Tag: 200-300

On October 1, 2018, Erokhina, Svetlana A.; Stogniy, Marina Yu.; Suponitsky, Kyrill Yu.; Kosenko, Irina D.; Sivaev, Igor B.; Bregadze, Vladimir I. published an article.COA of Formula: C10H8BrNO2 The title of the article was Synthesis of new nido-carborane based carboxylic acids and amines. And the article contained the following:

New nido-carborane based carboxylic acids 10-HOOC(CH2)n(Me)S-7,8-C2B9H11 (n = 1-4) were prepared by alkylation of Bu4N salt of 10-methylthio-7,8-dicarba-nido-borane with ω-haloalkyl esters or nitriles followed by acid hydrolysis. Likewise nido-carborane based amines 10-H2N(CH2)n(Me)S-7,8-C2B9H11 (n = 2, 3) were obtained using ω-bromoalkylphthalimides as alkylating agents followed by removal of the protecting group with hydrazine. Structure of 10-C6H4(CO)2NCH2CH2(Me)S-7,8-C2B9H11 was determined by single crystal x-ray diffraction. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).COA of Formula: C10H8BrNO2

The Article related to amine carboranylthioalkyl derivative preparation, carboxylic acid carboranylthioalkyl derivative preparation, carboranyl thioalkylphthalimide preparation crystal structure reaction hydrazine, mol structure carboranyl thioalkylphthalimide, alkylation thiodicarbaborane haloalkyl ester nitrile and other aspects.COA of Formula: C10H8BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 10, 2022, Chen, Chen published a patent.Related Products of 111010-07-2 The title of the patent was Preparation of cyclic iminopyridimdine compounds and their bicyclic derivatives as kinase inhibitors and uses thereof. And the patent contained the following:

Provided are the title compounds I [G1 = N or CRa; G2 = N or CRb; n = 1 or 2; m = 0-3; Ra and Rb = (independently) H, halo, CN, etc.; each R1 = (independently) halo, (un)substituted alkyl, alkoxy; or two R1 groups with the carbon atom they connect to form (un)substituted 4-7 membered carbocyclic or heterocyclic ring; R2 = H, (un)substituted alkyl, alkoxy, etc.; R3 = H, halo, (un)substituted alkyl, alkoxy; R4 = H, (un)substituted alkyl, heterocyclyl, etc.; and R5 = H, alkyl, or heterocyclyl; or NR4R5 = (un)substituted heterocyclyl or heteroaryl; with the provisos] or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds or compositions, such as methods of treating a proliferation disorder, such as a cancer or a tumor, or in some embodiments disease or disorders related to the dysregulation of kinase such as, but not limited to kinases such as MAPK, PDGFR, Src, PAKs, c-Kit, EphA2, EphB4, FGFR, Axl, and c-Met. E.g., a multi-step synthesis of II, starting from 4-amino-2-(methylthio)pyrimidine-5-carboxaldehyde and Me 2-(2,4-dichlorophenyl)acetate, was described. The effect of the exemplified compounds I on the activity of various kinases were assessed (data given for representative compounds I). The experimental process involved the reaction of 5-Bromo-4-chloro-2-fluoroaniline(cas: 111010-07-2).Related Products of 111010-07-2

The Article related to cyclic iminopyrimidine bicyclic derivative preparation kinase inhibitor antitumor, mapk pdgfr src pak kinase inhibitor imidazopyridopyrimidinamine pyridodipyrimidinamine preparation, ckit epha2 ephb4 kinase inhibitor imidazopyridopyrimidinamine pyridodipyrimidinamine preparation antitumor and other aspects.Related Products of 111010-07-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mumtaz, Saira; Robertson, Mark J.; Oelgemoller, Michael published an article in 2019, the title of the article was Continuous flow photochemical and thermal multi-step synthesis of bioactive 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione And the article contains the following content:

An effective multi-step continuous flow approach towards N-(diamino)alkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones I [R = H, Me, OMe, F, R1 = Me, Et, X = (CH2)n, n = 2, 3], including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochem.-thermal-thermal flow setup rapidly provides the desired target compounds I in superior yields and significantly shorter reaction times. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to arylmethylene isoindolinone preparation continuous flow photochem thermal, bromoalkyl phthalimide arylactetate continuous flow photochem thermal reaction, arylmethylene isoindolinones, continuous-flow photochemistry, multi-step synthesis, photochemistry, photodecarboxylation, phthalimide and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 22, 2014, Dominique, Romyr; Lopez-Tapia, Francisco Javier; Mertz, Eric; So, Sung-Sau published a patent.Recommanded Product: 2-Bromo-4-fluoro-5-methylbenzoic acid The title of the patent was Preparation of substituted pyridinones as inhibitors of bruton’s tyrosine kinase. And the patent contained the following:

The title compounds I [A = (un)substituted unsaturated or partially saturated monocyclic or bicyclic heteroaryl or phenyl; R1 = halo, hydroxyalkyl, alkyl; m = 0-2; R2 = Me, pyrazolyl; n = 0-1; X = a bond, CH2, NHC(O)], useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity, were prepared E.g., a multi-step synthesis of II, starting from 6-tert-butyl-8-fluoro-2H-phthalazin-1-one and 1-bromo-4-chloromethylbenzene, was described. Exemplified compounds I were evaluated for their Btk inhibitory activity (data given). The compounds I are useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds I and at least one carrier, diluent or excipient. The experimental process involved the reaction of 2-Bromo-4-fluoro-5-methylbenzoic acid(cas: 1003709-39-4).Recommanded Product: 2-Bromo-4-fluoro-5-methylbenzoic acid

The Article related to pyridinone phthalazinone preparation bruton’s tyrosine kinase btk inhibitor antiinflammatory, phthalazinone oxopyridinylbenzyl preparation auto immune disease aberrant bcell proliferation, rheumatoid arthritis treatment antirheumatic pyridinone phthalazinone preparation btk inhibitor and other aspects.Recommanded Product: 2-Bromo-4-fluoro-5-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 15, 2015, Dominique, Romyr; Lopez-Tapia, Francisco Javier; Mertz, Eric; So, Sung-Sau published a patent.Application In Synthesis of 2-Bromo-4-fluoro-5-methylbenzoic acid The title of the patent was Inhibitors of bruton’s tyrosine kinase. And the patent contained the following:

This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient. The experimental process involved the reaction of 2-Bromo-4-fluoro-5-methylbenzoic acid(cas: 1003709-39-4).Application In Synthesis of 2-Bromo-4-fluoro-5-methylbenzoic acid

The Article related to pyridinone phthalazinone preparation brutons tyrosine kinase btk inhibitor antiinflammatory, phthalazinone oxopyridinylbenzyl preparation auto immune disease aberrant bcell proliferation, rheumatoid arthritis treatment antirheumatic pyridinone phthalazinone preparation btk inhibitor and other aspects.Application In Synthesis of 2-Bromo-4-fluoro-5-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Organic Chemistry included an article by Baydoun, Orsola; De Rycke, Nicolas; Leonce, Estelle; Boutin, Celine; Berthault, Patrick; Jeanneau, Erwann; Brotin, Thierry. Safety of Benzyl 2-bromoacetate. The article was titled 《Synthesis of Cryptophane-223-Type Derivatives with Dual Functionalization》. The information in the text is summarized as follows:

The authors present the synthesis of new cryptophane-type hosts capable of binding xenon in aqueous media and that may be useful for the development of xenon-based magnetic resonance imaging derivatives The synthetic route proposed was chosen to facilitate both the introduction of water-solubilizing substituents and the functionalization of the host with a single arm showing recognition properties that constitute two crucial steps. This was made possible by preparing new cryptophane-223 derivatives bearing two different chem. functions that can be easily modified at a later stage. Thus, subsequent reactions allowed the design of a new cryptophane host able to bind zinc or nickel cations. The ability of this mol. to bind cationic species was assessed by calorimetric titration experiments and hyperpolarized 129Xe NMR. The advantages and disadvantages of this approach are discussed. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Safety of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Organic Chemistry included an article by Ding, Shao-Lei; Ji, Yang; Su, Yan; Li, Rui; Gu, Peiming. Synthetic Route of C7H13BrO2. The article was titled 《Schmidt Reaction of ω-Azido Valeryl Chlorides Followed by Intermolecular Trapping of the Rearrangement Ions: Synthesis of Assoanine and Related Pyrrolophenanthridine Alkaloids》. The information in the text is summarized as follows:

The Schmidt reaction of ω-azido valeryl chlorides in the presence of an addnl. nucleophile was explored. The arenes, alcs., and amines were demonstrated as the intermol. trapping reagents for isocyanate ion and N-acyliminium ion from the Schmidt rearrangement, affording the corresponding products with moderate to excellent yields. Two 2-oxoindoles from the reaction were successfully converted into four natural alkaloids, namely, assoanine, anhydrolycorine, oxoassoanine, and anhydrolycorinone. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Synthetic Route of C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Synthetic Route of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ACS Medicinal Chemistry Letters included an article by Mori, Mattia; Dasso Lang, Maria Chiara; Saladini, Francesco; Palombi, Nastasja; Kovalenko, Lesia; De Forni, Davide; Poddesu, Barbara; Friggeri, Laura; Giannini, Alessia; Malancona, Savina; Summa, Vincenzo; Zazzi, Maurizio; Mely, Yves; Botta, Maurizio. Product Details of 1129-28-8. The article was titled 《Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein》. The information in the text is summarized as follows:

Small mol. inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested in vitro 18 NC inhibitors (NCIs) bearing a double functionalization. In these NCIs, one part of the mol. is designed to interact noncovalently with the NC hydrophobic pocket, while the second portion is designed to interact with the N-terminal domain of NC. This binding hypothesis was verified by mol. dynamics simulations, while the linkage between these two pharmacophores was found to enhance antiretroviral activity both on the wild-type virus and on HIV-1 strains with resistance to currently licensed drugs. The two most interesting compounds, I and II, showed no cytotoxicity, thus becoming valuable leads for further investigations. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Product Details of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Product Details of 1129-28-8 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 3-Bromo-2-nitrobenzoic acidOn June 4, 2004, Fatemi, M. H. published an article in Journal of Chromatography A. The article was 《Prediction of the electrophoretic mobilities of some carboxylic acids from theoretically derived descriptors》. The article mentions the following:

A 4-4-1 artificial neural network was constructed and trained for the prediction of the electrophoretic mobilities of some aliphatic and aromatic carboxylic acids based on quant. structure-property relations. The inputs of this network are theor. derived descriptors that were chosen by the stepwise variables selection techniques. These descriptors are: shape factor, mol. surface area, the maximum value of electron d. on atom in mol., and the sum of at. polarizability. To assess the accuracy and predictability of the proposed model, the cross-validation test was employed. The results obtained showed the ability of developed artificial neural network to prediction of electrophoretic mobilities of aliphatic and carboxylic acids. Also result reveals the superiority of the artificial neural network over the multiple linear regression models. The experimental process involved the reaction of 3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4Safety of 3-Bromo-2-nitrobenzoic acid)

3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Safety of 3-Bromo-2-nitrobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Two-dimensional zinc(II) and copper(I) coordination polymers for photoluminescence》 was written by Jeong, Ah Rim; Shin, Hye Jin; Jang, Yoon Jung; Min, Kil Sik. Recommanded Product: 623-24-5This research focused onzinc copper polypyridine coordination polymer preparation photoluminescence thermal stability; crystal structure zinc copper polypyridine coordination polymer. The article conveys some information:

Two-dimensional (2-D) coordination polymers [Zn2(bpab)(CH3CO2)4]·H2O (1), [Zn(bpab)(H2O)2](NO3)2 (2), [Cu2(bpab)I2]·CH3OH (3), and [Cu2(tpmd)I2] (4) have been synthesized by the reaction of zinc(II)/copper(I) ions and tetradentate polypyridine ligands (bpab = bis-1,4-(di-4-pyridylaminomethyl)benzene and tpmd = N,N,N’,N’-tetrakis(pyridine-4-yl)methanediamine). The zinc(II) ions of 1 and 2 have distorted tetrahedral and trigonal bipyramidal geometries, resp. By coordinating zinc(II) ions and bpab ligands, 1 and 2 formed a brick wall and puckered 2-D networks, resp. The copper(I) ions of 3 and 4 are both tetrahedral structures with Cu2I2 rhomboidal geometry. By linking the Cu2I2 cores and bpab/tpmd ligands, 3 and 4 exhibited interwoven and interconnected bilayered 2-D networks, resp. Compared to free bpab and tpmd ligands, polymers 1 and 2 show strongly blue-shifted emissions, whereas polymers 3 and 4 show strongly red-shifted emissions. Therefore, the shifts of emission wavelengths are strongly dependent on the zinc(II) and copper(I) ions that linked the bpab/tpmd tetradentate ligands, resp. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Recommanded Product: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 623-24-5 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary