Tag: 200-300

Ruan, Qing; Zhang, Xuran; Lin, Xiao; Duan, Xiaojiang; Zhang, Junbo published an article in 2018, the title of the article was Novel 99mTc labelled complexes with 2-nitroimidazole isocyanide: design, synthesis and evaluation as potential tumor hypoxia imaging agents.Formula: C10H8BrNO2 And the article contains the following content:

Radiolabeled 2-nitroimidazoles have been used for imaging hypoxia. With the aim of developing novel 99mTc radiotracers for imaging hypoxia, four novel 2-nitroimidazole isocyanide derivatives (2a, 2b, 2c, and 2d) were synthesized and radiolabelling was carried out for preparing their corresponding 99mTc complexes. These 99mTc complexes were stable in vitro and could exhibit good hypoxic selectivity. The partition coefficient results indicated that they were hydrophilic, and an evaluation of biodistribution in mice bearing S180 tumors indicated that all of the complexes could accumulate in the tumors. Among them, 99mTc-2c exhibited the highest tumor uptake and tumor/blood and tumor/muscle ratios at 2 h post-injection. Further, single photon emission computed tomog. (SPECT) imaging studies indicated clear accumulation in tumors, suggesting that 99mTc-2c was a promising candidate for hypoxia imaging. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Formula: C10H8BrNO2

The Article related to technetium99 isotope agent tumor hypoxia spect imaging, Placeholder for records without volume info and other aspects.Formula: C10H8BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 5, 2021, Quiroga-Campano, Cinthia; Gomez-Machuca, Horacio; Moris, Silvana; Pessoa-Mahana, Hernan; Jullian, Carolina; Saitz, Claudio published an article.Product Details of 574-98-1 The title of the article was Synthesis of calix[4]arenes bearing thiosemicarbazone moieties with naphthalene groups: Highly selective turn off/on fluorescent sensor for Cu(II) recognition.. And the article contained the following:

Calix[4]arenes-based fluorescent chemosensors containing thiosemicarbazone as a binding site and naphthalene as a fluorogenic unit in a 1,3-alternate (L1) and cone (L2) conformation, were synthesized and examined for their binding abilities towards anions and cations using different spectroscopic techniques. Both receptors L1 and L2, exhibited an off/on fluorescence behavior due to complex formation with Cu(II). They showed selective recognition of Cu(II) in presence of other cations and anions detecting up to 4.25 μg/L for L1 and 1.58 μg/L for L2, both in acetonitrile. The complexation behavior was studied by 1H NMR and FT-IR spectral anal., indicating that copper interacts with sulfur and with imine nitrogen of the thiosemicarbazone. No major differences in the selectivity and sensitivity were found between calix[4]arene receptors in 1,3-alternate and cone conformation. The 1H NMR spectra indicates that receptor L2 changed its conformation from cone to pinched cone, stiffening the conformation due to interaction of the thiosemicarbazone moiety with copper. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Product Details of 574-98-1

The Article related to calixarene fluorescent indicator copper ion, Placeholder for records without volume info and other aspects.Product Details of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On August 23, 2021, Xu, Donghan; Zhang, Cuijuan; Zhen, Yihan; Li, Yongdan published an article.Computed Properties of 574-98-1 The title of the article was Ferrocene/Phthalimide Ionic Bipolar Redox-Active Molecule for Symmetric Nonaqueous Redox Flow Batteries. And the article contained the following:

Sym. nonaqueous redox flow batteries (NARFBs) that utilize bipolar redox-active organic mols. (BROMs) provide a facile strategy to mitigate the crossover issue. However, their performance has lagged behind due to the low solubility of organic redox species and poor high-current operations. To address these tech. hurdles, a series of ionic BROMs based on ferrocene (Fc) and phthalimide (Ph) moieties with fast mass and charge-transfer kinetic are synthesized, which show high solubility and ionic conductivity Both computational and exptl. results show that the extended chain length between phthalimide moiety and quaternary nitrogen atom and the acidity of the solvent play a pivotal part in determining the stability of active materials and thus the cycling stability of NARFB. The assembled sym. NARFB shows an open-circuit voltage of 2.04 V, cycling capacity retention of 99.8% per cycle, and energy efficiency of 77.0% over 50 cycles at 20 mA cm-2. Furthermore, the battery yields a peak power d. of 110 mW cm-2 at 90 mA cm-2, which outperforms most NARFBs. This work demonstrates a promising mol. engineering strategy to improve the cycling stability of BROMs and to enable the high-current operation of sym. NARFB. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Computed Properties of 574-98-1

The Article related to ferrocene phthalimide redox flow battery, Placeholder for records without volume info and other aspects.Computed Properties of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On March 4, 2020, Liu, Bin; Pappas, Charalampos G.; Ottele, Jim; Schaeffer, Gael; Jurissek, Christoph; Pieters, Priscilla F.; Altay, Meniz; Maric, Ivana; Stuart, Marc C. A.; Otto, Sijbren published an article.HPLC of Formula: 574-98-1 The title of the article was Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids. And the article contained the following:

The conditions that led to the formation of the first organisms and the ways that life originates from a lifeless chem. soup are poorly understood. The recent hypothesis of “RNA-peptide coevolution” suggests that the current close relationship between amino acids and nucleobases may well have extended to the origin of life. We now show how the interplay between these compound classes can give rise to new self-replicating mols. using a dynamic combinatorial approach. We report two strategies for the fabrication of chimeric amino acid/nucleobase self-replicating macrocycles capable of exponential growth. The first one relies on mixing nucleobase- and peptide-based building blocks, where the ligation of these two gives rise to highly specific chimeric ring structures. The second one starts from peptide nucleic acid (PNA) building blocks in which nucleobases are already linked to amino acids from the start. While previously reported nucleic acid-based self-replicating systems rely on presynthesis of (short) oligonucleotide sequences, self-replication in the present systems start from units containing only a single nucleobase. Self-replication is accompanied by self-assembly, spontaneously giving rise to an ordered one-dimensional arrangement of nucleobase nanostructures. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).HPLC of Formula: 574-98-1

The Article related to nucleobase amino acid self replication, Placeholder for records without volume info and other aspects.HPLC of Formula: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 5, 2021, Grollier, Kevin; Chefdeville, Emmanuel; De Zordo-Banliat, Arnaud; Pegot, Bruce; Dagousset, Guillaume; Magnier, Emmanuel; Billard, Thierry published an article.HPLC of Formula: 2567-29-5 The title of the article was Fe-mediated nucleophilic trifluoromethylselenolation of activated alkyl bromides via umpolung reactivity of trifluoromethyl tolueneselenosulfinate. And the article contained the following:

Trifluoromethyl tolueneselenosulfonate is a versatile reagent which can be reduced by iron powder to generate in situ trifluoromethylselenolate anion which can then react with alkyl bromide to form (trifluoromethyl)selanes RSeCF3 [R = Bn, CH2Bn, CH2C(O)Ph, etc.] through SN2 reaction. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).HPLC of Formula: 2567-29-5

The Article related to trifluoromethyl selane preparation, alkyl bromide trifluoromethyl tolueneselenosulfinate trifluoromethylselenolation iron powder, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bian, Kang-Jie; Li, Yan; Zhang, Kai-Fan; He, Yan; Wu, Tian-Rui; Wang, Cheng-Yu; Wang, Xi-Sheng published an article in 2020, the title of the article was Iron-catalyzed remote functionalization of inert C(sp3)-H bonds of alkenes via 1,n-hydrogen-atom-transfer by C-centered radical relay.Product Details of 574-98-1 And the article contains the following content:

Enabled by 1,n (n = 5, 6)-hydrogen atom transfer (HAT), a most prevalent moiety, alkene, as the precursor to an sp3 C-centered radical to promote selective cleavage of inert C(sp3)-H bonds for the generation of azidotrifluoromethylated mols. I [R1 = Me, n-Bu, Ph, etc.; R2 = H, Me, Et, n-octyl; R1R2 = (CH2)3, (CH2)4, (CH2)2O(CH2)2, etc.; X = C(CO2Et)2, C(CH2OBz)2, NTs] was used. Mild conditions, broad scope and excellent regioselective control (>20 : 1) were observed in the reactions. Deuterium labeling studies disclosed the kinetic characteristics of the transformations and verify a direct 1,n-HAT pathway. The key to this C-centered radical relay was that iron played a dual role as a radical initiator and terminator to incorporate the azide functionality through radical oxidation via azido-ligand-transfer. The methods and the later derivatization promised expeditious synthesis of CF3-containing organic azides, γ-lactam and triazoles that were widely used in designing new fluorescent tags and functional materials. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Product Details of 574-98-1

The Article related to azidotrifluoromethylated mol preparation regioselective, alkene trimethylsilyl azide azidotrifluoromethylation iron catalyzed, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 17, 2021, Zhang, Min; Lin, Jin-Hong; Xiao, Ji-Chang published an article.Synthetic Route of 2567-29-5 The title of the article was HCF2Se/HCF2S Installation by Tandem Substitutions from Alkyl Bromides. And the article contained the following:

Herein authors describe an efficient construction of HCF2Se and HCF2S groups by tandem substitutions between alkyl bromides and a reagent system consisting of MSeCN (or MSCN) and Ph3P+CF2H Br-. The tandem process occurs via the first nucleophilic substitution of alkyl bromides by -SeCN (or -SCN) and the subsequent nucleophilic difluoromethylation. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Synthetic Route of 2567-29-5

The Article related to difluoromethylseleno difluoromethylthio preparation, alkyl bromides difluoromethylselenolation difluoromethylthiolation, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gao, Nanxing; Li, Yanshun; Teng, Dawei published an article in 2022, the title of the article was Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides.Related Products of 574-98-1 And the article contains the following content:

The structure of primary alkylated arenes plays an important role in the mol. action of drugs and natural products. The nickel/spiro-bidentate-pyox catalyzed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp2-Csp3 bond, which provided an efficient method for the synthesis of primary alkylated arenes. The reactions could tolerate functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Related Products of 574-98-1

The Article related to alkylated arene preparation nickel catalyst, primary alkyl bromide arylbromide cross electrophile coupling reaction, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On June 21, 2021, Zhang, Chun; Zhang, Chao; Tang, Jie; Ye, Shengqing; Ma, Mingliang; Wu, Jie published an article.HPLC of Formula: 2567-29-5 The title of the article was Synthesis of γ-Keto Sulfones through a Three-Component Reaction of Cyclopropanols, DABCO·(SO2)2 and Alkyl Halides. And the article contained the following:

A route to γ-keto sulfones RC(O)(CH2)2SO2R1 [R = 4-FC6H4, Bn, 2-naphthyl, etc.; R1 = Me, Bn, 4-BrC6H4CH2, etc.] through a metal-free reaction of cyclopropanols, DABCO·(SO2)2 and alkyl halides was described. This reaction occurs under mild conditions in the absence of any catalysts, additives, or oxidants. Various functional groups including as ester, amino, methoxy, bromo, trifluoromethyl, nitro and carbonyl were tolerated well in this transformation and the corresponding γ-keto sulfones were afforded in 35% to 95% yields. The proposed mechanism implies that this reaction proceeded through γ-keto sulfinate intermediate generated in situ, which further undergoes nucleophilic substitution with alkyl halides leading to γ-keto sulfones. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).HPLC of Formula: 2567-29-5

The Article related to gamma keto sulfone preparation, cyclopropanol alkyl halide dabco bissulfur dioxide three component, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On June 1, 2022, Liu, Yi; Zhou, Cuihan; Jiang, Meijing; Arndtsen, Bruce A. published an article.Synthetic Route of 574-98-1 The title of the article was Versatile Palladium-Catalyzed Approach to Acyl Fluorides and Carbonylations by Combining Visible Light- and Ligand-Driven Operations. And the article contained the following:

The development of a general palladium-catalyzed carbonylative method to synthesize acyl fluorides RC(O)F (R = n-Bu, cyclohexyl, 4-methylphenyl, pyridin-3-yl, etc.) from aryl, heteroaryl, alkyl, and functionalized organic halides RX was described. Mechanistic anal. suggests that the reaction proceeds via the unique, synergistic combination of visible light photoexcitation of Pd(0) to induce oxidative addition with a ligand-favored reductive elimination. These together create a unidirectional catalytic cycle that is uninhibited by the classical effect of carbon monoxide coordination. Coupling the catalytic formation of acyl fluorides with their subsequent nucleophilic reactions has opened a method to perform carbonylation reactions with unprecedented breadth, including the assembly of highly functionalized carbonyl-containing products. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Synthetic Route of 574-98-1

The Article related to acyl fluoride preparation, acyl halide carbon monoxide photochem carbonylation palladium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary