Tag: 200-300

Synthetic Route of C6H12Br2In 2022 ,《Thermosensitive Microgels Containing AIEgens: Enhanced Luminescence and Distinctive Photochromism for Dynamic Anticounterfeiting》 was published in ACS Applied Materials & Interfaces. The article was written by Dong, Shunni; Zang, Qiguang; Ma, Zhao-Yu; Tang, Meiqi; Xu, Zhi-Kang; Nie, Jingjing; Du, Binyang; Sun, Jing Zhi; Tang, Ben Zhong. The article contains the following contents:

The proposal of the aggregation-induced emission (AIE) effect shines a light on the practical application of luminescent materials. The AIE-active luminescence microgels (TPEC MGs) with photo-induced color-changing behavior were developed by integrating pos. charged AIE luminogens (AIEgens) into the anionic network of microgels, where AIEgens of TPEC were obtained from the quaternization reaction between tetra-(4-pyridylphenyl)ethylene (TPE-4Py) and 7-(6-bromohexyloxy)-coumarin. The aqueous suspensions of TPEC MGs exhibit a significant AIE effect following the enhancement of quantum yield. In addition, further increase in fluorescence intensity and blueshift occur at elevated temperatures due to the collapse of microgels. The distinctive photochromic behavior of TPEC MGs was observed, which presents as the transition from orange-yellow to blue-green color under UV irradiation, which is different from TPEC in good organic solvents. The phenomenon of color changing can be ascribed to the competition between photodimerization of the coumarin part and photocyclization of TPE-4Py in TPEC. The photochromic TPEC MG aqueous suspensions can be conducted as aqueous microgel inks for information display, encryption, and dynamic anticounterfeiting. In the experimental materials used by the author, we found 1,6-Dibromohexane(cas: 629-03-8Synthetic Route of C6H12Br2)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Synthetic Route of C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 626-40-4In 2022 ,《Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer》 was published in Journal of Medicinal Chemistry. The article was written by Biernacki, Karol; Ciupak, Olga; Dasko, Mateusz; Rachon, Janusz; Kozak, Witold; Rak, Janusz; Kubinski, Konrad; Maslyk, Maciej; Martyna, Aleksandra; Sliwka-Kaszynska, Magdalena; Wietrzyk, Joanna; Switalska, Marta; Nocentini, Alessio; Supuran, Claudiu T.; Demkowicz, Sebastian. The article contains the following contents:

Here development of new sulfamoylated 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives I [R = 3-Cl, 3-Br, 3-Et, etc.; X = H, SO2NH2] via sulfamoylation reaction of 4-(1-phenyl1H-1,2,3-triazol-4-yl)phenol derivatives with sulfamoyl chloride as potent steroid sulfatase (STS) inhibitors for the treatment of breast cancer was presented. Prompted by promising biol. results and in silico anal., the initial series of similar compounds were extended, appending a variety of m-substituents at the outer Ph ring. The inhibition profiles of the newly synthesized compounds were evaluated using a radioisotope enzymic assay and, together with the preceding reported derivatives, using a radioisotope assay in MCF-7 cells. The most active compound, I [R = 3,5-di-F, X = SO2NH2], demonstrated an extraordinary STS inhibitory potency in MCF-7 cells with an IC50 value improved 5-fold compared to that of the reference Irosustat (0.21 vs 1.06 nM). The five most potent compounds were assessed in vivo in a 67NR mouse mammary gland cancer model, with I [R = 3,5-di-Cl, X = SO2NH2] measured to induce up to 51% tumor growth inhibition at 50 mg/kg with no evidence of side effects and toxicity. In addition to this study using 3,5-Dibromoaniline, there are many other studies that have used 3,5-Dibromoaniline(cas: 626-40-4Application of 626-40-4) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C8H8Br2In 2020 ,《Triblock Copolymer/Polyoxometalate Nanocomposite Electrolytes with Inverse Hexagonal Cylindrical Nanostructures》 was published in Macromolecular Rapid Communications. The article was written by Zhai, Liang; Chai, Shengchao; Wang, Gang; Zhang, Wei; He, Haibo; Li, Haolong. The article contains the following contents:

The primary issue of polymer electrolytes is to achieve high ion conductivity while retaining mech. properties. A nanocomposite electrolyte with the inverse hexagonal cylindrical phase (three-dimensionally continuous domains for ion conduction and embedded domains for mech. support) is prepared through the electrostatic self-assembly of a polyoxometalate (H3PW12O40, PW) and a triblock copolymer poly(N-vinyl pyrrolidone)-block-polystyrene-block-poly(N-vinyl pyrrolidone) (PSP). The cylindrical nanocomposite exhibits a conductivity of 1.32 mS cm-1 and a storage modulus of 4.6 × 107 Pa at room temperature These two values are higher than those of pristine PSP by two orders of magnitudes and a factor of six, resp. PW clusters are used as multifunctional nano-additives (morphol. inducer, proton conductor, and nano-enhancer) and their incorporation achieves the simultaneous improvement in both conductive and mech. performance. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Formula: C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Formula: C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C9H9BrO2In 2020 ,《On the electron withdrawing nature of ethers in glycosylation chemistry》 appeared in Carbohydrate Research. The author of the article were Marqvorsen, Mikkel H. S.; Brinkoe, Anne; Jensen, Henrik H.. The article conveys some information:

The present review paper is a commentary on the electronic effects that protecting groups exert on glycosylation chem (with new data). Specifically, its purpose is to rectify the misguided use of the term electron donating benzyl groups, which hardly makes sense in the context of protecting groups on alcs. in saturated systems such as carbohydrates. It is argued that benzyl ethers (OBn) should rightfully be referred to as being inductively electron withdrawing, even if they are less so than benzoyl esters (OBz). In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6COA of Formula: C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.COA of Formula: C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Isomechanical Groups in Molecular Crystals and Role of Aromatic Interactions》 was written by Gabriele, Benjamin P. A.; Williams, Craig J.; Lauer, Matthias Eckhard; Derby, Brian; Cruz-Cabeza, Aurora J.. Application of 586-76-5 And the article was included in Crystal Growth & Design in 2020. The article conveys some information:

We have measured mech. properties in mol. crystals of a series of para-substituted benzoic acids using nanoindentation. Two linear correlations were found for these materials: first between the Young’s modulus and the m.p. per unit of volume, and second between the hardness and the crystal cohesive energy d. These correlations, however, were found to only hold within isomech. groups. These are groups of materials with similar interaction strengths and dimensionalities. A close anal. of the intermol. interactions present in these crystals revealed that structures with aromatic rings interacting through t-type interactions may achieve higher interaction dimensionalities and thus result in harder crystals than those with rings interacting through aromatic stacking. In these systems, thus, the dimensionality of the aromatic interactions in the crystals appears to play the major role in their mech. behavior. We correlate mech. properties measured in mol. crystals of a series of para-substituted benzoic acids, first with their m.p. per unit of volume and second with the crystals’ cohesive energy d. Structures with aromatic rings interacting through t-type interactions may achieve higher interaction dimensionalities and thus result in harder crystals than those with rings interacting through aromatic stacking. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of Ionic Ultramicroporous Polymers for Selective Separation of Acetylene from Ethylene》 was written by Suo, Xian; Cui, Xili; Yang, Lifeng; Xu, Nan; Huang, Yuqi; He, Yi; Dai, Sheng; Xing, Huabin. Quality Control of 1,4-Bis(bromomethyl)benzene And the article was included in Advanced Materials (Weinheim, Germany) in 2020. The article conveys some information:

The design of highly stable and efficient porous materials is essential for developing breakthrough hydrocarbon separation methods based on physisorption to replace currently used energy-intensive distillation/absorption technologies. Efforts to develop advanced porous materials such as zeolites, coordination frameworks, and organic polymers have met with limited success. Here, a new class of ionic ultramicroporous polymers (IUPs) with high-d. inorganic anions and narrowly distributed ultramicroporosity is reported, which are synthesized by a facile free-radical polymerization using branched and amphiphilic ionic compounds as reactive monomers. A covalent and ionic dual-crosslinking strategy is proposed to manipulate the pore structure of amorphous polymers at the ultramicroporous scale. The IUPs exhibit exceptional selectivity (286.1-474.4) for separating acetylene from ethylene along with high thermal and water stability, collaboratively demonstrated by gas adsorption isotherms and exptl. breakthrough curves. Modeling studies unveil the specific binding sites for acetylene capture as well as the interconnected ultramicroporosity for size sieving. The porosity-engineering protocol used in this work can also be extended to the design of other ultramicroporous materials for the challenging separation of other key gas constituents. The results came from multiple reactions, including the reaction of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Quality Control of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Quality Control of 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Supramolecular Energetic and Topological Study of Halogenated Aryl Carboxylic Acids》 was written by Teixeira Campos, Patrick; Cunha da Rosa, Bruno Felipe; Saija Hilsinger, Henrique; Auler Milani, Marceo; Uecker Kruger, Vanessa. HPLC of Formula: 586-76-5 And the article was included in Crystal Growth & Design in 2020. The article conveys some information:

A supramol. energetic and topol. study of 12 monohalogenated aryl carboxylic acids (F, Cl, Br, I) in the ortho, meta, and para positions was performed. The energy of intermol. interactions was determined from long-range corrected hybrid d. functional theor. computational calculations, using the ωB97X-D3 method. The surface of contact between the mols. and the mol. coordination numbers were determined From these data, all intermol. interactions were classified, and the robustness of the interactions was evaluated. Thus, the mol. (Mn) allocations around a central mol. (M1) are proposed. In addition, the energy from the intermol. interactions present in the first coordination sphere, which involves the central mol., the energy resulting from the interactions between the peripheral mols. and the total energy of the cluster provided by all interactions, was determined The role of hydrogen bonding (O-H···O, C-H···O, and C-H···X), π···π interactions, and halogen bonding (X···X) were evaluated, in the formation of the first coordination sphere and in the nucleation process. Information from the first coordination sphere helps one to understand the crystal. There is a proposal for nucleation initiation from hydrogen bonds forming dimers and subsequent π···π interactions forming a block. The approximation of these blocks results in the interactions C-H···O, C-H···Cl, and halogen bonds, which lead to three-dimensional supramol. growth until the formation of the crystal. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5HPLC of Formula: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.HPLC of Formula: 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein》 was written by Wang, Mingliang; Lu, Jianfeng; Wang, Mi; Yang, Chao-Yie; Wang, Shaomeng. Application of 14660-52-7 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Src homol. 2 domain-containing phosphatase 2 (SHP2) is an attractive therapeutic target for human cancers and other human diseases. Herein, we report our discovery of potent small-mol. SHP2 degraders whose design is based upon the proteolysis-targeting chimera (PROTAC) concept. This work has led to the discovery of potent and effective SHP2 degraders, exemplified by SHP2-D26. SHP2-D26(I) achieves DC50 values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, resp., and is capable of reducing SHP2 protein levels by >95% in cancer cells. SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines. This study demonstrates that induced SHP2 degradation is a very effective approach to inhibit the function of SHP2. Further optimization of these SHP2 degraders may lead to the development of a new class of therapies for cancers and other human diseases. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Application of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Application of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Ultra-Low Power Electrochromic Heat Shutters Through Tailoring Diffusion-Controlled Behaviors》 was written by In, Ye Ryeong; Kim, Yong Min; Lee, Yujeong; Choi, Won Young; Kim, Se Hyun; Lee, Seung Woo; Moon, Hong Chul. Category: bromides-buliding-blocks And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

In this study, we propose low power consumption, all-in-one type electrochromic devices (ECDs) for effective heat shutters. Considering diffusion-controlled device operation, polymeric viologens (poly-viologens) are synthesized to lower the diffusivity of EC chromophores and to minimize self-bleaching. In comparison with devices based on mono-viologens corresponding to the monomer of poly-viologens, poly-viologen-containing ECDs exhibit advantages of lower coloration voltage (ca, -0.55 V) and higher coloration/bleaching cyclic stability (>1500 cycles). In particular, poly-viologen ECDs show remarkably reduced self-bleaching as designed, resulting in extremely low power consumption (~8.3μW/cm2) to maintain the colored state. Moreover, we successfully demonstrate solar heat shutters that suppress the increment of indoor temperature by taking the advantage of low-power operation and near-IR absorption of the colored poly-viologen-based ECDs. Overall, these results imply that the control of the diffusivity of EC chromophores is an effective methodol. for achieving single-layered, low-power electrochem. heat shutters that can save indoor cooling energy when applied as smart windows for buildings or vehicles.1,4-Bis(bromomethyl)benzene(cas: 623-24-5Category: bromides-buliding-blocks) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Configurationally Random Polythiophene for Improved Polymer Ordering and Charge-Transporting Ability》 was published in ACS Applied Materials & Interfaces in 2020. These research results belong to Opoku, Henry; Lee, Ji Hyeon; Nketia-Yawson, Benjamin; Bae, Seunghwan; Lee, Jae-Joon; Ahn, Hyungju; Jo, Jea Woong. COA of Formula: C4H2Br2S The article mentions the following:

Random polythiophene polymers are characterized by the arbitrary sequence of monomeric units along polymer backbones. These untailored orientations generally results in the twisting of thiophene rings out of the conjugation planarity in addition to steric repulsions experienced among substituted alkyl chains. These tendencies have limited close polymer packing which has been detrimental to charge transport in these moieties. To ameliorate charge transport in these class of polymers, we make use of simple Stille coupling polymerization to synthesize highly random polythiophene polymers. We induced a pos. microstructural change between polymer chains by attuning the ratio between alkyl substituted and non-alkyl substituted monomer units along the backbones. The optimized random polythiophene was found to have enhanced intermol. interaction, increased size of crystallites, and stronger tendency to take edge-orientation compared to both regiorandom and regioregular poly(3-hexylthiophene) polymers. Incorporation of the optimized random polythiophene as an active material in a solid-state electrolyte gate insulator-gated organic field-effect transistors exhibited better performance than control device using regioregular poly(3-hexylthiophene), with a high hole mobility up to 4.52 cm2 V-1 s-1 in ambient condition. The results came from multiple reactions, including the reaction of 2,5-Dibromothiophene(cas: 3141-27-3COA of Formula: C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.COA of Formula: C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary