Tag: 200-300

Recommanded Product: 586-76-5In 2021 ,《Synthesis and Acidity of 5-(m-Terphenyl-2′-yl)-1H-tetrazoles: Evidence for an Enhanced Polar-π Effect Compared to Carboxylic Acids》 was published in Journal of Medicinal Chemistry. The article was written by Bookser, Brett C.; Do, Quyen-Quyen; Sritana-Anant, Yongsak; Baldridge, Kim K.; Siegel, Jay S.. The article contains the following contents:

The polar-π effect on tetrazoles, medicinal chem. isosteres of carboxylate, is tested by a Hammett pKa (microtitration) anal. over a series of 5-(m-terphenyl-2′-yl)-1H-tetrazoles. A comparison with m-terphenyl-2′-yl-carboxylic acids supports the isostere analogy also in response to environmental changes. Computational (B97D/def2TZVPPD) extension of the series plus a scan of solvents (vacuum to water) demonstrates the trend with the dielec. constant The effect is energetically small but may make statistically significant contributions to the tetrazole pharmacol. profile. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of Methyl 3-(bromomethyl)benzoateIn 2017 ,《Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation》 was published in Journal of Medicinal Chemistry. The article was written by Smith, Thomas P.; Windsor, Ian W.; Forest, Katrina T.; Raines, Ronald T.. The article contains the following contents:

Transthyretin (TTR) is a homotetrameric protein. Its dissociation into monomers leads to the formation of fibrils that underlie human amyloidogenic diseases. The binding of small mols. to the thyroxin-binding sites in TTR stabilizes the homotetramer and attenuates TTR amyloidosis. Herein, we report on boronic acid-substituted stilbenes that limit TTR amyloidosis in vitro. Assays of affinity for TTR and inhibition of its tendency to form fibrils were coupled with X-ray crystallog. anal. of nine TTR·ligand complexes. The ensuing structure-function data led to a sym. diboronic acid that forms a boronic ester reversibly with serine 117. This diboronic acid inhibits fibril formation by both wild-type TTR and a common disease-related variant, V30M TTR, as effectively as does tafamidis, a small-mol. drug used to treat TTR-related amyloidosis in the clinic. These findings establish a new modality for covalent inhibition of fibril formation and illuminate a path for future optimization. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Quality Control of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of Methyl 3-(bromomethyl)benzoate Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 3141-27-3In 2022 ,《Silver salt enabled H/D exchange at the β-position of thiophene rings: synthesis of fully deuterated thiophene derivatives》 was published in Organic & Biomolecular Chemistry. The article was written by Sheng, Fei-Fei; Li, En-Ci; Bai, Jing-Wen; Wang, Cai-Xia; Hu, Guang-Qi; Liu, Kai-Hui; Sun, Zheng-Yi; Shen, Kang; Zhang, Hong-Hai. The article contains the following contents:

We disclose a silver catalyzed H/D exchange reaction, which can introduce the deuterium atom at the β position of thiophene rings without the assistance of any coordinating groups. The advantages of this reaction include operation in open air, usage of D2O as the deuterium source, good tolerance to a range of functional groups and obtaining high atom% deuterium incorporation. In addition, this H/D exchange reaction is employed for direct deuteration of a thiophene based monomer, which is usually prepared by multistep synthesis from expensive deuterated starting materials. In addition to this study using 2,5-Dibromothiophene, there are many other studies that have used 2,5-Dibromothiophene(cas: 3141-27-3SDS of cas: 3141-27-3) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .SDS of cas: 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C9H9BrO2In 2016 ,《Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors》 appeared in Organic & Biomolecular Chemistry. The author of the article were De Vreese, Rob; Depetter, Yves; Verhaeghe, Tom; Desmet, Tom; Benoy, Veronick; Haeck, Wanda; Van Den Bosch, Ludo; D’hooghe, Matthias. The article conveys some information:

The synthesis of novel isoform-selective HDAC inhibitors is considered to be an important, emerging field in medicinal chem. In this paper, the preparation and assessment of thirteen selective HDAC6 inhibitors is disclosed, elaborating on a previously developed thiaheterocyclic Tubathian series. All compounds were evaluated in vitro for their ability to inhibit HDAC6, and a selection of five potent compounds was further screened toward all HDAC isoforms (HDAC1-11). The capability of these Tubathian analogs to inhibit α-tubulin deacetylation was assessed as well, and ADME/Tox data were collected. This thorough SAR evaluation revealed that the oxidized, para-substituted hydroxamic acids can be recognized as valuable lead structures in the pursuit of novel potent and selective HDAC6 inhibitors. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Electric Literature of C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Electric Literature of C9H9BrO2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jankowska, Agnieszka; Satala, Grzegorz; Swierczek, Artur; Pociecha, Krzysztof; Partyka, Anna; Jastrzebska-Wiesek, Magdalena; Gluch-Lutwin, Monika; Bojarski, Andrzej J.; Wyska, Elzbieta; Chlon-Rzepa, Grazyna published an article in 2021. The article was titled 《A new class of 5-HT1A receptor antagonists with procognitive and antidepressant properties》, and you may find the article in Future Medicinal Chemistry.Quality Control of Ethyl 5-bromovalerate The information in the text is summarized as follows:

5-HT1A receptor antagonists constitute a potential group of drugs in the treatment of CNS diseases. The aim of this study was to search for new procognitive and antidepressant drugs among amide derivatives of aminoalkanoic acids with 5-HT1A receptor antagonistic properties. Thirty-three amides were designed and evaluated in silico for their drug-likeness. The synthesized compounds were tested in vitro for their 5-HT1A receptor affinity and functional profile. Moreover, their selectivity over 5-HT7, 5-HT1A and D2 receptors and ability to inhibit phosphodiesterases were evaluated. A selected 5-HT1A receptor antagonist 20 (Ki = 35 nM, Kb = 4.9 nM) showed procognitive and antidepressant activity in vivo. Novel 5-HT1A receptor antagonists were discovered and shown as potential psychotropic drugs. In addition to this study using Ethyl 5-bromovalerate, there are many other studies that have used Ethyl 5-bromovalerate(cas: 14660-52-7Quality Control of Ethyl 5-bromovalerate) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Quality Control of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Song, Yang; Zhang, Hao; Guo, Jiabao; Shao, Yifei; Ding, Yuzhou; Zhu, Li; Yao, Xiaoquan published an article in 2021. The article was titled 《Visible-light-induced oxidative α-alkylation of glycine derivatives with ethers under metal-free conditions》, and you may find the article in European Journal of Organic Chemistry.Recommanded Product: 5437-45-6 The information in the text is summarized as follows:

In this work, a visible-light-induced oxidative α-alkylation of glycine derivatives with ethers has been developed in the presence of catalytic Eosin Y. Under the blue light of a 3 W LED, a range of α-etherized glycine derivatives, including α-amino esters, α-amino ketones and α-amino amides, were achieved with good to excellent yields and functional group tolerance with tert-Bu hydroperoxide (TBHP) as oxidant at ambient temperature The operationally easy procedure provides an economical, metal-free, and mild alternative for the synthesis of the α-etherized glycine derivatives The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Recommanded Product: 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vankova, Karolina; Rahm, Michal; Choutka, Jan; Pohl, Radek; Parkan, Kamil published their research in Chemistry – A European Journal in 2021. The article was titled 《Facile Approach to C-Glucosides by Using a Protecting-Group-Free Hiyama Cross-Coupling Reaction: High-Yielding Dapagliflozin Synthesis》.Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene The article contains the following contents:

Access to unprotected (hetero)aryl pseudo-C-glucosides via a mild Pd-catalyzed Hiyama cross-coupling reaction of protecting-group-free 1-diisopropylsilyl-D-glucal with various (hetero)aryl halides has been developed. In addition, selected unprotected pseudo-C-glucosides were stereoselectively converted into the corresponding α- and β-C-glucosides, as well as 2-deoxy-β-C-glucosides. This methodol. was applied to the efficient and high-yielding synthesis of dapagliflozin, a medicament used to treat type 2 diabetes mellitus. Finally, the versatility of our methodol. was proved by the synthesis of other analogs of dapagliflozin. In addition to this study using 1-Bromo-3,4,5-trimethoxybenzene, there are many other studies that have used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Q.; Sun, L. X.; Gao, W. T.; Zhu, Z. Y.; Gao, X.; Zhang, Q. G.; Zhu, A. M.; Liu, Q. L. published their research in Journal of Colloid and Interface Science in 2021. The article was titled 《Crown ether-based anion exchange membranes with highly efficient dual ion conducting pathways》.Formula: C6H12Br2 The article contains the following contents:

Anion exchange membranes (AEMs) are a crucial constituent for alk. fuel cells. As the core component of fuel cells, the low performance AEMs restrict the development and application of the fuel cells. Herein, the trade-off between the OH- conductivity and dimensional stability was solved by constructing AEMs with adequate OH- conductivity and satisfactory alkali resistance using Troger′s base (TB) poly (crown ether)s (PCEs) as the main chain, the embedded quaternary ammonium (QA) and Na+-functionalized crown ether units as the cationic group. Crown ether is an electron donator, and can capture Na+ to form Na+-functionalized crown ether units to conveniently transfer OH- and significantly promote the alk. stability of the AEMs. The influence of the Na+-functionalized crown ether units on the performance of AEMs was studied in detail. The PCEs based AEMs show an obvious hydrophobic-hydrophilic microphase separation These features make them ideal platforms for the OH- conduction applications. As expected, the as-prepared PCEs-QA-100% (100% is the degree of crosslinking) AEM with an ionic exchange capacity (IEC) of 2.07 meq g-1 has a high OH- conductivity of 159 mS cm-1 at 80 °C. Furthermore, the membrane electrode assemblies fabricated using the PCEs-QA-100% AEM possess a maximum power d. of 291 mW cm-2 under the c.d. of 500 mA cm-2. In addition to this study using 1,6-Dibromohexane, there are many other studies that have used 1,6-Dibromohexane(cas: 629-03-8Formula: C6H12Br2) was used in this study.

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Formula: C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rech, Jeromy James; Yan, Liang; Wang, Zhen; Zhang, Qianqian; Bradshaw, Spencer; Ade, Harald; You, Wei published their research in ACS Applied Polymer Materials in 2021. The article was titled 《Functionalization of Benzotriazole-Based Conjugated Polymers for Solar Cells: Heteroatom vs Substituents》.Synthetic Route of C4H2Br2S The article contains the following contents:

With the recent remarkable advances in the efficiency of organic solar cells, the need to distill key structure-property relationships for semiconducting materials cannot be understated. The fundamental design criteria based on these structure-property relationships will help realize low-cost, scalable, and high-efficiency materials. In this study, we systematically explore the impact of a variety of functional groups, including nitrogen heteroatoms, fluorine substituents, and cyano groups, on benzotriazole (TAZ)-based acceptor moieties that are incorporated into the conjugated polymers. Specifically, a pyridine heterocycle was used to replace the benzene unit of TAZ, leading to the PyTAZ polymer, and a cyano substituent was added to the benzene of the TAZ unit, resulting in the CNTAZ polymer. The PyTAZ polymer suffers from low mobility and poor exciton harvesting, driven by large and excessively pure domains when blended with PCBM. The inclusion of fluorine substituents, placed strategically along the polymer backbone, can mitigate these issues, as shown with 4FT-PyTAZ. However, when this same approach is used for the cyano-functionalized polymer (CNTAZ), the resulting polymer (4FT-CNTAZ) is overfunctionalized and suffers from impure domains and recombination issues. The cyano group has a larger impact on the TAZ core compared to the nitrogen heteroatom due to the strong electron-withdrawing strength of the cyano group. Because of this, further functionalization of the cyano-based polymers has less fruitful impact on the polymer properties and results in deterioration of the solar cell efficiency. Overall, this work highlights some of the benefits, thresholds, and limitations for functionalization of conjugated polymers for organic solar cells. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Synthetic Route of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Synthetic Route of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Borlinghaus, Niginia; Kaschel, Johannes; Klee, Johanna; Haller, Vanessa; Schetterl, Jasmin; Heitz, Stephanie; Lindner, Tanja; Dietrich, Justin D.; Braje, Wilfried M.; Jolit, Anais published their research in Journal of Organic Chemistry in 2021. The article was titled 《Reagent and Catalyst Capsules: A Chemical Delivery System for Reaction Screening and Parallel Synthesis》.Category: bromides-buliding-blocks The article contains the following contents:

Com. available hydroxypropyl methylcellulose capsules are employed as a fast, safe, and user-friendly chem. delivery system containing all reagents (catalyst, ligand, and base) for three important transition-metal-catalyzed reactions: Buchwald-Hartwig, Suzuki-Miyaura, and metallophotoredox C-N cross-coupling reactions. This encapsulation methodol. simplifies the screening of reaction conditions and the preparation of compound libraries using parallel synthesis in organic solvents or aqueous media. These reagents-containing HPMC capsules are easy to prepare, come in different sizes, and can be stored on the bench under noninert conditions. In addition to this study using 1-Bromo-4-(trifluoromethyl)benzene, there are many other studies that have used 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Category: bromides-buliding-blocks) was used in this study.

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary