Tag: 200-300

In 2018,Bioconjugate Chemistry included an article by Veerapen, Natacha; Kharkwal, Shalu Sharma; Jervis, Peter; Bhowruth, Veemal; Besra, Amareeta K.; North, Simon J.; Haslam, Stuart M.; Dell, Anne; Hobrath, Judith; Quaid, Padraic J.; Moynihan, Patrick J.; Cox, Liam R.; Kharkwal, Himanshu; Zauderer, Maurice; Besra, Gurdyal S.; Porcelli, Steven A.. HPLC of Formula: 17696-11-6. The article was titled 《Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation》. The information in the text is summarized as follows:

Activation of invariant natural killer T lymphocytes (iNKT cells) by α-galactosylceramide (α-GC) elicits a range of pro-inflammatory or anti-inflammatory immune responses. We report the synthesis and characterization of a series of α-GC analogs with acyl chains of varying length and a terminal benzophenone. These bound efficiently to the glycolipid antigen presenting protein CD1d, and upon photoactivation formed stable CD1d-glycolipid covalent conjugates. Conjugates of benzophenone α-GCs with soluble or cell-bound CD1d proteins retained potent iNKT cell activating properties, with biol. effects that were modulated by acyl chain length and the resulting affinities of conjugates for iNKT cell antigen receptors. Anal. by mass spectrometry identified a unique covalent attachment site for the glycolipid ligands in the hydrophobic ligand binding pocket of CD1d. The creation of covalent conjugates of CD1d with α-GC provides a new tool for probing the biol. of glycolipid antigen presentation, as well as opportunities for developing effective immunotherapeutics. In the experiment, the researchers used many compounds, for example, 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.HPLC of Formula: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Organometallics included an article by Martinez, Gabriel Espinosa; Nugent, Joseph W.; Fout, Alison R.. Category: bromides-buliding-blocks. The article was titled 《Simple Nickel Salts for the Amination of (Hetero)aryl Bromides and Iodides with Lithium Bis(trimethylsilyl)amide》. The information in the text is summarized as follows:

Recent developments in the chem. of C-N bond formation and the synthesis of anilines have allowed for the use of 1st-row transition metals to catalyze these transformations. Much of the progress in this area was driven by comprehensive screening for privileged/tailored ligands, which can be costly and not readily available in a research laboratory setting. The authors report a protocol in which simple Ni salts catalyze the C-N cross-coupling reaction between (hetero)aryl bromides and iodides with Li bis(trimethylsilyl)amide without the need for any additive ligand. This method is amenable to low Ni catalyst loadings (1%) as well as gram-scale reactions. Because of the good functional group tolerance and compatibility with heterocyclic moieties, this method is useful for academic laboratory settings where access to tailored ligands and noble-metal catalysts could be challenging. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Category: bromides-buliding-blocks)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 5437-45-6In 2021 ,《Enantioselective Rauhut-Currier Reaction with β-Substituted Acrylamides Catalyzed by N-Heterocyclic Carbenes》 appeared in Organic Letters. The author of the article were Pitchumani, Venkatachalam; Breugst, Martin; Lupton, David W.. The article conveys some information:

β-Substituted acrylamides have low electrophilicity and are yet to be exploited in the enantioselective Rauhut-Currier reaction. Exploiting electron-withdrawing protection of the amide, and moderate nucleophilicity N-heterocyclic carbenes (NHCs), such substrates have been converted to enantioenriched quinolones. The reaction proceeds with complete diastereoselectivity, good yield, and modest enantioselectivity. Derivatizations are reported, as are computational studies, supporting decreased amide bond character with electron-withdrawing protection of the nitrogen. The experimental part of the paper was very detailed, including the reaction process of Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Application of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 76006-33-2In 2020 ,《Nickel-catalyzed dual C(sp2)-H activation of arenes: a new route to diaryl ethers》 appeared in Organic Chemistry Frontiers. The author of the article were Lv, Ningning; Chen, Zhengkai; Yu, Shuling; Liu, Zhanxiang; Zhang, Yuhong. The article conveys some information:

Diaryl ethers were synthesized directly from simple arenes for the first time through dual C(sp2)-H activation with the aid of a bidentate auxiliary by nickel catalysis. The anion of the additive is crucial to the transformation, and the control experiments revealed that the acyloxylated benzamide was the key intermediate. The results came from multiple reactions, including the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Li, Wanjiang; Chen, Longbin; Dong, Jiao; Feng, Yancong; Wang, Yao; Li, Hao; Zhou, Guofu published an article in ACS Applied Polymer Materials. The title of the article was 《Water- and Heat-Induced Crack-Healing of UCST-Type Poly(acrylamide-co-acrylonitrile) with Intrinsic Controllability and Reversibility》.Application of 623-24-5 The author mentioned the following in the article:

Autonomic crack-healing technol. has become a common option for reconstructing polymer networks against mech. degradation, structure mismatch, material fatigue, and even performance failure, but how to precisely and easily trigger this healing process on the crack interfaces is still a huge challenge. Here, we first found an autonomic physicochem. crack-healing behavior featuring intrinsic controllability and reversibility, based on nonionic poly(acrylamide-co-acrylonitrile) [P(AAm-co-AN)] with an upper critical solution temperature (UCST). Under the fast synergistic action between extrinsic deionized water and heat, the scratched P(AAm-co-AN) layer fully returned to the original flat form and was reworked at least five times. Meanwhile, their corresponding optical and mech. performances also recovered almost 100%. In particular, the intrinsic thermoresponsiveness of P(AAm-co-AN) takes a leading role in this crack-healing process, in which both interchain transition and topol. entanglement come into play. It provides a facile, rapid, precise, green, and autonomic crack-healing strategy for improving polymer durability. The results came from multiple reactions, including the reaction of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application of 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Application of 623-24-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Liyan; Jin, Tengda; Guo, Yingjie; Martin, A. C.; Sun, Keju; Dudley, Gregory B.; Yang, Jingyue published an article in 2021. The article was titled 《Synthesis of gem-Dimethylcyclopentane-Fused Arenes with Various Topologies via TBD-Mediated Dehydro-Diels-Alder Reaction》, and you may find the article in Journal of Organic Chemistry.Reference of 2,5-Dibromothiophene The information in the text is summarized as follows:

The development of efficient methods for the synthesis of substituted polycyclic arenes with various topologies is in high demand due to their excellent elec. and optical properties. In this work, a series of gem-dimethylcyclopentane-fused arenes with more than ten topologies were synthesized via a 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)-mediated dehydro-Diels-Alder reaction with moderate to good yields. The introduction of the near-planar gem-dimethylcyclopentane moiety not only impacts the mol. conjugative system but also regulates the intermol. π-π interactions and crystal packing, which are critical for the photoelec. performance of arenes. The photophys. properties, mol. geometry, mol. packing of these compounds, and electrochem. properties were investigated by UV-vis absorption, fluorescence emission spectra, DFT calculations, single-crystal X-ray structure anal., and cyclic voltammetry study. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Reference of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.Reference of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pu, Mingrui; Chen, Hui; Chao, Pengjie; Zhu, Yulin; Zheng, Nan; Lai, Hanjian; Zhao, Tingxing; He, Feng published their research in ACS Applied Polymer Materials in 2021. The article was titled 《Chlorinated Random Terpolymers with Efficient Solar Conversion and Low Batch-to-Batch Variation》.Electric Literature of C4H2Br2S The article contains the following contents:

The strategy of random terpolymn. has been shown to be a flexible and effective method with which to construct state-of-the-art polymer donors, and chlorination has frequently been utilized to fine-tune material properties in these polymers with the aim of improving the solar conversion efficiency. Herein, three random terpolymers consisting of BDT, BDD, and Th-Cl monomers in the optimized ratio of 1:0.85:0.15 were synthesized in parallel in an effort to understand the effect of chlorination in terpolymer systems and the chlorine-containing derviatives (named PBDB-Th15, PBDB-ThCl15, and PBDB-Th2Cl15). Among these three polymers, PBDB-ThCl15 shows a low-lying HOMO level, the most balanced hole and electron mobility, and enhanced aggregation behavior in blend film as a result of the introduction of one chlorine atom. When blended with a small mol. acceptor Y6, the resulting PBDB-ThCl15:Y6-based device showed the highest PCE of 15.63% of the three polymers. The PBDB-Th15- and PBDB-Th2Cl15-based devices present relatively poor conversion efficiencies of 14.91% and 12.62%. Interestingly, the terpolymer PBDB-ThCl15 was repeatedly prepared by random terpolymn. under the same conditions, and a low batch-to-batch variation was observed with a PCE of 1̃5.50%. These results indicate that the synergy of chlorination with random terpolymn. promises to contribute to the preparation of stable and high-performance solar cell polymers. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Electric Literature of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Electric Literature of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Chang-Cheng; Zhang, Guo-Xiang; Zuo, Zhi-Wei; Zeng, Rong; Zhai, Dan-Dan; Liu, Feng; Shi, Zhang-Jie published their research in Science China: Chemistry in 2021. The article was titled 《Photo-induced deep aerobic oxidation of alkyl aromatics》.Synthetic Route of C7H5BrO2 The article contains the following contents:

In this report, e.g., photo-induced deep aerobic oxidation of (poly)alkyl benzene toluene to benzene (poly)carboxylic acids e.g., benzoic acid was developed. CeCl3 was proved to be an efficient HAT (hydrogen atom transfer) catalyst in the presence of alc. as both hydrogen and electron shuttle. Dioxygen (O2) was found as a sole terminal oxidant. In most cases, pure products were easily isolated by simple filtration, implying large-scale implementation advantages. The reaction provides an ideal protocol to produce valuable fine chems. from naturally abundant petroleum feedstocks. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Guang-Ya; Ruan, Sun-Hong; Li, Yan-Yun; Gao, Jing-Xing published their research in Chinese Chemical Letters in 2021. The article was titled 《Manganese catalyzed asymmetric transfer hydrogenation of ketones》.Safety of Bromopentacarbonylmanganese(I) The article contains the following contents:

The asym. transfer hydrogenation (ATH) of a wide range of ketones catalyzed by manganese complex as well as chiral PxNy-type ligand under mild conditions was investigated. Using 2-propanol as hydrogen source, various ketones could be enantioselectively hydrogenated by combining cheap, readily available [MnBr(CO)5] with chiral, 22-membered macrocyclic ligand (R,R,R’,R’)-CyP2N4 I with 2 mol% of catalyst loading, affording highly valuable chiral alcs. with up to 95% ee. The results came from multiple reactions, including the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Safety of Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Safety of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Alkynyl-functionalized chain-extended PCL for coupling to biological molecules》 was published in European Polymer Journal in 2020. These research results belong to Izraylit, Victor; Hommes-Schattmann, Paul J.; Neffe, Axel T.; Gould, Oliver E. C.; Lendlein, Andreas. Computed Properties of C8H15BrO2 The article mentions the following:

Chem. functionalization of poly(ε-caprolactone) (PCL) enables a mol. integration of addnl. function. Here, the authors report an approach to incorporate reactive alkynyl side-groups by synthesizing a chain-extended PCL, where the reactive site is introduced through the covalently functionalizable chain extender 3-(prop-2-yn-1-yloxy)propane-1,2-diol (YPD). Chain-extended PCL with Mw of 101 to 385 kg·mol-1 were successfully synthesized in a one-pot reaction from PCL-diols with various molar masses, L-lysine Et ester diisocyanate (LDI) or trimethyl(hexamethylene)diisocyanate (TMDI), and YPD, in which the d. of functionalizable groups and spacing between them can be controlled by the composition of the polymer. The employed diisocyanate compounds and YPD possess an asym. structure and form a non-crystallizable segment leaving the PCL crystallites to dominate the material′s mech. properties. The mixed glass transition temperature Tg = -60 to -46° of the PCL/polyurethane amorphous phase maintains the synthesized materials in a highly elastic state at ambient and physiol. conditions. Reaction conditions for covalent attachment in copper(I)-catalyzed azide-alkyne-cycloaddition reactions (CuAAC) in solution were optimized in a series of model reactions between the alkyne moieties of the chain-extended PCL and benzyl azide, reaching conversions over 95% of the alkyne moieties and with yields of up to 94% for the purified functionalized PCL. This methodol. was applied for reaction with the azide-functionalized cell adhesion peptide GRGDS. The required modification of the peptide provides selectivity in the coupling reactions. The obtained results suggest that YPD could potentially be employed as versatile mol. unit for the creation of a variety of functionalizable polyesters as well as polyurethanes and polycarbonates offering efficient and selective click-reactions. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6Computed Properties of C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Computed Properties of C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary