Tag: 200-300

On August 5, 2020, Sidhu, Jagpreet Singh; Raj, Pushap; Pandiyan, Thangarasu; Singh, Narinder published an article.Formula: C10H8BrNO2 The title of the article was Synthesis of Nickel(II) Complexes of Novel Naphthalimide Based Heterodipodal Schiff Base Ligands, Structure, Characterization and Application for Degradation of Pesticides. And the article contained the following:

To degrade the highly toxic pesticide into less harmful components, authors have synthesized four nickel complexes of naphthalimide based organic ligands. These complexes catalyze the hydrolysis of phosphorothioate bonds of organophosphates in an aqueous medium. The metal complexes {[Ni(L1)2]-[Ni(L4)2]} were synthesized by the electrochem. method and characterized using single-crystal x-ray crystallog. and mass spectrometry. Anal. techniques revealed that complexes are mononuclear and possess octahedral geometry. The rate of degradation of chlorpyriphos and parathion Me was evaluated using 31P NMR and LC-MS chromatogram. The byproduct of chlorpyriphos upon catalytic degradation with complex was confirmed from mass spectrometry. It was found that chlorpyriphos degrade into 3,5,6-trichloropyridin-2-ol after 50 min of incubation with catalyst. However, parathion Me took only 20 min to hydrolyze into its byproduct. Moreover, the inhibition assay of acetylcholinesterase was performed for pesticides in the presence of metal complex and the interesting outcome was recorded. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Formula: C10H8BrNO2

The Article related to nickel naphthalimide heterodipodal schiff base preparation degrade pesticide, crystal mol structure naphthalimide heterodipodal schiff base, phosphorothioate organophosphate hydrolysis catalyst naphthalimide heterodipodal schiff base nickel and other aspects.Formula: C10H8BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On March 1, 2022, Meng, Depei; Lyu, Yichong; Ni, Chuanfa; Zhou, Min; Li, Yang; Hu, Jinbo published an article.Electric Literature of 2567-29-5 The title of the article was S-(Trifluoromethyl)Benzothioate (TFBT): A KF-Based Reagent for Nucleophilic Trifluoromethylthiolation. And the article contained the following:

S-(Trifluoromethyl)benzothioate (TFBT) was developed as an inexpensive, bench-stable and user-friendly trifluoromethylthiolation reagent which was easily synthesized by using KF as the only fluorine source. By using TFBT, trifluoromethylthiolates with various counterions was readily obtained. The synthetic application of TFBT was demonstrated by trifluoromethylthiolation-halogenation of arynes, bis(trifluoromethylthiolation)-halogenation of 1,2-benzdiynes, nucleophilic substitution of alkyl halides, deoxytrifluoromethylthiolation of alcs., and cross-coupling with aryl and vinyl boronic acids. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5

The Article related to trifluoromethyl benzothioate preparation aryne halogenation trifluoromethylthiolation, halo trifluoromethylthio arene preparation, s-(trifluoromethyl)benzothioate, aryne, multifunctionalization, potassium fluoride, trifluoromethylthiolation and other aspects.Electric Literature of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gong, Lingzhen; Zhao, He; Yang, Jian; Jiang, Huanfeng; Zhang, Min published an article in 2021, the title of the article was Selective construction of fused heterocycles by an iridium-catalyzed reductive three-component annulation reaction.Computed Properties of 2567-29-5 And the article contains the following content:

Here, through an initial pretreatment of N-heteroarenes with alkyl bromide, a syn-selective construction of functional fused heterocycles, chromenoquinolinones I [R1 = H, 7-Br, 10-NO2, etc.; R2 = CH2CH=CH2, Ph, 4-MeC6H4, etc.; R3 = H, Me; R4 = Me, Ph, 2-furyl] and chromenopyranoquinolinones II [R5 = H, 10-Me, 7-Br, etc.; R6 = H, 3-MeO, 2-Br, etc.] via iridium catalyzed reductive annulation of N-heteroarenium salts with formaldehyde and cyclic 1,3-diketones or 4-hydroxycoumarins, proceeding with broad substrate scope, good functional group compatibility, readily available feedstocks, and high step and atom efficiency was described. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Computed Properties of 2567-29-5

The Article related to chromenoquinolinone preparation diastereoselective, cyclohexanedione quinolinium bromide selective reductive annulation iridium catalyzed, chromenopyranoquinolinone preparation diastereoselective, hydroxycoumarin quinolinium bromide selective reductive annulation iridium catalyzed and other aspects.Computed Properties of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 17, 2021, Li, Wangbing; Lu, Zhichao; Hammond, Gerald B.; Xu, Bo published an article.Electric Literature of 2567-29-5 The title of the article was Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride. And the article contained the following:

An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerated nucleophilic fluorinations using easy handling KF. An inexpensive and com. available ion-exchange resin was successfully converted to the polymer-supported ion pair promoter (A26-SO42-), which could be reused after filtration. Moreover, A26-SO42- could be used in continuous flow conditions. Water was well-tolerated. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5

The Article related to alkyl fluoride preparation, methanesulfonate alkyl nucleophilic fluorination unbalanced ion pair catalyst, bromide alkyl nucleophilic fluorination unbalanced ion pair catalyst, sulfonyl fluoride preparation, chloride sulfonyl nucleophilic fluorination unbalanced ion pair catalyst and other aspects.Electric Literature of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 28, 2019, de O. Assis, Shalom P.; da Silva, Moara T.; da Silva, Filipe Torres; Sant’Anna, Mirella P.; de Albuquerque Tenorio, Carolina M. B.; dos Santos, Caroline F. Brito; da Fonseca, Caique S. M.; Seabra, Gustavo; Lima, Vera L. M.; de Oliveira, Ronaldo N. published an article.Category: bromides-buliding-blocks The title of the article was Design and synthesis of triazole-phthalimide hybrids with anti-inflammatory activity. And the article contained the following:

Phthalimido-alkyl-1H-1,2,3-triazole derivatives were efficiently synthesized using 1,3-dipolar cycloaddition reaction. Anti-inflammatory activity and toxicity studies were performed. The results demonstrated that all the tested compounds reduced carrageenan-induced paw edema and indicated no lethality for toxicity against Artemia salina and acute toxicity in vivo (LD50 up to 1 g kg-1). Furthermore, the structure of phthalimide linked to Ph group proved to be more active than the compounds containing benzothiazole moiety. Structural modifications such as removal of the phthalimide group and subsequent acetylation, to exemplify a non-cyclic amide, demonstrate that the phthalimide and triazole moieties were important for design of potent candidates with anti-inflammatory drug proprieties. Docking into the cyclooxygenase-2 (COX-2) confirmed the importance of the phthalimide and triazole groups in the anti-inflammatory activity. The histopathol. studies showed that the compounds did not cause serious pathol. lesions liver or kidneys. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Category: bromides-buliding-blocks

The Article related to benzothiazolyl sulfanyl methyl phthalimidoylalkyl triazole regioselective preparation, phenyl phthalimido alkyl triazole regioselective preparation, antiinflammatory activity sar acute toxicity lipophilicity mol docking, anti-inflammatory activity, phthalimide, toxicity, triazole and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 31, 2020, Liang, Xiao; Fu, Huansheng; Xiao, Peng; Fang, Hao; Hou, Xuben published an article.Category: bromides-buliding-blocks The title of the article was Design, synthesis and biological evaluation of imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as lymphoid-specific tyrosine phosphatase inhibitors. And the article contained the following:

Synthesized imidazolidine-2,4-dione derivatives I [R = carboxymethyl, Ph, benzyl, (4-carboxyphenyl)methyl, (4-phenylphenyl)methyl] and 2-thioxothiazolidin-4-one derivatives II (R1 = Bu, cyclohexyl, 2-chlorophenyl, thiazol-2-yl, etc.; R2 = carboxy, 4-carboxyphenyl, 2-carboxyeth-1-en-1-yl, etc.) as new LYP inhibitors were designed. Among them, the cinnamic acids-based inhibitors II [R1 = 2-methoxyphenyl, R2 = ((4-((1E)-2-carboxyeth-1-en-1-yl)phenyl)methyl)oxidanyl; R1 = 4-chlorophenyl, R2 = ((4-((1E)-2-carboxyeth-1-en-1-yl)phenyl)methyl)oxidanyl (III)] displayed good LYP inhibitory activities (IC50 = 2.85-6.95μM). Especially, the most potent inhibitor III was identified as competitive inhibitor (Ki = 1.09μM) and bind LYP reversibly. Meanwhile, III exhibited better selectivity over other phosphatases than known LYP inhibitor A15. Furthermore, compound III could regulate TCR associated signaling pathway in Jurkat T cell. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Category: bromides-buliding-blocks

The Article related to thioxothiazolidinone preparation docking lymphoid tyrosine phosphatase inhibitor autoimmunity, imidazolidinedione preparation diastereoselective docking lymphoid tyrosine phosphatase inhibitor autoimmunity, autoimmune diseases, inhibitor, lymphoid-specific tyrosine phosphatase and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 1, 2020, Serran- Aguilera, Lucia; Mariotto, Elena; Rubbini, Gianluca; Castro Navas, Francisco Fermin; Marco, Carmen; Carrasco-Jimenez, Maria Paz; Ballarotto, Marco; Macchiarulo, Antonio; Hurtado-Guerrero, Ramon; Viola, Giampietro; Lopez-Cara, Luisa Carlota published an article.Computed Properties of 2567-29-5 The title of the article was Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism. And the article contained the following:

Seeking for new anticancer drugs with strong antiproliferative activity and simple mol. structure, we designed a novel series of compounds based on our previous reported pharmacophore model composed of five moieties. Antiproliferative assays on four tumoral cell lines and evaluation of human choline kinase CKα1 enzymic activity was performed for these compounds Among tested mols., those ones with biphenylmethyl groups showed better enzymic and antiproliferative activities. Docking and crystallization studies validate the hypothesis and confirm the results. The most active compound, the biphenylmethylquinolinium bromide I·Br-, induced significant arrest of the cell cycle in G0/G1 phase that ultimately lead to apoptosis, following the mitochondrial pathway, as demonstrated for other choline kinase inhibitors. However, addnl. assays reveal that the inhibition of choline uptake could also be involved in the antiproliferative activity of this class of compounds The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Computed Properties of 2567-29-5

The Article related to benzylquinolinium benzylpyridinium benzylquinuclidinium preparation choline kinase inhibition, structure benzylpyridinium benzylquinolinium benzylquinuclidinium inhibition choline kinase antitumor activity, benzylpyridinium bromide complex choline kinase mol crystal structure and other aspects.Computed Properties of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 30, 2021, Al-Hamashi, Ayad A.; Chen, Dongxing; Deng, Youchao; Dong, Guangping; Huang, Rong published an article.Application of 574-98-1 The title of the article was Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5. And the article contained the following:

Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthesis of bisubstrate analogs for PRMTs that incorporate a S-adenosylmethionine (SAM) analog moiety and a tripeptide through an alkyl substituted guanidino group. Compound AH237 is a potent and selective inhibitor for PRMT4 and PRMT5 with a half-maximal inhibition concentration (IC50) of 2.8 and 0.42 nmol/L, resp. Computational studies provided a plausible explanation for the high potency and selectivity of AH237 for PRMT4/5 over other 40 methyltransferases. This proof-of-principle study outlines an applicable strategy to develop potent and selective bisubstrate inhibitors for PRMTs, providing valuable probes for future structural studies. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Application of 574-98-1

The Article related to amino acids role: bsu (biological study, unclassified), biol (biological study), computational biology, drug design, homo sapiens, human, methylation, molecular docking, molecular modeling, tripeptides role: bsu (biological study, unclassified), biol (biological study) (rgk), tripeptides role: bsu (biological study, unclassified), biol (biological study) (rgr) and other aspects.Application of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On June 23, 2011, Hardy, Larry Wendell; Heffernan, Michele L. R.; Wu, Frank Xinhe; Spear, Kerry L.; Saraswat, Lakshmi D. published a patent.Reference of 2-Amino-6-bromonicotinic acid The title of the patent was Preparation of substituted quinazolinones and their analogs for treating disorders mediated by metabotropic glutamate receptor 5. And the patent contained the following:

The title compounds I [R1 = H, alkyl, heteroalkyl, etc.; R2 = H, alkyl, cycloalkyl, etc.; R3 = H, alkyl, heteroalkyl, etc.; G = CHR2 or NR2 when b and c are both single bonds, or G = CR2 or N when one of b and c is a double bond; Q = NH or CH2 when d and e are single bonds, or N or CH one of d or e is a double bond; X = CH or N when f is a single bond, or C when f is a double bond; Z = CH2, C(O), C(S) or a bond when b is a single bond, or CH or N when b is a double bond; Y1-Y3 = CH, C(halo), C(alkyl), N (provided that no more than one of Y2 and Y3 = N); L1 = CC, HC=CH, CH2CH2, etc.] which modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery, and therefore are useful for the treatment, prevention, and/or management of various disorders, such as neurol. disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer, were prepared Thus, Pd-catalyzed coupling of 7-bromoquinazolin-4(3H)-one with 1-ethynyl-4-fluorobenzene afforded II. Exemplified compounds I were tested in in vitro cell-based assay for modulation of the activation of mGluR5 by glutamate (data given for representative compounds I). Pharmaceutical formulations containing the compounds I and their methods of use are also provided herein. The experimental process involved the reaction of 2-Amino-6-bromonicotinic acid(cas: 1196157-51-3).Reference of 2-Amino-6-bromonicotinic acid

The Article related to quinazolinone pyridoquinazolinone pyridopyrimidinone diazepinoquinazolinone preparation metabotropic glutamate receptor mglur5, neurol neurodegenerative neuropsychiatric learning memory disorder treatment quinazolinone preparation, cognition enhancer gastrointestinal antitumor quinazolinone pyridoquinazolinone pyridopyrimidinone diazepinoquinazolinone preparation and other aspects.Reference of 2-Amino-6-bromonicotinic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 5, 2022, Zhang, Yan-Dong; Li, Xiao-Yu; Mo, Qian-Kun; Shi, Wen-Bin; Zhao, Jia-Bao; Zhu, Shou-Fei published an article.HPLC of Formula: 2567-29-5 The title of the article was Highly Regioselective Cobalt-Catalyzed Hydroboration of Internal Alkynes. And the article contained the following:

Herein, we report the development of new Co complexes that have cyclopropane-based diphosphine ligands and can catalyze highly chemo-, regio-, and stereoselective hydroboration reactions of unsym. internal alkynes. These reactions exhibited unusual regioselectivity: specifically, reactions of aryl alkyl internal alkynes showed excellent cis-β-addition selectivity, and reactions of dialkyl internal alkynes gave excellent cis-α-addition selectivity. Highly regioselective hydroboration of unsym. dialkyl internal alkynes cannot be achieved by other known methods. The reactions described herein are highly synthetically useful, particularly for the stereoselective synthesis of trisubstituted alkenylborates and alkenes. Mechanistic studies indicate that a CoI-H species is a plausible active catalyst and the rigid structure of the cyclopropane skeleton of the ligands and the crowded reaction pocket were responsible for the unprecedented regioselectivity. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).HPLC of Formula: 2567-29-5

The Article related to regioselective stereoselective cobalt catalyst hydroboration internal alkyne dft mechanism, cobalt cyclopropanediphosphine complex preparation catalyst regioselective hydroboration internal alkyne, crystal structure mol cobalt cyclopropane diphosphine complex preparation, alkenylborates, cobalt catalysis, diphosphine ligands, hydroboration, internal alkynes and other aspects.HPLC of Formula: 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary