Tag: 200-300

Yan, Qiwen; Mao, Lina; Feng, Bang; Zhang, Lidong; Wu, Yiqian; Huang, Wei published an article in 2021. The article was titled 《Reversible Patterning Cross-Linked, Humidity-Responsive Polymer Films with Programmatically and Accurately Controlled Deformation》, and you may find the article in ACS Applied Materials & Interfaces.Safety of 1,6-Dibromohexane The information in the text is summarized as follows:

A series of novel humidity-responsive and photosensitive polymer films (PCA-PAA-PEG) are prepared These films can be patterning crosslinked by the photodimerization of coumarin pendant groups. The humidity-induced deformation can be well controlled by the pattern because of the different modulus and hydrophilicity between crosslinked and un-crosslinked segments. In addition, the pattern can be erased and the deformation direction can be changed programmatically by the de-crosslinking-re-crosslinking approach due to the reversible photodimerization of coumarin groups. The crosslinking degree also affects the humidity responsiveness of the film. The deformation of the gradient patterning crosslinked film can be more accurately controlled. Moreover, the length and width ratio (L/Ws/Wh) of the un-crosslinked segment to the crosslinked segment affects the deformation of the films as well. When L/Ws/Wh is 5/2/1 or 5/3/1, the deformation is controllable, and when L/Ws/Wh is 5/1/1 or 5/4/1, the deformation is random at the initial stage, but the whole film will bend along the short axis in the end. In addition to this study using 1,6-Dibromohexane, there are many other studies that have used 1,6-Dibromohexane(cas: 629-03-8Safety of 1,6-Dibromohexane) was used in this study.

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.Safety of 1,6-Dibromohexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase》 was published in ACS Medicinal Chemistry Letters in 2020. These research results belong to Tanaka, Yuta; Kurasawa, Osamu; Yokota, Akihiro; Klein, Michael G.; Saito, Bunnai; Matsumoto, Shigemitsu; Okaniwa, Masanori; Ambrus-Aikelin, Geza; Uchiyama, Noriko; Morishita, Daisuke; Kimura, Hiromichi; Imamura, Shinichi. HPLC of Formula: 76006-33-2 The article mentions the following:

In this work, a new chem. series possessing fused ring scaffolds designed from high-throughput screening hit compounds was synthesized, discovering a 5,6-dihydrothieno[2,3-c]pyridine derivative I [R = (R)-i-Bu] with potent inhibitory activity. Furthermore, the X-ray crystallog. anal. of the DHPS complex with I [R = (R)-i-Bu] demonstrated a distinct allosteric binding mode compared to a previously reported inhibitor. These findings could be significantly useful in the functional anal. of conformational changes in DHPS as well as the structure-based design of allosteric inhibitors. In the part of experimental materials, we found many familiar compounds, such as 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. HPLC of Formula: 76006-33-2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Dual-Functionalized Fluorescent Cationic Organic Network: Highly Efficient Detection and Removal of Dichromate from Water》 were Li, Zhi-Jun; Xue, Hua-Dong; Ma, Yun-Xiang; Zhang, Qi; Li, Yan-Chun; Xie, Miao; Qi, Hui-Li; Zheng, Xu-Dong. And the article was published in ACS Applied Materials & Interfaces in 2019. Formula: C8H8Br2 The author mentioned the following in the article:

Dichromate is one of widespread contaminants in wastewater, it has threatened the health of human and other organisms. Therefore, effective detection and removal of dichromate from water is of great significance. Herein, a tetraphenylethylene functionalized cationic organic network (CON-LDU2) was constructed via a facile quaternization reaction. CON-LDU2 was successfully integrated with both detection and removal functionalities towards dichromate. On the one hand, benefitting from the strong fluorescence, CON-LDU2 was employed as a chemosensor, it could efficiently and selectively probe Cr2O72- in water with “”turn-off”” fluorescent response. On the other hand, the cationic skeleton and free anions inside framework make CON-LDU2 an excellent adsorbent for Cr2O72-, it could capture Cr2O72- from water with rapid kinetic and high capacity. The kinetic constant for adsorption of Cr2O72- can reach up to 1.784 g mg-1 min-1, while the capacity is determined as 325 mg g-1. Furthermore, CON-LDU2 displayed good recyclability and can be reused at least for 5 cycles. Therefore, CON-LDU2 can serve as an ideal candidate not only in detection but also in removal of Cr2O72- in water medium. After reading the article, we found that the author used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Formula: C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Formula: C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Solid State Chemistry included an article by Liu, Jian-Jun; Yu, Li-Mei; Han, Fu-Xu; Chen, Fu-Yu; Cheng, Fei-Xiang. Category: bromides-buliding-blocks. The article was titled 《A thioether-containing luminescent metal-organic framework for highly selective and sensitive detection of Ag(I) ion》. The information in the text is summarized as follows:

A stable three-dimensional coordination polymer, [Eu2(pbbp)(pbsd)3] (1) (H2pbsd = 2,2′-((1,4-phenylenebis(methylene))bis(sulfanediyl))dinicotinic acid, H2pbbp·2Cl = 1,1′-(1,4-phenylene-bis(methylene))-bis(3-carboxy pyridinium) dichloride), was prepared by the solvothermal reaction of Eu(NO3)3·6H2O, H2pbbp·2Cl and H2pbsd in mixed solvent of DMF and H2O, which was characterized by single-crystal X-ray diffraction, powder X-ray diffraction, IR spectroscopy, and thermogravimetric analyses. 1 exhibits a 3D 6-connected sqcl network decorated by uncoordinated Lewis basic thioether groups. In particular, 1 shows excellent application as luminescent sensor for sensing Ag+ ions in ethylene glycol solution with high sensitivity and selectivity based on luminescence quenching effect. The experimental part of the paper was very detailed, including the reaction process of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Category: bromides-buliding-blocks)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Advanced Synthesis & Catalysis included an article by Han, Wen-Jing; Pu, Fan; Li, Chao-Jun; Liu, Zhong-Wen; Fan, Juan; Shi, Xian-Ying. SDS of cas: 76006-33-2. The article was titled 《Carboxyl-Directed Conjugate Addition of C-H Bonds to α,β-Unsaturated Ketones in Air and Water》. The information in the text is summarized as follows:

A simple ruthenium-catalyzed conjugate addition of C-H bonds to α,β-unsaturated ketones directed by a removable carboxyl group was developed as an effective protocol to synthesize ortho-alkylated benzoic acids in a greener manner. Without any additives, satisfactory to excellent yields of the targeted products were achieved in neat water, and the process characterizes in mild reaction conditions (in air and water), simple operations, and broad substrate scope. Noteworthy features of this method include mild reaction conditions (in air and water), operational simplicity and broad substrate scope. The versatility and utility of the addition products were demonstrated through further transformation into commonly inaccessible but highly useful motifs of meta-substituted alkylbenzenes and 3-substituted isochromanones. The results came from multiple reactions, including the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2SDS of cas: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. SDS of cas: 76006-33-2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Chu, Shidong; Zhou, Guangyan; Gochin, Miriam published 《Evaluation of ligand-based NMR screening methods to characterize small molecule binding to HIV-1 glycoprotein-41》.Organic & Biomolecular Chemistry published the findings.Formula: C9H9BrO2 The information in the text is summarized as follows:

Small mol. inhibitors of glycoprotein-41 (gp41) are able to prevent HIV infection by binding to a hydrophobic pocket (HP) contained within the gp41 ectodomain, and preventing progression of fusion. There is little structural information on gp41-ligand complexes, owing to hydrophobicity of the ligands, occlusion of the HP in folded gp41 ectodomain, and failure to form crystals of complexes. Here the authors used an engineered gp41 ectodomain protein containing an exposed HP and a small mol. designed to bind with weak affinity to the HP. The authors evaluated NMR methods, including WaterLOGSY, Saturation Transfer Difference spectroscopy (STD-NMR) and 1H relaxation rate difference spectroscopy with and without target irradiation (DIRECTION) for their ability to probe complex formation and structure. WaterLOGSY was the most sensitive technique for monitoring formation of the complex. STD-NMR and DIRECTION experiments gave similar pharmacophore mapping profiles, although the low dynamic range of the DIRECTION experiment limited its discrimination and sensitivity. A unique binding pose was identified from the STD data and provided clues for future optimization. Advantages and disadvantages of the techniques are discussed. This is the first example of the use of STD for structural anal. of a gp41-small mol. complex. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Formula: C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C9H9BrO2 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Schmidt, Andrea; Molano, Viviana; Hollering, Manuela; Poethig, Alexander; Casini, Angela; Kuehn, Fritz E. published 《Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin》.Chemistry – A European Journal published the findings.Name: 3,5-Dibromoaniline The information in the text is summarized as follows:

Self-assembled metallocages are very promising drug-delivery systems among supramol. complexes. Thus, exo-functionalized Pd2L4 (L=ligand) cages were synthesized and characterized, and the encapsulation of the anticancer drug cisplatin in their cavity has been documented. The antiproliferative effects of the metallocages and their combination with cisplatin were examined in vitro in cancer cell lines, while fluorescence microscopy was used to monitor their uptake. Notably, the hydroxymethyl-functionalized PdII cage encapsulating cisplatin showed improved cytotoxic effect against human ovarian cancer cells compared to free cisplatin. The toxicity of Pd2L4 cages was evaluated for the first time ex vivo in healthy rat-liver tissues using the precision cut-tissue slices technol., demonstrating in some cases scarce effects on liver viability. These results further highlight the potential of self-assembled Pd2L4 cages for biol. applications. In the experimental materials used by the author, we found 3,5-Dibromoaniline(cas: 626-40-4Name: 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Name: 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Zhang, Zongyao; Zheng, Kunyi; Xia, Tianlong; Xu, Lijin; Cao, Rui published 《Ni3 versus Ni30: A Truncated Octahedron Metal-Organic Cage Constructed with [Ni5(CN)4]6+ Squares and Tripodal Tris-tacn Ligands That are Large and Flexible》.Chemistry – A European Journal published the findings.Related Products of 1129-28-8 The information in the text is summarized as follows:

Reactions of trinickel complex of tripodal tris-tacn ligand N(CH2-m-C6H4-CH2tacn)3 (L, tacn = 1,4,7-triazacyclononane) in acetonitrile-methanol solution with and without phosphate led to two complexes of distinct nuclearities, [(NiIICl)3(CH3OH)3(HPO4)L](PF6) (Ni3, 1) and [(NiII5(CN)4(H2O)8Cl)6L8]Cl30 (Ni30, 2). Ligand L takes upward and downward conformation in the structure of 1 and 2, resp. It is proposed that phosphate directs the upward conformation of Ni3L to form 1. In the absence of phosphate, Ni3L assembles with cyanide ions, which are formed by Ni-catalyzed C-CN bond cleavage of acetonitrile, to give a nano-sized Ni30 cage. Complex 2 represents a discrete truncated octahedron cage assembled with [Ni5(CN)4]6+ squares and large and flexible triangular ligands, which is scarcely observed for self-assembled metal-organic cages. The magnetic properties of 1 and 2 were examined, showing intriguing magnetic properties.Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Related Products of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2015,Zhao, Xinge; Xin, Minhang; Huang, Wei; Ren, Yanliang; Jin, Qiu; Tang, Feng; Jiang, Hailong; Wang, Yazhou; Yang, Jie; Mo, Shifu; Xiang, Hua published 《Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton’s tyrosine kinase inhibitors》.Bioorganic & Medicinal Chemistry published the findings.Reference of 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

A series of novel reversible Btk inhibitors has been designed based on the structure of the recently reported preclin. drug RN486. The synthesis and SAR of these compounds are described. Among these derivatives, compound (I) was identified to be a potent and orally available reversible agent with satisfactory Btk enzymic and cellular inhibition in vitro, as well as favorable PK properties and inhibition of arthritis in vivo. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Reference of 3-Bromo-2-methylbenzoic acid The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2010,Pan, Shifeng; Wu, Xu; Jiang, Jiqing; Gao, Wenqi; Wan, Yongqin; Cheng, Dai; Han, Dong; Liu, Jun; Englund, Nathan P.; Wang, Yan; Peukert, Stefan; Miller-Moslin, Karen; Yuan, Jing; Guo, Ribo; Matsumoto, Melissa; Vattay, Anthony; Jiang, Yun; Tsao, Jeffrey; Sun, Fangxian; Pferdekamper, AnneMarie C.; Dodd, Stephanie; Tuntland, Tove; Maniara, Wieslawa; Kelleher, Joseph F. III; Yao, Yung-mae; Warmuth, Markus; Williams, Juliet; Dorsch, Marion published 《Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist》.ACS Medicinal Chemistry Letters published the findings.Synthetic Route of C8H7BrO2 The information in the text is summarized as follows:

The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was performed, and the lead structure (1) was identified as an inhibitor of the Hh pathway via antagonism of the Smoothened receptor (Smo). Structure-activity relation studies led to the discovery of a potent and specific Smoothened antagonist N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4′-(trifluoromethoxy)biphenyl-3-carboxamide (5m, NVP-LDE225), which is currently in clin. development. In the experiment, the researchers used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Synthetic Route of C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Synthetic Route of C8H7BrO2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary