Tag: 200-300

In 2022,Ado, Genyir; Noda, Naotaka; Vu, Hue T.; Perron, Amelie; Mahapatra, Amarjyoti D.; Arista, Karla Pineda; Yoshimura, Hideaki; Packwood, Daniel M.; Ishidate, Fumiyoshi; Sato, Shin-ichi; Ozawa, Takeaki; Uesugi, Motonari published an article in Chemical Science. The title of the article was 《Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells》.Related Products of 14660-52-7 The author mentioned the following in the article:

Phase-separated membraneless organelles or biomol. condensates play diverse functions in cells, however recapturing their characteristics using small organic mols. has been a challenge. In the present study, cell-lysate-based screening of 843 self-assembling small mols. led to the discovery of a simple organic mol., named huezole, that forms liquid droplets to selectively sequester tubulin. Remarkably, this small mol. enters cultured human cells and prevents cell mitosis by forming tubulin-concentrating condensates in cells. The present study demonstrates the feasibility of producing a synthetic condensate out of non-peptidic small mols. for exogenous control of cellular processes. The modular structure of huezole provides a framework for designing a class of organelle-emulating small mols. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Gausas, Laurynas; Donslund, Bjarke S.; Kristensen, Steffan K.; Skrydstrup, Troels published an article in ChemSusChem. The title of the article was 《Evaluation of Manganese Catalysts for the Hydrogenative Deconstruction of Commercial and End-of-Life Polyurethane Samples》.Application In Synthesis of Bromopentacarbonylmanganese(I) The author mentioned the following in the article:

Polyurethane (PU) is a thermoset plastic that is found in everyday objects, such as mattresses and shoes, but also in more sophisticated materials, including windmills and airplanes, and as insulation materials in refrigerators and buildings. Because of extensive inter-cross linkages in PU, current recycling methods are somewhat lacking. In this work, the effective catalytic hydrogenation of PU materials is carried out by applying a catalyst based on the earth-abundant metal manganese, to give amine and polyol fractions, which represent the original monomeric composition In particular, Mn-PhMACHO is found to catalytically deconstruct flexible foam, molded foams, insulation, and end-of-life materials at 1 weight% catalyst loading by applying a reaction temperature of 180°C, 50 bar of H2, and 0.9 weight% of KOH in iso-Pr alc. The protocol is showcased in the catalytic deconstruction of 2 g of mattress foam using only 0.13 weight% catalyst, resulting in 90% weight recovery and a turnover number of 905.Bromopentacarbonylmanganese(I)(cas: 14516-54-2Application In Synthesis of Bromopentacarbonylmanganese(I)) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Application In Synthesis of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yu, Mingming; Gao, Yuhan; Zhang, Lin; Zhang, Yingjie; Zhang, Yiyan; Yi, Hong; Huang, Zhiliang; Lei, Aiwen published an article in Green Chemistry. The title of the article was 《Electrochemical-induced benzyl C-H amination towards the synthesis of isoindolinones via aroyloxy radical-mediated C-H activation》.Category: bromides-buliding-blocks The author mentioned the following in the article:

A novel electrochem. strategy to selectively and sustainably access isoindolinones I [R1 = H, 7-Me, 5-F, etc.; R2 = H, Me, Et, n-Pr, i-Pr, n-Bu; R3 = Me, n-Pr, i-Pr, n-Bu, cyclopropyl, CD3] using simple o-alkyl benzoic acids and nitriles as substrates under metal catalyst and external oxidant-free conditions was developed. Meanwhile, nitrile as the nitrogen source plays a vital role, as its derived intermediate facilitates the construction of the amide bond in the product. Mechanistic investigations suggest that aroyloxy radicals were involved in this transformation, which initiated the benzylic C-H amination event by a 1,5-HAT process. The protocol showed a very good functional group tolerance.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Category: bromides-buliding-blocks) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yan, Yonggang; Sun, Jinjin; Li, Gang; Yang, Liu; Zhang, Wei; Cao, Rui; Wang, Chao; Xiao, Jianliang; Xue, Dong published an article in Organic Letters. The title of the article was 《Photochemically Enabled, Ni-Catalyzed Cyanation of Aryl Halides》.Reference of 5-Bromobenzo[d][1,3]dioxole The author mentioned the following in the article:

A light-promoted Ni-catalyzed cyanation of aryl halides employing 1,4-dicyanobenzene as a cyanating agent was reported. A broad array of aryl bromides, chlorides and druglike mols. could be converted into their corresponding nitriles (65 examples). Mechanistic studies suggest that upon irradiation, the oxidative addition product Ni(II)(dtbbpy)(p-C6H4CN)(CN) underwent homolytic cleavage of the Ni-aryl bond to generate an aryl radical and a Ni(I)-CN species, the latter of which initiated subsequent cyanation reactions. The experimental part of the paper was very detailed, including the reaction process of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Reference of 5-Bromobenzo[d][1,3]dioxole)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Reference of 5-Bromobenzo[d][1,3]dioxole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Horvat, Monika; Iskra, Jernej published an article in Green Chemistry. The title of the article was 《Oxidative cleavage of C-C double bond in cinnamic acids with hydrogen peroxide catalysed by vanadium(V) oxide》.Application of 586-76-5 The author mentioned the following in the article:

A cheap, green, mild and environmentally friendly method for the selective cleavage of carbon-carbon double bonds with a 30% aqueous solution of hydrogen peroxide as the oxidant and vanadium(V) oxide as the catalyst have been developed. The selectivity of the oxidative cleavage of cinnamic acid derivatives RCH=CHC(O)OR1 (R = 4-hydroxyphenyl, 2,4-dichlorophenyl, 4-hydroxy-3-methoxyphenyl, etc.; R1 = H, Et) depends on the substituents and the solvent used (DME – MeOCH2CH2OMe, TFE – 2,2,2-trifluoroethanol or MeCN). In DME, p-hydroxy derivatives were selectively converted to benzaldehyde derivatives RCHO, and in TFE, oxidative cleavage led to the formation of benzoquinone derivatives I (R2 = H, OMe), while in MeCN, cinnamic acid derivatives were selectively converted to benzoic acid derivatives RC(O)OH. Ferulic acid was quant. and selectively converted to vanillin in a 91% isolated yield on a gram scale. 3,6-Bis(4-hydroxy-3-methoxyphenyl)tetrahydro-1H,4H-furo[3,4-c]furan-1,4-dione was isolated as an intermediate, which was confirmed by in situ ATR-IR spectroscopy, while the formation of diols or epoxides was not observed The analogus styrene derivative, 4-vinylguaiacol 1e was also selectively converted to either vanillin or 2-methoxyquinone in a high yield. The green metric for the conversion of ferulic acid to vanillin by different methods was calculated and compared to this method, and showed the method has better environmental parameters.4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Jiajia; Kerr, Andrew; Song, Qiao; Yang, Jie; Hakkinen, Satu; Pan, Xiangqiang; Zhang, Zhengbiao; Zhu, Jian; Perrier, Sebastien published an article in 2021. The article was titled 《Manganese-Catalyzed Batch and Continuous Flow Cationic RAFT Polymerization Induced by Visible Light》, and you may find the article in ACS Macro Letters.Recommanded Product: 14516-54-2 The information in the text is summarized as follows:

We present a robust manganese-catalyzed cationic reversible addition-fragmentation chain transfer (RAFT) polymerization induced by visible light. Well-defined poly(vinyl ether)s with controlled mol. weight and mol. weight distributions (MWDs) can be conveniently prepared at room temperature without monomer purification The com. available manganese carbonyl bromide is used as the photocatalyst for cationic RAFT polymerization Moreover, this method has been further applied in both batch and continuous flow systems, providing a visible light induced flow cationic polymerization under mild conditions. The experimental process involved the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Recommanded Product: 14516-54-2)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Recommanded Product: 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Nickel-Catalyzed Transformation of Diazoacetates to Alkyl Radicals Using Alcohol as a Hydrogen Source》 were Zhao, Jingjing; Li, Pan; Xu, Yaohua; Shi, Yixin; Li, Fuwei. And the article was published in Organic Letters in 2019. Name: Benzyl 2-bromoacetate The author mentioned the following in the article:

A nickel-catalyzed transformation of diazoacetates to α-carbonyl methylene radicals has been disclosed in the presence of hyperoxide using ethanol as a hydrogen source and solvent. This strategy is successfully applied in the formation of indolin-2-ones or 1,4-dicarbonyl compounds from acrylamides or enamides in moderate to good yields. These reactions underwent radical addition onto C-C double bonds followed by a cyclization/oxidation or an oxidation/hydrolysis process, resp. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Name: Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Name: Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Dalton Transactions included an article by Gong, Dawei; Hu, Bowen; Chen, Dafa. COA of Formula: C7H5BrO2. The article was titled 《Bidentate Ru(II)-NC complexes as catalysts for the dehydrogenative reaction from primary alcohols to carboxylic acids》. The information in the text is summarized as follows:

Four Ru(II)-NC complexes were synthesized by one-step processes from the corresponding NC ligands with RuHCl(CO)(PPh3)3. These complexes were tested as catalysts for alc. dehydrogenative reactions, and complex {(C5H4N)-(C6H4)}RuCl(CO)(PPh3)2 (1) showed the highest activity. With KOH as the nucleophile and 0.5 mol% catalyst loading, a series of carboxylic acids were synthesized in toluene without any oxidant. Catalyst 1 could be transformed to complex {(C5H4N)-(C6H4)}RuH(CO)(PPh3)2 (6) when treated with KOH and benzyl alc. Complex 6 further reacted with PhCHO and H2O to generate product {(C5H4N)-(C6H4)}Ru(OCOPh)(CO)(PPh3)2 (7). Complexes 6 and 7 exhibited similar efficiency to complex 1, suggesting that they can be regarded as the catalytic intermediates of. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzoic acid(cas: 586-76-5COA of Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.COA of Formula: C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2012,Ueno, Satoshi; Komiya, Sadakazu; Tanaka, Takeshi; Kuwano, Ryoichi published 《Intramolecular SN’-Type Aromatic Substitution of Benzylic Carbonates at their Para-Position》.Organic Letters published the findings.Category: bromides-buliding-blocks The information in the text is summarized as follows:

The benzylic carbonates, which connect with an active methine through an o-phenylene tether at their meta-position, are cyclized by Pd(η3-C3H5)Cp-S-Phos catalyst, yielding 3-methyl-9,10-dihydrophenanthrenes, e.g., I. In the catalytic cyclization, the internal nucleophile attacks not the ortho-carbon but the para-carbon of the benzylic ester. The [3 + 2] cycloaddition of m-(silylmethyl)benzyl carbonates with alkylidene malonates was developed from the palladium-catalyzed intramol. SN’-type aromatic substitution. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Category: bromides-buliding-blocks)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Science included an article by Cheng, Cang; Wan, Bin; Zhou, Bo; Gu, Yichao; Zhang, Yanghui. Reference of 4-Bromo-1-(bromomethyl)-2-fluorobenzene. The article was titled 《Enantioselective synthesis of quaternary 3,4-dihydroisoquinolinones via Heck carbonylation reactions: development and application to the synthesis of Minalrestat analogues》. The information in the text is summarized as follows:

Minalrestat and its analogs represent structurally novel aldose reductase inhibitors, and the asym. synthesis of such pharmaceutically privileged mols. has not been reported yet. We have developed a palladium-catalyzed enantioselective intramol. carbonylative Heck reaction by using formate esters as the source of CO, which represents the first enantioselective synthesis of quaternary 3,4-dihydroisoquinolines. The reaction provides a facile and efficient method for the synthesis of enantiopure nitrogen-containing heterocyclic compounds bearing an all-carbon quaternary stereocenter. The reaction has been successfully applied to the first asym. synthesis of Minalrestat analogs. The experimental part of the paper was very detailed, including the reaction process of 4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Reference of 4-Bromo-1-(bromomethyl)-2-fluorobenzene)

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Reference of 4-Bromo-1-(bromomethyl)-2-fluorobenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary