Tag: 200-300

The author of 《A laser driven flow chemistry platform for scaling photochemical reactions with visible light》 were Harper, Kaid C.; Moschetta, Eric G.; Bordawekar, Shailendra V.; Wittenberger, Steven J.. And the article was published in ACS Central Science in 2019. Synthetic Route of C7H4BrF3 The author mentioned the following in the article:

Visible-light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multikilogram production We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high-intensity laser to drive photochem. reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer-Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochem. reactions. The experimental process involved the reaction of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Synthetic Route of C7H4BrF3)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Synthetic Route of C7H4BrF3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Interchain doubly-bridged α-helical peptides for the development of protein binders》 were Chen, Yaqi; Liang, Jingjing; Li, Tao; Lin, Ping; Zhao, Yibing; Wu, Chuanliu. And the article was published in Chinese Chemical Letters in 2019. Computed Properties of C8H8Br2 The author mentioned the following in the article:

Constrained peptide scaffolds that are tolerant to extensive sequence manipulation and amenable to bioactive peptide design are of great value to the development of novel protein binders and peptide therapeutics. The authors reported strategies for the design and synthesis of a kind of novel interchain doubly-bridged α-helical peptides, involving mutual stabilization of two peptide α-helixes linked by two interchain bisthioether crosslinkers. By taking a MDM2-binding peptide with an α-helical tendency as a model, α-helical dimers with significantly improved structural and proteolytic stability and nanomolar binding affinity to the target protein can be obtained. By modulating the surface charges on the dimeric peptides, the authors also obtained a dimeric peptide with enhanced cell-penetrating capability, which can efficiently penetrate into cancer cells and inhibit the intracellular MDM2-p53 interactions to promote cell apoptosis. Considering that many proteins take a surface α-helical segment as the binding motif to mediate their interactions with other proteins, the authors believe that the authors’ interchain doubly-bridged α-helical peptides would provide a promising scaffold for the development of novel high-affinity protein binders.1,4-Bis(bromomethyl)benzene(cas: 623-24-5Computed Properties of C8H8Br2) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Computed Properties of C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Catalysts included an article by Willot, Sebastien J.-P.; Tieves, Florian; Girhard, Marco; Urlacher, Vlada B.; Hollmann, Frank; de Gonzalo, Gonzalo. Quality Control of Ethyl 5-bromovalerate. The article was titled 《P450BM3-catalyzed oxidations employing dual functional small molecules》. The information in the text is summarized as follows:

A set of dual functional small mols. (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P 450 monooxygenase P450BM3 from Bacillus megaterium in H2O2-dependent oxidation reactions. These DFSMs enhance P450BM3 activity with hydrogen peroxide as an oxidant, converting these enzymes into formal peroxygenases. This system has been employed for the catalytic epoxidation of styrene and in the sulfoxidation of thioanisole. Various P450BM3 variants have been evaluated in terms of activity and selectivity of the peroxygenase reactions. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Quality Control of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Quality Control of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Nature Communications included an article by Wang, Xu-Qing; Wang, Wei; Li, Wei-Jian; Chen, Li-Jun; Yao, Rui; Yin, Guang-Qiang; Wang, Yu-Xuan; Zhang, Ying; Huang, Junlin; Tan, Hongwei; Yu, Yihua; Li, Xiaopeng; Xu, Lin; Yang, Hai-Bo. Product Details of 626-40-4. The article was titled 《Dual stimuli-responsive rotaxane-branched dendrimers with reversible dimension modulation》. The information in the text is summarized as follows:

With the aim of mimicking biol. machines, in which the delicate arrangement of nanomech. units lead to the output of specific functions upon the external stimulus, the construction of dual stimuli-responsive rotaxane-branched dendrimers was realized in this study. Starting from a switchable organometallic [2]rotaxane precursor, the employment of a controllable divergent approach allowed for the successful synthesis of a family of rotaxane-branched dendrimers up to the third generation with 21 switchable rotaxane moieties located on each branch. More importantly, upon the addition and removal of dimethylsulfoxide (DMSO) mol. or acetate anion as the external stimulus, the amplified responsiveness of the switchable rotaxane units endowed the resultant rotaxane-branched dendrimers the solvent- or anion-controlled mol. motions, thus leading to the dimension modulation. Therefore, we successfully constructed a family of rotaxane-branched dendrimers with dual stimuli-responsiveness that will be a privileged platform for the construction of dynamic supramol. materials. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Product Details of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 3141-27-3In 2022 ,《Stable room temperature ferroelectricity in hydrogen-bonded supramolecular assemblies of ambipolar π-systems》 was published in Chemical Science. The article was written by Mukherjee, Anurag; Barman, Shubhankar; Ghosh, Anupam; Chakraborty, Saptarshi; Datta, Ayan; Datta, Anuja; Ghosh, Suhrit. The article contains the following contents:

This article reports H-bonding driven supramol. polymerization of naphthalimide (A)-thiophene (D)-naphthalimide (A) (ADnA, n = 1-4) conjugated ambipolar π-systems and its remarkable impact on room temperature ferroelectricity. Electrochem. studies confirm the ambipolar nature of these ADnA mols. with the HOMO-LUMO gap varying between 2.05 and 2.29 eV. Electron d. mapping from ESP calculations reveals intra-mol. charge separation as typically observed in ambipolar systems. In the aggregated state, AD1A and AD2A exhibit bathochromically shifted absorption bands while AD3A and AD4A show typical H-aggregation with a hypsochromic shift. Polarization vs. elec. field (P-E) measurements reveal stable room temperature ferroelectricity for these supramol. assemblies, most prominent for the AD2A system, with a Curie temperature (Tc) ∼ 361 K and saturation polarization (Ps) of ∼2μC cm-2 at a rather low coercive field of ∼2 kV cm-1. Control mols., lacking either the ambipolar chromophore or the amide functionality, do not show any ferroelectricity, vindicating the present mol. and supramol. design. Computational studies enable structural optimization of the stacked oligomer(s) of AD2A mols. and reveal a significant increase in the macro-dipole moment (in the range of 10-12 Debye) going from the monomer to the oligomer(s), which provides the rationale for the origin of ferroelectricity in these supramol. polymers. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Related Products of 3141-27-3)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Related Products of 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Singh, Varinder; Abudayyeh, Abdullah M.; Robb, Matthew G.; Brooker, Sally published an article in Dalton Transactions. The title of the article was 《Mono-copper far more active than analogous di-copper complex for electrocatalytic hydrogen evolution》.Recommanded Product: 623-24-5 The author mentioned the following in the article:

The di-copper(II) analog, [CuII2(bis-LEt)](BF4)2 (2), of the previously reported mono-copper(II) complex [CuIILEt]BF4 (1) which resulted in long lived electrocatalytic hydrogen evolution reaction (HER), has been prepared, characterised and tested for HER. The new bis-macrocycle, bis-HLEt, was formed from two HLEt Schiff base macrocycles (prepared by 1 + 1 condensation of 2,2′-iminobisbenzaldehyde and diethylenetriamine) being connected by selective alkylation of the less sterically hindered secondary alkyl amine group (NH) of each, using α,α′-dibromo-para-xylene to form a linker between them. The desired dicopper(II) complex, [Cu2II(bis-LEt)](BF4).4H2O (2.4H2O), was readily prepared, as a yellowish brown solid in 82% yield. SCXRD on yellow-brown crystals of [CuII2(bis-LEt)](BF4)2.2MeCN (2.2MeCN) revealed both copper(II) centers are square planar with a very similar copper(II) coordination environment to that of square planar 1. Although dicopper(II) complex 2 is easier to reduce than the analogous monocopper(II) complex 1 in MeCN (E1/2(ΔE): 2 -1.20(0.12) V, 1 -1.39(0.09) V, vs. 0.01 M AgNO3/Ag), electrocatalytic HER testing of dicopper complex 2·4H2O, in MeCN with 80 equiv of acetic acid, revealed it was inactive, in stark contrast to the high and ongoing activity of 1 under the same conditions. So two is definitely not better than one metal ion in this case. Rather, it may be that the presence of an NH group in the macrocycle of 1, but absent in the bis-macrocycle of 2 (due to alkylating that NH to link the two macrocycles), may be key to the HER activity seen for 1. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Recommanded Product: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Recommanded Product: 623-24-5 Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Xu, Kaidi; Zhang, Zhi-Yuan; Zhou, Zihao; Li, Chunju published an article in Chinese Chemical Letters. The title of the article was 《Prospering the biphen[n]arenes family by tailoring reaction modules》.Application In Synthesis of 1-Bromo-3,4,5-trimethoxybenzene The author mentioned the following in the article:

Reported here is the comprehensive investigation on the formation of biphen[n]arenes by tailoring reaction modules. Five new macrocyclic arenes and four oligomers were synthesized by the condensation of monomers possessing different multimethoxyphenyl reaction modules and paraformaldehyde. We proved that the number and sites of methoxy on reaction modules greatly affected the reaction activity, shape, and connection mode of macrocycles. Moreover, the triangular and saddle-shaped configuration of macrocycles were revealed by single crystal structures. The results provided a typical and fundamental guidance in designing new macrocyclic arenes. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application In Synthesis of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application In Synthesis of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Di; Lin, Liming; Xie, Yunji; Pang, Jinhui; Jiang, Zhenhua published an article in 2021. The article was titled 《Anion exchange membrane based on poly(arylene ether ketone) containing long alkyl densely quaternized carbazole derivative pendant》, and you may find the article in Journal of Membrane Science.SDS of cas: 629-03-8 The information in the text is summarized as follows:

A series of poly(arylene ether ketone) copolymers (PAEK-HQACz-x) containing long alkyl densely quaternized carbazole derivative pendant was designed and synthesized for anion exchange membrane. It was found that constructing long alkyl chain between hydrophobic polymer backbone and hydrophilic densely functionalized hydrophilic pendant effective promoted the formation of well-defined microscopic phase separation morphol., in turn enabling high hydroxide conduction and confined dimensional variation. The PAEK-HQACz-0.7 membrane exhibited the hydroxide conductivity of 98.1 mS cm-1 at 80°C, while the swelling ratio was only 13.5%. The toughness and alk. stability of PAEK-HQACz-x membranes were also significantly improved by attaching the long alkyl chain onto the quaternized carbazole derivative pendant. The PAEK-HQACz-0.7 membrane was selected for membrane electrode assembly and showed acceptable results. These properties demonstrated such membranes to be promising anion exchange membrane candidates. In the experiment, the researchers used 1,6-Dibromohexane(cas: 629-03-8SDS of cas: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.SDS of cas: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ibrahim, Tarek S.; Malebari, Azizah M.; Mohamed, Mamdouh F. A. published an article in 2021. The article was titled 《Design, Synthesis, In Vitro Anticancer Evaluation and Molecular Modelling Studies of 3,4,5-Trimethoxyphenyl-Based Derivatives as Dual EGFR/HDAC Hybrid Inhibitors》, and you may find the article in Pharmaceuticals.Category: bromides-buliding-blocks The information in the text is summarized as follows:

Recently, combining histone deacetylase (HDAC) inhibitors with chemotherapeutic drugs or agents, in particular epidermal growth factor receptor (EGFR) inhibitors, is considered to be one of the most encouraging strategy to enhance the efficacy of the antineoplastic agents and decrease or avoid drug resistance. Therefore, in this work, based on introducing 3,4,5-trimethoxy Ph group as a part of the CAP moiety, in addition to incorporating 4-6 aliphatic carbons linker and using COOH or hydroxamic acid as ZBG, 12 novel EGFR/HDAC hybrid inhibitors 2a-c, 3a-c, 4a-c and 5a-c were designed, constructed, and evaluated for their anticancer activities against 4 cancer cell lines (HepG2, MCF-7, HCT116 and A549). Among all, hybrids with hydroxamic acid 4a-c and 5a, exhibited the highest inhibition against all cancer cell lines with IC50 ranging from 0.536 to 4.892 μM compared to Vorinostat (SAHA) with IC50 ranging from 2.43 to 3.63 μM and Gefitinib with IC50 ranging from 1.439 to 3.366 μM. Mechanistically, the most potent hybrids 4a-c and 5a were further tested for their EGFR and HDACs inhibitory activities. The findings disclosed that hybrid 4b displayed IC50 = 0.063 μM on the target EGFR enzyme which is slightly less potent than the standard Staurosporine (IC50 = 0.044 μM). Furthermore, hybrid 4b showed less HDAC inhibitory activity IC50 against HDAC1 (0.148), 2 (0.168), 4 (5.852), 6 (0.06) and 8 (2.257) than SAHA. In addition, the investigation of apoptotic action of the most potent hybrid 4b showed a significant increase in Bax level up to 3.75-folds, with down-regulation in Bcl2 to 0.42-fold, compared to the control. Furthermore, hybrid 4b displayed an increase in the levels of Caspases 3 and 8 by 5.1 and 3.15 folds, resp. Addnl., the cell cycle anal. of hybrid 4b revealed that it showed programmed cell death and cell cycle arrest at G1/S phase. Moreover, all these outcomes together with the mol. docking study recommended the rationalized target hybrids 4a-c and 5a, particularly 4b, may be considered to be promising lead candidates for discovery of novel anticancer agents via dual inhibition of both EGFR/HDAC enzymes. In addition to this study using Ethyl 5-bromovalerate, there are many other studies that have used Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Furniel, Lucas G.; Echemendia, Radell; Burtoloso, Antonio C. B. published their research in Chemical Science in 2021. The article was titled 《Cooperative copper-squaramide catalysis for the enantioselective N-H insertion reaction with sulfoxonium ylides》.COA of Formula: C7H5BrO2 The article contains the following contents:

The first examples of a highly efficient and enantioselective carbene-mediated insertion reaction, from a sulfur ylide, were described. By way of a catalytic asym. insertion reaction into N-H bonds from carbonyl sulfoxonium ylides and anilines, using a copper-bifunctional squaramide cooperative catalysis approach, thirty-seven α-arylglycine esters were synthesized in enantiomeric ratios up to 92:8 (99:1 after a single recrystallization) and reaction yields ranging between 49-96%. Furthermore, the protocol benefited from quick reaction times and was conducted in a straightforward manner. The experimental process involved the reaction of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4COA of Formula: C7H5BrO2)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.COA of Formula: C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary