Tag: 200-300

《Liquid crystal dimers containing Cholesteryl and Triazole-containing mesogenic units》 was written by Al-shargabi, Arwa; Yeap, Guan-Yeow; Mahmood, Wan Ahmad Kamil; Han, Chun-Chieh; Lin, Hong-Cheu; Ito, Masato M.. Safety of 8-Bromooctanoic acid And the article was included in Liquid Crystals in 2020. The article conveys some information:

New liquid crystals categorized as cholesteryl dimers have been successfully synthesized through the reaction between cholesteryl 4-(prop-2-ynyloxy)benzoate moieties with n-azido(cholesteryloxy-carbonyl)alkane. All the dimers display enantiotropic mesophases. While the odd-numbered dimers exhibit chiral nematic (N*), twisted grain boundary (TGB) and chiral smectic C (SmC*) phases, the even-numbered members from the same series show chiral smectic A and C. A detailed inspection on mesophase reveals that the chiral centers and the bent conformation of the odd-numbered members are essential for the induction of TGB phase. However, upon decreasing the temperature, the ratio of the transition temperatures (TSmC*-SmA*/TSmA*-I) is found to be 0.95, which indicate the second order transition according to the McMillan’s mol. theory. In addition, the X-ray diffraction study supports the presence of the smectic A phase on the even members rather than the N* by the appearance of the Bragg diffraction peaks at 190°. A comparison study with the other analogs in which the cholesterol entity is substituted by azobenzene or bipheny tails has been carried out to assess the relationship between the mol. structure and mesomorphic behavior.8-Bromooctanoic acid(cas: 17696-11-6Safety of 8-Bromooctanoic acid) was used in this study.

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Safety of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Organic Letters included an article by Elek, Gabor Zoltan; Koppel, Kaur; Zubrytski, Dzmitry M.; Konrad, Nele; Jarving, Ivar; Lopp, Margus; Kananovich, Dzmitry G.. Computed Properties of C7H13BrO2. The article was titled 《Divergent access to histone deacetylase inhibitory cyclopeptides via a late-stage cyclopropane ring cleavage strategy. Short synthesis of chlamydocin》. The information in the text is summarized as follows:

A unified step-economical strategy for accessing histone deacetylase inhibitory peptides is proposed, based on the late-stage installation of multiple zinc-binding functionalities via the cleavage of the strained cyclopropane ring in the common pluripotent cyclopropanol precursor. The efficacy of the proposed diversity-oriented approach has been validated by short stereoselective synthesis of natural product chlamydocin, containing a challenging-to-install fragment of (2S,9S)-2-amino-8-oxo-9,10-epoxydecanoic acid (Aoe) and a range of its analogs, derivatives of 2-amino-8-oxodecanoic and 2-aminosuberic acids. After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7Computed Properties of C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Computed Properties of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,New Journal of Chemistry included an article by Li, Zhi-Jun; Xue, Hua-Dong; Zhang, Yu-Quan; Hu, Huai-Sheng; Zheng, Xu-Dong. Application of 623-24-5. The article was titled 《Construction of a cationic organic network for highly efficient removal of anionic contaminants from water》. The information in the text is summarized as follows:

Widespread water contamination has become a great threat to human survival, and therefore developing an efficient strategy for decontamination of wastewater is of great significance. Herein, a new cationic organic network (CON-1) has been constructed by a facile method from com. available precursors, 1,4-bis(bromomethyl)benzene (BBMB) and 5,10,15,20-tetra(4-pyridyl)porphyrin (TPP), via a quaternization reaction. After being well characterized, CON-1 was employed as an adsorbent for removal of anionic contaminants in aqueous media. Benifitting from the charged framework and exchangeable counter ions, CON-1 exhibits fast adsorption kinetics and high adsorption capacity towards organic dyes and dichromate. The maximum adsorption capacity for the organic dye orange G and Cr2O72- can reach up to 718 mg g-1 and 293 mg g-1, resp. Moreover, CON-1 displays good stability in the adsorption process, it can be regenerated and it can be reused for several cycles. The facile synthesis, high efficiency, and good stability endow CON-1 with great potential in the purification of wastewater. In the experiment, the researchers used many compounds, for example, 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application of 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Application of 623-24-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chinese Chemical Letters included an article by Zhang, Ding; Sha, Min; Pan, Renming; Lin, Xiangyang; Xing, Ping; Jiang, Biao. Application In Synthesis of 1,4-Bis(bromomethyl)benzene. The article was titled 《Design and synthesis of the novel branched fluorinated surfactant intermediates with CF3CF2CF2C(CF3)2 group》. The information in the text is summarized as follows:

Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) was one of the most prominent fluorosurfactants and applied widely in fire-fighting and daily chem., etc. However, these surfactants have recently been identified as toxic and undegradability in the environment. Developing an efficient approach to environment-friendly fluorosurfactants is essential. A fluorocarbon branched chain strategy was adopted to develop /PFOS substitutes. A series of intermediates of novel branched fluorinated surfactants with CF3CF2CF2C(CF3)2 group were synthesized from perfluoro-2-methyl-2-pentene. All the steps were mild, easy-handled and cheap. It is expected to be a very significant direction for the development of non-bioaccumulable alternatives of PFOA or PFOS. In the experiment, the researchers used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application In Synthesis of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Application In Synthesis of 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kaplan, Justin M.; Hruszkewycz, Damian P.; Strambeanu, Iulia I.; Nunn, Christopher J.; VanGelder, Kelsey F.; Dunn, Anna L.; Wozniak, Derek I.; Dobereiner, Graham E.; Leitch, David C. published an article on January 14 ,2019. The article was titled 《Scalable and Chemoselective Synthesis of γ-Keto Esters and Acids via Pd-Catalyzed Carbonylation of Cyclic β-Chloro Enones》, and you may find the article in Organometallics.HPLC of Formula: 76283-09-5 The information in the text is summarized as follows:

The Pd-catalyzed carbonylation of cyclic β-chloro enones using simple phosphine ligands is described. Screening identified P(Me)(t-Bu)2 as the most general ligand for an array of chloro enone electrophiles. The reaction scope was evaluated on a milligram scale across 80 examples, with excellent reactivity observed in nearly every case. Carbonylation can be achieved even in the presence of potentially sensitive or inhibitory functional groups, including basic nitrogens as well as aryl chlorides or bromides. Twenty examples were run on a gram scale, demonstrating scalability and practical utility. Using P(Me)(t-Bu)2, the reaction rate depends on both nucleophile and electrophile identity, with completion times varying between 3 and >18 h under a standard set of conditions. Switching to P(t-Bu)3 for the carbonylation of 3-chlorocyclohex-2-enone with MeOH results in a dramatic rate increase, enabling effective catalysis with kinetics consistent with rate-limiting mass transfer. Stoichiometric oxidative addition of 3-chlorocyclohex-2-enone and 3-oxocyclohex-1-enecarbonyl chloride to both Pd[P(t-Bu)3]2 and Pd(PCy3)2 has enabled characterization and isolation of several potential catalytic intermediates, including Pd-vinyl and Pd-acyl species supported by P(t-Bu)3 and PCy3 ligands. Monitoring the oxidative addition of 3-chlorocyclohex-2-enone to Pd(PCy3)2 by NMR spectroscopy indicates that coordination of the alkene precedes oxidative addition As a result of these studies, Me 3-oxocyclohex-1-enecarboxylate was synthesized via Pd-catalyzed carbonylation of 3-chlorocyclohex-2-enone in 90% yield on a 60 g scale with only 0.5 mol % catalyst loading.4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5HPLC of Formula: 76283-09-5) was used in this study.

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. HPLC of Formula: 76283-09-5 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Functionalization of triblock copolymer elastomers by cross-linking the end blocks via trans-N-alkylation-based exchangeable bonds》 was written by Hayashi, Mikihiro; Chen, Lei. Category: bromides-buliding-blocksThis research focused ontriblock copolymer elastomer crosslinking alkylation preparation property. The article conveys some information:

We demonstrate the functionalization of ABA triblock copolymer-based materials by introducing dynamic covalent bonded cross-links. The bond-exchange via trans-N-alkylation was operated in the domains of poly(4-vinylpyridine) end blocks, cross-linked by quaternization with dibromo cross-linkers, thus exhibiting vitrimer-like properties (e.g., softening and great stress relaxation) and other useful functions, such as re-processability, recyclability, and self-adhesion. The results came from multiple reactions, including the reaction of 1,6-Dibromohexane(cas: 629-03-8Category: bromides-buliding-blocks)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity》 was written by Bian, Jinlei; Ren, Jie; Li, Yongren; Wang, Jubo; Xu, Xi; Feng, Yifan; Tang, Hui; Wang, Yajing; Li, Zhiyu. Application of 17696-11-6This research focused onWogonin PROTAC CDK9 antitumor click chem; Antitumor; CDK9; Click Chemistry; PROTAC; Wogonin. The article conveys some information:

Wogonin is a natural product isolated from the Scutellaria baicalensis and has been proved to be a potent and selective inhibitor of CDK9. Using this scaffold, we designed and synthesized a series of proteolysis targeting chimeras (PROTACs) targeting CDK9 by recruiting ubiquitin E3 ligase cereblon (CRBN). For constructing diverse Wogonin-based PROTACs, a “”click chem.”” approach was employed for the synthesis of CDK9-targeting PROTACs. The results of western blotting assays showed that compounds containing triazole group in the linker could selectively downregulate the intracellular CDK9 level. Among these compounds, 11c could selectively degrade CDK9 in a concentration-dependent manner. In addition, the application of the proteasome inhibitor MG132 and CRBN siRNA silencing confirmed that 11c could promote the proteasome-dependent and CRBN-dependent degradation Consistent with the degradation of the CDK9 protein, 11c selectively inhibits proliferation of CDK9-overexpressed cancer cells. Thus, our Wogonin-based PROTAC would be an efficient probe that induces the degradation of CDK9. The results came from multiple reactions, including the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Application of 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Application of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Sen; Shen, Can; Jiang, Dongsheng; Qian, Cheng; Yang, Zhongmei; Wang, Jianquan; Ye, Wei published an article in Macromolecular Bioscience. The title of the article was 《Cascade Tumor Therapy Platform for Sensitized Chemotherapy and Penetration Enhanced Photothermal Therapy》.Recommanded Product: Bromopentacarbonylmanganese(I) The author mentioned the following in the article:

As a stand-alone therapy strategy may not be sufficient for effective cancer treatment and a combination of chemotherapy with other therapies is a main trend in cancer treatment. A combination of chemotherapy and photothermal therapy (PTT) is reported here to achieve the goal of cascade multistage cancer treatment. A thermally responsive amphiphilic copolymer is designed and then a CuS nanoparticles (NPs)-based carbon monoxide (CO) photoinduced release system and doxorubicin (Dox) are encapsulated to construct the nanomedicine. The large-sized nanomedicine can accumulate in tumors after long circulation in vivo and will generate heat to act as a photothermal therapeutic agent by near IR (NIR) light. Moreover, synergically release of CO and Dox is achieved and acted as a sensitized chemotherapeutic agent. The combination of PTT and chemotherapy sensitization can effectively eliminate active tumor cells in the periphery of the tumor. CuS NPs are also released after the degradation of nanomedicine and small-sized CuS NPs possess better tumor penetration and achieve penetration-enhanced PTT by further NIR irradiation, thereby effectively eliminating tumor cells inside solid tumors. Hence, cascade multistage cancer treatment of “”combined PTT and chemotherapy sensitization””-“”penetration-enhanced PTT”” is achieved, and tumor cells are comprehensively and effectively eliminated. The results came from multiple reactions, including the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Recommanded Product: Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Recommanded Product: Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Chang-Sheng; Shao, Ya-Ping; Zhang, Fu-Min; Han, Xue; Zhang, Xiao-Ming; Zhang, Kun; Tu, Yong-Qiang published an article in Chemical Science. The title of the article was 《Cu(II)/SPDO complex catalyzed asymmetric Baeyer-Villiger oxidation of 2-arylcyclobutanones and its application for the total synthesis of eupomatilones 5 and 6》.Reference of 1-Bromo-3,4,5-trimethoxybenzene The author mentioned the following in the article:

A novel classical kinetic resolution of 2-aryl-substituted or 2,3-disubstituted cyclobutanones of Baeyer-Villiger oxidation catalyzed by a Cu(II)/SPDO complex is reported for the first time, producing normal lactones in excellent enantioselectivities (up to 96% ee) and regioselectivities (up to >20/1), along with unreacted ketones in excellent enantioselectivities (up to 99% ee). The current transformation features a wide substrate scope. Moreover, catalytic asym. total syntheses of natural eupomatilones 5 and 6 are achieved in nine steps from com. available 3-methylcyclobutan-1-one. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Reference of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Reference of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chakraborty, Mithun; Mahesh, Gaddam; Nakel, Omkar R.; Chavda, Gautamee; Anusha, Susarla; Sudhakar, Gangarajula published an article in 2021. The article was titled 《A Facile Approach to Access Multi-Substituted Indenes via Nazarov Cyclization of Aryl, Vinyl and Alkyl/Aryl Carbinols》, and you may find the article in ChemistrySelect.Related Products of 2675-79-8 The information in the text is summarized as follows:

A divergent approach to highly substituted functionalized indenes I [R1 = H, Me, Ph, etc.; R2 = H, Me; R3 = Me, Et, Ph; R4 = 6-OMe, 5,7-(OMe)2, 5,6,7-(OMe)3, etc.; R5 = CH2-CO2Et, 4-MeOC6H4, 2-FC6H4, etc.] was developed. The two-step reaction involved nucleophilic addition reaction of aryl vinyl ketone, an ideal intermediate with aryl or alkyl nucleophilic reagent, followed by electrocyclic reaction (Nazarov cyclization) in the presence of Lewis acid catalyst afforded indene derivatives I in good to excellent yield. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Related Products of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Related Products of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary