Tag: 200-300

In 2019,Reactive & Functional Polymers included an article by Zhang, Shuai; Zhu, Xiuling; Jin, Cuihong; Hu, Huilan. HPLC of Formula: 629-03-8. The article was titled 《Pyridinium-functionalized crosslinked anion exchange membrane based on multication side chain tethered elastomeric triblock poly(styrene-b-(ethylene-co-butylene)-b-styrene)》. The information in the text is summarized as follows:

Hydroxide ion conductivity and long-term chem. stability play an important role in the development of anion exchange membranes (AEMs) for application of alk. anion exchange membrane fuel cells (AAEMFCs). Herein, the high alk. stable elastomeric triblock copolymer, poly(styrene-b-(ethylene-co-butylene)-b-styrene) (SEBS) with pendent multi-cation side chain and 4,4-bipyridine was develop for AEMs. The three cations in a side chain were tethered to the SEBS backbone and the length of the spacer between cations was six methylene (-CH2-) groups (TNQN). More importantly, the 4,4-bipridine was introduced to the membranes as the crosslinker and functional groups, which exhibited the significant improvement in hydroxide ion conductivity of the membranes. The hydroxide conductivity of the cross-linked quaternized SEBS (TNQN-SEBS-Bpy) membranes was 30.41-69.04 mS·cm-1 from 30°C to 80°C, which could be ascribed to well micromorphol. and more functional groups. Compared to the uncross-linked TNQN-SEBS, the TNQN-SEBS-Bpy membranes showed higher mech. property and thermal stability. All the membranes exhibited good alk. stability which the hydroxide conductivity maintained above 90% of the original ionic conductivity after 300 h of alk. treatment (1 M aqueous NaOH) at 80°C. Based on these outstanding properties, the cross-linked membranes show great potential application as alk. anion exchange membranes. In the experimental materials used by the author, we found 1,6-Dibromohexane(cas: 629-03-8HPLC of Formula: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.HPLC of Formula: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Medicinal Chemistry included an article by Lee, Taekyu; Christov, Plamen P.; Shaw, Subrata; Tarr, James C.; Zhao, Bin; Veerasamy, Nagarathanam; Jeon, Kyu Ok; Mills, Jonathan J.; Bian, Zhiguo; Sensintaffar, John L.; Arnold, Allison L.; Fogarty, Stuart A.; Perry, Evan; Ramsey, Haley E.; Cook, Rebecca S.; Hollingshead, Melinda; Davis Millin, Myrtle; Lee, Kyung-min; Koss, Brian; Budhraja, Amit; Opferman, Joseph T.; Kim, Kwangho; Arteaga, Carlos L.; Moore, William J.; Olejniczak, Edward T.; Savona, Michael R.; Fesik, Stephen W.. Application of 1129-28-8. The article was titled 《Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer》. The information in the text is summarized as follows:

Overexpression of myeloid cell leukemia-1 (Mcl-1) in cancers correlates with high tumor grade and poor survival. Addnl., Mcl-1 drives intrinsic and acquired resistance to many cancer therapeutics, including B cell lymphoma 2 family inhibitors, proteasome inhibitors, and antitubulins. Therefore, Mcl-1 inhibition could serve as a strategy to target cancers that require Mcl-1 to evade apoptosis. Herein, we describe the use of structure-based design to discover a novel compound (42) that robustly and specifically inhibits Mcl-1 in cell culture and animal xenograft models. Compound 42 binds to Mcl-1 with picomolar affinity and inhibited growth of Mcl-1-dependent tumor cell lines in the nanomolar range. Compound 42 also inhibited the growth of hematol. and triple neg. breast cancer xenografts at well-tolerated doses. These findings highlight the use of structure-based design to identify small mol. Mcl-1 inhibitors and support the use of 42 as a potential treatment strategy to block Mcl-1 activity and induce apoptosis in Mcl-1-dependent cancers. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 1129-28-8 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ChemistrySelect included an article by de Oliveira, Adeildo Junior; Souza, Isis Torres; Bernardo, Vanderson Barbosa; Santos, Larissa C.; de Lima, Maria Raquel Ferreira; Goulart, Henrique Fonseca; Goulart Santana, Antonio Euzebio. Formula: C6H12Br2. The article was titled 《Monobromination of α,ω-Diols: Highly Efficient Preparation of Synthetic Intermediates》. The information in the text is summarized as follows:

The present work aimed to evaluate different conditions to perform monobromination reactions of α,ω-diols HOCH2(CH2)nCH2OH (n = 4, 5, 6, 8) using HBr. Three solvents such as, toluene, isooctane, 1,2-dichloroethane were tested in two distinct molar proportions between 1,8-octanediol and HBr (1:1 and 1:2 equiv). All reactions occurred under reflux. After establishing the best reactional conditions, assays with four sym. α,ω-diols, 1,6-hexanediol; 1,7-heptanediol; 1,8-octanediol; and 1,10-decanediol, with 2 equivalent HBr in 1,2-dichloroethane, were conducted. Using toluene as solvent lead to the best reaction yields (81-95%), producing the least amount of unwanted dibrominated product BrCH2(CH2)nCH2Br. Reactions in 1,2-dichloroethane gave similar results to the ones with toluene when 2 equivalent HBr were used. The lowest reactional efficiency registered in these assays occurred in isooctane, forming the highest amount of dibromide. Diols 1,7-heptanediol and 1,8-octanediol showed the best results under the conditions studied, in 1,2-dichloroethane. In the experiment, the researchers used many compounds, for example, 1,6-Dibromohexane(cas: 629-03-8Formula: C6H12Br2)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Formula: C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Basak, Akash; Abouelhassan, Yasmeen; Norwood, Verrill M. IV; Bai, Fang; Nguyen, Minh Thu; Jin, Shouguang; Huigens, Robert W. III published 《Synthetically Tuning the 2-Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways》.Chemistry – A European Journal published the findings.Synthetic Route of C6H5Br2N The information in the text is summarized as follows:

Agents capable of eradicating bacterial biofilms are of great importance to human health as biofilm-associated infections are tolerant to our current antibiotic therapies. We have recently discovered that halogenated quinoline (HQ) small mols. are: (1) capable of eradicating methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE) and vancomycin-resistant Enterococcus faecium (VRE) biofilms, and (2) synthetic tuning of the 2-position of the HQ scaffold has a significant impact on antibacterial and antibiofilm activities. Here, we report the chem. synthesis and biol. evaluation of 39 HQ analogs that have a high degree of structural diversity at the 2-position. We identified diverse analogs that are alkylated and aminated at the 2-position of the HQ scaffold and demonstrate potent antibacterial (MIC≤0.39 μM) and biofilm eradication (MBEC 1.0-93.8 μM) activities against drug-resistant Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecium strains while demonstrating <5 % haemolysis activity against human red blood cells (RBCs) at 200 μM. In addition, these HQs demonstrated low cytotoxicity against HeLa cells. Halogenated quinolines are a promising class of antibiofilm agents against Gram-pos. pathogens that could lead to useful treatments against persistent bacterial infections. In the experiment, the researchers used many compounds, for example, 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Quan; Snider, Barry B. published their research in Journal of Organic Chemistry on December 3 ,2010. The article was titled 《Synthesis of Hexacyclic Parnafungin A and C Models》.Category: bromides-buliding-blocks The article contains the following contents:

Unstable hexacyclic parnafungin A and C models isoxazolophenanthridones I (R = R1 = H; R = MeO, R1 = H; R = H, R1 = MeO) and benzopyranoisoxazolophenanthridinediones II (R2 = H, Me) were prepared using Suzuki coupling reactions, reductive cyclizations of o-nitrobenzoates to benzisoxazolones and the cyclocondensations of hydroxymethylarylbenzisoxazolones to fused isoxazoloquinolines as key steps. Iodoxanthones III (R2 = H, Me) were prepared in four or five steps and 33-50% overall yields from Me salicylate and either 5-Me or 5-(hydroxymethyl)resorcinol; Suzuki-Miyaura coupling of III (R2 = H, Me) with an excess of readily available 3-carbomethoxy-2-nitrophenyl pinacolboronate (prepared in three steps from 3-methyl-2-nitro-1-bromobenzene) afforded the hindered highly functionalized (methoxycarbonyl)nitrophenyl-substituted xanthones in 53-58% yields. Zinc reduction of the (methoxycarbonyl)nitrophenyl-substituted xanthones gave benzisoxazolinones that were treated with MsCl and then with base to generate the unstable hexacyclic parnafungin A and C models II (R = H) and II (R = Me) in 13% overall yield for 8 steps and in 8% overall yield for 9 steps, resp. Analogously to the parnafungins, II (R2 = Me) decomposes to a phenanthridine with a half-life of 2 d in CDCl3. The experimental part of the paper was very detailed, including the reaction process of 3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4Category: bromides-buliding-blocks)

3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of steroid analogs of tubuloclustin, their cytotoxicity and effect on microtubules of A549 carcinoma cells》 was written by Nurieva, E. V.; Zefirov, N. A.; Mamaeva, A. V.; Wobith, B.; Kuznetsov, S. A.; Zefirova, O. N.. Reference of 8-Bromooctanoic acidThis research focused ontubuloclustin methoxyestradiol analog preparation antitumor microtubule lung carcinoma. The article conveys some information:

Synthesis of analogs of tubuloclustin (N-(7-adamant-2-yloxy-7-oxoheptanoyl)-N-deacetylcolchicine ) with the colchicine fragment replaced with 2-methoxyestradiol scaffold attached via phenolic hydroxy group was described. Esters 3a-c exhibit moderate cytotoxicity (EC50 = 5-6 μmol L-1) and exert a weak effect on the microtubule network in A549 human lung carcinoma cells similar to the clustering effect of tubuloclustin and its derivatives Conjugates 6a-c and 7a-c with the phenolic ester bond are low stable and compounds 7a-c are inactive to the microtubules of A549 cells, while compounds 6a-c cause an unusual effect of curling of the microtubules. In the experimental materials used by the author, we found 8-Bromooctanoic acid(cas: 17696-11-6Reference of 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Reference of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Catalytic impact of twin headed geminis in study of ninhydrin with aspartic acid in an acetate buffer system》 was written by Kumar, Dileep; Rub, Malik Abdul; Bhattarai, Ajaya. SDS of cas: 629-03-8This research focused ontwin headed gemini surfactant ninhydrin aspartic acid reaction kinetics; Ruhemann’s purple. The article conveys some information:

Herein, catalytic impact of aqueous-micellar solution of twin headed 16-s-16 (s = spacer) gemini surfactants (GS) was measured in the study of ninhydrin (nin) with aspartic (Asp) amino acid. The study was performed over the different range of reactants’ concentration, temperature and pH. Reaction obeyed the order to be resp. fractional and unity in [nin] and [Asp]. The values of several quantities, viz., critical micellar concentration (cmc), thermodn. parameters, and binding parameters were calculated and described herewith. The exptl. outcomes depict that the reaction is catalyzed, significantly, by twin headed gemini surfactants and follow the order at all concentration as: GS-4 > GS-5 > GS-6. In the rate constant (kψ) vs. [GS] rate profiles, kψ intensifies even at below cmc values of surfactants (region I), and previously observe practically unchanged behavior (region II). Finally, a fast changes in kψ is detected (region III). Catalytic impact of twin headed GS achieved in this study is deduced by using a model called as micellar pseudo-phase in which rate constant depends on both the reactants. The numerous kinetic constants in twin headed geminis were evaluated and elaborated. An acceptable mechanism reliable with kinetics comprising the development of Ruhemanns’ purple between nin and Asp has been proposed. The experimental part of the paper was very detailed, including the reaction process of 1,6-Dibromohexane(cas: 629-03-8SDS of cas: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.SDS of cas: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C9H11BrO3In 2021 ,《Synthesis of Thio-lignan Analogues, Bioequivalent Salvinal without Unfavored Aldehyde》 was published in Journal of Organic Chemistry. The article was written by Saito, Yohei; Kobayashi, Yukiko; Yoshida, Nanami; Goto, Masuo; Nakagawa-Goto, Kyoko. The article contains the following contents:

The oxygen in the benzofuran (BF) of three antiproliferative natural neolignans, salvinal, obovaten, and 2-[7-methoxy-2-(4-methoxyphenyl)-3-methylbenzofuran-5-yl]ethanol, was replaced with sulfur to form the new biol. scaffold benzothiophene (BT) thio-lignans. The synthesized derivatives were evaluated for antiproliferative activity against five human cancer cell lines, including a multidrug-resistant cell line. Thio-salvinal displayed significant antiproliferative effects with half-maximal inhibitory concentration (IC50) values of 0.57-0.95μM against all tested cell lines, except for the HER2 neg. breast cancer cell line MCF-7. This thio-lignan was 6.5-9.4 times more potent than the parent. However, the related thio-lignans showed much weaker antiproliferative effects and were less potent than the parent natural benzofuran lignans. Newly synthesized thio-lignan I affected cell cycle progression at 24 and 48 h in the G2/M transition and S phase, resp., as well as promoted sub-G1 induction by stimulating microtubule depolymerization and nuclear fragmentation. Since a highly reactive aldehyde in salvinal is generally not appropriate for drug development, we have successfully found nonaldehyde derivative I showing biol. activity similar to salvinal by replacing BF with BT and an aldehyde with 1,3-dioxolane. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Synthetic Route of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Synthetic Route of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fischer, H.; Ernst, Paul published an article in 1926, the title of the article was Halogen-substituted pyrroles. IV. New preparation of pyrrole-α-aldehydes and stable tripyrrylmethanes.Formula: C7H8BrNO And the article contains the following content:

2,4-Dimethyl-5-carbethoxypyrrole and Br in CCl4 give nearly quant. the 3-Br derivative (IV), m. 150°, which, on further bromination, gives 85% of 2-bromomethyl-3-bromo-4-methyl-5-carbethoxypyrrole (V), decomposing 165-7°. The free acid (VI) from IV treated with 3 mols. Br in a little CCl4 gives [2,4-dimethyl-3-bromopyrryl][2,4-dibromo-3-methylpyrryl]methene, dark red, m. 192°. VI (5 g.), through the Gattermann aldehyde synthesis, gives 1 g. 2,4-dimethyl-3-bromo-5-formylpyrrole (VII), m. 166-7° (decomposition) (phenylhydrazone, decomposes 99-100°; semicarbazone, m. 223-4° (decomposition)). VII, warmed with EtOH-HCl, gives bis-[2,4-dimethyl-3-bromopyrrole-5]-methene, decomposes 187°. All attempts to prepare the corresponding alc. from V by heating with H2O failed. With AcOK there results quant. 2-acetoxymethyl-3-bromo-4-methyl-5-carbethoxypyrrole, m. 107-9°; the Ehrlich reaction is negative. The corresponding 2-chloroacetoxymethyl derivative, m. 150-3°, decomposes 172°; the 2-formoxymethyl derivative, m. 146-8° (decomposition). 2-Anilinomethyl derivative, m. 128-9° (50-60% yield); dehydration with KMnO4 in Me2CO-H2O gives 70% of the Schiff base, C15H15O2N2Br, m. 127-8°, which is catalytically reduced to the anilide and adds HCl, giving the compound C15H16O2N2BrCl, decomposes 216°. In boiling H2O containing the calculated amount of HCl, the base gives 70% of 2-carbethoxy-3-methyl-4-bromo-5-formylpyrrole (VIII), m. 134-6° (phenylhydrazone, m. 144°; oxime, m. 155-6°; semicarbazone, decomposes 260°). The free acid has no characteristic decomposition point, gives a positive Ehrlich reaction in the hot and on boiling with concentrated HCl gives a violet-red color. The Schiff base, C13H20O4N2, m. 82°, from 2-anilinomethyl-4-methyl-3,5-dicarbethoxypyrrole, gives 2-formyl-4-methyl-3,5-dicarbethoxypyrrole (IX), m. 124°; 1 l. boiling H2O dissolves 0.65 g.; it reduces NH4OH-AgNO3 but not Fehling solution; 1 g. in EtONa (1 g. Na and 10 cc. EtOH) gives 2-formyl-3-carbethoxy-4-methyl-5-pyrrolecarboxylic acid, decomposing 195°; 1 l. boiling H2O dissolves 6.5 g. Excess alkali gives 2-formyl-4-methylpyrrole-3,5-dicarboxylic acid, does not decompose at 250°. 2-Anilinomethyl-3-carbethoxy-4-methyl-5-pyrrolecarboxylic acid, decomposes 186°; dry distillation gives a non-crystalline oil, giving positive PhNH2 and Ehrlich aldehyde reactions. 2-Anilinomethyl-3-bromo-4-methyl-5-pyrrolecarboxylic acid, decomposes 197°. IX and 2,4-dimethyl-3-carbethoxypyrrole give [bis-(2,4-dimethyl-3-carbethoxy)]-3,5-dicarbethoxy-4-methylpyrryl-2-methane, m. 179°. The corresponding 3-Ac derivative, m. 254-5° the 5-carbethoxy derivative, m. 109-200°. VIII gives [bis-(2,4-dimethyl-3-carbethoxy)]-3-bromo-4-methyl-5-carbethoxypyrryl-2-methane, m. 227-8°. They readily take up EtOH of crystallization and are best crystallized from H2O. The AcOH solution gives a deep red color with K2Cr2O7 but does not show an absorption spectrum. Ehrlich’s reagent in the hot gives a positive reaction but is accompanied by a hydrolysis; they are stable towards concentrated HCl. Catalytic reduction of IX gives 2-hydroxymethyl-3,5-dicarbethoxy-4-methylpyrrole, m. 116°; Ac derivative, m. 113°; CrO3 oxidizes it to IX. HBr gives the 2-bromomethyl derivative, m. 156°. Upon heating, HCHO is slowly evolved with the formation of II’. Heating with pyrroles gives the corresponding methanes. 2,4-Dimethyl-3-ethyl-5-carbethoxypyrrole and Br in AcOH at 35-40° give about 75% of the 2-bromomethyl derivative, m. 132-4° (decomposition); 2-anilinomethyl derivative, m. 144-5° (40-50% yield); the Schiff base, C17H20O2N2, yellow, m. 133°; the HCl addition product, light yellow, m. 196° (decomposition); with aqueous AcONa there results a compound, m. 119-20°; boiling with a large amount of H2O gives 90% of 2-formyl-3-ethyl-4-methyl-5-carbethoxypyrrole, m. 90°; 500 g. hot H2O dissolves about 0.2 g.; oxime, m. 150°. With 2 mols. 2,4-dimethyl-3-carbethoxypyrrole in EtOH-HCl there results the HCl salt of the methene. The experimental process involved the reaction of 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde(cas: 89909-51-3).Formula: C7H8BrNO

4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde(cas:89909-51-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Formula: C7H8BrNO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Marzin, Adolf published an article in 1933, the title of the article was 2,5-Dibromotoluic acid.Computed Properties of 90326-61-7 And the article contains the following content:

2,5,4-Br2MeC6H2CO2H, m. 195°, NaOH and MeOH, refluxed 8 days, give 45-50% of 5-bromo-2-methoxy-p-toluic acid (I), m. 130-3°; with HI there is a quant. yield of 5-bromo-4-methylsalicylic acid, m. 205-8°. Oxidation of I with alk. KMnO4 gives 5-bromo-2-methoxyterephthalic acid, m. 265-8°; HI gives the 2-HO derivative, pale yellow, which gives a deep blue-red color with FeCl3. 2,5-Dibromoterephthalic acid and AcONa give about 90% of the 2,5-di-HO derivative, m. above 300°. The experimental process involved the reaction of 5-Bromo-2-methoxy-4-methylbenzoic acid(cas: 90326-61-7).Computed Properties of 90326-61-7

5-Bromo-2-methoxy-4-methylbenzoic acid(cas:90326-61-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Computed Properties of 90326-61-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary