Tag: 200-300

Formation of C(sp²)-boronate esters by borylative cyclization of alkynes using BCl₃ was written by Warner, Andrew J.;Lawson, James R.;Fasano, Valerio;Ingleson, Michael J.. And the article was included in Angewandte Chemie, International Edition in 2015.Computed Properties of C9H11BrO This article mentions the following:

Arylpropargyl compounds R¹C₆H₄YCH₂C椤氬挵R² undergo cyclization in a reaction with BCl₃ and pinacol, yielding cyclic alkenylboronates I (2, R¹ = H, Me, MeO, Cl; Y = CH₂, NTs, O; R² = Ph, ClC₆H₄, C₆F₅, 3-CF₃C₆H₄, 4-NCC₆H₄, MeC₆H₄, Br, Me, 1-naphthyl, PhCH:CH, 4-NO₂C₆H₄, 4-EtO₂CC₆H₄). Diynes R³C椤氬挵CH₂YCH₂C椤氬挵R³ gave boronates II (R³ = Ph, 10a,b; Y = CH₂, NTs) or III (11, R³ = H, Y = CH₂). BCl₃ is an inexpensive electrophile which induces the borylative cyclization of a wide range of substituted alkynes to regioselectively form polycycles containing synthetically versatile C(sp²)-boronate esters. It proceeds rapidly, with good yields and is compatible with a range of functional groups and substitution patterns. Intermol. 1,2-carboboration of alkynes Ar¹C椤氬挵Me is also achieved using BCl₃ and arene Ar²H to generate trisubstituted vinyl boronate esters Ar¹Ar²C:CMe(Bpin) (12, Ar¹ = Ph, Ar² = 5-methyl-2-thienyl). In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Computed Properties of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Polycyclic heteroaromatics via hydrazine-catalyzed ring-closing carbonyl-olefin metathesis was written by Cho, Eun Kee;Quach, Phong K.;Zhang, Yunfei;Sim, Jae Hun;Lambert, Tristan H.. And the article was included in Chemical Science in 2022.Application of 85118-24-7 This article mentions the following:

The use of hydrazine-catalyzed ring-closing carbonyl-olefin metathesis (RCCOM) to synthesize polycyclic heteroaromatic (PHA) compounds is described. In particular, substrates bearing Lewis basic functionalities such as pyridine rings and amines, which strongly inhibit acid catalyzed RCCOM reactions, are shown to be compatible with this reaction. Using 5 mol% catalyst loadings, a variety of PHA structures can be synthesized from biaryl alkenyl aldehydes, which themselves are readily prepared by cross-coupling. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Application of 85118-24-7).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 85118-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Meta-substituent effects on benzyl free-radical stability was written by Fisher, Thomas H.;Dershem, Stephen M.;Prewitt, M. Lynn. And the article was included in Journal of Organic Chemistry in 1990.COA of Formula: C7H7BrN2O2 This article mentions the following:

A series of 5-substituted 3-cyanotoluenes was synthesized, and the relative rates of N-bromosuccinimide bromination were determined in benzene at 80 鎺矯. The resulting 锜?sub>F^{閳?/sup> values for meta Me, H, Br, NO₂, and CN were found to be 0.03, 0.00, -0.03, -0.04, and -0.10, resp. Of these meta substituents, all but Me were found to be destabilizing to the intermediate benzyl free radical. These meta substituent results are consistent with reported 锜?sub>浼?/sub>閳?/sup> and 锜?sub>c閳?/sup> values and cast doubt upon reports that assume meta substituents have no influence on free-radical stability. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7COA of Formula: C7H7BrN2O2).}

2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.COA of Formula: C7H7BrN2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers was written by Zhao, Peng;Zhuang, Linghang;Wang, Xiangzhu;Huang, Song;Wu, Heping;Zhou, Yu;Yan, Yuna;Zhang, Fan;Shen, Ru;Li, Jing;Liu, Suxing;Zhang, Rumin;Dong, Ping;Mao, Yuchang;Fan, Yuanmin;He, Chunyong;Sun, Jiakang;Zhang, Lei;Hu, Qiyue;Wan, Hong;Feng, Jun;Bai, Chang;He, Feng;Tao, Weikang. And the article was included in European Journal of Medicinal Chemistry in 2022.Formula: C7H7BrFN This article mentions the following:

The RAS-RAF-MEK-ERK signaling pathway plays a key role to regulate multiple cellular functions. Acquired resistance to the first-generation RAF inhibitors that only targeted the bRAF^V600E mutation prompted the need for a new generation of RAF inhibitors to target cancers bearing mutant RAS and wild type RAF activity by inhibition of paradoxical activation. Starting from the company’s previously reported RAF inhibitor 1 (I), extensive drug potency and drug-like properties optimizations led to the discovery of mol. 33 (SHR902275, II) with greatly improved in vitro potency and solubility Mol. 33 exhibited good DMPK (Drug Metabolism and Pharmacokinetics) properties, excellent permeability, and outstanding mouse/rat oral PK. It was further evaluated in an in vivo RAS mutant Calu6 xenograft mouse model and demonstrated dose dependent efficacy. To achieve high exposure in a toxicity study, pro-drug 48 (III) was also explored. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-fluoro-4-methylaniline (cas: 945244-29-1Formula: C7H7BrFN).

5-Bromo-2-fluoro-4-methylaniline (cas: 945244-29-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Formula: C7H7BrFN

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The Skraup reaction of 3,4-dihaloanilines was written by Blatchly, Richard A.;Greeley, Michael A.;Markgraf, J. Hodge. And the article was included in Heterocycles in 1989.SDS of cas: 615-55-4 This article mentions the following:

Six 3,4-dihaloanilines I (R = Br, Cl, F; R¹ = Br, Cl, F, iodo) were converted by the sulfo-mix variation of the Skraup reaction to mixtures of 5,6- and 6,7-dihaloquinolines, II and III resp. Inductive effects were the dominant influence on the course of cyclization: the more highly electron-withdrawing the substituents of I, the greater was the proportion of III. Steric effects were absent. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4SDS of cas: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.SDS of cas: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular palladium(II)/(IV) catalysed C(sp³)-H arylation of tertiary aldehydes using a transient imine directing group was written by St John-Campbell, Sahra;Bull, James A.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Related Products of 61150-57-0 This article mentions the following:

Palladium catalyzed 灏?C(sp³)-H activation of tertiary aldehydes RCH₂C(R₁)(R₂)CHO [R = 2-Br-5-ClC₆H₃, 2-IC₆H₄, 2-Br-4-H₃COC₆H₃, etc.; R₁ = Me, Et, n-Pr; R₂ = Me, Et] using a transient imine directing group enables intramol. arylation to form substituted indane-aldehydes I (R₄ = H, 5-F, 4-Cl, 5-CF₃, etc.). A simple amine bearing a Me ether (2-methoxyethan-1-amine) is the optimal TDG to promote C-H activation and reaction with an unactivated proximal C-Br bond. Substituent effects are studied in the preparation of various derivatives Preliminary mechanistic studies identify a reversible C-H activation and product inhibition and suggest that oxidative addition is the turnover limiting step. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

1-Ethoxy-3-trifluoromethyl-1,3-butadiene and congeners as Diels-Alder components opening an entry to functionalized (trifluoromethyl)benzenes and -pyridines was written by Volle, Jean-Noel;Schlosser, Manfred. And the article was included in European Journal of Organic Chemistry in 2002.Related Products of 107317-58-8 This article mentions the following:

1-Ethoxy-3-trifluoromethyl-1,3-butadiene and its 2-bromo- and 2-phenyl-substituted derivatives have been prepared by Wittig methylenation of the corresponding 4-ethoxy-1,1,1-trifluoro-3-buten-2-ones, which in turn are readily accessible from trifluoroacetic acid. The electron-rich/electron-poor dienes combine smoothly with di-Me acetylenedicarboxylate and Me propiolate to provide trifluoromethyl-substituted phthalates or benzoates. Satisfactory yields of 4-(trifluoromethyl)pyridinecarboxylic acids can even be achieved with Me cyanoformate, a less reactive dienophile, if a large excess of the dienophile is employed. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8Related Products of 107317-58-8).

Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 107317-58-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-catalyzed cross-electrophile coupling of aryl bromides and cyclic secondary alkyl bromides with spiro-bidentate-pyox ligands was written by Gao, Nanxing;Li, Yanshun;Cao, Guorui;Teng, Dawei. And the article was included in New Journal of Chemistry in 2021.Category: bromides-buliding-blocks This article mentions the following:

The cross-electrophile coupling of aryl bromides RBr [R = Ph, 4-(ethoxycarbonyl)phenyl, 1-(1H-indol-1-yl)ethan-1-one, etc.] and cyclic secondary alkyl bromides I [R¹ = ethoxycarbonyl, (benzyloxy)carbonyl, (4-methylbenzene)sulfonyl, etc., X = (CH₂)_n, n = 1, 2] catalyzed by nickel/spiro-bidentate-pyox ligands, e.g., II, with lithium chloride as the additive for the Csp²-Csp³ bond formation is reported. The reaction could tolerate functional groups such as sulfonamide, ester, aldehyde, ketone, protected indolyl, tert-butoxycarbonyl, aryl nitriles and aryl chloride. Various aryl-cyclic secondary alkyl Csp²-Csp³ bond products, e.g., III, were synthesized under optimal reaction conditions (19 examples). In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Category: bromides-buliding-blocks).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Diboronic Acid-Based Fluorescent Probes for the Sensitive Detection of Glucose in Aqueous Media and Biological Matrices was written by Wang, Kai;Zhang, Ruixiao;Yue, Xinmin;Zhou, Zheng;Bai, Lihuan;Tong, Yue;Wang, Bei;Gu, Dening;Wang, Shuo;Qiao, Yanqi;Liu, Qian;Xue, Xue;Yin, Yongmei;Xi, Rimo;Meng, Meng. And the article was included in ACS Sensors in 2021.HPLC of Formula: 166821-88-1 This article mentions the following:

Reliable and accurate glucose detection in biol. samples is of great importance in clin. diagnosis and medical research. Chem. probes are advantageous in simple operation and flexible design, especially for the development of fluorescent probes. Anthracene-based diboronic acid (P-DBA) has shown potential in glucose probing because of its high sensitivity. However, poor solubility limits its applications in aqueous media. In this work, we systemically modify P-DBA by introducing fluoro (F-), chloro (Cl-), methoxyl (MeO-), or cyano (CN-) substituents. Among these probes, the cyano-substituted probe (CN-DBA) displays the highest glucose-binding constant (6489.5 M^-1, 33% MeOH). More importantly, it shows good water solubility in the aqueous solution (0.5% MeOH), with ultrasensitive recognition with glucose (LOD = 1.51 娓璏) and robust sensing from pH 6.0 to 9.0. Based on these features, the CN-DBA is finally applied to detect glucose in cell lysates and plasma, with satisfactory recovery and precision. These results demonstrate that CN-DBA could serve as an accurate, sensitive fluorescent probe for glucose assays in biol. samples. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1HPLC of Formula: 166821-88-1).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 166821-88-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Electroreductive Syntheses of Triphenylenes Using ortho-Dihalobenzene-Derived Benzynes was written by Li, Zhao-Ming;Shuai, Bin;Ma, Cong;Fang, Ping;Mei, Tian-Sheng. And the article was included in Chinese Journal of Chemistry in 2022.HPLC of Formula: 615-55-4 This article mentions the following:

Electrochem. nickel-catalyzed syntheses of triphenylenes e.g., I, by a reductive trimerization of ortho-dibromobenzenes e.g.., 5,6-dibromoindane or ortho-bromoarylsulfurofluoridates e.g., 2-bromo-4-fluorophenyl sulfurofluoridate, or by reductive cross-coupling of ortho-dibromobenzenes to 2,2′-diiodobiphenyls, were described. The former provides a practical means for the construction of triphenylene derivatives e.g., ,I in up to 87% isolated yield at room temperature For 1,2-dihalo-3-methylbenzenes and related ortho-trisubstituted substrates, trimerizations proceed with high substrate-controlled regioselectivity for the non-C3h sym. triphenylene isomer. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4HPLC of Formula: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary