:

A three-component reaction from readily available low-cost materials of benzoic acids, formaldehyde, and malonates for the preparation of indanones by rhodium catalysis is reported. The annulation is initiated by an ortho-hydroarylation of benzoic acids, and a Lewis acid is not required. The solvent has a significant influence to the reaction, and 2-substituted or nonsubstituted indanones are obtained by the change of solvent. In addition to this study using 3-Bromo-2-methylbenzoic acid, there are many other studies that have used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Product Details of 76006-33-2) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Product Details of 76006-33-2 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Manganese Catalyzed α-Olefination of Nitriles with Secondary Alcohols》 was published in ACS Catalysis in 2020. These research results belong to Yadav, Vinita; Landge, Vinod G.; Subaramanian, Murugan; Balaraman, Ekambaram. COA of Formula: C5BrMnO5 The article mentions the following:

An expedient catalytic approach for α-olefination of nitriles using secondary alcs. with the liberation of mol. hydrogen and water as the only byproducts is reported. This reaction is catalyzed by a molecularly defined manganese(I) pincer complex and operates in the absence of any hydrogen acceptors. A broad range of substrates including cyclic, acy-clic, and benzylic alcs. as well as various nitrile derivatives such as arylmethyl and hetroarylmethyl nitriles are employed in the reaction to provide diverse range of α-vinyl nitriles in good to excellent yields. Mechanistic studies showed that the reaction proceeds via dehydrogenative pathway and the activation of α(C-H) bond of the alc. is the rate determining step. Kinetic experiments clearly indicate the first order rate kinetics for alcs. as well as nitriles.Bromopentacarbonylmanganese(I)(cas: 14516-54-2COA of Formula: C5BrMnO5) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.COA of Formula: C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary