Tag: 200-300

《Water-soluble UV/visible light activated Mn-CO-releasing molecules: Synthesis, structure, CO releasing and biological activities evaluation》 was published in Inorganic Chemistry Communications in 2020. These research results belong to Hu, Mixia; Zhu, Baohua; Zhou, Haofei; Qiao, Lu; Fan, Jianming; Du, Yanqing; Chang, Fei; Yu, Shiyong. Safety of Bromopentacarbonylmanganese(I) The article mentions the following:

By reactions of MnBr(CO)5 with 2,2′-bipyridyl-4,4′-dicarboxylic acid and 2,5-pyridinedicarboxylic acid, resp., authors obtained two new Mn-CORMs, [Mn(CO)3(H2O)(HBPDC)] (1) and [Mn(CO)3(CH3CN)(HPYDC)]·CH3CN (2). Complexes 1 and 2 are stable in the absence of light, but they exhibit good CO release ability upon exposure to UV and visible light (blue and green). The CO releasing rate depends on the wavelength of irradiation light, i.e., UV > blue > green, which may make them act as visible light regulated CORMs. It is noteworthy that complexes 1 and 2 possess high water-solubility TD-DFT studies of complexes 1 and 2 reveal that the metal-to-ligand charge-transfer (MLCT) may be responsible for their CO releasing behaviors triggered by UV and visible light. The cellular viability and anti-inflammatory activities evaluation show that complexes 1 and 2 can inhibit the secretion of NO and TNF-α in LPS-stimulated RAW264.7 macrophages with fine biol. compatibility and without apparent cytotoxicity. Furthermore, during the synthesis of complexes 1 and 2, when the pH of solution is hinger than 7, complexes {[Mn(BPDC)]}n (1A) and [Mn(H2O)2(HPYDC)2] (2A) are obtained. Complex 1A is a new 3D Mn-MOF and complex 2A is a zero-dimensional mononuclear compound, which are all without -CO ligand. In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2Safety of Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Safety of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Binuclear manganese-iron complexes containing ferrocenyl thiosemicarbazones: Biological activity and carbon monoxide-releasing properties》 was published in Inorganica Chimica Acta in 2020. These research results belong to Lawrence, Madelyn L.; Shell, Steven M.; Beckford, Floyd A.. Name: Bromopentacarbonylmanganese(I) The article mentions the following:

This research aimed to pair a ferrocenyl TSC ligand with a {Mn(CO)3} subunit to create a photoactive complex. Six complexes were synthesized, characterized, and tested for their biol. activities as well as their propensity to act as photoCORMs. The results suggest that while the complexes release CO only slowly and likely to a small extent, good toxicity profiles were observed for the CORMs against bacteria and human cells, suggesting a broad mechanism of action. The CORM compounds represent a potential vehicle for future development of targeted antibiotic and antitumor compounds In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2Name: Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Name: Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of Benzyl 2-bromoacetateIn 2020 ,《Diastereoselective synthesis of spiro-cyclopropanyl-cyclohexadienones via direct sulfide-catalyzed [2 + 1] annulation of para-quinone methides with bromides》 appeared in Organic & Biomolecular Chemistry. The author of the article were Su, Yingpeng; Zhao, Yanan; Chang, Bingbing; Ling, Qinqin; Feng, Yawei; Zhao, Xiaolong; Huang, Danfeng; Wang, Ke-Hu; Huo, Congde; Hu, Yulai. The article conveys some information:

An efficient sulfide-catalyzed [2 + 1] annulation of para-quinone methides (p-QMs) with diverse bromides was achieved. This catalytic strategy provided an efficient and straightforward protocol for accessing a variety of spiro-cyclopropanyl-cyclohexadienone compounds in good to excellent yields (64% to 96% yields) with outstanding diastereoselectivities (>20 : 1 dr) displaying good functional group tolerance as well as gram-scale capacity. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Reference of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Reference of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 14660-52-7In 2019 ,《Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer》 appeared in Chemical Biology & Drug Design. The author of the article were Chen, Jinying; Sang, Zitai; Jiang, Youjun; Yang, Chao; He, Linhong. The article conveys some information:

Fifty-eight quinazoline-based compounds were designed and synthesized based on the structural optimizations from the lead compound 23bb in an attempt to search for more potent dual HDAC1 and HDAC6 inhibitors. Among them, 32c (HDAC1, IC50 = 31.10 ± 0.37 nM; HDAC6, IC50 = 16.15 ± 0.62 nM) and 32d (HDAC1, IC50 = 37.00 ± 0.24 nM; HDAC6, IC50 = 35.00 ± 0.71 nM) were not only identified as potent dual-acting HDAC1 and HDAC6 inhibitors with over 10-fold selectivity to the other HDACs, but also displayed activities in tubulin acetylation and histone H3 acetylation induction. Importantly, both of them displayed strong antiproliferative activities against various tumor cell lines in vitro with IC50 values <40 nM, especially for hematol. tumors cells (U266 and RPMI8226, IC50 < 1 nM), which were even better than 23bb and SAHA. Furthermore, 32c showed a significant tumor growth inhibition (antitumor rate = 63.98%, p < 0.05) in the resistant MCF-7/ADR xenograft model without any obvious body weight changes and abnormal behaviors. The authors' findings validate that 32c is a potent dual inhibitor of HDAC1/6 that can be an efficacious treatment for breast cancer with Adriamycin resistance. In the experiment, the researchers used Ethyl 5-bromovalerate(cas: 14660-52-7Application of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 626-40-4In 2018 ,《Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase》 appeared in Journal of Medicinal Chemistry. The author of the article were Volkov, Oleg A.; Brockway, Anthony J.; Wring, Stephen A.; Peel, Michael; Chen, Zhe; Phillips, Margaret A.; De Brabander, Jef K.. The article conveys some information:

New therapeutic options are needed for treatment of human African trypanosomiasis (HAT) caused by protozoan parasite Trypanosoma brucei. S-Adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the polyamine pathway of T. brucei. Previous attempts to target this enzyme were thwarted by the lack of brain penetration of the most advanced series. Herein, the authors describe a T. brucei AdoMetDC inhibitor series based on a pyrimidineamine pharmacophore that the authors identified by target-based high-throughput screening. The pyrimidineamines showed selectivity for T. brucei AdoMetDC over the human enzyme, inhibited parasite growth in whole-cell assay, and had good predicted blood-brain barrier penetration. The medicinal chem. program elucidated structure-activity relationships within the series. Features of the series that were required for binding were revealed by determining the x-ray crystal structure of TbAdoMetDC bound to one analog. The pyrimidineamine series provides a novel starting point for an anti-HAT lead optimization. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4SDS of cas: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.SDS of cas: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 17696-11-6In 2022 ,《Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands》 appeared in Journal of Medicinal Chemistry. The author of the article were Zhao, Hong-Yi; Wang, Hai-Peng; Mao, Yu-Ze; Zhang, Hao; Xin, Minhang; Xi, Xiao-Xiao; Lei, Hao; Mao, Shuai; Li, Dong-Hui; Zhang, San-Qi. The article conveys some information:

To overcome the intractable problem of drug resistance, proteolysis targeting chimeras (PROTACs) targeting EGFR mutants were developed by optimizing covalent EGFR ligands. Covalent or reversible covalent pyrimidine- or purine-containing PROTACs were designed, synthesized, and evaluated. As a consequence, covalent PROTAC I, with a novel purine-containing EGFR ligand, was discovered as a highly potent degrader against EGFRL858R/T790M and EGFRdel19, reaching the lowest DC50 values among all reported EGFR-targeting PROTACs. Furthermore, I exhibited excellent cellular activity against the H1975 and HCC827 cell lines with high selectivity. Mechanism investigation indicated that the lysosome was involved in the degradation process. Importantly, the covalent binding strategy was proven to be an effective approach for the design of PROTACs targeting EGFRL858R/T790M, which laid the practical foundation for further development of potent EGFR-targeting PROTACs. After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6Product Details of 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Product Details of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C4H2Br2SIn 2022 ,《Microwave-Assisted Synthesis of 2-Aryl and 2,5-Diarylthiophene Derivatives via Suzuki-Miyaura Cross-Coupling Using Novel Palladium Complex as a Catalyst》 appeared in Polycyclic Aromatic Compounds. The author of the article were Khormi, Afaf Y.; Farghaly, Thoraya. A.; Shaaban, Mohamed R.. The article conveys some information:

A novel phosphine-free pyrimidine-based palladium(II) complex was synthesized from easily accessible starting materials and its ability to be a catalyst for cross-coupling reactions namely, Suzuki-Miyaura (SMC) was investigated. The structure of the new formamidinyl pyrimidine-based complex was elucidated by using spectroscopic as well as phys. characterization techniques. The novel palladium(II) complex showed its applicability as a catalyst for SMC of 2-bromothiophene and 2,5-dibromothiophene with arylboronic acids under conventional and microwaves irradiation conditions. The developed catalytic system exhibited reasonable catalytic activity to obtain 2-aryl and 2,5-diarylthiophene derivatives using mild reaction conditions. The results came from multiple reactions, including the reaction of 2,5-Dibromothiophene(cas: 3141-27-3Computed Properties of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Computed Properties of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 76006-33-2In 2014 ,《Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei》 appeared in Journal of Medicinal Chemistry. The author of the article were Ferrins, Lori; Gazdik, Michelle; Rahmani, Raphael; Varghese, Swapna; Sykes, Melissa L.; Jones, Amy J.; Avery, Vicky M.; White, Karen L.; Ryan, Eileen; Charman, Susan A.; Kaiser, Marcel; Bergstrom, Christel A. S.; Baell, Jonathan B.. The article conveys some information:

A whole-organism screen of approx. 87000 compounds against Trypanosoma brucei identified a number of promising compounds for medicinal chem. optimization. One of these classes of compounds the authors termed the pyridyl benzamides. While the initial hit had an IC50 of 12 μM, it was small enough to be attractive for further optimization, and the authors utilized three parallel approaches to develop the structure-activity relationships. The authors determined that the physicochem. properties for this class are generally favorable with particular positions identified that appear to block metabolism when substituted and others that modulate solubility The most active compound is 79, which has an IC50 of 0.045 μM against the human pathogenic strain Trypanosoma brucei rhodesiense and is more than 4000 times less active against the mammalian L6 cell line. In the experiment, the researchers used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Recommanded Product: 76006-33-2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C8H8Br2In 2021 ,《Static Retention of Dynamic Chiral Arrangements for Achiral Shear Thinning Metal-Organic Colloids》 appeared in Chemistry – A European Journal. The author of the article were Huang, Jian-Cai; Xiao, Hui; Chen, Zhixin; Zheng, Wenxu; Huang, Chang-Cang; Wu, Shu-Ting; Xie, Zenghong; Zhuang, Naifeng. The article conveys some information:

Chiral compounds are known to be important not only because they are the fundamental components of living organisms, but also for their unique chiroptical properties. In recent years, scientists have fabricated several chiral organic supramol. aggregates by using chiral phys. fields, such as vortex flow. Herein, the relationship between dynamic chiroptical properties and rheol. nature is discussed, suggesting the shear thinning properties of non-Newtonian fluids might help colloidal particles adopt a chiral arrangement in vortices. Furthermore, the storage modulus of colloids could be increased by adding a linking agent, which successfully kept the dynamic chiroptical properties in the static state. Moreover, the salt effect on the host-guest interaction involved in the colloids was studied, the results suggested a significant enhancement of the transferred dynamic CD for the achiral guest mol. In the experiment, the researchers used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Electric Literature of C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Electric Literature of C8H8Br2 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2675-79-8In 2020 ,《Tellurides Bearing Sulfonamides as Novel Inhibitors of Leishmanial Carbonic Anhydrase with Potent Antileishmanial Activity》 appeared in Journal of Medicinal Chemistry. The author of the article were Angeli, Andrea; Etxebeste-Mitxeltorena, Mikel; Sanmartin, Carmen; Espuelas, Socorro; Moreno, Esther; Azqueta, Amaya; Parkkila, Seppo; Carta, Fabrizio; Supuran, Claudiu T.. The article conveys some information:

A novel series of tellurides bearing sulfonamide has been reported for the first time as selective and potent inhibitors of the β-class carbonic anhydrase (CA; EC 4.2.1.1) enzyme expressed in Leishmania donovani protozoa. Such derivatives showed high activity against axenic amastigotes, and among them, 4-(((3,4,5-trimethoxyphenyl)tellanyl)methyl)benzenesulfonamide showed an IC50 of 0.02μM being highly selective for the parasites over THP-1 cells with a selectivity index of 300. The in vitro and in vivo toxicity experiments showed this compound to possess a safe profile thus paving the way for tellurium-containing compounds as novel drug entities.1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application of 2675-79-8) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary