Tag: 200-300

HPLC of Formula: 14660-52-7In 2021 ,《Novel Nonsecosteroidal Vitamin D Receptor Modulator Combined with Gemcitabine Enhances Pancreatic Cancer Therapy through Remodeling of the Tumor Microenvironment》 appeared in Journal of Medicinal Chemistry. The author of the article were Kang, Zisheng; Wang, Cong; Tong, Yu; Li, Yanyi; Gao, Yi; Hou, Siyuan; Hao, Meixi; Han, Xiaolin; Wang, Bin; Wang, Qianqian; Zhang, Can. The article conveys some information:

In a pancreatic tumor microenvironment, activated pancreatic stellate cells (PSCs) produce extracellular matrix (ECM) to form a barrier to drug penetration. Moreover, the interaction between cancer cells and activated PSCs promotes the tumor growth. Vitamin D receptor (VDR), as a key regulator to promote the recovery of PSCs to the resting state, is an attractive therapeutic target for pancreatic cancer. Herein, we reported the design and synthesis of 57 nonsecosteroidal VDR modulators based on the skeleton of phenyl-pyrrolyl pentane. Among them, compounds C4, I5, and I8 exhibited excellent VDR affinity and effective inhibition of the activation of PSCs, as well as potent suppression of the interaction between cancer cells and PSCs in vitro. In vivo, compound I5 combined with gemcitabine achieved efficacious antitumor activity without causing hypercalcemia. In conclusion, the compounds designed in our study can remodel the tumor microenvironment and are expected to be candidates for the treatment of pancreatic cancer. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7HPLC of Formula: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.HPLC of Formula: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 629-03-8In 2022 ,《Effect of the Crosslinking Degree on Self-Healing Poly(1,2,3-Triazolium) Adhesive》 appeared in Macromolecular Rapid Communications. The author of the article were Zhang, Jun; Shang, Chengyuan; Yu, Zhuoer; Wang, Linxiao; Tang, Junkun; Huang, Farong. The article conveys some information:

Dynamic covalent materials are a class of polymer that could be stress-relaxation, reprocessable, and self-healing due to dynamic crosslinks in network. Dynamic crosslinks play an important role in the typical characteristic of self-healing polymers. It is meaningful to understand the effect of crosslinking degree on the properties of poly(1,2,3-triazolium) (PTAM). In this article, the dynamic covalent network of PTAM adhesive was used to study the effect of crosslinking degree. PTAM adhesive with different crosslinking degrees were obtained by changing the amount of crosslinker. Adhesion property can rise then fall down with the increase of crosslinking degree and the best lap-shear strength is >20 MPa. Creep resistance and solvent resistance can be enhanced with the increase of crosslinking degree. Self-healing studies showed that crosslinking degree can enhance the ability of self-healing, but too high crosslinking degree raises the temperature of self-healing and causes side reaction which reduces the self-healing efficiency. These results provide some insights for the influence of the crosslinking degree on the self-healing and the structural design of dynamic covalent materials. After reading the article, we found that the author used 1,6-Dibromohexane(cas: 629-03-8HPLC of Formula: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.HPLC of Formula: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hasegawa, Yoko; Cantin, Thomas; Decaens, Jonathan; Couve-Bonnaire, Samuel; Charette, Andre B.; Poisson, Thomas; Jubault, Philippe published an article in 2022. The article was titled 《Catalytic Asymmetric Syntheses of Alkylidenecyclopropanes from Allenoates with Donor-Acceptor and Diacceptor Diazo Reagents》, and you may find the article in Chemistry – A European Journal.Safety of Benzyl 2-bromoacetate The information in the text is summarized as follows:

The first diastereo- and enantioselective cyclopropanation reactions of electron-deficient allenes with donor-acceptor and diacceptor diazo reagents was described. The desired enantioenriched alkylidenecyclopropanes (ACPs) were obtained in high yields with high diastereo- and enantioselectivities in the presence of Rh2((S)-TCPTAD)4 or Rh2((R)-BTPCP)4 catalysts (up to 95% yield, >95 : 5 d.r. and 99 : 1 e.r.). This methodol. gave a direct access to ACPs bearing multiple electron-deficient substituents and allows to further expand the availability of ACPs chem. Interestingly, during the examination of the scope of this reaction, the asym. intramol. C-H insertion reaction into tert-Bu group was observed as a side reaction with up to 94 : 6 e.r. In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Safety of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Kezhuo; Huang, Jiaxin; Zhao, Wanxiang published an article in 2022. The article was titled 《Rh-Catalyzed Coupling of Aldehydes with Allylboronates Enables Facile Access to Ketones》, and you may find the article in Chemistry – A European Journal.SDS of cas: 14660-52-7 The information in the text is summarized as follows:

A novel strategy for the preparation of ketones R1C(O)CHR2CH2CH2R3 (R1 = n-pentyl, cyclohexyl, Ph, 2-thienyl, 4-pyridinyl, etc., R2 = R3 = H; R1 = Ph, R2 = Ph, 4-MeC6H4, 2-naphthyl, 3-furyl, etc., R3 = H; R1 = Ph, R2 = H, R3 = Et, Ph; etc.) from aldehydes R1CHO and allylic boronic esters R2CH:CHCHR3Bpin is presented. This reaction involves the allylation of aldehydes with allylic boronic esters and the Rh-catalyzed chain-walking of homoallylic alcs. The key to this successful development is the protodeboronation of alkenyl boryl ether intermediate via a tetravalent borate anion species in the presence of KHF2 and MeOH. This approach features mild reaction conditions, broad substrate scope, and excellent functional group tolerance. Mechanistic studies also supported that the tandem allylation and chain-walking process are involved.Ethyl 5-bromovalerate(cas: 14660-52-7SDS of cas: 14660-52-7) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.SDS of cas: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Feng, Liheng; Deng, Yang; Wang, Xiaoju; Liu, Mingguang published 《Polymer fluorescent probe for Hg(II) with thiophene, benzothiazole and quinoline groups》.Sensors and Actuators, B: Chemical published the findings.Application of 626-40-4 The information in the text is summarized as follows:

A facile polymer consisted of quinoline, thiophene and benzothiazole groups was designed and synthesized by Suzuki coupling reaction. The study of photophys. property indicated that the polymer was a red light emitter with maximum absorption (490 nm) and emission (610 nm) peaks. The assays of thermal gravimetric anal. (TGA) and cyclic voltammetry (CV) revealed that the polymer possesses good thermal (Td, 228°C) and electrochem. properties. The exptl. data based on the cyclic voltammetry were in good agreement with the results of theor. calculations The sensing processes of the polymer to metal ions were investigated by UV-vis absorption and fluorescence emission spectra. The results showed that the polymer had high selectivity and sensitivity for Hg(II) ions with an obvious “”turn-on”” fluorescence in the presence of Hg(II). Noticeably, the polymer as a fluorescence probe can be applied in the detection in practical samples. The attribution of the work lies in providing a new strategy for design and application of polymer probes in anal. and testing fields. In the experiment, the researchers used 3,5-Dibromoaniline(cas: 626-40-4Application of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Duan, Hongliang; Li, Yu; Arora, Daleep; Xu, Depeng; Lim, Hui-Ying; Wang, Weidong published 《Discovery of a Benzamide Derivative That Protects Pancreatic β-Cells against Endoplasmic Reticulum Stress》.Journal of Medicinal Chemistry published the findings.COA of Formula: C9H9BrO2 The information in the text is summarized as follows:

Endoplasmic reticulum (ER) stress-mediated pancreatic insulin-producing β-cell dysfunction and death are critical elements in the onset and progression of both type 1 and type 2 diabetes. Here, through cell-based high throughput screening the authors identified benzamide derivatives as a novel class of β-cell protective agents against ER stress-induced dysfunction and death. Through structure-activity relationship optimization, a 3-(N-piperidinyl)methyl benzamide derivative I markedly protects β-cells against ER stress-induced dysfunction and death with near 100% maximum rescue activity and an EC50 value of 0.032 μM. Compound I alleviates ER stress in β-cells by suppressing ER stress-mediated activation of all three branches of unfolded protein response (UPR) and apoptotic genes. Finally, the authors show that I significantly lowers blood glucose levels and increases concomitant β-cell survival and number in a streptozotocin-induced diabetic mouse model. Identification of β-cell-protective small mols. against ER stress provides a new promising modality for the treatment of diabetes. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8COA of Formula: C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. COA of Formula: C9H9BrO2 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2015,Park, Kwang-su; Seo, Yujin; Kim, Mi Kyoung; Kim, Kyungdo; Kim, Yun Kyung; Choo, Hyunah; Chong, Youhoon published 《A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer’s disease》.Organic & Biomolecular Chemistry published the findings.Product Details of 626-40-4 The information in the text is summarized as follows:

In recent years, there has been growing interest in the near-IR (NIR) fluorescence imaging of tau fibrils for the early diagnosis of Alzheimer’s disease (AD). In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties. To meet these requirements, we designed a novel curcumin scaffold with various aromatic substituents. Among the series, the curcumin derivative 1c with a (4-dimethylamino-2,6-dimethoxy)phenyl moiety showed a significant change in its fluorescence properties (22.9-fold increase in quantum yield; Kd, 0.77 μM; λem, 620 nm; Φ, 0.32) after binding to tau fibrils. In addition, fluorescence imaging of tau-green fluorescent protein-transfected SHSY-5Y cells with 1c confirmed that 1c detected tau fibrils in live cells. After reading the article, we found that the author used 3,5-Dibromoaniline(cas: 626-40-4Product Details of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Product Details of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2006,Xiao, Xiangshu; Antony, Smitha; Pommier, Yves; Cushman, Mark published 《Total Synthesis and Biological Evaluation of 22-Hydroxyacuminatine》.Journal of Medicinal Chemistry published the findings.Electric Literature of C8H7BrO2 The information in the text is summarized as follows:

A total synthesis of 22-hydroxyacuminatine, a cytotoxic alkaloid isolated from Camptotheca acuminata, is reported. The key step in the synthesis involves the reaction of 2,3-dihydro-1H-pyrrolo[3,4-b]quinoline with a brominated phthalide to generate a substituted pentacyclic 12H-5,11a-diazadibenzo[b,h]fluoren-11-one intermediate. Despite its structural resemblance to camptothecin and luotonin A, a biol. evaluation of 22-hydroxyacuminatine in a topoisomerase I-deficient cell line P388/CPT45 has confirmed that the observed cytotoxicity is not due to topoisomerase I inhibition, even though 22-hydroxyacuminatine has a hydroxyl group that can theor. hydrogen bond to Asp533. This result is consistent with the hypothesis that π-π stacking is more important than hydrogen-bonding interactions in determining topoisomerase I inhibitor binding in the ternary cleavage complex. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Electric Literature of C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Electric Literature of C8H7BrO2 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2003,Gohier, Frederic; Mortier, Jacques published 《ortho-Metalation of Unprotected 3-Bromo and 3-Chlorobenzoic Acids with Hindered Lithium Dialkylamides》.Journal of Organic Chemistry published the findings.Name: 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

Upon treatment of 3-chloro/bromobenzoic acids with hindered lithium dialkylamides (LDA or LTMP) at -50 °C, lithium 3-chloro/bromo-2-lithiobenzoates are generated. These dianions can be trapped as such to afford after electrophilic quenching a variety of simple 2-substituted-3-chloro/bromobenzoic acids. The 3-bromo-2-lithiobenzoate is less stable than the 3-chloro analog and partly eliminates lithium bromide, thus setting free lithium 2,3- and 3,4-dehydrobenzoates that can be intercepted in situ with the hindered base. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Name: 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 3-Bromo-2-methylbenzoic acid Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Temperature-controlled sequential Suzuki-Miyaura reactions for preparing unsymmetrical terphenyls》 were Li, Xinmin; Liu, Chun; Wang, Lei; Ye, Qing; Jin, Xin; Jin, Zilin. And the article was published in Organic & Biomolecular Chemistry in 2018. Quality Control of potassium (3-bromophenyl)trifluoroborate The author mentioned the following in the article:

A one-pot protocol of double Suzuki-Miyaura reactions was developed for the synthesis of unsym. teraryls. In the absence of a ligand, potassium bromophenyltrifluoroborate reacted with arylboronic acid and then sequentially with a hetero/aryl bromide by controlling the reaction temperature, providing unsym. p- and m-teraryl compounds in moderate to good overall yields. This protocol provided a convenient and practically approached to unsym. terphenyls under ligand-free and aerobic conditions.potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8Quality Control of potassium (3-bromophenyl)trifluoroborate) was used in this study.

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Quality Control of potassium (3-bromophenyl)trifluoroborate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary