Tag: 200-300

Grollier, Kevin; Taponard, Alexis; De Zordo-Banliat, Arnaud; Magnier, Emmanuel; Billard, Thierry published an article in 2020, the title of the article was Metal-free nucleophilic trifluoromethylselenolation via an iodide-mediated umpolung reactivity of trifluoromethylselenotoluenesulfonate.Related Products of 2567-29-5 And the article contains the following content:

Herein, a practical method to generate CF3Se- (and RFSe-) anions from shelf-stable reagents under iodide activation was reported. Metal-free nucleophilic trifluoromethylselenolations have been then performed with this in situ-generated anion. Perfluoroalkylselenolations have also been described. The umpolung reactivity of trifluoromethylselenotoluenesulfonates 4-CH3C6H4S(O)2SeR (R = trifluoromethyl, 1,1,2,2,2-pentafluoroethyl, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexyl) can be performed under reductive or oxidative conditions with alkyl halides R1X (R1 = dodecyl, Bn, (5-nitrofuran-2-yl)methyl, etc.; X = Br, Cl) to give desired products R1SeR. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5

The Article related to selenide preparation, trifluoromethyl selenotoluenesulfonate alkyl halide perfluoroalkylselenolation, fluorine, nucleophilic substitution, perfluoroalkylselenolation, selenium, trifluoromethylselenolation and other aspects.Related Products of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shu, Chenglin; Liu, Caiping; Wu, Mingyan; Chen, Cheng; Hong, Maochun published an article in 2021, the title of the article was Simultaneous fluorescence and phosphorescence in Zn(II)-zwitterionic coordination polymers with tunable colors.SDS of cas: 2567-29-5 And the article contains the following content:

Three similar ionic-type ligands which can provide ligand-centered charge transfer (LCCT) have been employed to synthesize three isostructural complexes, resp. Due to the coordination of the ligands to the metal centers, all of the above mentioned complexes feature fluorescence and phosphorescence properties simultaneously. The mechanism of the luminous process is ligand-centered charge transfer (LCCT) combined with metal-to-ligand charge transfer (MLCT) processes. More interestingly, one compound manifests tunable colors from yellow to blue emissions involving white emission by varying the temperature and/or excitation wavelength directly. Exptl. and computational results indicate that the differences in luminous properties originate from the ligand distortion combined with different electron states. Thus, this study provides a facile method to synthesize new single-component tunable-color luminescent coordination polymers with simultaneous fluorescence and phosphorescence. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).SDS of cas: 2567-29-5

The Article related to bipyridylmethyl azidobipyridylmethyl carboxylatobipyridylmethyl pyridyldicarboxylate zinc coordination polymer preparation structure, fluorescence phosphorescence zinc zwitterionic polymer tunable color and other aspects.SDS of cas: 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 1, 2020, Varano, Flavia; Catarzi, Daniela; Vincenzi, Fabrizio; Pasquini, Silvia; Pelletier, Julie; Lopes Rangel Fietto, Juliana; Espindola Gelsleichter, Nicolly; Sarlandie, Marine; Guilbaud, Audrey; Sevigny, Jean; Varani, Katia; Colotta, Vittoria published an article.Recommanded Product: 574-98-1 The title of the article was Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents. And the article contained the following:

Adenosine pathway, including its generating enzyme (CD73) and its receptors represents a key target for cancer immunotherapy. Here we aimed to search for novel compounds able to co-target the CD73 and the A2A adenosine receptor (A2A AR) as dual-blockers of adenosine generation and activity. The design project was to combine in the same mol. the thiazolo[5,4-d]pyrimidine core, an essential pharmacophoric feature to block the A2A AR, with a benzenesulfonamide group which is a characteristic group of CD73 inhibitors. Most of the reported compounds resulted in inverse agonists of the human (h) A2A AR endowed with high affinity, selectivity and potency. However they were weak inhibitors of CD73 enzyme. Nevertheless, this study can be considered as a starting point to develop more active compounds The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 574-98-1

The Article related to cancer immunotherapy a2aar inverse agonists cd37 inhibitor antitumor agents, adenosine a(2a) receptor inverse agonists, antitumor agents, cd73 inhibitors, cancer immunotherapy, thiazolo[5,4-d]pyrimidine and other aspects.Recommanded Product: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kwon, Ye-Mi; Kim, Sou Hyun; Jung, Young-Suk; Kwak, Jae-Hwan published an article in 2021, the title of the article was Synthesis and Biological Evaluation of (S)-2-(Substituted arylmethyl)-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide Analogs and Their Synergistic Effect against PTEN-Deficient MDA-MB-468 Cells.Reference of 4-(Bromomethyl)-1,1′-biphenyl And the article contains the following content:

A series of twenty-six compounds of furfuryl or benzyl tetrahydropyrazino[1,2-a]indole analogs were synthesized and evaluated for cytotoxic activity against the estrogen receptor (ER)-pos. breast cancer cell line (MCF-7) and the epidermal growth factor receptor (EGFR) over-expressed triple-neg. breast cancer cell line (MDA-MB-468). Among them, compounds 2b, 2f and 2i showed more potent activity and selectivity against MDA-MB-468 cells than gefitinib, as an EGFR- tyrosine kinase inhibitor. In addition, it was confirmed by means of isobologram anal. of combinational treatment with gefitinib that they have a synergistic effect, especially compounds 2b and 2f, which inhibit Akt T308 phosphorylation. Moreover, it was confirmed that 2-benzyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide analogs (2b, 2f, and Ref 2) tend to selectively inhibit PI3Kβ, which is involved in the phosphorylation of Akt. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Reference of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to arylmethyl tetrahydropyrazinoindole carboxamide analog synergistic effect pten cancer cell, egfr-tki resistance, pten-deficient cancer cells, anti-tnbc, pyrazinoindolone scaffold, synergistic effects and other aspects.Reference of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sisto, Francesca; Carradori, Simone; Guglielmi, Paolo; Spano, Mattia; Secci, Daniela; Granese, Arianna; Sobolev, Anatoly P.; Grande, Rossella; Campestre, Cristina; Marcantonio, Maria Carmela Di; Mincione, Gabriella published an article in 2021, the title of the article was Synthesis and evaluation of thymol-based synthetic derivatives as dual-action inhibitors against different strains of H. pylori and AGS cell line.Related Products of 2567-29-5 And the article contains the following content:

Herein, the synthesis of a new series of thymol-based ethers I [R = Me, H2C:CH, CN, EtO2C, Ph, 2-BrC6H4, etc.] and their microbiol. screening against eight strains of H. pylori and the cytotoxic activity against human gastric adenocarcinoma (AGS) cells are reported. Structural anal. comprehended elemental anal. and 1H/13C/19F NMR spectra. The anal. of structure-activity relationships within this mol. library of these structurally-related compounds showed that some chem. modifications of the OH group of thymol led to broad-spectrum growth inhibition on all isolates. Preferred substitutions were benzyl groups compared to alkyl chains and the specific presence of functional groups at para position of the benzyl moiety such as 4-CN and 4-Ph endowed the most anti-H. pylori activity toward all the strains with min. inhibitory concentration (MIC) values up to 4μg/mL. Poly-substitution on the benzyl ring was not essential. Moreover, several compounds characterized by the lowest min. inhibitory concentration/min. bactericidal concentration (MIC/MBC) values against H. pylori were also tested in order to verify a cytotoxic effect against AGS cells with respect to 5-fluorouracil and carvacrol. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5

The Article related to thymol ether preparation helicobacter pylori antibacterial gastric adenocarcinoma, ags cells, helicobacter pylori, drug resistance, dual-action agents, antimicrobial activity, semi-synthesis, thymol and other aspects.Related Products of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On November 5, 2021, Tak, Raj K.; Noda, Hidetoshi; Shibasaki, Masakatsu published an article.Category: bromides-buliding-blocks The title of the article was Ligand-enabled, copper-catalyzed electrophilic amination for the asymmetric synthesis of β-amino acids. And the article contained the following:

Catalytic asym. nitrene transfer has emerged as a reliable method for the synthesis of nitrogen-containing chiral compounds Herein, we report the copper-catalyzed intramol. asym. electrophilic amination of aromatic rings. The reactive intermediate is a copper-alkyl nitrene generated from isoxazolidin-5-ones. Copper catalysis promotes three classes of asym. transformations, namely, asym. desymmetrization, parallel kinetic resolution, and kinetic resolution, expanding the repertoire of alkyl nitrene transfer and providing various cyclic and linear β-amino acids in their enantioenriched forms. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Category: bromides-buliding-blocks

The Article related to amino acid beta cyclic linear enantioselective synthesis solvent effect, electrophilic amination copper catalyst isoxazolidinone nitrene, asym desymmetrization kinetic resolution nitrene transfer and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Han-Qi; Gu, Xing-Wei; Zhou, Xiao-Hua; Li, Li; Ye, Fei; Yin, Guan-Wu; Xu, Zheng; Xu, Li-Wen published an article in 2021, the title of the article was Enantioselective palladium-catalyzed C(sp2)-C(sp2) σ bond activation of cyclopropenones by merging desymmetrization and (3+2) spiroannulation with cyclic 1,3-diketones.Application of 2567-29-5 And the article contains the following content:

Herein, an unprecedented palladium-catalyzed (3+2) spiro-annulation merging C(sp2)-C(sp2) σ bond activation and click desymmetrization to form synthetically versatile and value-added oxaspiro products I [R1 = Me, Et; R2 = n-Pr, but-2-yn-1-yl, naphthalen-2-ylmethyl, thiophen-2-ylmethyl, etc.; R3 = n-Pr, Ph, 4-fluorophenyl, 3-methylphenyl, etc.; R4 = i-Pr, n-Pr, Ph, 4-fluorophenyl, etc.] have been presented. The operationally straightforward and enantioselective palladium-catalyzed atom-economic annulation process exploits a TADDOL-derived bulky P-ligand bearing a large cavity to control enantioselective spiro-annulation that converts cyclopropenones II and cyclic 1,3-diketones III, 2′,3′-dihydrospiro[cyclopentane-1,1′-inden]-3-ene-2,5-dione and 5-((tert-butyldimethylsilyl)oxy)naphthalene-1,4-dione into chiral oxaspiro cyclopentenone-lactone scaffolds I with good diastereo- and enantio-selectivity. The click-like reaction is a successful methodol. with a facile construction of two vicinal carbon quaternary stereocenters and can be used to deliver addnl. stereocenters during late-state functionalization for the synthesis of highly functionalized or more complex mols. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Application of 2567-29-5

The Article related to oxaspiro cyclopentenone lactone preparation regioselective diastereoselective enantioselective, cyclopropenone cyclic diketone bond activation desymmetrization spiroannulation palladium catalyst and other aspects.Application of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Czopek, Anna; Partyka, Anna; Bucki, Adam; Pawlowski, Maciej; Kolaczkowski, Marcin; Siwek, Agata; Gluch-Lutwin, Monika; Koczurkiewicz, Paulina; Pekala, Ezzbieta; Jaromin, Anna; Tyliszczak, Bozena; Wesolowska, Anna; Zagorska, Agnieszka published an article in 2020, the title of the article was Impact of N-alkylamino substituents on serotonin receptor (5-HTR) affinity and phosphodiesterase 10A (PDE10A) inhibition of isoindole-1,3-dione derivatives.SDS of cas: 574-98-1 And the article contains the following content:

In this study, a series of compounds derived from 1H-isoindole-1,3(2H)-dione I (R = H, OMe; R1 = 1,2,3,4-tetrahydroisoquinolin-2-yl, 1,2,3,4-tetrahydroisoquinolin-2-yl, pyridin-2-yl, 1H-1,3-benzimidazol-2-yl, etc.; X = (CH2)n, n = 1-5), potential ligands of phosphodiesterase 10A and serotonin receptors, were investigated as potential antipsychotics. A library of I with various amine moieties was synthesized and examined for their phosphodiesterase 10A (PDE10A)-inhibiting properties and their 5-HT1A and 5-HT7 receptor affinities. Based on in vitro studies, the most potent compound, I [R = OMe; R1 = 1H-1,3-benzimidazol-2-yl; n = 4 (II)], was selected and its safety in vitro was evaluated. In order to explain the binding mode of compound II in the active site of the PDE10A enzyme and describe the mol. interactions responsible for its inhibition, computer-aided docking studies were performed. The potential antipsychotic properties of compound II in a behavioral model of schizophrenia were also investigated. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).SDS of cas: 574-98-1

The Article related to isoindoledione preparation phosphodiesterase inhibition serotonin receptor affinity antitumor activity, antipsychotic activity, benzimidazole derivatives, phosphodiesterase 10a, schizophrenia and other aspects.SDS of cas: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 24, 2011, Sone, Toshihiko; Nakajima, Tomoko; Takai, Kentaro published a patent.Formula: C7H8BrCl2N The title of the patent was Preparation of bicyclic urea derivatives as soluble epoxide hydrolase inhibitors. And the patent contained the following:

Title compounds I [R1 = (un)substituted cycloalkyl, (un)substituted heterocyclyl, (un)substituted aryl, etc.; R2a, R2b = H, halo, hydroxy, etc.; m = 0-5; ring A = Q1, etc.; R3a, R3b, R3c = H, halo, hydroxy, etc.] or pharmaceutically acceptable salts thereof were prepared For example, alkxoycarbonylation of nortropine·HCl with Boc2O, reaction with 2-fluoropyridine, deprotection using HCl, and treatment with 4-(trifluoromethyl)phenylisocyanate afforded endo-II. In soluble epoxide hydrolase (sEH) inhibition assay, endo-II showed 97% inhibition activity. Compounds I are claimed useful for the treatment of hypertension, kidney disease (primary and secondary), etc. The experimental process involved the reaction of (4-Bromo-2-chlorophenyl)methanamine hydrochloride(cas: 874482-96-9).Formula: C7H8BrCl2N

The Article related to bicyclic urea preparation soluble epoxide hydrolase inhibitor, hypertension treatment bicyclic urea seh inhibition, primary secondary kidney disease treatment bicyclic urea seh inhibition and other aspects.Formula: C7H8BrCl2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 28, 2022, Li, Zhi-Ying; Xu, Guang-Sen; Song, Yu-Liang; Li, Xun published an article.Application of 574-98-1 The title of the article was Structural optimizations and bioevaluation of N-substituted acridone derivatives as strong topoisomerase II inhibitors. And the article contained the following:

Previously, an array of N-substituted acridone derivatives have been reported as potent topoisomerase II (topo II) inhibitors, and preliminary structure-activity relationship (SAR) outcomes revealed that the linker between 1-NH and N-Me piperazine motif of the tricyclic acridone scaffold significantly affected their anti-proliferative potencies. To further explore the SARs of acridone-derived topo II inhibitors, a wider range of novel acridone derivatives were herein synthesized via two rounds of structural optimizations on two validated hits, E17 and E24. Initially, the linker length was optimized, and then influences of N-Me piperazinyl moiety and disposition of three N atoms on the bioactivity were investigated. As a result, a newly developed topo II inhibitor 6 h was found to be more potent than E17 and E24, thereby serving as a tool compound for the follow-up mechanistic study. Compound 6 h functioned as a strong topo IIα/β inhibitor, caused obvious DNA damage, and induced apoptosis by triggering the loss of mitochondrial membrane potential (Δψm). Further mol. docking and MD study illustrated the favorable interactions of 6 h with both topo IIα and topo IIβ subtypes. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Application of 574-98-1

The Article related to topoisomerase ii inhibitors structure activity relationship anticancer, n-substituted acridone derivatives, structural optimization, structure-activity relationship, topo iiα/β inhibitor and other aspects.Application of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary