Tag: 200-300

On April 30, 2019, Xie, Ruliang; Mei, Xiangdong; Ning, Jun published an article.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Design, synthesis and insecticide activity of novel acetylcholinesterase inhibitors: triazolinone and phthalimide heterodimers. And the article contained the following:

A new series of 1,2,4-triazolin-3-one and phthalimide heterodimers I [X = (CH2)n; n = 1, 2, 9, etc.] was synthesized and evaluated for their insecticidal and acetylcholinesterase inhibitory activities. Most of the synthesized compounds I showed good in vitro inhibitory activities against both Drosophila melanogaster acetylcholinesterase (DmAChE) and Musca domestica acetylcholinesterase (MdAChE). Among them, compound I (n = 7) was found to be most potent AChE inhibitor (IC50 = 8.07 μM to DmAChE, IC50 = 32.24 μM to MdAChE), whose activities were 2.31- and 1.35-fold more active than the pos. control ethion (CP, IC50 = 18.62 μM to DmAChE, IC50 = 43.56 μM to MdAChE). The docking model study revealed that compound I (n = 7) possessed fitted spatial structure and bound to central pocket and peripheral site of DmAChE. Moreover, most of the compounds I demonstrated high insecticidal activity to Lipaphis erysimi and Tetranychus cinnabarinus at concentration of 300 mg/L. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to triazolyl isoindoline dione preparation insecticide acetylcholinesterase inhibitor mol docking, acetylcholinesterase, acetylcholinesterase inhibiting potency, dual binding site, heterodimer, insecticidal activity and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On January 31, 2020, Dato, Florian M.; Neudoerfl, Joerg-Martin; Guetschow, Michael; Goldfuss, Bernd; Pietsch, Markus published an article.Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was ω-Quinazolinonylalkyl aryl ureas as reversible inhibitors of monoacylglycerol lipase. And the article contained the following:

The serine hydrolase monoacylglycerol lipase (MAGL) is involved in a plethora of pathol. conditions, in particular pain and inflammation, various types of cancer, metabolic, neurol. and cardiovascular disorders, and is therefore a promising target for drug development. Although a large number of irreversible-acting MAGL inhibitors have been discovered over the past years, there are only few compounds known so far which inhibit the enzyme in a reversible manner. Therefore, much effort is put into the development of novel chem. entities showing reversible inhibitory behavior, which is thought to cause less undesired side effects. To explore a wide range of chem. structures as MAGL binders, we have applied a virtual screening approach by docking small mols. into the crystal structure of human MAGL (hMAGL) and envisaged a library of 45 selected compounds which were then synthesized. Biochem. investigations included the determination of the inhibitory potency on hMAGL and two related hydrolases, i.e. human fatty acid amide hydrolase (hFAAH) and murine cholesterol esterase (mCEase). The most promising candidates from theses analyses, i.e. three ω-quinazolinonylalkyl aryl ureas bearing alkyl spacers of three to five methylene groups, exhibited IC50 values of 20-41μM and reversible, detergent-insensitive behavior towards hMAGL. Among these compounds, the inhibitor 1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl)urea (96) was selected for further kinetic characterization, yielding a dissociation constant Ki = 15.4μM and a mixed-type inhibition with a pronounced competitive component (α = 8.94). This mode of inhibition was further supported by a docking experiment, which suggested that the inhibitor occupies the substrate binding pocket of hMAGL. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to quinazolinonylalkyl aryl urea inhibitor monoacylglycerol lipase, cholesterol esterase, enzyme kinetics, fatty acid amide hydrolase, inhibitors, monoacylglycerol lipase, promiscuous inhibition, serine hydrolases and other aspects.Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

McGrory, Rochelle; Faggyas, Reka J.; Sutherland, Andrew published an article in 2021, the title of the article was One-pot synthesis of N-substituted benzannulated triazoles via stable arene diazonium salts.HPLC of Formula: 574-98-1 And the article contains the following content:

A mild and effective one-pot synthesis of benzothiatriazine-1,1(2H)-dioxides I [R = Me, Bn, Ph, etc.] and 1,2,3-benzotriazin-4(3H)-ones II [R1 = H, 5-F, 7-CF3, etc.; R2 = H, cyclohexyl, Ph, etc.] was developed. The method involved the diazotization and subsequent cyclization of 2-aminobenzamides and 2-aminobenzenesulfonamides via stable diazonium salts, prepared using a polymer-supported nitrite reagent and p-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotizaton-cyclization process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).HPLC of Formula: 574-98-1

The Article related to benzotriazinone preparation, aminobenzamide polymer supported nitrite diazotizaton cyclization, benzothiatriazine dioxide preparation, aminobenzenesulfonamide polymer supported nitrite diazotizaton cyclization and other aspects.HPLC of Formula: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Asadi, Mehdi; Ebrahimi, Mostafa; Mohammadi-Khanaposhtani, Maryam; Azizian, Homa; Sepehri, Saghi; Nadri, Hamid; Biglar, Mahmood; Amanlou, Massoud; Larijani, Bagher; Mirzazadeh, Roghieh; Edraki, Najmeh; Mahdavi, Mohammad published an article in 2019, the title of the article was Design, synthesis, molecular docking, and cholinesterase inhibitory potential of phthalimide-dithiocarbamate hybrids as new agents for treatment of Alzheimer’s disease.Product Details of 574-98-1 And the article contains the following content:

A novel series of phthalimide-dithiocarbamate hybrids was synthesized and evaluated for in vitro inhibitory potentials against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The anti-cholinesterase results indicated that among the synthesized compounds, the compounds 7g and 7h showed the most potent anti-AChE and anti-BuChE activities, resp. Mol. docking and dynamic studies of the compounds 7g and 7h, resp., in the active site of AChE and BuChE revealed that these compounds as well interacted with studied cholinesterases. These compounds also possessed drug-like properties and were able to cross the BBB. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Product Details of 574-98-1

The Article related to synthesis docking cholinesterase inhibitor phthalimide dithiocarbamate hybrid antialzheimer, alzheimer’s disease, acetylcholinesterase, butyrylcholinesterase, dithiocarbamate, inhibitory activity, phthalimide and other aspects.Product Details of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Shichao; Li, Muyao; Li, Shu-Sen; Wang, Jianbo published an article in 2022, the title of the article was Pd-Catalyzed coupling of benzyl bromides with BMIDA-substituted N-tosylhydrazones: synthesis of trans-alkenyl MIDA boronates.Electric Literature of 2567-29-5 And the article contains the following content:

A palladium-catalyzed stereoselective synthesis of alkenyl boronates from N-methyliminodiacetyl boronate (BMIDA)-substituted N-tosylhydrazone and benzyl bromides is developed. A range of trans-alkenyl MIDA boronates as single stereoisomers were obtained in moderate yields with good functional group compatibility. The resultant boronate products may be transformed to other boron-containing compounds and may also be directly used in cross-coupling reactions. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5

The Article related to palladium catalyzed coupling benzyl bromide bmida nitrogen tosylhydrazone, trans alkenyl mida boronate preparation, methyliminodiacetyl boronate palladium catalyzed stereoselective reaction benzyl bromide, alkenyl methyliminodiacetyl boronate stereoselective synthesis and other aspects.Electric Literature of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 20, 2021, Wang, Qian; Tao, Quan; Dong, Hui; Ni, Chuanfa; Xie, Xiaoming; Hu, Jinbo published an article.Related Products of 2567-29-5 The title of the article was Fluorination Triggers Fluoroalkylation: Nucleophilic Perfluoro-tert-butylation with 1,1-Dibromo-2,2-bis(trifluoromethyl)ethylene (DBBF) and CsF. And the article contained the following:

Perfluoro-tert-butylation reaction has long remained a challenging task. We now report the use of 1,1-dibromo-2,2-bis(trifluoromethyl)ethylene (DBBF, I) as a practical reagent for perfluoro-tert-butylation reactions for the first time. Through a consecutive triple-fluorination process with DBBF and CsF, the (CF3)3C- species can be liberated and observed, which is able to serve as a robust nucleophilic perfluoro-tert-butylating agent for various electrophiles. The power of this synthetic protocol is evidenced by the efficient synthesis of structurally diverse perfluoro-tert-butylated mols. Multiple applications demonstrate the practicability of this method, as well as the superiority of perfluoro-tert-butylated compounds as sensitive probes. The perfluoro-tert-butylated product was successfully applied in 1H- and 19F-magnetic resonance imaging (MRI) experiment with an ultra-low field (ULF) MRI system. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5

The Article related to electrophile fluorination fluoroalkylation dibromo bistrifluoromethylethylene magnetic resonance imaging safety, perfluoro tert butylated compound preparation, fluorination, fluoroalkylation, imaging probes, magnetic resonance imaging, perfluoro-tert-butylation and other aspects.Related Products of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On January 15, 2021, Rezaei, Mohammad Taher; Keypour, Hassan; Bayat, Mehdi; Soltani, Elham; Jamshidi, Mahdi; Gable, Robert William published an article.Category: bromides-buliding-blocks The title of the article was Synthesis of a tertiary amine by direct reductive amination of a carbonyl compound to form a scorpionate ligand; formation of Mn (II), Zn (II) and Cd (II) complexes, DFT calculations and, molecular docking studies. And the article contained the following:

A hexadentate, asym. tripodal scorpionate type ligand, [[N1-Pyridin-2-ylmethyl-N1-[2-(4-pyridine-2-ylmethyl-piperazine-1-yl)-ethyl]-ethane-1,2-diamine]] (L) was prepared To form this ligand, the direct reductive amination of a carbonyl compound by NaBH4 was used for the synthesis of tertiary amine. The complexes [MnL](ClO4)2, [CdL](ClO4)2, [ZnL](ClO4)2 also were prepared The synthesized compounds were characterized by elemental analyses, FTIR, ESI-MS and, NMR spectroscopy. An X-ray crystal structure of [MnL] (ClO4)2, shows that the coordination environment around the manganese is a distorted trigonal prism. The nature of metal-ligand bonding in the complexes was studied by Natural Bond Orbital anal., Energy Decomposition Anal. and Energy Decomposition Anal. using Natural Orbitals for Chem. Valence variation. Mol. docking was used for the biol. evaluation of the anticancer and antioxidant activities of the synthesized compounds The docking results indicated that the Cd, Mn, and Zn-complexes had the highest binding affinity (MolDock Score) for the binding sites of cytochrome P 450, myeloperoxidase, and cytochrome P 450, resp. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Category: bromides-buliding-blocks

The Article related to preparation manganese cadmium zinc scorpionate complex, crystal mol structure manganese cadmium zinc scorpionate complex, mol docking manganese cadmium zinc scorpionate complex, anticancer antioxidant activity manganese cadmium zinc scorpionate complex and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 19, 2022, Wang, Jixin; Duan, Zhili; Liu, Xingchen; Dong, Shoucheng; Chen, Kaixin; Li, Jie published an article.Name: 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Salt-Stabilized Silylzinc Pivalates for Nickel-Catalyzed Carbosilylation of Alkenes. And the article contained the following:

The authors herein report the preparation of solid and salt-stabilized silylzinc pivalates from the corresponding silyllithium reagents via transmetalation with Zn(OPiv)2. These resulting organosilylzinc pivalates show enhanced air and moisture stability and unique reactivity in the silylative difunctionalization of alkenes. Thus, a practical chelation-assisted Ni-catalyzed regioselective alkyl and benzylsilylation of alkenes was developed, which provides an easy method to access alkyl silanes with broad substrate scope and wide functional group compatibility. Kinetic experiments highlight that the OPiv-coordination is crucial to improve the reactivity of silylzinc pivalates. Also, late-stage functionalizations of druglike mols. and versatile modifications of the products illustrate the synthetical utility of this protocol. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Name: 4-(Bromomethyl)-1,1′-biphenyl

The Article related to silylzinc pivalate preparation reactivity nickel catalyzed carbosilylation alkene, organosilane preparation, silyllithium reagent transmetalation zinc pivalate, alkene difunctionalizations, carbosilylation, cross-coupling, nickel, silylzinc pivalates and other aspects.Name: 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 20, 2021, Zhang, Rongyi; Li, Qigang; Xie, Qiqiang; Ni, Chuanfa; Hu, Jinbo published an article.Related Products of 2567-29-5 The title of the article was Difluorocarbene-Induced Ring-Opening Difluoromethylation-Halogenation of Cyclic (Thio)Ethers with TMSCF2X (X=Br, Cl). And the article contained the following:

The ring-opening difluoromethylation-halogenation of cyclic (thio)ethers is reported through a simple strategy relying on carbon-chalcogen bond activation with difluorocarbene. The reaction proceeds through in situ protonation of the previously little-known difluoromethylene oxonium or sulfonium ylide intermediate followed by ring-opening with halide ion to afford halogenated acyclic difluoromethyl (thio)ethers that can then be employed for further elaboration. TMSCF2X (X=Br, Cl) are unique reagents to achieve this synthetic purpose, which serve as both the difluorocarbene source and the halide ion source. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5

The Article related to halogenated acyclic difluoromethyl ether thioether preparation, cyclic ether trimethylsilyl difluoromethyl halide ring opening difluoromethylation halogenation, difluorocarbene, difluoromethyl ether, orthogonal synthesis, oxonium ylide, ring-opening and other aspects.Related Products of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On June 27, 2022, Huang, Ming-Yao; Zhao, Yu-Tao; Zhang, Cheng-Da; Zhu, Shou-Fei published an article.Recommanded Product: 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Highly Regio-, Stereo-, and Enantioselective Copper-Catalyzed B-H Bond Insertion of α-Silylcarbenes: Efficient Access to Chiral Allylic gem-Silylboranes. And the article contained the following:

Herein, we report the development of a method for highly regio-, stereo-, and enantioselective B-H bond insertion reactions of α-silylcarbenes generated from 1-silylcyclopropenes in the presence of a chiral copper(I)/bisoxazoline catalyst for the construction of chiral γ,γ-disubstituted allylic gem-silylboranes, which cannot be prepared by any other known methods. This reaction is the first highly enantioselective carbene insertion reaction of α-silylcarbenes ever to be reported. The method shows general applicability for various 3,3-disubstituted silylcyclopropenes and exclusively affords E-products. The novel chiral γ,γ-disubstituted allylic gem-silylborane products are versatile allylic bimetallic reagents with high stability and have great synthetic potential, especially for the construction of complex mols. with continuous chiral centers. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Recommanded Product: 4-(Bromomethyl)-1,1′-biphenyl

The Article related to regioselective stereoselective enantioselective copper catalyst insertion silylcarbene mechanism, crystal structure mol allylic silyl borane preparation chiral, asymmetric catalysis, b−h bond insertion, carbenes, copper catalysis, cyclopropenes and other aspects.Recommanded Product: 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary