Tag: 200-300

《Photocatalytic α-Alkylation of Amines with Alkyl Halides》 was published in ACS Catalysis in 2020. These research results belong to Leng, Lingying; Ready, Joseph M.. Application of 1129-28-8 The article mentions the following:

α-Branched amines represent essential building blocks for organic synthesis. They are traditionally prepared through nucleophilic addition to imines. These methods often require highly reactive organometallic reagents and proceed under rigorous air- and moisture-free conditions. Here, an alternative approach that involves a C-alkylation of amines with alkyl bromides is described. Mechanistically, the reaction likely involves photocatalytic generation of an α-amino radical and a stabilized carbon-centered radical (allyl, benzyl, α-carbonyl) followed by radical recombination. This approach offers a mild, atom-economical, redox neutral synthesis of α-branched amines that shows broad scope and avoids premetalated reagents. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Application of 1129-28-8 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Organic Photoredox-Catalyzed Synthesis of δ-Fluoromethylated Alcohols and Amines via 1,5-Hydrogen-Transfer Radical Relay》 were Wang, Huiqiao; Zhang, Jinjin; Shi, Jianxue; Li, Fan; Zhang, Sheng; Xu, Kun. And the article was published in Organic Letters in 2019. Electric Literature of C6H5Br2N The author mentioned the following in the article:

The hydrotrifluoromethylation of benzyl-protected homoallylic alc. and amine derivatives catalyzed by 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN) was developed. This reaction delivered δ-fluoromethylated free alcs. and amines with in situ deprotection of benzyl protecting group under mild irradiation conditions. 4CzIPN was found to be a competent metal-free photoredox catalyst for activating several types of fluoromethylation reagents including CF3SO2Cl, Togni’s reagent, and 2-bromo-2,2-difluoroacetate via oxidative quenching and also CF3SO2Na through reductive quenching to allow direct hydrotrifluoromethylation of simple alkenes and Michael acceptors. In the experimental materials used by the author, we found 3,5-Dibromoaniline(cas: 626-40-4Electric Literature of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Electric Literature of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Site-selective C-H activation and regiospecific annulation using propargylic carbonates》 were Lu, Qingquan; Mondal, Shobhan; Cembellin, Sara; Gressies, Steffen; Glorius, Frank. And the article was published in Chemical Science in 2019. Product Details of 586-76-5 The author mentioned the following in the article:

An unprecedented RuII-catalyzed site-selective and regiospecific annulation of benzoic acids ArC(O)OH (2-CH3C6H4, thiophen-2-yl, 1-methyl-1H-indol-3-yl, etc.) with propargylic carbonates R1CCC(R2)(R3)(OCO2CH3) [R1 = C6H5, thiophen-3-yl; R2 = Me, Et, n-propyl; R3 = Me, Et; R2R3 = -(CH2)4-] has been described. The weakly coordinating carboxylic acid moiety outperformed other typically used directing groups in C-H activation, including ketone, nitrile, sulfonamide, amide and strongly coordinating nitrogen heterocycles. This is an important step towards the application of C-H activation reactions in complex (functional) real-world mols.4-Bromobenzoic acid(cas: 586-76-5Product Details of 586-76-5) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Product Details of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Dyes and Pigments included an article by Colom, E.; Andres-Castan, J. M.; Barrios, D.; Duerto, I.; Franco, S.; Garin, J.; Orduna, J.; Villacampa, B.; Blesa, M. J.. HPLC of Formula: 14660-52-7. The article was titled 《Modification of the electronic properties of the π-spacer of chromophores linked to calix[4]arene platform for DSSCs applications》. The information in the text is summarized as follows:

We have developed two novel dyes based on p-tert-butyl-calix[4]arene in order to evaluate their behavior as sensitizer in photovoltaic devices. These dyes consist in a difunctionalized calix[4]arene with triphenylamine (TPA)-donor, a heteroaromatic π-conjugated spacer, thiophene and benzothiadiazole-Ph ring, resp. and cyanoacetic acid as acceptor group. The effect of the π-spacer has been studied by UV-vis spectroscopy and Differential Pulse Voltammetry and the models compounds have been theor. investigated. The dye bearing phenylbenzothiadiazole results in a bathochromic shifted absorption and an adequate efficiency to transfer charge from D to A. The considerable increase of the photocurrent d. results in a better efficiency of the devices prepared with these novel dyes with respect to the p-tert-butyl-calix[4]arene derivatives bearing TPA dye. In particular, p-tert-butyl-calix[4]arene derivative based on phenylbenzothiadiazole has reached an efficiency value of 5.84% which means an increase of 33% of the efficiency over those calix[4]arene derivatives with TPA dye. In the experiment, the researchers used Ethyl 5-bromovalerate(cas: 14660-52-7HPLC of Formula: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.HPLC of Formula: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Langmuir included an article by Almeida, Marcio M.; Perez, Katia R.; Faig, Allison; Uhrich, Kathryn E.; Riske, Karin A.. SDS of cas: 17696-11-6. The article was titled 《Location of the Positive Charges in Cationic Amphiphiles Modulates Their Mechanism of Action against Model Membranes》. The information in the text is summarized as follows:

Synthetic cationic amphiphiles (CAms) with physicochem. properties similar to antimicrobial peptides are promising mols. in the search for alternative antibiotics to which pathogens cannot easily develop resistance. Here, we investigate two types of CAms based on tartaric acid and containing two hydrophobic chains (of 7 or 11 carbons) and two pos. charges, located either at the end of the acyl chains (bola-like, B7 and B11) or at the tartaric acid backbone (gemini-like, G7 and G11). The interaction of the CAms with biomimetic membrane models (anionic and neutral liposomes) was studied with zeta potential and dynamic light scattering measurements, isothermal titration calorimetry, and a fluorescent-based leakage assay. We show that the type of mol. determines the mechanism of action of the CAms. Gemini-like mols. (G7 and G11) interact mainly via electrostatics (exothermic process) and reside in the external vesicle leaflet, altering substantially the vesicle surface potential but not causing significant membrane lysis. On the other hand, the interaction of bola-like CAms (B7 and B11) is endothermic and thus entropy-driven, and these mols. reach both membrane leaflets and cause substantial membrane permeabilization, likely after clustering of anionic lipids. The lytic ability is clearly higher against anionic membranes as compared with neutral membranes. Within each class of mol., longer alkyl chains (i.e., B11 and G11) exhibit higher affinity and lytic ability. Overall, the mol. B11 exhibits a high potential as antimicrobial agent, since it has a high membrane affinity and causes substantial membrane permeabilization. The results came from multiple reactions, including the reaction of 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.SDS of cas: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Synthesis included an article by Iskryk, Marharyta; Barysevich, Maryia; Oseka, Maksim; Adamson, Jasper; Kananovich, Dzmitry. Synthetic Route of C7H13BrO2. The article was titled 《Asymmetric Kulinkovich Hydroxycyclopropanation of Alkenes Mediated by Titanium(IV) TADDOLate Complexes》. The information in the text is summarized as follows:

Asym. Kulinkovich cyclopropanation of carboxylic esters with prochiral alkenes was reported. The process was mediated by titanium(IV) (4R,5R)-TADDOLate complexes and afforded correspondingly (Z)- or (E)-cyclopropanols with up to 84-87% ee in the event of intra- or intermol. olefin ligand exchange in intermediate titanacyclopropane [titanium(II)-alkene] species. Configuration of the olefin double bond was preserved in the cyclopropane products, pointing out on total retention of configuration at Ti-C bond in the cyclopropane forming step. The results were interpreted in the framework of ate complex mechanism, suggesting formation of pentacoordinated titanium ate species as a prerequisite of high enantiocontrol. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7Synthetic Route of C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Synthetic Route of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Tetrahedron included an article by Rashad, Adel A.; Neyts, Johan; Leyssen, Pieter; Keller, Paul A.. Category: bromides-buliding-blocks. The article was titled 《A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of Chikungunya virus replication》. The information in the text is summarized as follows:

Mycophenolic acid (MPA) has been previously reported as an inhibitor of the Chikugunya virus (CHIKV) with an EC50 value of 0.2 μM. We used MPA as a lead compound designing and synthesizing a series of isatins and benzolactones in a typical medicinal chem. program. The synthesis and testing of 19 derivatives produced compounds with no desired activity which prompted us to retest the lead compound, MPA. We can reveal that MPA shows no anti-CHIKV activity and therefore needs to be reassessed as a lead compound for this target. In addition to this study using 3-Bromo-2-methylbenzoic acid, there are many other studies that have used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Category: bromides-buliding-blocks) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Category: bromides-buliding-blocks Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Shukla, Jyoti; Illathvalappil, Rajith; Kumar, Sharvan; Chorol, Sonam; Pandikassala, Ajmal; Kurungot, Sreekumar; Mukhopadhyay, Pritam published an article in Organic Letters. The title of the article was 《Synthesis of a Highly Electron-Deficient, Water-Stable, Large Ionic Box: Multielectron Accumulation and Proton Conductivity》.Application of 623-24-5 The author mentioned the following in the article:

π-Acidic boxes exhibiting electron reservoir and proton conduction are unprecedented because of their instability in water. We present the synthesis of one of the strongest electron-deficient ionic boxes showing e- uptake as well as proton conductivity Two large anions fit in the box to form anion-π interactions and form infinite anion-solvent wires. The box with NO3-···water wires confers high proton conductivity and presents the first example that manifests redox and ionic functionality in an organic electron-deficient macrocycle. The results came from multiple reactions, including the reaction of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application of 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 623-24-5 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Khaled, Rabaa M.; Habashy, Danira A.; Ahmed, Amr Y.; Ismael, Omneya S.; Ibrahim, Sara S.; Abdelfatah, Mennattallah; Radacki, Krzysztof; Mansour, Ahmed M. published an article in Polyhedron. The title of the article was 《Photoactivatable properties of water-soluble fac-Mn(CO)3 bearing N-O bidentate pyridine ligands》.Recommanded Product: 14516-54-2 The author mentioned the following in the article:

Two water-soluble fac-Mn(CO)3 based complexes of the general formula fac-[MnBr(CO)3(N-O)] (1, 2; N-O = pyridine-2-carboxaldehyde, 2-acetylpyridine) were described for their potential CO releasing properties upon illumination at 468 nm, solvatochromism features and cytotoxicity against different malignant cell lines in both the dark and upon the exposure to light source. Neg. solvatochromism may be responsible for the red shift of the metal-to-ligand charge transfer band in increasingly less polar solvents. Compound 2, which had been functionalized with 2-acetylpyridine, released CO in water faster than complex 1, suggesting the role of the Me group in regulating the CO release kinetics. According to myoglobin assay, the CO release pathway in water is slower than in DMSO revealing to the role of the solvent in controlling the CO release kinetics of Mn(I) carbon monoxide releasing mols. The experimental part of the paper was very detailed, including the reaction process of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Recommanded Product: 14516-54-2)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Recommanded Product: 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Yong; Ertem, Mehmed Z.; Duan, Lele published an article in 2021. The article was titled 《An amide-based second coordination sphere promotes the dimer pathway of Mn-catalyzed CO2-to-CO reduction at low overpotential》, and you may find the article in Chemical Science.Related Products of 14516-54-2 The information in the text is summarized as follows:

The [fac-Mn(bpy)(CO)3Br] complex is capable of catalyzing the electrochem. reduction of CO2 to CO with high selectivity, moderate activity and large overpotential. Several attempts have been made to lower the overpotential and to enhance the catalytic activity of this complex by manipulating the second-coordination sphere of manganese and using relatively stronger acids to promote the protonation-first pathway. We report herein that the complex [fac-Mn(bpy-CONHMe)(CO)3(MeCN)]+ ([1-MeCN]+; bpy-CONHMe = N-methyl-(2,2′-bipyridine)-6-carboxamide) as a pre-catalyst could catalyze the electrochem. reduction of CO2 to CO with low overpotential and high activity and selectivity. Combined exptl. and computational studies reveal that the amide NH group not only decreases the overpotential of the Mn catalyst by promoting the dimer and protonation-first pathways in the presence of H2O but also enhances the CO2 electroreduction activity by facilitating C-OH bond cleavage, making [1-MeCN]+ an efficient CO2 reduction pre-catalyst at low overpotential. The results came from multiple reactions, including the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Related Products of 14516-54-2)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Related Products of 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary