Tag: 200-300

In 2022,Abdellaoui, O.; Chraibi, M.; Skalli, M. K.; Haoudi, A.; Fikri-Benbrahim, K.; Rodi, Y. Kandri; Mazzah, A.; Senhaji, O. published an article in Asian Journal of Chemistry. The title of the article was 《Synthesis and antibacterial evaluation of three quaternary ammonium surfactants based on isatin》.Safety of 1,6-Dibromohexane The author mentioned the following in the article:

In present study, several isatin-derived quaternary ammonium surfactants I [n = 3, 6, 12] with different carbon chain lengths were designed and synthesized. They were synthesized by alkylation of indoline-2,3-dione with various dibromo-alkanes, then quaternization with trimethylamine. Further, the critical micelle concentrations (CMC) value of surfactants I synthesized was determined in an aqueous solution using elec. conductivity The synthesized surfactants I had CMC ranging from 0.01 to 0.012 mol/L. The antibacterial activity of the titer compounds I was evaluated against gram-neg. bacteria (P. aeruginosa and E. coli), as well as gram-pos. bacteria (S. aureus). The surfactant with a long hydrocarbon chain I [n = 12] showed activity against all bacteria tested (min. inhibitory concentration = 1.25-2.5 mg/mL), whereas those with a short hydrocarbon chain proved to be inactive. After reading the article, we found that the author used 1,6-Dibromohexane(cas: 629-03-8Safety of 1,6-Dibromohexane)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Safety of 1,6-Dibromohexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Sien; He, Bangyue; Li, Hongyi; Zhang, Xiaofeng; Shang, Yaping; Su, Weiping published their research in Chemistry – A European Journal in 2021. The article was titled 《Facile Synthesis of Alkylidene Phthalides by Rhodium-Catalyzed Domino C-H Acylation/Annulation of Benzamides with Aliphatic Carboxylic Acids》.Related Products of 76006-33-2 The article contains the following contents:

Facile synthesis of alkylidene phthalides I [R1 = H, Me, Ph, etc.; R2 = H, 3-Me, 3-Ph, etc.; R3 = H, Me, Et, etc.; R4 = Et, i-Pr, n-Bu, etc; R3R4 = CH2(CH2)2CH2, CH2(CH2)4CH2] by rhodium-catalyzed domino C-H acylation/annulation of benzamides with aliphatic carboxylic acids. The Rh-catalyzed ortho-C(sp2)-H functionalization of 8-aminoquinoline-derived benzamides with aliphatic acyl fluorides generated in situ from the corresponding acids was developed. This reaction initiated with 8-aminoquinoline-directed ortho-C(sp2)-H acylation, which was accompanied by subsequent intramol. nucleophilic acyl substitution of amide group to produce alkylidene phthalides. This approach exhibited high stereo-selectivity for Z-isomer products and tolerates a variety of functional groups as well as aliphatic carboxylic acids with diverse structural scaffolds. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Deoxyfluorination of Carboxylic, Sulfonic, Phosphinic Acids and Phosphine Oxides by Perfluoroalkyl Ether Carboxylic Acids Featuring CF2O Units》 was written by Zhao, Shiyu; Guo, Yong; Su, Zhaoben; Wu, Chengying; Chen, Wei; Chen, Qing-Yun. COA of Formula: C8H15BrO2 And the article was included in Chinese Journal of Chemistry in 2021. The article conveys some information:

The synthesis of acyl fluorides RCOF [R = Br(CH2)6CH2, Ph, 1-naphthyl, etc.], sulfonyl fluorides R1SO2F [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.] and phosphoric fluorides R2PO(F)R3 [R2 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R3 = Me, F, Ph, etc.] could be realized via carbonic difluoride (COF2) generated in situ from thermal degradation of the PFECA salt. The use of potassium salts of perfluoroalkyl ether carboxylic acids (PFECA) was reported featuring CF2O units as deoxyfluorination reagents, which were generated mainly as byproducts in the manufacture of hexafluoropropene oxide (HFPO). After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6COA of Formula: C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.COA of Formula: C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs》 was written by Carter, David S.; Jacobs, Robert T.; Freund, Yvonne R.; Berry, Pamela W.; Akama, Tsutomu; Easom, Eric E.; Lunde, Christopher S.; Rock, Fernando; Stefanakis, Rianna; McKerrow, James; Fischer, Chelsea; Bulman, Christina A.; Lim, Kee Chong; Suzuki, Brian M.; Tricoche, Nancy; Sakanari, Judy A.; Lustigman, Sara; Plattner, Jacob J.. Synthetic Route of C8H7BrO2 And the article was included in ACS Infectious Diseases in 2020. The article conveys some information:

The optimization of a series of benzimidazole-benzoxaborole hybrid mols. linked via a ketone that exhibit good activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness, is described. The lead identified in this series, 21 (AN15470), was found to have acceptable pharmacokinetic properties to enable an evaluation following oral dosing in an animal model of onchocerciasis. Compound 21was effective in killing worms implanted in Mongolian gerbils when dosed orally as a suspension at 100 mg/kg/day for 14 days but not when dosed orally at 100 mg/kg/day for 7 days. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Synthetic Route of C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Synthetic Route of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Stereoselective Bromoboration of Acetylene with Boron Tribromide: Preparation and Cross-Coupling Reactions of (Z)-Bromovinylboronates》 was published in Journal of Organic Chemistry in 2020. These research results belong to Polasek, Jan; Paciorek, Jan; Stosek, Jakub; Semrad, Hugo; Munzarova, Marketa; Mazal, Ctibor. Quality Control of 1-Bromo-3,4,5-trimethoxybenzene The article mentions the following:

The mechanism of acetylene bromoboration in neat boron tribromide was studied carefully by means of experiment and theory. Besides the syn-addition mechanism through a four-center transition state, radical and polar anti-addition mechanisms are postulated, both triggered by HBr, which is evidenced also to take part in the Z/E isomerization of the product. The proposed mechanism is well supported by ab initio calculations at the MP2/6-31+G* level with Ahlrichs’ SVP all-electron basis for Br. Implicit solvation in CH2Cl2 has been included using the PCM and/or SMD continuum solvent models. Comparative case studies have been performed involving the B3LYP/6-31+G* with Ahlrichs’ SVP for Br and MP2/Def2TZVPP levels. The mechanistic studies resulted in development of a procedure for stereoselective bromoboration of acetylene yielding E/Z mixtures of dibromo(bromovinyl)borane (I) with the Z-isomer as a major product (up to 85%). Transformation to the corresponding pinacol and neopentyl glycol boronates and stereoselective decomposition of their E-isomer provided pure (Z)-(2-bromovinyl)boronates in 57-60% overall yield. Their reactivity in a Negishi cross-coupling reaction was tested. An example of the one-pot reaction sequence of Negishi and Suzuki-Miyaura cross-couplings for synthesis of combretastatin A4 is also presented. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Quality Control of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Quality Control of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Lin, Lucy; Olson, Margaret E.; Sugane, Takashi; Turner, Lewis D.; Tararina, Margarita A.; Nielsen, Alexander L.; Kurbanov, Elbek K.; Pellett, Sabine; Johnson, Eric A.; Cohen, Seth M.; Allen, Karen N.; Janda, Kim D.. Reference of 8-Bromooctanoic acid The article mentions the following:

Botulinum neurotoxins have remarkable persistence (~weeks to months in cells), outlasting the small-mol. inhibitors designed to target them. To address this disconnect, inhibitors bearing two pharmacophores-a zinc binding group and a Cys-reactive warhead-were designed to leverage both affinity and reactivity. A series of first-generation bifunctional inhibitors was achieved through structure-based inhibitor design. Through X-ray crystallog., engagement of both the catalytic Zn2+ and Cys165 was confirmed. A second-generation series improved on affinity by incorporating known reversible inhibitor pharmacophores; the mechanism was confirmed by exhaustive dialysis, mass spectrometry, and in vitro evaluation against the C165S mutant. Finally, a third-generation inhibitor was shown to have good cellular activity and low toxicity. In addition to our findings, an alternative method of modeling time-dependent inhibition that simplifies assay setup and allows comparison of inhibition models is discussed. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Reference of 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Reference of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Pd/C as Heterogeneous Catalyst for the Direct Arylation of (Poly)fluorobenzenes》 were Mao, Shuxin; Shi, Xinzhe; Soule, Jean-Francois; Doucet, Henri. And the article was published in Chemistry – A European Journal in 2019. Synthetic Route of C7H4BrF3 The author mentioned the following in the article:

The potential of the heterogeneous catalyst 10 % Pd/C in the direct arylation of (poly)fluorobenzene derivatives with aryl bromides has been investigated. In general, high yields of biaryl derivatives were obtained by using tri-, tetra-, and pentafluorobenzenes, whereas mono- and difluorobenzenes exhibited poor reactivity. The regioselectivities of the arylation reactions were similar to those observed with homogeneous palladium catalysts. Both electron-withdrawing and -donating substituents, such as nitrile, nitro, acetyl, ester, trifluoromethyl, tert-Bu, methoxy, or Me, on the aryl bromide were tolerated. Unexpectedly, tetrafluoro-substituted [1,1′-biphenyl]-4-ols were obtained from pentafluorobenzene at 150° due to a formal regioselective hydroxylation, whereas at lower temperatures the expected pentafluorobiphenyls were obtained. However, no C-F bond cleavage was observed with the other polyfluorobenzene derivatives These arylation reactions were carried out with only 1 mol % Pd/C as the catalyst and KOAc as an inexpensive base. Therefore, this protocol represents a very attractive access to (poly)fluoro-substituted biphenyls in terms of cost, simplicity, and sustainable chem. because the Pd/C catalyst can be easily removed at the end of the reaction, there is no contamination with phosphine ligand residues, and the major side-product of the reaction is KOAc.HBr. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Synthetic Route of C7H4BrF3)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Synthetic Route of C7H4BrF3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Pillar[5]arene-Based Resilient Supramolecular Gel with Dual-Stimuli Responses and Self-Healing Properties》 were Chen, Jin-Fa; Chen, Pangkuan. And the article was published in ACS Applied Polymer Materials in 2019. Application of 629-03-8 The author mentioned the following in the article:

Pillararene-based supramol. gels represent a new type of soft matter due to the dynamic assembly and promising applications in biomaterials. However, few examples of these gel materials were previously reported on their remarkable elasticity and self-healing properties. To address this issue, we herein demonstrated a novel pillar[5]arene-based fluorescent supramol. gel by using the two cooperative interactions. In our work, the host-guest complexation led first to the formation of a pillararene-based supramol., which was further polymerized with the monomer via UV initiation, resulting in strong cross-links for the gelation of this supramol. system. The dynamic host-guest recognition enabled a quick self-healing process of the gel. In addition, this supramol. gel also exhibits dual-stimuli responsive behaviors. We expect the current investigation to afford another avenue to robust bioinspired soft materials with macrocyclic functionality involved in the polymeric networks. In the part of experimental materials, we found many familiar compounds, such as 1,6-Dibromohexane(cas: 629-03-8Application of 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.Application of 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A Photostable AIEgen for Specific and Real-time Monitoring of Lysosomal Processes》 were Zhang, Weijie; Zhou, Fan; Wang, Zhiming; Zhao, Zujin; Qin, Anjun; Tang, Ben Zhong. And the article was published in Chemistry – An Asian Journal in 2019. Application In Synthesis of 1,6-Dibromohexane The author mentioned the following in the article:

Lysosomes are recognized as advanced organelles involved in many cellular processes and are also considered as crucial regulators of cell homeostasis. The current strategies for monitoring activities of lysosomes exhibit some limitations. Herein, the authors synthesized a novel fluorescent probe named 2M-DPAS with AIE characteristics, which has significant advantages of good biocompatibility, high selectivity, bright emission and excellent photostability. Based on those, 2M-DPAS can be used to continuously monitor the dynamic changes of lysosomes, including autophagy and mitophagy, as well as to track the process of endocytosis of macromols. in lysosomes, which are of benefit to better know about the lysosomes-related diseases. The experimental process involved the reaction of 1,6-Dibromohexane(cas: 629-03-8Application In Synthesis of 1,6-Dibromohexane)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.Application In Synthesis of 1,6-Dibromohexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Bioorganic Chemistry included an article by Karamitri, Angeliki; Sadek, Mirna S.; Journe, Anne-Sophie; Gbahou, Florence; Gerbier, Romain; Osman, Mai B.; Habib, Samy A. M.; Jockers, Ralf; Zlotos, Darius P.. Recommanded Product: 14660-52-7. The article was titled 《O-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors》. The information in the text is summarized as follows:

A series of dimeric melatonin analogs 3a-e obtained by connecting two melatonin mols. through the methoxy oxygen atoms with spacers spanning 16-24 atoms and the agomelatine dimer 7 were synthesized and characterized in 2-[125-I]-iodomelatonin binding assays, bioluminescence resonance energy transfer (BRET) experiments, and in functional cAMP and β-arrestin recruitment assays at MT1 and MT2 receptors. The binding affinity of 3a-e generally increased with increasing linker length. Bivalent ligands 3a-e increased BRET signals of MT1 dimers up to 3-fold compared to the monomeric control ligand indicating the simultaneous binding of the two pharmacophores to dimeric receptors. Bivalent ligands 3c and 7 exhibited important changes in functional properties on the Gi/cAMP pathway but not on the β-arrestin pathway compared to their monomeric counterparts. Interestingly, 3c (20 atoms spacer) shows inverse agonistic properties at MT2 on the Gi/cAMP pathway. In conclusion, these findings indicate that O-linked melatonin dimers are promising tools to develop signaling pathway-based bivalent melatonin receptor ligands. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary