Tag: 200-300

Liao, Xudong; Zhou, Yi; Ai, Chengmei; Ye, Cuijiao; Chen, Guanghui; Yan, Zhaohua; Lin, Sen published their research in Tetrahedron Letters in 2021. The article was titled 《SO2F2-mediated oxidation of primary and tertiary amines with 30% aqueous H2O2 solution》.Recommanded Product: 626-40-4 The article contains the following contents:

A highly efficient and selective oxidation of primary and tertiary amines employing SO2F2/H2O2/base system was described. Anilines were converted to the corresponding azoxybenzenes I [R = H, 4-Me, 3-Cl-4-Me, etc.], while primary benzylamines were transformed into nitriles ArC≡N [Ar = Ph, 4-ClC6H4, 4-MeOC6H4, etc.] and secondary benzylamines were rearranged to amides ArNHC(O)R1 [Ar = Ph; R1 = Me, Et]. For tertiary amine substrates quinolines, isoquinolines and pyridines, their oxidation products were the corresponding N-oxides II [R1 = R2 = Me; R3 = Me, Ph], III [R4 = H, 7-Me, 6-NO2; R5 = 2-Me, 3-Me, 4-Me], IV [R6 = H, 8-Cl, 6-Br] and V [R7 = H, 2,6-di-Me, 4-MeO, 2-Br, 4-oxiran-2-yl]. The reaction conditions were very mild and just involve SO2F2, amines, 30% aqueous H2O2 solution, and inorganic base at room temperature One unique advantage was that this oxidation system was just composed of inexpensive inorganic compounds without the use of any metal and organic compounds The results came from multiple reactions, including the reaction of 3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Xin; Liu, Jun; Chen, Jinyao; Zhang, Ming; Tian, Chuan; Peng, Xiaoping; Li, Gang; Chang, Wenqiang; Lou, Hongxiang published their research in Bioorganic Chemistry in 2021. The article was titled 《Azole-triphenylphosphonium conjugates combat antifungal resistance and alleviate the development of drug-resistance》.HPLC of Formula: 17696-11-6 The article contains the following contents:

Azole antifungals are commonly used to treat fungal infections but have resulted in the occurrence of drug resistance. Therefore, developing azole derivatives (AZDs) that can both combat established drug-resistant fungal strains and evade drug resistance is of great importance. In this study, we synthesized a series of AZDs with a fluconazole (FLC) skeleton conjugated with a mitochondria-targeting triphenylphosphonium cation (TPP+). These AZDs displayed potent activity against both azole-sensitive and azole-resistant Candida strains without eliciting obvious resistance. Moreover, two representative AZDs, I and II, exerted synergistic antifungal activity with Hsp90 inhibitors against C. albicans strains resistant to the combination treatment of FLC and Hsp90 inhibitors. AZD 25, which had minimal cytotoxicity, was effective in preventing C. albicans biofilm formation. Mechanistic investigation revealed that AZD II inhibited the biosynthesis of the fungal membrane component ergosterol and interfered with mitochondrial function. Our findings provide an alternative approach to address fungal resistance problems. The experimental part of the paper was very detailed, including the reaction process of 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.HPLC of Formula: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Yahuan; Wang, Zheng; Zhao, Ziwei; Gao, Pengxiang; Ma, Ning; Liu, Qingbin published their research in Molecular Catalysis in 2021. The article was titled 《Efficient base-free hydrodehalogenation of organic halides catalyzed by a well-defined diphosphine-ruthenium(II) complex》.Related Products of 2635-13-4 The article contains the following contents:

A base-free, robust catalytic system based on the diphosphine-ruthenium(II) complex cation has been developed for the hydrodehalogenation of a wide range of aryl- and alkyl-chlorides/bromides (27 examples) with mol. hydrogen. Notably, the reaction proceeds at 120°C with low catalyst loading (0.1 mol%) and exhibits a good tolerance toward functional groups, such as amido, carboxyl, sulfonyl, methoxyl, ester groups. Moreover, a mechanism for the diphosphine-ruthenium(II) complex cation catalyzed dehalogenation process has been proposed. This hydrodehalogenation methodol. shows a potential application for the organic transformation and degradation of organic halides.5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Related Products of 2635-13-4) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Related Products of 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Klingstedt, Therese; Shirani, Hamid; Ghetti, Bernardino; Vidal, Ruben; R. Nilsson, K. Peter published their research in ChemBioChem in 2021. The article was titled 《Thiophene-Based Optical Ligands That Selectively Detect Aβ Pathology in Alzheimer′s Disease》.Synthetic Route of C4H2Br2S The article contains the following contents:

In several neurodegenerative diseases, the presence of aggregates of specific proteins in the brain is a significant pathol. hallmark; thus, developing ligands able to bind to the aggregated proteins is essential for any effort related to imaging and therapeutics. Here we report the synthesis of thiophene-based ligands containing nitrogen heterocycles. The ligands selectively recognized amyloid-β (Aβ) aggregates in brain tissue from individuals diagnosed neuropathol. as having Alzheimer′s disease (AD). The selectivity for Aβ was dependent on the position of nitrogen in the heterocyclic compounds, and the ability to bind Aβ was shown to be reduced when introducing anionic substituents on the thiophene backbone. Our findings provide the structural and functional basis for the development of ligands that can differentiate between aggregated proteinaceous species comprised of distinct proteins. These ligands might also be powerful tools for studying the pathogenesis of Aβ aggregation and for designing mols. for imaging of Aβ pathol. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Synthetic Route of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Synthetic Route of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Highly Active Manganese-Based CO2 Reduction Catalysts with Bulky NHC Ligands: A Mechanistic Study》 was written by Yang, Yong; Zhang, Zhenyu; Chang, Xiaoyong; Zhang, Ya-Qiong; Liao, Rong-Zhen; Duan, Lele. Safety of Bromopentacarbonylmanganese(I) And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

Because of the strong σ-donor and weak π-acceptor of the N-heterocyclic carbene (NHC), Mn-NHC complexes are active for the reduction of CO2 to CO with high activity. However, some NHC-based Mn complexes showed low catalytic activity and required very neg. potentials. The authors report herein that complex fac-[MnI(bis-MesNHC)(CO)3Br] [1; bis-MesNHC = 3,3-bis(2,4,6-trimethylphenyl)-(1,1′-diimidazolin-2,2′-diylidene)methane] could catalyze the electrochem. reduction of CO2 to CO with high activity (TOFmax = 3180 ± 6 s-1) at a less neg. potential. Due to the introduction of the bulky Mes groups, a 1-electron-reduced intermediate {[Mn0(bis-MesNHC)(CO)3]0 (2•)} was isolated as a packed dimer and crystallog. characterized. Stopped-flow FTIR spectroscopy was used to prove the direct reaction between doubly reduced intermediate fac-[Mn(bis-MesNHC)(CO)3]- and CO2; the tetracarbonyl Mn complex [Mn+(bis-MesNHC)(CO)4]+ ([2-CO]+) was captured, and its further reduction proposed as the rate-limiting step. The Mes groups on the NHC ligand improve the catalytic performance of 1 with respect to electrochem. reduction of CO2 to CO. The rate-limiting step probably is the reduction of the tetracarbonyl Mn+ species. In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2Safety of Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Safety of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate》 was published in Scientific Reports in 2020. These research results belong to Holmes, Toby; Brown, Andrew W.; Suggitt, Marie; Shaw, Lucy A.; Simpson, Lucy; Harrity, Joseph P. A.; Tozer, Gillian M.; Kanthou, Chryso. Formula: C9H11BrO3 The article mentions the following:

Combretastatin A-4 phosphate (CA4P) is a microtubule-disrupting tumor-selective vascular disrupting agent (VDA). While hypoxia renders tumors resistant to many conventional therapies, little is known about its influence on VDA activity. Here, we found that active RhoA and ROCK effector phospho-myosin light chain (pMLC) were downregulated in endothelial cells by severe hypoxia. CA4P failed to activate RhoA/ROCK/pMLC but its activity was restored upon reoxygenation. Hypoxia also inhibited CA4P-mediated actinomyosin contractility, VE-cadherin junction disruption and permeability rise. Glucose withdrawal downregulated pMLC, and coupled with hypoxia, reduced pMLC faster and more profoundly than hypoxia alone. Concurrent inhibition of glycolysis (2-deoxy-D-glucose, 2DG) and mitochondrial respiration (rotenone) caused profound actin filament loss, blocked RhoA/ROCK signalling and rendered microtubules CA4P-resistant. Withdrawal of the metabolism inhibitors restored the cytoskeleton and CA4P activity. The AMP-activated kinase AMPK was investigated as a potential mediator of pMLC downregulation. Pharmacol. AMPK activators that generate AMP, unlike allosteric activators, downregulated pMLC but only when combined with 2DG and/or rotenone. Altogether, our results suggest that Rho/ROCK and actinomyosin contractility are regulated by AMP/ATP levels independently of AMPK, and point to hypoxia/energy depletion as potential modifiers of CA4P response. In the experiment, the researchers used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Formula: C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Formula: C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2022 ,《Iron-Catalyzed Ring Expansion of Cyclobutanols for the Synthesis of 1-Pyrrolines by Using MsONH3OTf》 appeared in Organic Letters. The author of the article were Zhuang, Daijiao; Gatera, Tharcisse; An, Zhenyu; Yan, Rulong. The article conveys some information:

The synthesis of 1-pyrrolines I [R = Ph, 4-MeC6H4, 2-thienyl, etc.; R1 = H, Bn, 4-MeOC6H4CH2] from cyclobutanol derivatives and aminating reagent (MsONH3OTf) had been developed. This one-pot procedure achieved C-N single bond/C = N double bond formation via ring expansion reaction. A series of 1-pyrroline derivatives was synthesized in moderate to good yields under mild conditions. In addition to this study using 5-Bromobenzo[d][1,3]dioxole, there are many other studies that have used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Category: bromides-buliding-blocks) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of Bromopentacarbonylmanganese(I)In 2020 ,《Redox Noninnocent Nature of Acridine-Based Pincer Complexes of 3d Metals and C-C Bond Formation》 appeared in Organometallics. The author of the article were Daw, Prosenjit; Kumar, Amit; Oren, Dror; Espinosa-Jalapa, Noel Angel; Srimani, Dipankar; Diskin-Posner, Yael; Leitus, Gregory; Shimon, Linda J. W.; Carmieli, Raanan; Ben-David, Yehoshoa; Milstein, David. The article conveys some information:

Acridine-based PNP pincer complexes were previously used for several environmentally benign catalytic processes. In light of the recent growth in interest in base-metal catalysis, the authors report here the synthesis of acridine-PNP pincer complexes of Ni, Co, Fe, and Mn. The authors also report here the noninnocent redox nature of these complexes that results in the dimerization of pincer complexes by forming a C-C bond at the C9 position of the acridine ring.Bromopentacarbonylmanganese(I)(cas: 14516-54-2Safety of Bromopentacarbonylmanganese(I)) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Safety of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhu, Peiyu; Zhang, Jian; Yang, Yifei; Wang, Lixun; Zhou, Jinpei; Zhang, Huibin published an article in Molecular Diversity. The title of the article was 《Design, synthesis and biological evaluation of isoxazole-containing biphenyl derivatives as small-molecule inhibitors targeting the programmed cell death-1/ programmed cell death-ligand 1 immune checkpoint》.HPLC of Formula: 76006-33-2 The author mentioned the following in the article:

Monoclonal antibodies targeting the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) immune checkpoint have achieved enormous success in cancer immunotherapy. But the antibody-based immunotherapies carry a number of unavoidable deficiencies such as poor pharmacokinetic properties and immunogenicity. Small-mol. PD-1/PD-L1 inhibitors offer the superiority of complementarity with monoclonal antibodies and represent an appealing alternative. A novel series of isoxazole-containing biphenyl compounds were designed, synthesized and evaluated as PD-1/PD-L1 inhibitors in this paper. The structure-activity relationship of the novel synthesized compounds indicated that the ring-closure strategy of introducing isoxazole could be employed and the 3-cyanobenzyl group was significant for the inhibitory activity against the PD-1/PD-L1 protein-protein interactions. Mol. docking studies were performed to help understand the binding mode of the small-mol. inhibitor with the PD-L1 dimer. In particular, compound II-12 was a promising anti-PD-1/PD-L1 inhibitor with the IC50 value of 23.0 nM, providing valuable information for future drug development. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. HPLC of Formula: 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Pieters, Priscilla F.; Laine, Antoine; Li, He; Lu, Yi-Hsien; Singh, Yashpal; Wang, Lin-Wang; Liu, Yi; Xu, Ting; Alivisatos, A. Paul; Salmeron, Miquel published an article in ACS Nano. The title of the article was 《Multiscale Characterization of the Influence of the Organic-Inorganic Interface on the Dielectric Breakdown of Nanocomposites》.SDS of cas: 17696-11-6 The author mentioned the following in the article:

Nanoscale engineered materials such as nanocomposites can display or be designed to enhance their material properties through control of the internal interfaces. Here, we unveil the nanoscale origin and important characteristics of the enhanced dielec. breakdown capabilities of gold nanoparticle/polymer nanocomposites. Our multiscale approach spans from the study of a single chem. designed organic/inorganic interface to micrometer-thick films. At the nanoscale, we relate the improved breakdown strength to the interfacial charge retention capability by combining scanning probe measurements and d. functional theory calculations At the meso- and macroscales, our findings highlight the relevance of the nanoparticle concentration and distribution in determining and enhancing the dielec. properties, as well as identifying this as a crucial limiting factor for the achievable sample size. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.SDS of cas: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary