Tag: 200-300

Feizi, Zahra Hosseinpour; Fatehi, Pedram published their research in Carbohydrate Polymers in 2021. The article was titled 《Interaction of hairy carboxyalkyl cellulose nanocrystals with cationic surfactant: Effect of carbon spacer》.Quality Control of 8-Bromooctanoic acid The article contains the following contents:

Tuning the surface chem. of nanocellulose is essential for developing its end-use applications. Herein, different carboxyalkylated cellulose nanocrystals (CNC) with similar charge densities but with tunable hairy structures were produced. The effect of carbon spacer of the grafted groups on the interaction of the CNC and a cationic surfactant, myristyl tri-Me ammonium bromide (MTAB), at different pH and salinity was explored. The CNC with longer grafted chain length was more hydrophobic, adsorbed more MTAB, and formed a more compact MTAB ad-layer than did CNC with the shorter chain length. Also, the adsorption was higher at neutral pH, implying a high electrostatic attraction and hydrophobic interaction between substrates. The hydrophobic interaction of MTAB and hairy CNC in saline systems improved its adsorption. Although MTAB adsorbed more when its concentration was higher than its critical micelle concentration (CMC), the adsorbed ad-layer had a less compact structure on the CNC surfaces. The experimental part of the paper was very detailed, including the reaction process of 8-Bromooctanoic acid(cas: 17696-11-6Quality Control of 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Quality Control of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

OuYang, Yiqiang; Gao, Jian; Zhao, Lei; Lu, Junfeng; Zhong, Haiqing; Tang, Hua; Jin, Shuanglong; Yue, Lu; Li, Yuezhen; Guo, Wenjie; Xu, Qiang; Lai, Yisheng published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Design, Synthesis, and Evaluation of o-(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy In Vivo》.Product Details of 76006-33-2 The article contains the following contents:

Two series of novel o-(biphenyl-3-ylmethoxy)nitrophenyl compounds I (R1 = 2-hydroxyethylamino, furan-ylmethylamino, (2-acetamidoethyl)aminyl, etc.; R2 = H, Me, Br) and II (R3 = 3-cyanobenzyloxy, 3-pyridinylmethoxy, 2-cyanopyridin-4-ylmethoxy) were designed as programmed cell death protein 1 (PD-1)/PD-ligand 1 (PD-L1) inhibitors. All compounds showed significant inhibitory activity with IC50 values ranging from 2.7 to 87.4 nM except compound I (R1 = (2S)-2-aminyl-3-hydroxybutanoic acid), and compound II (III, R1 = (2S)-2-aminyl-3-hydroxybutanoic acid; R3 = 3-cyanobenzyloxy) displayed the best activity. Further experiments showed that III bound to the PD-L1 protein without obvious toxicity in Lewis lung carcinoma (LLC) cells. Furthermore, III significantly promoted interferon-gamma secretion in a dose-dependent manner in vitro and in vivo. Especially, III exhibited potent in vivo anticancer efficacy in an LLC-bearing allograft mouse model at a low dose of 5 mg/kg, which was more active than BMS-1018 (tumor growth inhibition rate: 48.5% vs 17.8%). A panel of immunohistochem. and flow cytometry assays demonstrated that III effectively counteracted PD-1-induced immunosuppression in the tumor microenvironment, thereby triggering antitumor immunity. These results indicate that III is a promising PD-1/PD-L1 inhibitor worthy of further development. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Product Details of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. Product Details of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Su, Yingpeng; He, Haiyang; Zhao, Yanan; Li, Qinling; Feng, Yawei; Cao, Guiyan; Huang, Danfeng; Wang, Ke-Hu; Huo, Congde; Hu, Yulai published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Sulfide-Catalyzed Diastereoselective Spirocyclopropanation: Constructing Spiro-cyclopropanyl-pyrazolones From α-Arylidenepyrazolones》.Category: bromides-buliding-blocks The article contains the following contents:

An efficient and diastereoselective [2+1] annulation of arylidenepyrazolones with bromides was developed that relies on in-situ formation of sulfur ylide via a direct sulfide-catalyzed process. A variety of spirocyclopropanyl pyrazolones were achieved in good to excellent yields (up to 93% yield) with high diastereoselectives (up to 20 : 1 dr). Meanwhile, several spirocyclopropanyl compounds were also prepared from corresponding enones. This catalytic strategy exhibited good functional group tolerance, gram-scale capacity and broad substrate scope and provided various spirocyclopropanyl derivativesBenzyl 2-bromoacetate(cas: 5437-45-6Category: bromides-buliding-blocks) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Xiaoju; Li, Ying; Zhou, Sirong; Feng, Liheng published their research in Shanxi Daxue Xuebao, Ziran Kexueban in 2021. The article was titled 《Effective antibacterial agent with double arm clamp configuration for treatment of wound infections》.Application In Synthesis of 1,4-Bis(bromomethyl)benzene The article contains the following contents:

Pathogenic bacteria are always one of threat to human health. Developing novel and effective bactericides to replace current antibiotics is significant and imperative. A pyridine quaternary ammonium salt with double arm clamp configuration as an antibacterial material was designed and synthesized. By taking advantage of the bridging role and electron donating action of 2,2′-bis(4-(bromomethyl)benzyloxy)-1,1′-dinaphthalene, two pyridine mols. can join together to obtain increased pos. charges and antibacterial acivity. The synthesized antibacterial material can effectively kill three common pathogenic bacteria including Escherichia coli (ampicillin-resistant), Pseudomonas aeruginosa, and Salmonella typhimurium at a low concentration The mechanism of membrane-disrupted is proved to be related to the interaction with lipopolysaccharide. Furthermore, it is successfully applied to the treatment of bacteria-infected wound of living mice without obvious biotoxicity. In the experiment, the researchers used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application In Synthesis of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 1,4-Bis(bromomethyl)benzene Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Wang, Junhua; Li, Guo-Xing; He, Gang; Chen, Gong published 《Photoredox-mediated Minisci alkylation of N-heteroarenes using carboxylic acids and hypervalent iodine》.Asian Journal of Organic Chemistry published the findings.Related Products of 17696-11-6 The information in the text is summarized as follows:

A new protocol of photoredox-mediated Minisci alkylation of N-heteroarenes with aliphatic carboxylic acids was developed to obtain alkylated heterocycles e.g. I. Using Ru(bpy)3Cl2 as photocatalyst and acetoxybenziodoxole as oxidant, a variety of primary, secondary and tertiary alkyl groups could be efficiently incorporated into various electron-deficient N-heteroarenes. This protocol demonstrated excellent substrate scope and good functional group tolerance and could applied to late-stage functionalization of complex mols. The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Related Products of 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Related Products of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Legarda, Pablo D.; Garcia-Rubia, Alfonso; Gomez Arrayas, Ramon; Carretero, Juan C. published 《Palladium-Catalyzed Remote ortho-C-H Alkenylation of Alkyl Aryl Sulfones: Access to Densely Functionalized Indane Derivatives》.Advanced Synthesis & Catalysis published the findings.Safety of Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:

A practical method for the palladium-catalyzed ortho-olefination of benzyl and phenethyl 2-pyridyl sulfones with electron-deficient alkenes using N-fluoro-2,4,6-trimethylpyridinium triflate ([F+]) as the terminal oxidant is described. The chelating auxiliary (2-pyridyl)sulfonyl unit was demonstrated to be the key to the success of this reaction, which occurs efficiently with excellent regioselectivity and monosubstitution selectivity. A variety of steric and electronic changes to both coupling partners is tolerated, including substitution at the benzylic position of the sulfone compound Furthermore, no appreciable loss of enantiopurity is observed when using non-racemic substrates. This method provides access to indane derivatives holding three contiguous stereogenic centers with high diastereocontrol. The indane framework was constructed by intramol. Michael addition of the α-sulfonyl carbanion to the electrophilic alkene. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Safety of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Safety of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2011,Chandrakantha, B.; Isloor, Arun M.; Philip, Reji; Mohesh, M.; Shetty, Prakash; Vijesh, A. M. published 《Synthesis and nonlinear optical characterization of new 1,3,4-oxadiazoles》.Bulletin of Materials Science published the findings.Formula: C8H7BrO2 The information in the text is summarized as follows:

1,3,4-Oxadiazole derivatives containing 2-fluoro-4-methoxy Ph were synthesized by refluxing mixture of acid hydrazide with different aromatic carboxylic acids in phosphorous oxychloride. These newly synthesized compounds were characterized by NMR, mass spectral, and IR spectral studies, and also by C, H, N analyses. The open-aperture z-scan experiment was employed to measure the optical nonlinearity of the samples at 532 nm, using 5 ns laser pulses. The measurements indicate that one of the compounds which contains Br, behaves as an optical limiter at this wavelength, with potential applications in optoelectronics. The experimental part of the paper was very detailed, including the reaction process of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Formula: C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Formula: C8H7BrO2 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 1993,Stoilov, Ivan; Watt, David S.; Goodman, Jack P.; St. Pyrek, Jan published 《Synthesis of detomidine and medetomidine metabolites: 1,2,3-trisubstituted arenes with 4′(5′)-imidazolylmethyl groups》.Journal of Heterocyclic Chemistry published the findings.Electric Literature of C8H7BrO2 The information in the text is summarized as follows:

Two synthetic strategies permitted the synthesis of various metabolites of detomidine (I, R = H, X = Me) and medetomidine I (R = X = Me), potent α-2 adrenoceptor agonists that undergo rapid oxidative metabolism at the aromatic Me group distal to the imidazole ring. In the detomidine series, the addition of a Grignard reagent prepared from 2-[(3′,4′-dimethoxyphenyl)methoxy]methyl-6-bromotoluene to imidazole-4(5)-carboxyaldehyde provided 2-(((3′,4′-dimethoxyphenyl)methoxy)methyl)-6-(1′-hydroxy-1′-(5”-imidazolyl)methyl)toluene. In a subsequent reduction, it was possible to differentiate between the secondary benzylic hydroxyl group and the primary benzylic hydroxyl group protected as a 3,4-dimethoxybenzyl ether. Removal of the protecting group provided 3-(hydroxymethyl)detomidine (3-HD) I (R = H, X = CH2OH) and an oxidation furnished 3-carboxydetomidine (3-CD) I (R = H, X = CO2H). However, in the medetomidine series, a similar hydrogenolysis of 2-(((3′,4′-dimethoxyphenyl)methoxy)methyl)-6-(1′-hydroxy-1′-(5”-imidazolyl)methyl)toluene failed, and an alternate, longer route involving dehydration and reduction was necessary to secure 3-(hydroxymethyl)medetomidine (3-HM) I (R = Me, X = CH2OH) and following an oxidation, 3-carboxymedetomidine (3-CM) I (R = Me, X = CO2H). Finally, an expeditious route to 3-CM involved the addition of the Grignard reagent prepared from 2-(3-bromo-2-methylphenyl)-4,4-dimethyl-2-oxazoline to 4-acetyl-1H-imidazole and the hydrogenolysis and hydrolysis of 2-(1-(4,4-dimethyl-2-oxazolyl))-6-(1′-oxo-1′-(5′-imidazolyl)methyl)toluene. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Electric Literature of C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Electric Literature of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Triazine-Based Janus G-C Nucleobase as a Building Block for Self-Assembly, Peptide Nucleic Acids, and Smart Polymers》 was written by Meena, Chhuttan L.; Singh, Dharmendra; Kizhakeetil, Bhavya; Prasad, Manasa; George, Malini; Tothadi, Srinu; Sanjayan, Gangadhar J.. COA of Formula: C9H9BrO2This research focused ontriazine Janus carbon nucleobase building block selfassembly peptide; peptide nucleic acid smart polymer triazine Janus nucleobase selfassembly. The article conveys some information:

This communication reports on the utility of a triazine-based self-assembling system, reminiscent of a Janus G-C nucleobase, as a building block for developing (1) supramol. polymers, (2) peptide nucleic acids (PNAs), and (3) smart polymers. The strategically positioned self-complementary triple H-bonding arrays DDA and AAD facilitate efficient self-assembly, leading to a linear supramol. polymer. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6COA of Formula: C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.COA of Formula: C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase》 was written by Shaw, Scott A.; Vokits, Benjamin P.; Dilger, Andrew K.; Viet, Andrew; Clark, Charles G.; Abell, Lynn M.; Locke, Gregory A.; Duke, Gerald; Kopcho, Lisa M.; Dongre, Ashok; Gao, Ji; Krishnakumar, Arathi; Jusuf, Sutjano; Khan, Javed; Spronk, Steven A.; Basso, Michael D.; Zhao, Lei; Cantor, Glenn H.; Onorato, Joelle M.; Wexler, Ruth R.; Duclos, Franck; Kick, Ellen K.. Synthetic Route of C9H9BrO2This research focused ontriazolopyridine preparation myeloperoxidase inhibitor; structure arylmethyl aminophenylpropyl triazolopyridine inhibition myeloperoxidase selectivity; Atherosclerosis; Myeloperoxidase; Triazolopyridine. The article conveys some information:

Myeloperoxidase (MPO) is a heme peroxidase found in neutrophils, monocytes and macrophages that efficiently catalyzes the oxidation of endogenous chloride into hypochlorous acid for antimicrobial activity. Chronic MPO activation can lead to indiscriminate protein modification causing tissue damage, and has been associated with chronic inflammatory diseases, atherosclerosis, and acute cardiovascular events. A previously-known benzyloxy triazolopyrimidine was a reversible MPO inhibitor; however it suffered from poor stability in acid, and is an irreversible inhibitor of the DNA repair protein Me guanine Me transferase (MGMT). Structure-based drug design was employed to discover benzyl triazolopyridines such as I with improved MPO potency, as well as acid stability, no reactivity with MGMT, and selectivity against thyroid peroxidase (TPO). Structure-activity relationships, a crystal structure of the MPO-inhibitor complex, and acute in vivo pharmacodynamic data are described herein. In addition to this study using Methyl 3-(bromomethyl)benzoate, there are many other studies that have used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Synthetic Route of C9H9BrO2) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Synthetic Route of C9H9BrO2 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary