Tag: 200-300

《Activating Effect of 3-Benzylidene Oxindoles on AMPK: From Computer Simulation to High-Content Screening》 was published in ChemMedChem in 2020. These research results belong to Novikova, Daria S.; Grigoreva, Tatyana A.; Ivanov, Gleb S.; Melino, Gerry; Barlev, Nickolai A.; Tribulovich, Vyacheslav G.. Recommanded Product: 1129-28-8 The article mentions the following:

AMP-activated protein kinase (AMPK) is currently the subject of intensive study and active discussions. AMPK performs its functions both at the cellular level, providing the switch between energy-consuming and energy-producing processes, and at the whole body level, particularly, regulating certain aspects of higher nervous activity and behavior. Control of such a ′main switch′ compensates dysfunctions and associated diseases. In the present paper, we studied the binding of 3-benzylidene oxindoles to the kinase domain of the AMPK α-subunit, which is thought to prevent its interaction with the autoinhibitory domain and thus result in the AMPK activation. For this purpose, we developed the cellular test system based on the AMPKAR plasmid, which implements the FRET effect, synthesized a number of 3-benzylidene oxindole compounds and simulated their binding to various sites of the kinase domain. The most probable binding site for the studied compounds was established by the correlation of calculated and exptl. data. The obtained results allow to analyze various classes of AMPK activators using virtual and high-content screening. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Recommanded Product: 1129-28-8 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium-catalyzed cross-coupling of lithium acetylides》 was published in Nature Catalysis in 2020. These research results belong to Helbert, Hugo; Visser, Paco; Hermens, Johannes G. H.; Buter, Jeffrey; Feringa, Ben L.. SDS of cas: 2635-13-4 The article mentions the following:

The incorporation of alkynes into organic mols. is one of the most valuable transformations for the formation of C-C bonds and provides a versatile handle for further modifications. The Sonogashira cross-coupling of acetylenes holds a prominent position among the suite of catalytic cross-coupling reactions that are key to modern synthesis. Herein, a method that is complementary to the Sonogashira reaction, demonstrating cross-coupling of lithium acetylides with aryl bromides is presented. The reactions take place under ambient conditions with short reaction times, affording the corresponding aryl acetylenes in good to excellent yields while displaying a remarkable functional group tolerance for an organolithium reaction, allowing the presence of a variety of organolithium-sensitive carbonyl functionalities. This developed cross-coupling methodol. offers ample opportunities to access a wide variety of acetylenes, as is illustrated by the facile preparation of key intermediates for chem. biol. and optoelectronic materials. After reading the article, we found that the author used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4SDS of cas: 2635-13-4)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.SDS of cas: 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Highly Selective and Atom Economical Synthesis of 1,3-Enynes, Pyrroles and Furans by Manganese(I)-Catalyzed C-H Activation》 was published in ACS Catalysis in 2020. These research results belong to Cembellin, Sara; Dalton, Toryn; Pinkert, Tobias; Schaefers, Felix; Glorius, Frank. HPLC of Formula: 14516-54-2 The article mentions the following:

A highly selective Mn(I)-catalyzed alkenylation of arenes and heteroarenes with 1,3-diynes is described. The reported transformation overcomes regio-, chemo- and stereoselectivity challenges associated with the use of these coupling partners. Both sym. and unsym. diynes can be applied in this protocol, affording single isomers not only in the synthesis of 1,3-enynes I but also in the one-step preparation of pyrroles and furans. This simple and highly atom economical strategy features wide functional group tolerance, good reproducibility and preparative scale utility. The manganese catalyst plays a crucial role in this C-H activation protocol, enabling high selectivity with previously challenging internal alkynes. Furthermore, the synthetic value of the method is highlighted by diverse post-functionalizations of the final products. The experimental process involved the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2HPLC of Formula: 14516-54-2)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.HPLC of Formula: 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Rapid synthesis of acyl fluorides from carboxylic acids with Cu(O2CCF2SO2F)2》 was published in Tetrahedron Letters in 2020. These research results belong to Le, Bingjun; Wu, Hao; Hu, Xiaojun; Zhou, Xiumiao; Guo, Yong; Chen, Qing-Yun; Liu, Chao. Recommanded Product: 4-Bromobenzoic acid The article mentions the following:

A rapid, simple and efficient acyl fluoride RC(O)F [R = Ph, Bn, 2-thienyl, etc.] synthesis from carboxylic acids with Cu(O2CCF2SO2F)2 as a deoxofluorination reagent was developed. Notably, Cu(O2CCF2SO2F)2 was readily prepared in large scale from inexpensive starting material and previously used as a good trifluoromethylating reagent. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 4-Bromobenzoic acid It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis, properties and photo-responsive behavior of luminescent side chain polymers containing D-π-A α-cyanostilbene units》 were Yuan, Yongjie; He, Lifang; Li, Jindi; Zhang, Hailiang. And the article was published in Polymer Chemistry in 2019. HPLC of Formula: 629-03-8 The author mentioned the following in the article:

A series of luminescent side chain polymers containing a D-π-A structure and different flexible spacer lengths, namely, poly[(Z)-ω-(4-(1-cyano-2-(4-cyanophenyl)vinyl)phenoxy)alkyl methacrylate]s (PMmPVPCN, m = 2, 4, 6, 8), were successfully prepared With the combination of aggregation-induced emission enhancement (AIEE) luminogens and mesogens, the resultant polymers are expected to possess both liquid crystal characteristics and AIEE characteristics. The phase structure of PMmPVPCN was explored by differential scanning calorimetry (DSC), polarized optical microscopy (POM), and one-dimensional wide-angle X-ray diffraction (1D WAXD). Photophys. properties of PMmPVPCN were studied by UV spectra and fluorescence spectra. Test results suggested that the phase structure of PMmPVPCN transformed from the amorphous phase (PMmPVPCN, m = 2, 4) to the nematic phase (PMmPVPCN, m = 6, 8) with the increase of polymer spacer length. All the synthetic monomers and polymers exhibited AIEE properties and the luminescence behavior of PMmPVPCN was associated with their chem. structure. The solid fluorescence quantum yields of PMmPVPCN increased from 22.4% to 42.7% with increasing spacer length. The polymer films also showed reversible fluorescence photo-responsive properties. The emission color and the emission intensity of polymer films changed when exposed to a 365 nm UV lamp. The change process was reversible and they could turn back to their original state when irradiated with a 254 nm UV lamp or heated at higher temperature In the experiment, the researchers used 1,6-Dibromohexane(cas: 629-03-8HPLC of Formula: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.HPLC of Formula: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Fe/Fe3C Encapsulated in N-Doped Carbon Tubes: A Recyclable Catalyst for Hydrogenation with High Selectivity》 were Yun, Ruirui; Zhang, Shi; Ma, Wanjiao; Lv, Xiao; Liu, Shoujie; Sheng, Tian; Wang, Suna. And the article was published in Inorganic Chemistry in 2019. Product Details of 626-40-4 The author mentioned the following in the article:

Herein, a series of Fe-based catalysts have been designed and prepared by grinding a mixture of MIL-88d and melamine, and then the mixture was followed by pyrolysis. An unusual Fe/Fe3C-activated site is uniformly encapsulated in the N-doped carbon tubes obtained by pyrolysis of the film-like nanocrystals of MIL-88d. Exptl. characterizations and theor. calculations demonstrate that the surface N sites can effectively trap the nitrobenzene and aniline by their Ph groups with the formation of three C-N bonds that made the catalyst exhibit excellent catalytic activity (turnover frequencies of ≤11268 h-1 calculated on the basis of nitrobenzene) and chemoselectivity for the reduction of nitro derivatives under facile conditions. In the experiment, the researchers used many compounds, for example, 3,5-Dibromoaniline(cas: 626-40-4Product Details of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Product Details of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Shi, Shi; Du, Yu; Huang, Lei; Cui, Jiaqi; Niu, Jing; Xu, Yungen; Zhu, Qihua published an article in Bioorganic Chemistry. The title of the article was 《Discovery of novel potent covalent inhibitor-based EGFR degrader with excellent in vivo efficacy》.Product Details of 17696-11-6 The author mentioned the following in the article:

Although several Epidermal growth factor receptor (EGFR) inhibitors have been approved for the treatment of non-small-cell lung cancers (NSCLC), acquired drug resistance and side effects largely encumbered their application in clinic. The emerging technol. Proteolysis targeting chimera (PROTAC) could be an alternative strategy to overcome these problems. Here, we reported the discovery of Dacomitinib-based EGFR degraders. Promising compound I can effectively induce degradation of EGFRdel19 with DC50 value of 3.57 nM in HCC-827 cells, but not to other EGFR mutant, wild-type EGFR protein and the same family receptors (HER2 and HER4). Of note, I is the first EGFR-PROTAC to evaluate antitumor effect in vivo, and exhibited excellent antitumor efficacy (TGI = 90%) at a dose of 30 mg/kg without causing observable toxic effects. The preliminary mechanism study demonstrated that I can efficiently induce EGFR protein degradation through ubiquitin proteasome pathway and inhibit phosphorylation of downstream pathways in vitro and in vivo, which indicated that I exerted antitumor effect by degradation of EGFR protein in tumor tissue. Overall, our study provided further evidence to validate EGFR-PROTACs as a promising strategy for lung cancer therapy.8-Bromooctanoic acid(cas: 17696-11-6Product Details of 17696-11-6) was used in this study.

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Product Details of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhao, He; Wu, Yang; Ci, Chenggang; Tan, Zhenda; Yang, Jian; Jiang, Huanfeng; Dixneuf, Pierre H.; Zhang, Min published an article in Nature Communications. The title of the article was 《Intermolecular diastereoselective annulation of azaarenes into fused N-heterocycles by Ru(II) reductive catalysis》.HPLC of Formula: 5437-45-6 The author mentioned the following in the article:

Derivatization of azaarenes can create mols. of biol. importance, but reductive functionalization of weakly reactive azaarenes remains a challenge. Here the authors show a dearomative, diastereoselective annulation of azaarenes, via ruthenium(II) reductive catalysis, proceeding with excellent selectivity, mild conditions, and broad substrate and functional group compatibility. Mechanistic studies reveal that the products are formed via hydride transfer-initiated β-aminomethylation and α-arylation of the pyridyl core in the azaarenes, and that paraformaldehyde serves as both the C1-building block and reductant precursor, and the use of Mg(OMe)2 base plays a critical role in determining the reaction chemoselectivity by lowering the hydrogen transfer rate. The present work opens a door to further develop valuable reductive functionalization of unsaturated systems by taking profit of formaldehyde-endowed two functions. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6HPLC of Formula: 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.HPLC of Formula: 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Lo, Chang-Lun; Akula, Pavan Sudheer; Hong, Bor-Cherng; Lee, Gene-Hsiang; Chien, Su-Ying published an article in Organic Letters. The title of the article was 《Total Synthesis of Ulodione A via a Double-Alkylation and DABCO Promoted Ring-Expansion Rearrangement Sequence》.COA of Formula: C7H13BrO2 The author mentioned the following in the article:

First total synthesis of ulodione A has been achieved via the key-step reactions of DIPEA-promoted dialkylation of 1,3-cyclopentadione with a bromonitroolefin and DABCO promoted/catalytic semipinacol-like ring-expansion rearrangement, with regioselective transformation of the nitrocyclohexane intermediates to their cyclopentenone counterparts via a sequence of reactions in a one-pot operation. Structures of six products were unequivocally established by X-ray crystallog. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7COA of Formula: C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.COA of Formula: C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Li, Cheng-Kun; Tao, Ze-Kun; Shoberu, Adedamola; Zhang, Wei; Zou, Jian-Ping published an article in Organic Letters. The title of the article was 《Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp3)-P Bond Formation》.Recommanded Product: 8-Bromooctanoic acid The author mentioned the following in the article:

A Cu(I)-catalyzed cross-coupling of alkyl- and P-centered radicals for C(sp3)-P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H2O2, serve as a source for alkyl radicals and also an initiator for the generation of P radicals from H-P(O) compounds In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6Recommanded Product: 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Recommanded Product: 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary