Tag: 200-300

Varano, Flavia; Catarzi, Daniela; Vigiani, Erica; Vincenzi, Fabrizio; Pasquini, Silvia; Varani, Katia; Colotta, Vittoria published an article in 2020, the title of the article was Piperazine- and piperidine-containing thiazolo[5,4-d]pyrimidine derivatives as new potent and selective adenosine A2A receptor inverse agonists.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione And the article contains the following content:

The therapeutic use of A2A adenosine receptor (AR) antagonists for the treatment of neurodegenerative disorders, such as Parkinson and Alzheimer diseases, is a very promising approach. Moreover, the potential therapeutic role of A2A AR antagonists to avoid both immunoescaping of tumor cells and tumor development is well documented. Herein, authors report on the synthesis and biol. evaluation of a new set of piperazine- and piperidine- containing 7-amino-2-(furan-2-yl)thiazolo[5,4-d]pyrimidine derivatives designed as human A2A AR antagonists/inverse agonists. Binding and potency data indicated that a good number of potent and selective hA2A AR inverse agonists were found. Amongst them, the compound I exhibited the highest A2A AR binding affinity (Ki = 8.62 nM) as well as inverse agonist potency (IC50 = 7.42 nM). The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to piperazinyl piperidinyl thiazolopyrimidine preparation in silico adme prediction, adenosine a2a receptor inverse agonist human, g protein-coupled receptors, adenosine a2a receptor ligands, adenosine receptors, thiazolo[5,4-d]pyrimidines and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 26, 1987, Haga, Toru; Nagano, Hideyoshi; Okuda, Hiroki; Takase, Masayuki published a patent.Computed Properties of 111010-07-2 The title of the patent was Preparation of 5-bromo-4-chloro-2-fluoroaniline as intermediate for tetrahydrophthalimide herbicides. And the patent contained the following:

The title compound (I), useful as an intermediate for herbicidal tetrahydrophthalimides II (R = H, alkyl, Ph) were prepared by reduction of 1-bromo-2-chloro-4-fluoro-5-nitrobenzene (III). A mixture of 14 g III and 20 g Fe powder in AcOH 20, EtOAc 30, and 5% aqueous AcOH 50 mL was refluxed at 60-80° for 3 h to give 10.4 g I. The experimental process involved the reaction of 5-Bromo-4-chloro-2-fluoroaniline(cas: 111010-07-2).Computed Properties of 111010-07-2

The Article related to aniline trihalo preparation herbicide intermediate, herbicide intermediate bromochlorofluoroaniline preparation, phthalimide tetrahydro herbicide intermediate trihaloaniline, bromochlorofluoroaniline intermediate herbicide preparation and other aspects.Computed Properties of 111010-07-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 1, 2020, Sun, Nannan; Ma, Xiaojun; Zhou, Kaifeng; Zhu, Chen; Cao, Zhonglian; Wang, Yonghui; Xu, Jun; Fu, Wei published an article.Reference of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases. And the article contained the following:

In this study, authors designed and synthesized a series of N-sulfonamide-tetrahydroquinolines by mol. modeling and scaffold hopping strategy, aiming at improving the metabolic stabilities. Detailed SAR exploration led to identification of potent RORγt inverse agonists such as compound II with moderate binding affinity and inhibitory activity of Th17 cell differentiation. Binding mode of compound II with RORγt-LBD was revealed by mol. docking. Moreover, compound II showed lower intrinsic clearance in mouse liver microsomes compared with compound I and potent in-vivo efficacy and safety in psoriasis models, which can be used as a good starting point for the further optimization. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Reference of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to sulfonamido tetrahydroquinoline preparation rror inverse agonist sar safety, inverse agonists, metabolic stability, n-sulfonamide-tetrahydroquinolines, psoriasis, retinoic acid receptor-related orphan receptor γt (rorγt), th17 cells and other aspects.Reference of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Jian-An; Chen, Cheng; Huang, Jian-Gang; Liu, Hong-Wei; Cao, Song; Ji, Ya-Fei published an article in 2014, the title of the article was Cu(OAc)2-catalyzed remote benzylic C(sp3)-H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as the terminal oxidant under ligand- and additive-free conditions.Synthetic Route of 185345-46-4 And the article contains the following content:

A hindered para-hydroxyl group-directed remote benzylic C(sp3)-H oxyfunctionalization has been developed for the straightforward transformation of 2,6-disubstituted 4-cresols, 4-alkylphenols, 4-hydroxybenzyl alcs. and 4-hydroxybenzyl alkyl ethers into various aromatic carbonyl compounds The ligand- and additive-free Cu(OAc)2-catalyzed atm. oxidation-mediated by ethylene glycol unlocks a facile, atom-economical, and environmentally benign C=O formation for the functionalization of primary and secondary benzyl groups. Due to the pharmaceutical importance of 4-hydroxybenzaldehydes and 4-hydroxyphenones, the methodol. is expected to be of significant value for both fundamental research and practical applications. The experimental process involved the reaction of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde(cas: 185345-46-4).Synthetic Route of 185345-46-4

The Article related to cresol alkylphenol hydroxybenzyl alc ether copper catalyzed benzylic oxyfunctionalization, hindered phenol oxidation air ethylene glycol ligand additive free, hydroxybenzaldehyde hydroxyphenone environmentally benign preparation and other aspects.Synthetic Route of 185345-46-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 10, 2022, Wang, Yanwei; Zhao, Zhiwei; Pan, Deng; Wang, Siyi; Jia, Kangping; Ma, Dengke; Yang, Guoqing; Xue, Xiao-Song; Qiu, Youai published an article.Product Details of 2567-29-5 The title of the article was Metal-Free Electrochemical Carboxylation of Organic Halides in the Presence of Catalytic Amounts of an Organomediator. And the article contained the following:

Herein, an electroreductive carboxylation of organic carbon-halogen bonds (X=Br and Cl) promoted by catalytic amounts of naphthalene as an organic mediator is reported. This transformation proceeds smoothly under mild conditions with a broad substrate scope of 59 examples, affording the valuable and versatile carboxylic acids in moderate to excellent yields without the need of costly transition metal, wasted stoichiometric metal reductants, or sacrificial anodes. Further late-stage carboxylations of natural product and drug derivatives demonstrate its synthetic utility. Mechanistic studies confirmed the activation of carbon-halogen bonds via single-electron transfer and the key role of naphthalene in this reaction. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Product Details of 2567-29-5

The Article related to carboxylic acid aryl alkyl preparation, aryl chloride bromide carbon dioxide electroreductive carboxylation naphthalene catalyst, co2 utilization, carboxylation, electroreduction, organic halides, organic reductive mediator and other aspects.Product Details of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 31, 2022, Zhang, Naichen; Ye, Yuanzhi; Bai, Lu; Liu, Jingjing; Wang, Han; Luan, Xinjun published an article.Safety of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Transition metal-free dearomatization of halonaphthols with C(sp3)-electrophiles. And the article contained the following:

The first intermol. electrophilic dearomatization of halonaphthols I (R1 = H, 7-MeO, 6-Me3Si, 3-Cl, etc.) with benzyl/allyl bromides R2Br (R2 = PhCH2, PhCHMe, 4-MeO2CC6H4CH2, H2C:CHCH2, PhCH:CH, etc.) is described. Halonaphthols are used as carbon nucleophiles in dearomatization to form three-dimensional cyclic enones II with excellent chemoselectivity, in which etherification of phenolic hydroxyl group could be restrained by using cesium carbonate as the base. A wide range of cyclic enones was directly prepared from various substituted benzyl/allyl bromides and halonaphthols. Mechanistic investigations suggest a direct SN2 reaction pathway. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Safety of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to allylic bromide fluoronaphthol chemoselective electrophilic allylation dearomatization, allyl benzyl fluoro naphthalenone preparation, fluoronaphthol chemoselective electrophilic benzylation benzyl bromide dearomatization and other aspects.Safety of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cresp, T. M.; Sargent, M. V.; Elix, J. A.; Murphy, D. P. H. published an article in 1973, the title of the article was Formylation and bromination ortho to the hydroxy-group of 2-carbonyl-substituted phenols in the presence of titanium(IV) chloride.Name: Methyl 5-bromo-2-methoxy-4-methylbenzoate And the article contains the following content:

Formylation with Cl2CHOMe-TiCl4 of Me 2,4-dihydroxybenzoate, Me 2-hydroxy-4-methoxybenzoate, Et 2-hydroxy-4-methoxy-6-methylbenzoate, Me 2-hydroxy-4-methylbenzoate, and 2-hydroxy-4-methoxyacetophenone gave the 3-formyl derivatives as the major products. Bromination in the presence of TiCl4 gave similar results. Formation of a six-membered ring Ti complex (e.g., I) induces selective substitution ortho to the OH group. The experimental process involved the reaction of Methyl 5-bromo-2-methoxy-4-methylbenzoate(cas: 39503-58-7).Name: Methyl 5-bromo-2-methoxy-4-methylbenzoate

The Article related to selective formylation phenol derivative, formylation hydroxybenzoate titanium chloride, phenol carboxy formylation titanium, bromination hydroxybenzoate titanium chloride, chloromethyl ether formylation phenol derivative and other aspects.Name: Methyl 5-bromo-2-methoxy-4-methylbenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 22, 2022, Wang, Hui; Yang, Ren-Yin; Xu, Bo published an article.Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Synthesis of Cyclopropenes and Fluorinated Cyclopropanes via Michael Initiated Ring Closure of Alkyl Triflones. And the article contained the following:

A facile synthesis of cyclopropenes and fluorinated cyclopropanes from readily available alkyl triflones was developed. The reaction, regardless of electronic effect, gave products in good to excellent yields and moderate diastereoselectivity. The mechanism may involve tandem Michael addition of triflones/intramol. nucleophilic cyclization (elimination of -SO2CF3)/elimination of fluoride. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to cyclopropene fluorinated cyclopropane preparation diastereoselective, alkyl triflone chalcone michael initiated ring closure, michael initiated ring closure, alkyl triflones, cyclopropenes, fluorinated cyclopropanes and other aspects.Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 30, 2022, Ekinci, Orhan; Akkoc, Mitat; Khan, Siraj; Yasar, Sedat; Guerses, Canbolat; Noma, Samir; Balcioglu, Sevgi; Sen, Betuel; Ayguen, Muhittin; Yilmaz, Ismet published an article.Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Synthesis and biological evaluation of Au-NHC complexes. And the article contained the following:

New seven Au-N-heterocyclic carbene (NHC) complexes were synthesized via transmetalation from Ag-NHC complexes. NHC salts, Ag-NHC, and Au-NHC complexes were fully characterized by widely used spectroscopic techniques. The mol. and crystal structures of 3b and 3f Au-NHC complexes were clarified through the single-crystal x-ray diffraction method. According to x-ray diffraction anal. results, the coordination geometry around Au(I) atoms in the complexes are revealed to be almost linear with C-Au-Cl angle. Anticancer activity, DNA binding, xanthine oxidase (XO) inhibitory activity studies, and mol. docking studies were evaluated for all Au-NHC complexes to explore the binding mechanism at the active site. The IC50 value of Au-NHC complexes against human colorectal cancer (Caco-2) and breast cancer (MCF-7) cell lines was defined by MTT assay. The IC50 values for MCF-7 in the range of 5.2 ± 2 to 152.4 ± 1μM and Caco-2 5.2 ± 1 to 152.7 ± 2μM showed that 3a, 3b, 3c, 3d, and 3g have better anticancer activity than Cisplatin incredibly complex 3a against both cancer cell line. All Au-NHC complexes showed excellent antimicrobial activity against different bacteria and fungi. 3a was the complex that exhibited the best antimicrobial activity here as well. The XO inhibitory activity exptl. results indicated that all gold complexes showed remarkable inhibition activity against XO compared to the generally used standard, allopurinol. The range of IC50 value was determined from 0.407 to 2.681μM. 3d complex showed the lowest IC50 value at 0.407μM. DNA binding experiments were performed using agarose gel electrophoresis to observe the ability of synthesized Au-NHC complexes to interact with the supercoiled pUC19 plasmid DNA. Mol. docking studies were performed to determine the binding mode of all active compounds against the XO enzyme, antibacterial, antifungal, and MCF-7 cell lines. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to silver gold heterocyclic carbene complex halo preparation crystal structure, antitumor human silver gold heterocyclic carbene complex halo, antibacterial antifungal silver gold heterocyclic carbene complex halo dna and other aspects.Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On January 17, 2020, Gonzalez-Rodriguez, Jorge; Soto, Martin; Soengas, Raquel G.; Rodriguez-Solla, Humberto published an article.Category: bromides-buliding-blocks The title of the article was SmI2-promoted cross coupling reaction of N-2-bromoethylphthalimide and carbonyl compounds: Synthesis of α-aryl-α’-hydroxy ketones. And the article contained the following:

In this paper, the SmI2-mediated carbonyl-imide reductive cross coupling between N-2-bromoethylphthalimide and different aldehydes and ketones in the presence of anhydrous catalytic NiI2 was disclosed. This methodol. provided an effective tool to prepare α-aryl-α’-hydroxy ketones I [R1 = n-C7H15, 4-ClC6H4, C6H4CH=CH, etc; R1 = R2 = Et; R1R2 = (CH2)4, (CH2)5] under mild conditions which could be applied to various functionalized, aliphatic and aromatic aldehydes and ketones. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Category: bromides-buliding-blocks

The Article related to aryl alpha hydroxy ketone preparation chemoselective, bromoethylphthalimide aldehyde reductive cross coupling samarium iodide mediated, ketone bromoethylphthalimide reductive cross coupling samarium iodide mediated and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary