Tag: 200-300

Sawazaki, Taka; Shimizu, Yusuke; Oisaki, Kounosuke; Sohma, Youhei; Kanai, Motomu published their research in Organic Letters on December 21 ,2018. The article was titled 《Convergent and Functional-Group-Tolerant Synthesis of B-Organo BODIPYs》.Recommanded Product: potassium (3-bromophenyl)trifluoroborate The article contains the following contents:

Boron-dipyrromethenes (BODIPYs) are one of the most important fluorescent materials. Despite their potential unique properties, however, B,B-fluoro-organo BODIPYs (BFR-BODIPYs) possessing an organo group (R) on the boron center have not been studied in detail, due in part to challenges related to their synthesis. In this paper, a convergent synthesis of BFR-BODIPYs operative under mild conditions is reported. Conversions of the thus-synthesized functionalized BFR-BODIPYs by cross-coupling, condensation, and SN2 reactions at the R group are also demonstrated.potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8Recommanded Product: potassium (3-bromophenyl)trifluoroborate) was used in this study.

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: potassium (3-bromophenyl)trifluoroborate Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2011,Tetrahedron included an article by Bolla, Krishnavenu; Kim, Taejung; Song, Jung Ho; Lee, Seokjoon; Ham, Jungyeob. Reference of potassium (3-bromophenyl)trifluoroborate. The article was titled 《Efficient and rapid synthesis of regioselective functionalized potassium 1,2,3-triazoletrifluoroborates via 1,3-dipolar cycloaddition》. The information in the text is summarized as follows:

In this study, we present a previously unreported method of preparing regiospecific organo-[1,2,3]-triazol-1-aryl-trifluoroborates from haloaryltrifluoroborates via a one-pot 1,3-dipolar cycloaddition reaction. We found that the use of either electron-rich or electron-deficient haloaryltrifluoroborates led to the desired cycloaddition products with good to excellent yields. Furthermore, we successfully carried out the cross-coupling reactions of the obtained triazoles with various aryl halides by means of the Suzuki-Miyaura reaction in the presence of 3 mol % of Pd(PPh3)4 catalyst in a 20% aqueous 1,4-dioxane solution at 100 °C; all these reactions yielded complete conversion to the corresponding products. Besides providing a high level of personnel safety, our highly versatile approach allows the preparation of functionalized organotrifluoborates containing 1,2,3-triazoles with retained functionality.potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8Reference of potassium (3-bromophenyl)trifluoroborate) was used in this study.

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Reference of potassium (3-bromophenyl)trifluoroborate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of L-tricholomic acid analogs and pharmacological characterization at ionotropic glutamate receptors》 was written by Tamborini, Lucia; Mastronardi, Federica; Lo Presti, Leonardo; Nielsen, Birgitte; De Micheli, Carlo; Conti, Paola; Pinto, Andrea. Formula: C9H9BrO2This research focused ontricholomic acid analog synthesis ionotropic glutamate receptor crystal structure; hydroxy isoxazoline pyrazoline cycloaddition cyclization. The article conveys some information:

The synthesis of analogs of the natural compound L-tricholomic acid and of its threo diastereoisomer was accomplished in order to explore their affinity for glutamate ionotropic receptors. In this study, fourteen new unnatural amino acids, characterized by a 3-hydroxy-Δ2-isoxazoline or 3-hydroxy-Δ2-pyrazoline-skeleton, were obtained exploiting, as key reaction, a 1,3-dipolar cycloaddition or an intramol. cyclization. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Formula: C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Base-Free Mizoroki-Heck Reaction Catalyzed by Rhodium Complexes》 was written by Martinez, Remi; Voica, Florina; Genet, Jean-Pierre; Darses, Sylvain. Recommanded Product: potassium (3-bromophenyl)trifluoroborate And the article was included in Organic Letters on August 16 ,2007. The article conveys some information:

A base-free rhodium-catalyzed Mizoroki-Heck (M-H) reaction using potassium aryltrifluoroborates as the arylating agent of alkenes and acetone as a green “”oxidant”” is described. E.g., reaction of 4-ClC6H4BF3K and CH2:CH2CO2CMe3 in presence of [Rh(CH2:CH2)Cl]2 gave 71% arylated ester I. Thanks to the ready availability of organoboranes, this reaction should constitute an interesting alternative to conventional M-H reactions using aryl halides. The experimental process involved the reaction of potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8Recommanded Product: potassium (3-bromophenyl)trifluoroborate)

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: potassium (3-bromophenyl)trifluoroborate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C6H5Br2NIn 2017 ,《Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions》 was published in Organic Letters. The article was written by Rojas, Anthony J.; Pentelute, Bradley L.; Buchwald, Stephen L.. The article contains the following contents:

Authors report the use of a sulfonated biarylphosphine ligand (sSPhos) to promote the chemoselective modification of cysteine containing proteins and peptides with palladium reagents in aqueous medium. The use of sSPhos allowed for the isolation of several air-stable and water-soluble mono- and bis-palladium reagents, which were used in an improved protocol for the rapid S-arylation of cysteines under benign and physiol. relevant conditions. The cosolvent-free aqueous conditions were applied to the conjugation of a variety of biomols. with affinity tags, heterocycles, fluorophores, and functional handles. Addnl., bis-palladium reagents were used to perform macrocyclization of peptides bearing two cysteine residues. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Formula: C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 626-40-4In 2019 ,《Experimental and theoretical investigations of cyclometalated ruthenium(II) complex containing CCC-pincer and anti-inflammatory drugs as ligands: synthesis, characterization, inhibition of cyclooxygenase and in vitro cytotoxicity activities in various cancer cell lines》 was published in Dalton Transactions. The article was written by Tabrizi, Leila; Olasunkanmi, Lukman O.; Fadare, Olatomide A.. The article contains the following contents:

The new cyclometalated ruthenium(II) complex, [Ru(CCC-Nap)(Ibu)(PTA)], I (3), was designed and synthesized using ibuprofen (Ibu), 1,3,5-triaza-7-phosphaadamantane (PTA) and CCC-pincer containing naproxen moiety (CCC-Nap) as ligands. The compounds were fully characterized by elemental anal., FT-IR, multinuclear (1H, 13C, and 31P) NMR spectroscopy, and electrospray ionization mass spectrometry. The cytotoxicity of 3 was found to be low, and the complex was about twice as active as cisplatin with IC50 values in the range of 0.9-1.32 μM for both MCF-7 and MDA-MB-231 cell lines. Cyclooxygenase (COX) inhibition studies revealed that 3 displayed strong interactions with COX-2, about 16 and 5 times more than free Ibu and CCC-Nap ligands, resp. The complex 3 improved the production of reactive oxygen species (ROS) by 10.7 fold compared to the control (H2O2 as a pos. control) in MCF-7 cells. Quantum chem. calculations gave more insights into the geometry and electronic properties of the novel complex 3, while mol. docking provided theor. information on the interactions of 3 with human cyclooxygenase-2 (COX-2) and the results were compared with those of the interactions of the free ligands with COX-2. In the experiment, the researchers used many compounds, for example, 3,5-Dibromoaniline(cas: 626-40-4Product Details of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Product Details of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 5437-45-6In 2019 ,《Allenoate Prenucleophiles: A Triply Diastereoselective Approach to β-Hydroxy Esters Containing All-Carbon α-Quaternary Centers》 appeared in Organic Letters. The author of the article were Maki, Samantha L.; Maity, Pradip; Dougherty, Shannon; Johns, Jennifer; Lepore, Salvatore D.. The article conveys some information:

Allenyl esters activated by titanium(IV) underwent additions to a wide range of aldehydes in high regio- and diastereoselectivities leading to products containing an all-carbon quaternary center bearing an α-vinyl group that was installed with high selectivity for the Z-geometry. An aldol product was also converted to an indanone offering a new route to this important compound class. Product triple diastereoselectivity has been rationalized using a concerted transition-state model. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6HPLC of Formula: 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.HPLC of Formula: 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Shengwang; He, Peng; Dhindwal, Sonali; Grum-Tokars, Valerie L.; Li, Ying; Parker, Kelly; Modica, Justin A.; Bleher, Reiner; dos Reis, Roberto; Zuchniarz, Joshua; Dravid, Vinayak P.; Voth, Gregory A.; Roux, Benoit; Mrksich, Milan published an article in 2021. The article was titled 《Synthesis, characterization, and simulation of four-armed megamolecules》, and you may find the article in Biomacromolecules.Name: Benzyl 2-bromoacetate The information in the text is summarized as follows:

This paper describes the synthesis, characterization, and modeling of a series of mols. having four protein domains attached to a central core. The mols. were assembled with the “”megamol.”” strategy, wherein enzymes react with their covalent inhibitors that are substituted on a linker. Three linkers were synthesized, where each had four oligo(ethylene glycol)-based arms terminated in a para-nitrophenyl phosphonate group that is a covalent inhibitor for cutinase. This enzyme is a serine hydrolase and reacts efficiently with the phosphonate to give a new ester linkage at the Ser-120 residue in the active site of the enzyme. Neg.-stain transmission electron microscopy (TEM) images confirmed the architecture of the four-armed megamols. These cutinase tetramers were also characterized by X-ray crystallog., which confirmed the active-site serine-phosphonate linkage by electron-d. maps. Mol. dynamics simulations of the tetracutinase megamols. using three different force field setups were performed and compared with the TEM observations. Using the Amberff99SB-disp + pH7 force field, the two-dimensional projection distances of the megamols. were found to agree with the measured dimensions from TEM. The study described here, which combines high-resolution characterization with mol. dynamics simulations, will lead to a comprehensive understanding of the mol. structures and dynamics for this new class of mols. In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6Name: Benzyl 2-bromoacetate) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Name: Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Roy, Sayontani Sinha; Talukdar, Kallol; Jurss, Jonah W. published an article in 2021. The article was titled 《Electro- and Photochemical Reduction of CO2 by Molecular Manganese Catalysts: Exploring the Positional Effect of Second-Sphere Hydrogen-Bond Donors》, and you may find the article in ChemSusChem.Category: bromides-buliding-blocks The information in the text is summarized as follows:

A series of mol. Mn catalysts featuring aniline groups in the second-coordination sphere has been developed for electrochem. and photochem. CO2 reduction The arylamine moieties were installed at the 6 position of 2,2′-bipyridine (bpy) to generate a family of isomers in which the primary amine is located at the ortho- (1-Mn), meta- (2-Mn), or para-site (3-Mn) of the aniline ring. The proximity of the second-sphere functionality to the active site is a critical factor in determining catalytic performance. Catalyst 1-Mn, possessing the shortest distance between the amine and the active site, significantly outperformed the rest of the series and exhibited a 9-fold improvement in turnover frequency relative to parent catalyst Mn(bpy)(CO)3Br (901 vs. 102 s-1, resp.) at 150 mV lower overpotential. The electrocatalysts operated with high faradaic efficiencies (≥70 %) for CO evolution using trifluoroethanol as a proton source. Notably, under photocatalytic conditions, a concentration-dependent shift in product selectivity from CO (at high [catalyst]) to HCO2H (at low [catalyst]) was observed with turnover numbers up to 4760 for formic acid and high selectivities for reduced carbon products. In the experiment, the researchers used Bromopentacarbonylmanganese(I)(cas: 14516-54-2Category: bromides-buliding-blocks)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ni, Mengshan; Geng, Lijun; Kong, Fangfang; Du, Chengrun; Zhai, Ruiping; Lyu, Yingchen; Hu, Chaosu; Ying, Hongmei published an article in 2021. The article was titled 《Induction Chemotherapy Combined With Intensity-Modulated Radiotherapy for 129 Nasopharyngeal Carcinoma Patients With Synchronous Metastases: A Retrospective Study.》, and you may find the article in Frontiers in oncology.Recommanded Product: 626-40-4 The information in the text is summarized as follows:

OBJECTIVE: To analyze the therapeutic effect and prognostic factors of nasopharyngeal carcinoma (NPC) patients with distant metastases at initial diagnosis receiving induction chemotherapy with intensity-modulated radiotherapy (IMRT). METHODS: A total of 129 patients who underwent platinum-based induction chemotherapy followed by definitive IMRT with or without concurrent or adjuvant chemotherapy for newly diagnosed distant metastatic NPC in our center between March 2008 and November 2018 were retrospectively analyzed. 41 patients underwent local therapy for metastatic sites. Kaplan-Meier method was used to estimate survival rates, Log-rank test and Cox proportional hazards model were used to figure out independent prognostic factors of overall survival (OS). RESULTS: A total of 66 patients had been dead (median follow-up time, 51.5 months). The median overall survival (OS) time was 54.2 months (range, 7-136 months), and the 1-year, 2-year, 3-year, 5-year overall survival rates were 88.0%,71.0%,58.0%, and 47.0%. Multivariate analysis found that the factors correlated with poor overall survival were pre-treatment serum lactate dehydrogenase (SLDH) >180U/L, chemotherapy cycles<4, and M1 stage subdivision (M1b, single hepatic metastasis and/or multiple metastases excluding the liver; and M1c, multiple hepatic metastases). The 5-year OS rates for M1a, M1b and M1c were 62.6%,40.4% and 0%, respectively. CONCLUSION: Platinum-containing induction chemotherapy combined with IMRT seemed to be advantageous to prolong survival for some NPC patients with synchronous metastases at initial diagnosis. The independent factors to prognosticate OS were pre-treatment SLDH, number of chemotherapy cycles, and M1 subcategories. Prospective clinical trials are needed to confirm the result. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary